{"id":"https://openalex.org/W7225825978","doi":"https://doi.org/10.3390/nu18223738","title":"Whole-Blood Copper Concentrations in Patients with Atrial Fibrillation According to Amiodarone Use: An Exploratory Study","display_name":"Whole-Blood Copper Concentrations in Patients with Atrial Fibrillation According to Amiodarone Use: An Exploratory Study","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225825978","doi":"https://doi.org/10.3390/nu18223738"},"language":"en","primary_location":{"id":"doi:10.3390/nu18223738","doi":"https://doi.org/10.3390/nu18223738","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu18223738","pdf_url":null,"source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/nu18223738","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070222814","display_name":"Anna Olasi\u0144ska\u2010Wi\u015bniewska","orcid":"https://orcid.org/0000-0002-4213-8708","observed_orcids":["https://orcid.org/0000-0002-4213-8708"]},"institutions":[{"id":"https://openalex.org/I120230055","display_name":"Poznan University of Medical Sciences","ror":"https://ror.org/02zbb2597","country_code":"PL","type":"education","lineage":["https://openalex.org/I120230055"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Anna Olasi\u0144ska-Wi\u015bniewska","raw_affiliation_strings":["Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, 61-848 Pozna\u0144, Poland"],"raw_orcid":"https://orcid.org/0000-0002-4213-8708","affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, 61-848 Pozna\u0144, Poland","institution_ids":["https://openalex.org/I120230055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043728874","display_name":"Tomasz Kamil Urbanowicz","orcid":"https://orcid.org/0000-0001-8080-2764","observed_orcids":["https://orcid.org/0000-0001-8080-2764"]},"institutions":[{"id":"https://openalex.org/I120230055","display_name":"Poznan University of Medical Sciences","ror":"https://ror.org/02zbb2597","country_code":"PL","type":"education","lineage":["https://openalex.org/I120230055"]},{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT","PL"],"is_corresponding":false,"raw_author_name":"Tomasz Urbanowicz","raw_affiliation_strings":["Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, 61-848 Pozna\u0144, Poland","Department of Precision Medicine in Medical Surgical and Critical Area (Me.Pre.C.C.), University of Palermo, 90134 Palermo, Italy"],"raw_orcid":"https://orcid.org/0000-0001-8080-2764","affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery and Transplantology, Poznan University of Medical Sciences, 61-848 Pozna\u0144, Poland","institution_ids":["https://openalex.org/I120230055"]},{"raw_affiliation_string":"Department of Precision Medicine in Medical Surgical and Critical Area (Me.Pre.C.C.), University of Palermo, 90134 Palermo, Italy","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009950796","display_name":"Weronika Go\u015bciniak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I120230055","display_name":"Poznan University of Medical Sciences","ror":"https://ror.org/02zbb2597","country_code":"PL","type":"education","lineage":["https://openalex.org/I120230055"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Weronika Go\u015bciniak","raw_affiliation_strings":["Department of Cardiology, Poznan University of Medical Sciences, 61-848 Pozna\u0144, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Poznan University of Medical Sciences, 61-848 Pozna\u0144, Poland","institution_ids":["https://openalex.org/I120230055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023075740","display_name":"Anetta Ha\u0144\u0107","orcid":"https://orcid.org/0000-0001-7524-2897","observed_orcids":["https://orcid.org/0000-0001-7524-2897"]},"institutions":[{"id":"https://openalex.org/I59411706","display_name":"Adam Mickiewicz University in Pozna\u0144","ror":"https://ror.org/04g6bbq64","country_code":"PL","type":"education","lineage":["https://openalex.org/I59411706"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Anetta Han\u0107","raw_affiliation_strings":["Faculty of Chemistry, Department of Trace Analysis, Adam Mickiewicz University, 61-614 Pozna\u0144, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Chemistry, Department of Trace Analysis, Adam Mickiewicz University, 61-614 Pozna\u0144, Poland","institution_ids":["https://openalex.org/I59411706"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030096554","display_name":"Wojciech Seniuk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I120230055","display_name":"Poznan University of Medical Sciences","ror":"https://ror.org/02zbb2597","country_code":"PL","type":"education","lineage":["https://openalex.org/I120230055"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Wojciech Seniuk","raw_affiliation_strings":["Department of Cardiology, Poznan University of Medical Sciences, 61-848 Pozna\u0144, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Poznan University of Medical Sciences, 61-848 Pozna\u0144, Poland","institution_ids":["https://openalex.org/I120230055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072102757","display_name":"Kevser G\u00fclcihan Balc\u0131","orcid":"https://orcid.org/0000-0002-2311-1825","observed_orcids":["https://orcid.org/0000-0002-2311-1825"]},"institutions":[{"id":"https://openalex.org/I4399598363","display_name":"Ankara Bilkent City Hospital","ror":"https://ror.org/033fqnp11","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4399598363"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Kevser G\u00fclcihan Balc\u0131","raw_affiliation_strings":["Department of Cardiology, University of Health Sciences, Ankara Bilkent City Hospital, Ankara 06800, T\u00fcrkiye"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, University of Health Sciences, Ankara Bilkent City Hospital, Ankara 06800, T\u00fcrkiye","institution_ids":["https://openalex.org/I4399598363"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159417403","display_name":"Dagmara Tritt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I120230055","display_name":"Poznan University of Medical Sciences","ror":"https://ror.org/02zbb2597","country_code":"PL","type":"education","lineage":["https://openalex.org/I120230055"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Dagmara Tritt","raw_affiliation_strings":["Department of Cardiology, Poznan University of Medical Sciences, 61-848 Pozna\u0144, Poland"],"raw_orcid":"https://orcid.org/0009-0005-6980-5098","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Poznan University of Medical Sciences, 61-848 Pozna\u0144, Poland","institution_ids":["https://openalex.org/I120230055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088880658","display_name":"Filip Wa\u015bniewski","orcid":"https://orcid.org/0009-0004-2014-659X","observed_orcids":["https://orcid.org/0009-0004-2014-659X"]},"institutions":[{"id":"https://openalex.org/I120230055","display_name":"Poznan University of Medical Sciences","ror":"https://ror.org/02zbb2597","country_code":"PL","type":"education","lineage":["https://openalex.org/I120230055"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Filip Wa\u015bniewski","raw_affiliation_strings":["Department of Cardiology, Poznan University of Medical Sciences, 61-848 Pozna\u0144, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Poznan University of Medical Sciences, 61-848 Pozna\u0144, Poland","institution_ids":["https://openalex.org/I120230055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012791217","display_name":"Rafa\u0142 G\u00f3rniak","orcid":"https://orcid.org/0000-0002-7097-6610","observed_orcids":["https://orcid.org/0000-0002-7097-6610"]},"institutions":[{"id":"https://openalex.org/I59411706","display_name":"Adam Mickiewicz University in Pozna\u0144","ror":"https://ror.org/04g6bbq64","country_code":"PL","type":"education","lineage":["https://openalex.org/I59411706"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Rafa\u0142 G\u00f3rniak","raw_affiliation_strings":["Faculty of Chemistry, Department of Trace Analysis, Adam Mickiewicz University, 61-614 Pozna\u0144, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Chemistry, Department of Trace Analysis, Adam Mickiewicz University, 61-614 Pozna\u0144, Poland","institution_ids":["https://openalex.org/I59411706"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016616704","display_name":"Krzysztof B\u0142aszyk","orcid":"https://orcid.org/0000-0003-3228-2586","observed_orcids":["https://orcid.org/0000-0003-3228-2586"]},"institutions":[{"id":"https://openalex.org/I120230055","display_name":"Poznan University of Medical Sciences","ror":"https://ror.org/02zbb2597","country_code":"PL","type":"education","lineage":["https://openalex.org/I120230055"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Krzysztof B\u0142aszyk","raw_affiliation_strings":["Department of Cardiology, Poznan University of Medical Sciences, 61-848 Pozna\u0144, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Poznan University of Medical Sciences, 61-848 Pozna\u0144, Poland","institution_ids":["https://openalex.org/I120230055"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5070222814"],"corresponding_institution_ids":["https://openalex.org/I120230055"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"22","first_page":"3738","last_page":"3738"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.8720999956130981,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.8720999956130981,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":0.093299999833107,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2778094803","wikidata":"https://www.wikidata.org/wiki/Q410061","display_name":"Amiodarone","level":3,"score":0.9501000046730042},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7782999873161316},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6499999761581421},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.5950999855995178},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5580000281333923},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.4966999888420105},{"id":"https://openalex.org/C187960798","wikidata":"https://www.wikidata.org/wiki/Q7631152","display_name":"Subgroup analysis","level":3,"score":0.3939000070095062},{"id":"https://openalex.org/C2778131192","wikidata":"https://www.wikidata.org/wiki/Q241549","display_name":"Antiarrhythmic agent","level":3,"score":0.3416000008583069},{"id":"https://openalex.org/C3018260909","wikidata":"https://www.wikidata.org/wiki/Q1322871","display_name":"Exploratory analysis","level":2,"score":0.31839999556541443},{"id":"https://openalex.org/C544778455","wikidata":"https://www.wikidata.org/wiki/Q753","display_name":"Copper","level":2,"score":0.29100000858306885},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.28700000047683716},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.2847999930381775},{"id":"https://openalex.org/C515602321","wikidata":"https://www.wikidata.org/wiki/Q740","display_name":"Cobalt","level":2,"score":0.263700008392334},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.257099986076355}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/nu18223738","doi":"https://doi.org/10.3390/nu18223738","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu18223738","pdf_url":null,"source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/nu18223738","doi":"https://doi.org/10.3390/nu18223738","is_oa":true,"landing_page_url":"https://doi.org/10.3390/nu18223738","pdf_url":null,"source":{"id":"https://openalex.org/S110785341","display_name":"Nutrients","issn_l":"2072-6643","issn":["2072-6643"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Nutrients","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Background:":[0],"Trace":[1],"elements":[2,82],"are":[3,229],"essential":[4],"for":[5,75,110,161,201],"cardiovascular":[6,16,213],"physiology,":[7],"and":[8,18,27,51,90,119,122,130,163,183,204,222,231],"their":[9],"systemic":[10],"imbalance":[11],"has":[12],"been":[13],"linked":[14],"to":[15,100],"diseases":[17],"pharmacological":[19],"therapies.":[20],"However,":[21],"the":[22,86,170,178,217],"relationship":[23],"between":[24],"amiodarone":[25,53,87,115],"therapy":[26],"whole-blood":[28,44,196],"elemental":[29,45],"profiles":[30],"in":[31,47,85,169,180],"patients":[32,49,63,101,113,174],"with":[33,50,102,137,154,175,194],"atrial":[34],"fibrillation":[35],"(AF)":[36],"remains":[37],"unclear.":[38],"Objectives:":[39],"This":[40,56,207],"exploratory":[41],"study":[42,59],"evaluated":[43],"concentrations":[46,79,121,125,198],"AF":[48,62],"without":[52],"treatment.":[54],"Methods:":[55],"single-center":[57],"observational":[58],"included":[60],"51":[61],"(32":[64],"males,":[65],"62.8%;":[66],"median":[67],"(Q1\u2013Q3)":[68],"age":[69],"of":[70,80,219],"71":[71],"(60\u201376)":[72],"years)":[73],"referred":[74],"catheter":[76],"ablation.":[77],"Whole-blood":[78],"12":[81],"were":[83,165],"compared":[84],"(n":[88,92],"=18)":[89],"non-amiodarone":[91],"=":[93,127,145,152],"33)":[94],"subgroups.":[95],"A":[96],"subgroup":[97],"analysis":[98],"restricted":[99],"predefined":[103,176],"comorbidities":[104],"was":[105,192],"performed.":[106],"Results:":[107],"After":[108],"correction":[109],"multiple":[111],"comparisons,":[112],"receiving":[114],"had":[116],"higher":[117,138,195],"copper":[118,139,197],"cobalt":[120,162],"lower":[123],"rubidium":[124,164],"(q":[126],"0.01,":[128],"0.02,":[129],"0.04,":[131],"respectively).":[132],"Amiodarone":[133,190],"use":[134,191],"remained":[135,185],"associated":[136,193],"concentration":[140],"after":[141,187,199],"multivariable":[142],"adjustment":[143,200],"(B":[144],"86.3":[146],"\u00b5g/L,":[147],"95%":[148],"CI":[149],"25.3\u2013147.3;":[150],"p":[151],"0.007),":[153],"a":[155],"similar":[156],"bootstrap":[157],"estimate.":[158],"Adjusted":[159],"associations":[160],"not":[166,233],"statistically":[167],"significant":[168,186],"full":[171],"sample.":[172],"Among":[173],"comorbidities,":[177],"differences":[179],"copper,":[181],"cobalt,":[182],"lead":[184],"correction.":[188],"Conclusions:":[189],"selected":[202],"demographic":[203],"clinical":[205],"characteristics.":[206],"association":[208],"may":[209],"partly":[210],"reflect":[211],"underlying":[212],"disease":[214,220],"burden,":[215],"although":[216],"contributions":[218],"characteristics":[221],"treatment":[223],"exposure":[224],"remain":[225],"uncertain.":[226],"These":[227],"findings":[228],"hypothesis-generating":[230],"do":[232],"establish":[234],"causality.":[235]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
