{"id":"https://openalex.org/W7225825207","doi":"https://doi.org/10.5281/zenodo.24127852","title":"INHIBITORS OF FIMH AGAINST UROPATHOGENIC ESCHERICHIA COLI: COMBINATION THERAPY, ANTI-VIRULENCE MECHANISMS, AND RESISTANCE BIOLOGY","display_name":"INHIBITORS OF FIMH AGAINST UROPATHOGENIC ESCHERICHIA COLI: COMBINATION THERAPY, ANTI-VIRULENCE MECHANISMS, AND RESISTANCE BIOLOGY","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225825207","doi":"https://doi.org/10.5281/zenodo.24127852"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.24127852","doi":"https://doi.org/10.5281/zenodo.24127852","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24127852","pdf_url":null,"source":{"id":"https://openalex.org/S4210212542","display_name":"European Journal Pharmaceutical and Medical Research","issn_l":"2394-3211","issn":["2394-3211"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4383694718","host_organization_name":"World Journal of Pharmacy and Pharmaceutical Sciences","host_organization_lineage":["https://openalex.org/P4383694718"],"host_organization_lineage_names":["World Journal of Pharmacy and Pharmaceutical Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.5281/zenodo.24127852","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161465003","display_name":"Garima Avasthi2 Zoya Parveen*1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Zoya Parveen*1, Garima Avasthi2","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5161465003"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.7192000150680542,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11232","display_name":"Urinary Tract Infections Management","score":0.7192000150680542,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.24629999697208405,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.022700000554323196,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C179470777","wikidata":"https://www.wikidata.org/wiki/Q356661","display_name":"Bacterial adhesin","level":4,"score":0.8513000011444092},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.6758000254631042},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6309000253677368},{"id":"https://openalex.org/C57992300","wikidata":"https://www.wikidata.org/wiki/Q2066956","display_name":"Potency","level":3,"score":0.5654000043869019},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5637000203132629},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.5615000128746033},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.48159998655319214},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.3776000142097473},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3734000027179718},{"id":"https://openalex.org/C2775876089","wikidata":"https://www.wikidata.org/wiki/Q281082","display_name":"Nalidixic acid","level":4,"score":0.3555999994277954},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.3303999900817871},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.29980000853538513},{"id":"https://openalex.org/C3019249092","wikidata":"https://www.wikidata.org/wiki/Q274493","display_name":"Antibacterial agent","level":3,"score":0.29330000281333923},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.26930001378059387},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.2603999972343445},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.2547000050544739},{"id":"https://openalex.org/C2994294914","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired resistance","level":3,"score":0.2517000138759613}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.24127852","doi":"https://doi.org/10.5281/zenodo.24127852","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24127852","pdf_url":null,"source":{"id":"https://openalex.org/S4210212542","display_name":"European Journal Pharmaceutical and Medical Research","issn_l":"2394-3211","issn":["2394-3211"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4383694718","host_organization_name":"World Journal of Pharmacy and Pharmaceutical Sciences","host_organization_lineage":["https://openalex.org/P4383694718"],"host_organization_lineage_names":["World Journal of Pharmacy and Pharmaceutical Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.5281/zenodo.24127853","doi":"https://doi.org/10.5281/zenodo.24127853","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24127853","pdf_url":null,"source":{"id":"https://openalex.org/S4210212542","display_name":"European Journal Pharmaceutical and Medical Research","issn_l":"2394-3211","issn":["2394-3211"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4383694718","host_organization_name":"World Journal of Pharmacy and Pharmaceutical Sciences","host_organization_lineage":["https://openalex.org/P4383694718"],"host_organization_lineage_names":["World Journal of Pharmacy and Pharmaceutical Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.5281/zenodo.24127852","doi":"https://doi.org/10.5281/zenodo.24127852","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24127852","pdf_url":null,"source":{"id":"https://openalex.org/S4210212542","display_name":"European Journal Pharmaceutical and Medical Research","issn_l":"2394-3211","issn":["2394-3211"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4383694718","host_organization_name":"World Journal of Pharmacy and Pharmaceutical Sciences","host_organization_lineage":["https://openalex.org/P4383694718"],"host_organization_lineage_names":["World Journal of Pharmacy and Pharmaceutical Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"The":[0,56],"majority":[1],"of":[2,33,52,59,133],"urinary":[3],"tract":[4],"infections":[5],"(UTIs)":[6],"are":[7,15,91,142,160],"caused":[8],"by":[9],"Uropathogenic":[10],"Escherichia":[11],"coli":[12],"(UPEC),":[13],"which":[14,64,112],"difficult":[16],"to":[17,20,81,108,147],"treat":[18],"due":[19],"recurrence":[21],"and":[22,49,69,85,102,115,122,139,152,154,156,173,177],"growing":[23],"antibiotic":[24],"resistance.":[25],"FimH,":[26,60],"the":[27,31,50,61,70,75,119,148,164],"mannose-binding":[28],"adhesin":[29],"at":[30],"tip":[32],"type":[34],"1":[35],"pili,":[36],"is":[37],"an":[38,109],"appealing":[39],"target":[40],"for":[41,180],"anti-virulence":[42,120],"because":[43],"it":[44],"promotes":[45],"bladder":[46],"colonization,":[47],"invasion,":[48],"creation":[51],"intracellular":[53],"biofilm-like":[54],"communities.":[55],"structural":[57],"biology":[58],"ways":[62],"in":[63,94,106,113],"competitive":[65],"antagonists":[66,125],"block":[67],"it,":[68],"medicinal":[71],"chemistry":[72],"that":[73],"advanced":[74],"field":[76],"from":[77],"simple":[78],"alkyl":[79],"mannosides":[80],"ortho-substituted":[82],"biphenyl,":[83],"C-linked,":[84],"heterocyclic":[86],"molecules":[87],"with":[88,129,144],"nanomolar":[89],"potency":[90,151],"all":[92],"included":[93],"this":[95],"study.":[96],"After":[97],"that,":[98],"check":[99],"how":[100,123],"resistance":[101,168],"adaptation":[103],"could":[104,126],"develop":[105],"response":[107],"anti-adhesion":[110],"medication,":[111],"vitro":[114],"animal":[116],"evidence":[117],"support":[118],"effects,":[121],"FimH":[124],"be":[127],"used":[128],"antibiotics":[130],"or":[131],"inhibitors":[132],"other":[134],"adhesins":[135],"like":[136],"FmlH.":[137],"Pharmacokinetic":[138],"safety":[140],"factors":[141],"explored,":[143],"special":[145],"focus":[146],"trade-off":[149],"between":[150],"permeability,":[153],"computational":[155],"experimental":[157],"evaluation":[158],"techniques":[159],"described.":[161],"Lastly,":[162],"highlight":[163],"primary":[165],"gaps":[166],"direct":[167],"data,":[169],"thorough":[170],"combination":[171],"studies,":[172],"human":[174],"efficacy":[175],"trials":[176],"offer":[178],"recommendations":[179],"next-generation":[181],"design.":[182]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}