{"id":"https://openalex.org/W7225824886","doi":"https://doi.org/10.1038/s41531-026-01592-5","title":"Synergistic interplay between triazine and curcumin or resveratrol in mitigating rotenone-induced toxicity in Drosophila model","display_name":"Synergistic interplay between triazine and curcumin or resveratrol in mitigating rotenone-induced toxicity in Drosophila model","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225824886","doi":"https://doi.org/10.1038/s41531-026-01592-5"},"language":"en","primary_location":{"id":"doi:10.1038/s41531-026-01592-5","doi":"https://doi.org/10.1038/s41531-026-01592-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41531-026-01592-5","pdf_url":null,"source":{"id":"https://openalex.org/S2737664142","display_name":"npj Parkinson s Disease","issn_l":"2373-8057","issn":["2373-8057"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Parkinson's Disease","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1038/s41531-026-01592-5","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002048008","display_name":"Mai Fathy","orcid":"https://orcid.org/0000-0001-7429-7802","observed_orcids":["https://orcid.org/0000-0001-7429-7802"]},"institutions":[{"id":"https://openalex.org/I21376657","display_name":"Tanta University","ror":"https://ror.org/016jp5b92","country_code":"EG","type":"education","lineage":["https://openalex.org/I21376657"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Mai Fathy","raw_affiliation_strings":["Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt"],"raw_orcid":"https://orcid.org/0000-0002-7609-1418","affiliations":[{"raw_affiliation_string":"Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt","institution_ids":["https://openalex.org/I21376657"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5140099738","display_name":"Amal Seif","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I21376657","display_name":"Tanta University","ror":"https://ror.org/016jp5b92","country_code":"EG","type":"education","lineage":["https://openalex.org/I21376657"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Amal Seif","raw_affiliation_strings":["Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt","institution_ids":["https://openalex.org/I21376657"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068184763","display_name":"Samar El\u2010Kholy","orcid":"https://orcid.org/0000-0003-2816-7243","observed_orcids":["https://orcid.org/0000-0003-2816-7243"]},"institutions":[{"id":"https://openalex.org/I21376657","display_name":"Tanta University","ror":"https://ror.org/016jp5b92","country_code":"EG","type":"education","lineage":["https://openalex.org/I21376657"]}],"countries":["EG"],"is_corresponding":true,"raw_author_name":"Samar El Kholy","raw_affiliation_strings":["Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt"],"raw_orcid":"https://orcid.org/0000-0003-2816-7243","affiliations":[{"raw_affiliation_string":"Zoology Department, Faculty of Science, Tanta University, Tanta, Egypt","institution_ids":["https://openalex.org/I21376657"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5002048008","https://openalex.org/A5068184763"],"corresponding_institution_ids":["https://openalex.org/I21376657"],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":{"value":3890,"currency":"USD","value_usd":3890},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":0.004999999888241291,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2778250585","wikidata":"https://www.wikidata.org/wiki/Q312266","display_name":"Curcumin","level":2,"score":0.8389000296592712},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.758400022983551},{"id":"https://openalex.org/C2776816829","wikidata":"https://www.wikidata.org/wiki/Q407329","display_name":"Resveratrol","level":2,"score":0.6751000285148621},{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.5899999737739563},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.576200008392334},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5257999897003174},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.476500004529953},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.3871000111103058},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.3626999855041504},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35830000042915344},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34139999747276306},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.3321000039577484},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.32600000500679016},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.3057999908924103},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2768999934196472},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.25839999318122864},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2515999972820282},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.2500999867916107}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s41531-026-01592-5","doi":"https://doi.org/10.1038/s41531-026-01592-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41531-026-01592-5","pdf_url":null,"source":{"id":"https://openalex.org/S2737664142","display_name":"npj Parkinson s Disease","issn_l":"2373-8057","issn":["2373-8057"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Parkinson's Disease","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s41531-026-01592-5","doi":"https://doi.org/10.1038/s41531-026-01592-5","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41531-026-01592-5","pdf_url":null,"source":{"id":"https://openalex.org/S2737664142","display_name":"npj Parkinson s Disease","issn_l":"2373-8057","issn":["2373-8057"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","norway-1","oarl","poland-20","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Parkinson's Disease","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":83,"referenced_works":["https://openalex.org/W1504655784","https://openalex.org/W1544465315","https://openalex.org/W1768446746","https://openalex.org/W1839908039","https://openalex.org/W1963707072","https://openalex.org/W1965988091","https://openalex.org/W1984511005","https://openalex.org/W1987007018","https://openalex.org/W1991178530","https://openalex.org/W1996582918","https://openalex.org/W2003808638","https://openalex.org/W2020291601","https://openalex.org/W2033149299","https://openalex.org/W2037128138","https://openalex.org/W2043909083","https://openalex.org/W2057139423","https://openalex.org/W2062729049","https://openalex.org/W2065324486","https://openalex.org/W2079292785","https://openalex.org/W2079677766","https://openalex.org/W2080354721","https://openalex.org/W2084689377","https://openalex.org/W2086249507","https://openalex.org/W2091703402","https://openalex.org/W2093419082","https://openalex.org/W2099540110","https://openalex.org/W2104625973","https://openalex.org/W2129267587","https://openalex.org/W2131008756","https://openalex.org/W2131108901","https://openalex.org/W2136137878","https://openalex.org/W2141545183","https://openalex.org/W2142506572","https://openalex.org/W2156962460","https://openalex.org/W2158079348","https://openalex.org/W2160155244","https://openalex.org/W2162980036","https://openalex.org/W2185657910","https://openalex.org/W2203837084","https://openalex.org/W2260239598","https://openalex.org/W2346129900","https://openalex.org/W2346395796","https://openalex.org/W2430748732","https://openalex.org/W2516264461","https://openalex.org/W2584311212","https://openalex.org/W2604420014","https://openalex.org/W2621361823","https://openalex.org/W2738074786","https://openalex.org/W2753642667","https://openalex.org/W2767485144","https://openalex.org/W2789131406","https://openalex.org/W2796692882","https://openalex.org/W2808916207","https://openalex.org/W2887981960","https://openalex.org/W2892502951","https://openalex.org/W2897095232","https://openalex.org/W2912160894","https://openalex.org/W2969718750","https://openalex.org/W2978810474","https://openalex.org/W2990950261","https://openalex.org/W3135824766","https://openalex.org/W3168436232","https://openalex.org/W3185728462","https://openalex.org/W3197771274","https://openalex.org/W4283015250","https://openalex.org/W4294216483","https://openalex.org/W4313509463","https://openalex.org/W4316135806","https://openalex.org/W4321374384","https://openalex.org/W4327920388","https://openalex.org/W4385950555","https://openalex.org/W4387374469","https://openalex.org/W4388464011","https://openalex.org/W4389297951","https://openalex.org/W4392166652","https://openalex.org/W4403479110","https://openalex.org/W4404511389","https://openalex.org/W4408884121","https://openalex.org/W4413108649","https://openalex.org/W4414570423","https://openalex.org/W4414979836","https://openalex.org/W7097559103","https://openalex.org/W7161833567"],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Parkinson\u2019s":[1],"disease":[2],"(PD)":[3],"is":[4],"a":[5,26,42,208,214],"progressive":[6],"neurodegenerative":[7],"disorder":[8],"characterized":[9],"by":[10,60],"dopaminergic":[11],"neuronal":[12],"loss,":[13],"oxidative":[14,190],"stress,":[15,191],"and":[16,45,71,99,127,133,136,174,181,194,212],"debilitating":[17],"motor":[18,195],"dysfunction.":[19],"Targeting":[20],"the":[21,52,79,104,167,171],"Wnt":[22,38,64,204],"signaling":[23,205],"pathway":[24,57],"provides":[25],"powerful":[27],"disease-modifying":[28,225],"strategy.":[29],"Building":[30],"on":[31],"recent":[32],"evidence":[33],"that":[34,176],"triazine":[35,80,105,172],"derivatives":[36],"modulate":[37],"signaling,":[39,152],"we":[40],"used":[41],"Drosophila":[43],"model":[44],"in":[46,84],"silico":[47],"molecular":[48],"docking":[49],"to":[50],"validate":[51],"specific":[53],"interactions":[54],"driving":[55],"this":[56],"modulation,":[58],"followed":[59],"qPCR":[61],"of":[62,78,150,160,170,219],"key":[63],"signaling-related":[65],"genes:":[66],"armadillo":[67],",":[68,70],"wingless":[69],"frizzled":[72],"3":[73],".":[74],"The":[75,200],"neuroprotective":[76,109,168],"efficacy":[77],"derivative,":[81],"alone":[82],"or":[83,88,119],"combination":[85,178,221],"with":[86,103,117,141,179,198],"curcumin":[87,118,180],"resveratrol,":[89],"was":[90],"subsequently":[91],"evaluated":[92],"using":[93],"behavioral,":[94],"neurochemical,":[95],"biochemical,":[96],"apoptotic,":[97],"immunohistochemical,":[98],"ultrastructural":[100],"assessments.":[101],"Treatment":[102],"derivative":[106,173],"produced":[107],"marked":[108],"effects,":[110],"which":[111],"were":[112],"further":[113,202,217],"enhanced":[114,130,186],"when":[115],"combined":[116],"resveratrol.":[120],"This":[121],"treatment":[122],"significantly":[123],"restored":[124],"dopamine":[125],"levels":[126],"locomotor":[128],"performance,":[129],"superoxide":[131],"dismutase":[132],"catalase":[134],"activities,":[135],"reduced":[137],"lipid":[138],"peroxidation":[139],"compared":[140],"untreated":[142],"rotenone-exposed":[143],"flies.":[144],"Moreover,":[145],"immunohistochemical":[146],"analysis":[147],"indicated":[148],"attenuation":[149],"apoptotic":[151],"while":[153],"transmission":[154],"electron":[155],"microscopy":[156],"revealed":[157],"substantial":[158],"preservation":[159],"neural":[161,192],"ultrastructure.":[162],"Collectively,":[163],"these":[164],"findings":[165,201],"demonstrate":[166],"potential":[169,224],"suggest":[175],"its":[177],"resveratrol":[182],"may":[183],"provide":[184,213],"an":[185],"strategy":[187],"for":[188,216,227],"counteracting":[189],"apoptosis,":[193],"dysfunction":[196],"associated":[197],"PD.":[199,228],"support":[203],"modulation":[206],"as":[207,223],"promising":[209],"mechanistic":[210],"target":[211],"rationale":[215],"investigations":[218],"triazine-based":[220],"strategies":[222],"approaches":[226]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
