{"id":"https://openalex.org/W7225824646","doi":"https://doi.org/10.14740/wjon2817","title":"Steroid Hormone Receptor Isoform Diversity in Gynecologic Oncogenesis: Mechanisms, Biomarker Evidence, and Implications for Precision Oncology","display_name":"Steroid Hormone Receptor Isoform Diversity in Gynecologic Oncogenesis: Mechanisms, Biomarker Evidence, and Implications for Precision Oncology","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225824646","doi":"https://doi.org/10.14740/wjon2817"},"language":"en","primary_location":{"id":"doi:10.14740/wjon2817","doi":"https://doi.org/10.14740/wjon2817","is_oa":true,"landing_page_url":"https://doi.org/10.14740/wjon2817","pdf_url":null,"source":{"id":"https://openalex.org/S47071105","display_name":"World Journal of Oncology","issn_l":"1920-4531","issn":["1920-4531","1920-454X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4328135221","host_organization_name":"Elmer Press Inc.","host_organization_lineage":["https://openalex.org/P4328135221"],"host_organization_lineage_names":["Elmer Press Inc."],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.14740/wjon2817","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106380132","display_name":"Apeksha Padakannaya","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158688498","display_name":"Yenepoya University","ror":"https://ror.org/029zfa075","country_code":"IN","type":"education","lineage":["https://openalex.org/I158688498"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Apeksha Padakannaya","raw_affiliation_strings":["Yenepoya Deemed to be University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Yenepoya Deemed to be University","institution_ids":["https://openalex.org/I158688498"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038551140","display_name":"Chandrahas Koumar Ratnacaram","orcid":"https://orcid.org/0000-0002-8335-7691","observed_orcids":["https://orcid.org/0000-0002-8335-7691"]},"institutions":[{"id":"https://openalex.org/I158688498","display_name":"Yenepoya University","ror":"https://ror.org/029zfa075","country_code":"IN","type":"education","lineage":["https://openalex.org/I158688498"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Chandrahas Koumar Ratnacaram","raw_affiliation_strings":["Yenepoya Deemed to be University"],"raw_orcid":"https://orcid.org/0000-0002-8335-7691","affiliations":[{"raw_affiliation_string":"Yenepoya Deemed to be University","institution_ids":["https://openalex.org/I158688498"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I158688498"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"6","first_page":"790","last_page":"801"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10668","display_name":"Endometrial and Cervical Cancer Treatments","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.621399998664856},{"id":"https://openalex.org/C61367390","wikidata":"https://www.wikidata.org/wiki/Q416601","display_name":"Androgen receptor","level":4,"score":0.6040999889373779},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5526000261306763},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.54339998960495},{"id":"https://openalex.org/C189135053","wikidata":"https://www.wikidata.org/wiki/Q3454531","display_name":"Mineralocorticoid receptor","level":3,"score":0.5192000269889832},{"id":"https://openalex.org/C2779544216","wikidata":"https://www.wikidata.org/wiki/Q411546","display_name":"Steroid hormone receptor","level":5,"score":0.5192000269889832},{"id":"https://openalex.org/C98717036","wikidata":"https://www.wikidata.org/wiki/Q14872994","display_name":"Progesterone receptor","level":5,"score":0.5117999911308289},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5081999897956848},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48980000615119934},{"id":"https://openalex.org/C59493245","wikidata":"https://www.wikidata.org/wiki/Q14877410","display_name":"Glucocorticoid receptor","level":3,"score":0.47850000858306885},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.47609999775886536},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.44830000400543213},{"id":"https://openalex.org/C2781316041","wikidata":"https://www.wikidata.org/wiki/Q1230584","display_name":"Diversity (politics)","level":2,"score":0.4115999937057495},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.38179999589920044},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.34369999170303345},{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.3262999951839447},{"id":"https://openalex.org/C2776888042","wikidata":"https://www.wikidata.org/wiki/Q422137","display_name":"Steroid hormone","level":3,"score":0.31929999589920044},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3075999915599823},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.301800012588501},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.29440000653266907},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2930999994277954},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.28999999165534973},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.28139999508857727},{"id":"https://openalex.org/C23589133","wikidata":"https://www.wikidata.org/wiki/Q412005","display_name":"Hormone receptor","level":4,"score":0.27239999175071716},{"id":"https://openalex.org/C2777002142","wikidata":"https://www.wikidata.org/wiki/Q5031432","display_name":"Cancer biomarkers","level":3,"score":0.2694999873638153},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.263700008392334},{"id":"https://openalex.org/C2780435969","wikidata":"https://www.wikidata.org/wiki/Q5625186","display_name":"Gynecologic oncology","level":2,"score":0.2619999945163727},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.25220000743865967},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.250900000333786}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14740/wjon2817","doi":"https://doi.org/10.14740/wjon2817","is_oa":true,"landing_page_url":"https://doi.org/10.14740/wjon2817","pdf_url":null,"source":{"id":"https://openalex.org/S47071105","display_name":"World Journal of Oncology","issn_l":"1920-4531","issn":["1920-4531","1920-454X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4328135221","host_organization_name":"Elmer Press Inc.","host_organization_lineage":["https://openalex.org/P4328135221"],"host_organization_lineage_names":["Elmer Press Inc."],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.14740/wjon2817","doi":"https://doi.org/10.14740/wjon2817","is_oa":true,"landing_page_url":"https://doi.org/10.14740/wjon2817","pdf_url":null,"source":{"id":"https://openalex.org/S47071105","display_name":"World Journal of Oncology","issn_l":"1920-4531","issn":["1920-4531","1920-454X"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","ki-jl-1","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4328135221","host_organization_name":"Elmer Press Inc.","host_organization_lineage":["https://openalex.org/P4328135221"],"host_organization_lineage_names":["Elmer Press Inc."],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Aberrant":[0],"regulation":[1],"of":[2,96,159],"steroid":[3],"hormone":[4],"receptors":[5],"(SHRs)":[6],"can":[7,169],"alter":[8],"transcriptional":[9],"programs":[10],"relevant":[11,123],"to":[12,93,124],"gynecologic":[13,82,139,174],"tumor":[14,88],"initiation,":[15,37],"progression,":[16],"and":[17,38,70,80,90,107,134,144,156],"treatment":[18],"response.":[19],"Importantly,":[20],"receptor":[21,41,59,62,65,68,72,136,161],"diversity":[22,74],"arises":[23],"through":[24],"biologically":[25],"distinct":[26],"mechanisms,":[27],"including":[28],"alternative":[29,32,35],"pre-mRNA":[30],"splicing,":[31],"promoter":[33],"usage,":[34],"translation":[36],"post-translational":[39],"modification;":[40],"subtypes":[42],"encoded":[43],"by":[44,87],"different":[45],"genes":[46],"should":[47],"not":[48],"be":[49,164,170],"considered":[50],"splice":[51],"variants.":[52],"This":[53],"narrative":[54],"review":[55],"focuses":[56],"on":[57],"estrogen":[58],"(ER),":[60],"progesterone":[61],"(PR),":[63],"androgen":[64],"(AR),":[66],"glucocorticoid":[67],"(GR),":[69],"mineralocorticoid":[71],"(MR)":[73],"in":[75],"ovarian,":[76],"endometrial,":[77],"cervical,":[78],"vulvar,":[79],"related":[81],"malignancies.":[83],"Evidence":[84],"is":[85,130],"organized":[86],"type":[89],"interpreted":[91],"according":[92],"its":[94],"level":[95],"support,":[97],"distinguishing":[98],"mechanistic":[99,119],"preclinical":[100],"observations":[101],"from":[102],"patient":[103],"associations,":[104],"candidate":[105],"biomarkers,":[106],"clinically":[108],"evaluated":[109],"therapeutic":[110],"strategies.":[111],"Breast-cancer":[112],"studies":[113],"are":[114],"used":[115],"only":[116],"as":[117],"comparative":[118],"context":[120],"when":[121],"directly":[122],"SHR":[125],"isoform":[126],"biology.":[127],"Current":[128],"evidence":[129],"strongest":[131],"for":[132,141],"ER-":[133],"PR-related":[135],"forms,":[137],"whereas":[138],"data":[140],"AR,":[142],"GR,":[143],"especially":[145],"MR":[146],"variants":[147],"remain":[148],"limited.":[149],"Clarifying":[150],"the":[151],"molecular":[152],"origin,":[153],"tumor-specific":[154],"function,":[155],"clinical":[157],"validation":[158],"individual":[160],"forms":[162],"will":[163],"essential":[165],"before":[166],"isoform-directed":[167],"approaches":[168],"incorporated":[171],"into":[172],"precision":[173],"oncology.":[175]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
