{"id":"https://openalex.org/W7225825187","doi":"https://doi.org/10.3389/fimmu.2026.1840036","title":"Hemodialysis is associated with changes in plasma protein N-glycan profile: possibly promoting expression of anti-inflammatory traits","display_name":"Hemodialysis is associated with changes in plasma protein N-glycan profile: possibly promoting expression of anti-inflammatory traits","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225825187","doi":"https://doi.org/10.3389/fimmu.2026.1840036"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1840036","doi":"https://doi.org/10.3389/fimmu.2026.1840036","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1840036","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1840036/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1840036/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059385441","display_name":"Ivan Durlen","orcid":"https://orcid.org/0000-0002-3488-6490","observed_orcids":["https://orcid.org/0000-0002-3488-6490"]},"institutions":[{"id":"https://openalex.org/I2800813048","display_name":"University Hospital Dubrava","ror":"https://ror.org/00mgfdc89","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I2800813048"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Ivan Durlen","raw_affiliation_strings":["Department of Nephrology and Dialysis, Dubrava University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Dialysis, Dubrava University Hospital","institution_ids":["https://openalex.org/I2800813048"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051296329","display_name":"Matija Crnogorac","orcid":"https://orcid.org/0000-0003-3489-261X","observed_orcids":["https://orcid.org/0000-0003-3489-261X"]},"institutions":[{"id":"https://openalex.org/I2800813048","display_name":"University Hospital Dubrava","ror":"https://ror.org/00mgfdc89","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I2800813048"]}],"countries":["HR"],"is_corresponding":true,"raw_author_name":"Matija Crnogorac","raw_affiliation_strings":["Department of Nephrology and Dialysis, Dubrava University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Dialysis, Dubrava University Hospital","institution_ids":["https://openalex.org/I2800813048"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161443855","display_name":"Barbara Radovani Trbojevic","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barbara Radovani Trbojevic","raw_affiliation_strings":["Genos Glycoscience Research Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Genos Glycoscience Research Laboratory","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043761173","display_name":"David Visentin","orcid":"https://orcid.org/0009-0001-8502-3978","observed_orcids":["https://orcid.org/0009-0001-8502-3978"]},"institutions":[{"id":"https://openalex.org/I154347574","display_name":"University of Rijeka","ror":"https://ror.org/05r8dqr10","country_code":"HR","type":"education","lineage":["https://openalex.org/I154347574"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"David Visentin","raw_affiliation_strings":["Faculty of Biotechnology and Drug Development, University of Rijeka"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biotechnology and Drug Development, University of Rijeka","institution_ids":["https://openalex.org/I154347574"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084319446","display_name":"Ivan Gudelj","orcid":"https://orcid.org/0000-0003-0624-7170","observed_orcids":["https://orcid.org/0000-0003-0624-7170"]},"institutions":[{"id":"https://openalex.org/I181343428","display_name":"University of Zagreb","ror":"https://ror.org/00mv6sv71","country_code":"HR","type":"education","lineage":["https://openalex.org/I181343428"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Ivan Gudelj","raw_affiliation_strings":["Faculty of Pharmacy and Biochemistry , University of Zagreb"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy and Biochemistry , University of Zagreb","institution_ids":["https://openalex.org/I181343428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056363257","display_name":"Irzal Had\u017eibegovi\u0107","orcid":"https://orcid.org/0000-0002-3768-9134","observed_orcids":["https://orcid.org/0000-0002-3768-9134","https://orcid.org/0000-0001-9139-5009"]},"institutions":[{"id":"https://openalex.org/I2800813048","display_name":"University Hospital Dubrava","ror":"https://ror.org/00mgfdc89","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I2800813048"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Irzal Hadzibegovic","raw_affiliation_strings":["Department of Cardiovascular Medicine, Dubrava University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Dubrava University Hospital","institution_ids":["https://openalex.org/I2800813048"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161442158","display_name":"Goran Lauc","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181343428","display_name":"University of Zagreb","ror":"https://ror.org/00mv6sv71","country_code":"HR","type":"education","lineage":["https://openalex.org/I181343428"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Goran Lauc","raw_affiliation_strings":["Faculty of Pharmacy and Biochemistry , University of Zagreb","Genos Glycoscience Research Laboratory"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmacy and Biochemistry , University of Zagreb","institution_ids":["https://openalex.org/I181343428"]},{"raw_affiliation_string":"Genos Glycoscience Research Laboratory","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006512191","display_name":"Lada Zibar","orcid":"https://orcid.org/0000-0002-5454-2353","observed_orcids":["https://orcid.org/0000-0002-5454-2353"]},"institutions":[{"id":"https://openalex.org/I4210112868","display_name":"Klini\u010dka bolnica Merkur","ror":"https://ror.org/01b6d9h22","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I4210112868"]},{"id":"https://openalex.org/I51314090","display_name":"University of Osijek","ror":"https://ror.org/05sw4wc49","country_code":"HR","type":"education","lineage":["https://openalex.org/I51314090"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Lada Zibar","raw_affiliation_strings":["Department for Nephrology, University Hospital Merkur","Josip Juraj Strossmayer University of Osijek, School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department for Nephrology, University Hospital Merkur","institution_ids":["https://openalex.org/I4210112868"]},{"raw_affiliation_string":"Josip Juraj Strossmayer University of Osijek, School of Medicine","institution_ids":["https://openalex.org/I51314090"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5051296329"],"corresponding_institution_ids":["https://openalex.org/I2800813048"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9442999958992004,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10291","display_name":"Dialysis and Renal Disease Management","score":0.05339999869465828,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11124","display_name":"Protein purification and stability","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2778063415","wikidata":"https://www.wikidata.org/wiki/Q391744","display_name":"Hemodialysis","level":2,"score":0.91839998960495},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.7519000172615051},{"id":"https://openalex.org/C2779978075","wikidata":"https://www.wikidata.org/wiki/Q202301","display_name":"Dialysis","level":2,"score":0.6632999777793884},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6161999702453613},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.5257999897003174},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5110999941825867},{"id":"https://openalex.org/C146543888","wikidata":"https://www.wikidata.org/wiki/Q425056","display_name":"Blood proteins","level":2,"score":0.47609999775886536},{"id":"https://openalex.org/C2993356106","wikidata":"https://www.wikidata.org/wiki/Q736715","display_name":"Chronic renal failure","level":2,"score":0.4722000062465668},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4268999993801117},{"id":"https://openalex.org/C2776635150","wikidata":"https://www.wikidata.org/wiki/Q13365776","display_name":"Uremia","level":2,"score":0.37619999051094055},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.37310001254081726},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3700000047683716},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.36649999022483826},{"id":"https://openalex.org/C3017575891","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Plasma levels","level":2,"score":0.3580000102519989},{"id":"https://openalex.org/C2776575606","wikidata":"https://www.wikidata.org/wiki/Q79749","display_name":"Blood plasma","level":2,"score":0.33480000495910645},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.3066999912261963},{"id":"https://openalex.org/C2910901499","wikidata":"https://www.wikidata.org/wiki/Q202301","display_name":"Dialysis Therapy","level":3,"score":0.29739999771118164},{"id":"https://openalex.org/C3020079912","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Plasma concentration","level":2,"score":0.289000004529953},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2883000075817108},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.28040000796318054},{"id":"https://openalex.org/C2781195455","wikidata":"https://www.wikidata.org/wiki/Q422766","display_name":"C-reactive protein","level":3,"score":0.2653999924659729},{"id":"https://openalex.org/C20299238","wikidata":"https://www.wikidata.org/wiki/Q363928","display_name":"Lipocalin","level":2,"score":0.2606000006198883},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.257999986410141},{"id":"https://openalex.org/C2779922275","wikidata":"https://www.wikidata.org/wiki/Q1129105","display_name":"Diabetic nephropathy","level":3,"score":0.25529998540878296},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.25060001015663147},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.2502000033855438}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fimmu.2026.1840036","doi":"https://doi.org/10.3389/fimmu.2026.1840036","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1840036","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1840036/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1840036","doi":"https://doi.org/10.3389/fimmu.2026.1840036","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1840036","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1840036/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225825187.pdf","grobid_xml":"https://content.openalex.org/works/W7225825187.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W1970727081","https://openalex.org/W1974072757","https://openalex.org/W1984237037","https://openalex.org/W1988068836","https://openalex.org/W1992143229","https://openalex.org/W2011818634","https://openalex.org/W2014259599","https://openalex.org/W2024315081","https://openalex.org/W2025031903","https://openalex.org/W2025589168","https://openalex.org/W2035207334","https://openalex.org/W2040900310","https://openalex.org/W2042583677","https://openalex.org/W2066397423","https://openalex.org/W2103407301","https://openalex.org/W2120309176","https://openalex.org/W2122372709","https://openalex.org/W2123391323","https://openalex.org/W2148401148","https://openalex.org/W2151907290","https://openalex.org/W2156590509","https://openalex.org/W2158387380","https://openalex.org/W2158745632","https://openalex.org/W2161437331","https://openalex.org/W2163590752","https://openalex.org/W2238271553","https://openalex.org/W2482013437","https://openalex.org/W2520704601","https://openalex.org/W2560676548","https://openalex.org/W2770447301","https://openalex.org/W2783591628","https://openalex.org/W2790674042","https://openalex.org/W2792059755","https://openalex.org/W2801567296","https://openalex.org/W2884507766","https://openalex.org/W2919147259","https://openalex.org/W2921437380","https://openalex.org/W2964713081","https://openalex.org/W2971631326","https://openalex.org/W2982064349","https://openalex.org/W3011951168","https://openalex.org/W3016520717","https://openalex.org/W3019431792","https://openalex.org/W3106761249","https://openalex.org/W3115713292","https://openalex.org/W3119966503","https://openalex.org/W3171754953","https://openalex.org/W4206156738","https://openalex.org/W4206648263","https://openalex.org/W4281763856","https://openalex.org/W4281785428","https://openalex.org/W4283587952","https://openalex.org/W4293279859","https://openalex.org/W4300166901","https://openalex.org/W4386917549","https://openalex.org/W4390116044","https://openalex.org/W4392915942","https://openalex.org/W4401307963","https://openalex.org/W4402233413","https://openalex.org/W4402555364","https://openalex.org/W4402985115"],"related_works":[],"abstract_inverted_index":{"Introduction":[0],"Biomarkers":[1],"capable":[2],"of":[3,14,89,113,199,216,240],"predicting":[4,253],"outcomes":[5,255],"in":[6,21,31,37,49,55,155,166,175,181,201,230,236,256],"patients":[7,51,65,231],"undergoing":[8,66,232],"hemodialysis":[9,68,191,208,250],"(HD)":[10],"remain":[11],"limited.":[12],"N-glycosylation":[13,48,185,238],"plasma":[15,91,131,183,242],"proteins":[16,92,184,243],"plays":[17],"an":[18],"important":[19],"role":[20],"numerous":[22],"biological":[23,211],"processes,":[24],"including":[25,40],"immune":[26],"regulation":[27],"and":[28,60,76,101,160,219,252],"inflammation.":[29],"Alterations":[30],"N-glycan":[32,87,133],"profiles":[33,134],"have":[34,225],"been":[35],"described":[36],"several":[38],"diseases,":[39],"chronic":[41,67,233],"kidney":[42],"disease":[43],"(CKD).":[44],"However,":[45],"studies":[46],"investigating":[47],"dialysis":[50,111],"are":[52,170,178],"scarce,":[53],"particularly":[54],"those":[56],"receiving":[57],"hemodialysis.":[58],"Patients":[59],"methods":[61],"We":[62],"included":[63],"55":[64],"who":[69],"provided":[70],"informed":[71],"consent.":[72],"Demographic":[73],"data,":[74],"comorbidities,":[75],"dialysis-related":[77],"parameters":[78],"were":[79,106,135],"collected.":[80],"Along":[81],"with":[82,146,172],"C-reactive":[83,123],"protein":[84,124,132],"analyses,":[85],"the":[86,99,109,114,117,214,237],"profile":[88,239],"total":[90,182,241],"was":[93,126],"measured":[94,127],"before":[95,108],"hemodialysis,":[96],"immediately":[97],"after":[98],"procedure,":[100],"24":[102],"hours":[103],"later.":[104],"Measurements":[105],"performed":[107],"first":[110],"session":[112],"week,":[115],"following":[116],"longest":[118],"interdialytic":[119],"interval":[120],"(three":[121],"days).":[122],"(CRP)":[125],"using":[128,137],"immunoturbidimetry.":[129],"Total":[130],"analyzed":[136],"ultra-high":[138],"performance":[139],"liquid":[140],"chromatography":[141],"based":[142],"on":[143],"hydrophilic":[144],"interactions":[145],"fluorescence":[147],"detection":[148],"(HILIC-UHPLC-FLR).":[149],"Results":[150],"Our":[151,187],"study":[152],"showed":[153],"that":[154,190,207],"our":[156],"patient":[157],"cohort,":[158],"sialylsation":[159],"fucosylation,":[161],"as":[162],"previously":[163],"published":[164],"data":[165],"which":[167],"these":[168],"traits":[169,180],"associated":[171],"proinflammatory":[173,179],"milleu":[174],"various":[176],"diseases/conditions,":[177],"profile.":[186],"findings":[188],"demonstrate":[189],"itself":[192],"possibly":[193],"reduces":[194],"pro-inflammatory":[195],"glycosylation":[196],"patterns,":[197],"independently":[198],"changes":[200],"CRP":[202],"levels.":[203],"These":[204],"results":[205],"suggest":[206],"may":[209,224,244],"exert":[210],"effects":[212],"beyond":[213],"removal":[215],"excess":[217],"fluid":[218],"uremic":[220],"toxins.":[221],"Conclusion":[222],"Hemodialysis":[223],"a":[226],"measurable":[227],"anti-inflammatory":[228],"effect":[229],"treatment.":[234],"Changes":[235],"represent":[245],"potential":[246],"biomarkers":[247],"for":[248],"assessing":[249],"effectiveness":[251],"clinical":[254],"HD":[257],"patients.":[258]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}