{"id":"https://openalex.org/W7225824981","doi":"https://doi.org/10.3390/bios16110645","title":"Photonic Crystal Cellular Force Microscopy Reveals the Dynamic Mechanical Responses of Colorectal Cancer Cells to Low-Intensity Pulsed Ultrasound","display_name":"Photonic Crystal Cellular Force Microscopy Reveals the Dynamic Mechanical Responses of Colorectal Cancer Cells to Low-Intensity Pulsed Ultrasound","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225824981","doi":"https://doi.org/10.3390/bios16110645"},"language":"en","primary_location":{"id":"doi:10.3390/bios16110645","doi":"https://doi.org/10.3390/bios16110645","is_oa":true,"landing_page_url":"https://doi.org/10.3390/bios16110645","pdf_url":null,"source":{"id":"https://openalex.org/S150925516","display_name":"Biosensors","issn_l":"2079-6374","issn":["2079-6374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biosensors","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/bios16110645","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161493886","display_name":"Ying Zhang","orcid":"https://orcid.org/0009-0004-2660-2429","observed_orcids":["https://orcid.org/0009-0004-2660-2429"]},"institutions":[{"id":"https://openalex.org/I4387154005","display_name":"State Key Laboratory of Digital Medical Engineering","ror":"https://ror.org/03ab0at74","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4387154005","https://openalex.org/I76569877"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ying Zhang","raw_affiliation_strings":["Institute of Microphysiological Systems, Southeast University, Nanjing 211189, China","State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China"],"raw_orcid":"https://orcid.org/0009-0004-2660-2429","affiliations":[{"raw_affiliation_string":"Institute of Microphysiological Systems, Southeast University, Nanjing 211189, China","institution_ids":["https://openalex.org/I76569877"]},{"raw_affiliation_string":"State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China","institution_ids":["https://openalex.org/I4387154005","https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161464158","display_name":"Jiajia Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387154005","display_name":"State Key Laboratory of Digital Medical Engineering","ror":"https://ror.org/03ab0at74","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4387154005","https://openalex.org/I76569877"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiajia Zhang","raw_affiliation_strings":["State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China","institution_ids":["https://openalex.org/I4387154005","https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100395656","display_name":"Xinyi Liu","orcid":"https://orcid.org/0000-0001-8864-0528","observed_orcids":["https://orcid.org/0000-0001-8864-0528"]},"institutions":[{"id":"https://openalex.org/I4387154005","display_name":"State Key Laboratory of Digital Medical Engineering","ror":"https://ror.org/03ab0at74","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4387154005","https://openalex.org/I76569877"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyi Liu","raw_affiliation_strings":["State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China","institution_ids":["https://openalex.org/I4387154005","https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149757149","display_name":"Jikai Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387154005","display_name":"State Key Laboratory of Digital Medical Engineering","ror":"https://ror.org/03ab0at74","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4387154005","https://openalex.org/I76569877"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jikai Yu","raw_affiliation_strings":["State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China","institution_ids":["https://openalex.org/I4387154005","https://openalex.org/I76569877"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100436395","display_name":"Chenyang Li","orcid":"https://orcid.org/0000-0003-4244-8615","observed_orcids":["https://orcid.org/0000-0003-4244-8615","https://orcid.org/0009-0003-7162-5550"]},"institutions":[{"id":"https://openalex.org/I4210152119","display_name":"Jiangsu Province Hospital","ror":"https://ror.org/04py1g812","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152119"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chenyang Li","raw_affiliation_strings":["Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China"],"raw_orcid":"https://orcid.org/0009-0002-5172-2321","affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China","institution_ids":["https://openalex.org/I4210152119"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161444828","display_name":"Zhongze Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387154005","display_name":"State Key Laboratory of Digital Medical Engineering","ror":"https://ror.org/03ab0at74","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4387154005","https://openalex.org/I76569877"]},{"id":"https://openalex.org/I76569877","display_name":"Southeast University","ror":"https://ror.org/04ct4d772","country_code":"CN","type":"education","lineage":["https://openalex.org/I76569877"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongze Gu","raw_affiliation_strings":["Institute of Microphysiological Systems, Southeast University, Nanjing 211189, China","State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Microphysiological Systems, Southeast University, Nanjing 211189, China","institution_ids":["https://openalex.org/I76569877"]},{"raw_affiliation_string":"State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, Southeast University, Nanjing 210096, China","institution_ids":["https://openalex.org/I4387154005","https://openalex.org/I76569877"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100436395","https://openalex.org/A5161493886"],"corresponding_institution_ids":["https://openalex.org/I4210152119","https://openalex.org/I4387154005","https://openalex.org/I76569877"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2654},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2654},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"11","first_page":"645","last_page":"645"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5494999885559082},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5006999969482422},{"id":"https://openalex.org/C147080431","wikidata":"https://www.wikidata.org/wiki/Q1074953","display_name":"Microscopy","level":2,"score":0.4814000129699707},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4205999970436096},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4099000096321106},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.4092999994754791},{"id":"https://openalex.org/C2779178360","wikidata":"https://www.wikidata.org/wiki/Q902045","display_name":"Confocal microscopy","level":2,"score":0.4077000021934509},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4047999978065491},{"id":"https://openalex.org/C2780021956","wikidata":"https://www.wikidata.org/wiki/Q21020749","display_name":"Cell mechanics","level":4,"score":0.40230000019073486},{"id":"https://openalex.org/C102951782","wikidata":"https://www.wikidata.org/wiki/Q49295","display_name":"Atomic force microscopy","level":2,"score":0.3986000120639801},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.3871999979019165},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.3400000035762787},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3366999924182892},{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.31929999589920044},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.3158000111579895},{"id":"https://openalex.org/C2778236600","wikidata":"https://www.wikidata.org/wiki/Q592324","display_name":"Immunofluorescence","level":3,"score":0.3156999945640564},{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.31130000948905945},{"id":"https://openalex.org/C204366326","wikidata":"https://www.wikidata.org/wiki/Q3027650","display_name":"Deformation (meteorology)","level":2,"score":0.3034000098705292},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.2937999963760376},{"id":"https://openalex.org/C199723944","wikidata":"https://www.wikidata.org/wiki/Q3041998","display_name":"Force dynamics","level":2,"score":0.27810001373291016},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.27730000019073486},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.2599000036716461},{"id":"https://openalex.org/C3020610862","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue repair","level":2,"score":0.259799987077713},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.25850000977516174},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2563000023365021},{"id":"https://openalex.org/C67649825","wikidata":"https://www.wikidata.org/wiki/Q196538","display_name":"Microscope","level":2,"score":0.2515999972820282},{"id":"https://openalex.org/C2778383842","wikidata":"https://www.wikidata.org/wiki/Q815284","display_name":"Mechanical load","level":2,"score":0.25119999051094055}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/bios16110645","doi":"https://doi.org/10.3390/bios16110645","is_oa":true,"landing_page_url":"https://doi.org/10.3390/bios16110645","pdf_url":null,"source":{"id":"https://openalex.org/S150925516","display_name":"Biosensors","issn_l":"2079-6374","issn":["2079-6374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biosensors","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/bios16110645","doi":"https://doi.org/10.3390/bios16110645","is_oa":true,"landing_page_url":"https://doi.org/10.3390/bios16110645","pdf_url":null,"source":{"id":"https://openalex.org/S150925516","display_name":"Biosensors","issn_l":"2079-6374","issn":["2079-6374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biosensors","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W413440677","https://openalex.org/W1928745964","https://openalex.org/W1964847767","https://openalex.org/W1972071814","https://openalex.org/W1999720993","https://openalex.org/W2039931031","https://openalex.org/W2077534656","https://openalex.org/W2079595896","https://openalex.org/W2099052265","https://openalex.org/W2111412288","https://openalex.org/W2111811045","https://openalex.org/W2114207728","https://openalex.org/W2125644189","https://openalex.org/W2126486896","https://openalex.org/W2131614544","https://openalex.org/W2133054656","https://openalex.org/W2146337514","https://openalex.org/W2148454908","https://openalex.org/W2167896833","https://openalex.org/W2620809148","https://openalex.org/W2624734827","https://openalex.org/W2802421445","https://openalex.org/W2806450304","https://openalex.org/W2890637751","https://openalex.org/W2931549096","https://openalex.org/W3002211353","https://openalex.org/W3002782139","https://openalex.org/W3009206285","https://openalex.org/W3014145034","https://openalex.org/W3033089248","https://openalex.org/W3193636725","https://openalex.org/W4223582131","https://openalex.org/W4284707191","https://openalex.org/W4286498606","https://openalex.org/W4293217304","https://openalex.org/W4294884477","https://openalex.org/W4306178456","https://openalex.org/W4310456702","https://openalex.org/W4315796573","https://openalex.org/W4388665341","https://openalex.org/W4392947281","https://openalex.org/W4402809665","https://openalex.org/W4403428420","https://openalex.org/W4407299085","https://openalex.org/W4409318222","https://openalex.org/W4410632474","https://openalex.org/W4411299961","https://openalex.org/W4414443514","https://openalex.org/W4416858461","https://openalex.org/W7117119582","https://openalex.org/W7124161049","https://openalex.org/W7161286263","https://openalex.org/W7207754853","https://openalex.org/W7212183484"],"related_works":[],"abstract_inverted_index":{"Low-intensity":[0],"pulsed":[1],"ultrasound":[2],"(LIPUS)":[3],"has":[4],"antitumor":[5],"potential,":[6],"but":[7],"its":[8],"effects":[9],"on":[10],"tumor":[11,145,202],"cell":[12],"mechanics":[13],"remain":[14],"poorly":[15],"understood.":[16],"In":[17,132],"this":[18],"study,":[19],"photonic":[20],"crystal":[21],"cellular":[22,80,124,178],"force":[23,71,81,97,125,168],"microscopy":[24],"(PCCFM)":[25],"enabled":[26],"time-resolved":[27],"mechanical":[28,103,161,206],"measurements":[29,72],"of":[30,58,78,201],"colorectal":[31],"cancer":[32],"cells":[33,138,203],"after":[34,82],"LIPUS":[35,73,171,176],"treatment.":[36],"Serial":[37],"PCCFM":[38,164,186],"structural-color":[39],"and":[40,51,68,99,114,117,126,129,144,149,158,172,180,182,191],"corresponding":[41],"bright-field":[42],"images":[43],"were":[44,105],"acquired":[45],"to":[46,170,204],"reconstruct":[47],"the":[48,59,75,159,198],"vertical":[49,70,167],"stress":[50,61],"substrate":[52],"deformation":[53],"in":[54,96,123],"cell-associated":[55],"regions;":[56],"integration":[57],"reconstructed":[60],"over":[62],"defined":[63],"regions":[64],"yielded":[65],"quantitative":[66,192],"collective":[67,79,86],"single-cell":[69],"altered":[74,108],"time":[76],"course":[77],"seeding":[83],"exhibiting":[84],"distinct":[85],"response":[87],"patterns.":[88],"Single-cell":[89],"analysis":[90],"further":[91],"showed":[92],"marked":[93],"intercellular":[94],"heterogeneity":[95],"magnitude":[98],"temporal":[100,166],"profiles.":[101],"These":[102],"changes":[104,122],"accompanied":[106],"by":[107],"F-actin":[109],"organization,":[110],"fewer":[111],"peripheral":[112],"protrusions,":[113],"reduced":[115,140],"migration":[116],"invasion":[118],"indices,":[119],"indicating":[120],"concordant":[121],"motility-related":[127],"structural":[128],"functional":[130],"phenotypes.":[131,184],"vivo,":[133],"xenografts":[134],"derived":[135],"from":[136],"LIPUS-pretreated":[137],"had":[139],"final":[141],"xenograft":[142],"volume":[143],"weight.":[146],"Piezo1":[147],"immunofluorescence":[148],"Ca2+":[150],"imaging":[151],"suggested":[152],"an":[153],"association":[154],"between":[155],"mechanosensitive-channel":[156],"signaling":[157],"observed":[160],"changes.":[162],"Overall,":[163],"resolved":[165],"responses":[169,200],"revealed":[173],"associations":[174],"among":[175],"treatment,":[177],"mechanics,":[179],"motility-":[181],"growth-related":[183],"Therefore,":[185],"provides":[187],"a":[188],"label-free,":[189],"visual,":[190],"cellular-force":[193],"sensing":[194],"approach":[195],"for":[196],"assessing":[197],"dynamic":[199],"external":[205],"stimulation.":[207]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
