{"id":"https://openalex.org/W7225824507","doi":"https://doi.org/10.3389/fimmu.2026.1952347","title":"Mitochondria in cancer: unravelling their role in resistance to therapies","display_name":"Mitochondria in cancer: unravelling their role in resistance to therapies","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225824507","doi":"https://doi.org/10.3389/fimmu.2026.1952347"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1952347","doi":"https://doi.org/10.3389/fimmu.2026.1952347","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1952347","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3389/fimmu.2026.1952347","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161474860","display_name":"Salma Jannane","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Salma Jannane","raw_affiliation_strings":["Immunogenetics and Human Pathology Laboratory, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University of Casablanca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunogenetics and Human Pathology Laboratory, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University of Casablanca","institution_ids":["https://openalex.org/I99297268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106868298","display_name":"Zakia Harmak","orcid":"https://orcid.org/0009-0003-6741-761X","observed_orcids":["https://orcid.org/0009-0003-6741-761X"]},"institutions":[{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Zakia Harmak","raw_affiliation_strings":["Immunogenetics and Human Pathology Laboratory, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University of Casablanca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunogenetics and Human Pathology Laboratory, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University of Casablanca","institution_ids":["https://openalex.org/I99297268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139203865","display_name":"Hamza Baddi","orcid":"https://orcid.org/0009-0003-8143-9807","observed_orcids":["https://orcid.org/0009-0003-8143-9807"]},"institutions":[{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":false,"raw_author_name":"Hamza Baddi","raw_affiliation_strings":["Immunogenetics and Human Pathology Laboratory, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University of Casablanca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunogenetics and Human Pathology Laboratory, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University of Casablanca","institution_ids":["https://openalex.org/I99297268"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109855259","display_name":"Bouchra Ghazi","orcid":"https://orcid.org/0000-0003-1699-9085","observed_orcids":["https://orcid.org/0000-0003-1699-9085"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bouchra Ghazi","raw_affiliation_strings":["Immunopathology-Immunomonitoring-Immunotherapy Laboratory, Faculty of Medicine, Mohammed IV University of Sciences and Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunopathology-Immunomonitoring-Immunotherapy Laboratory, Faculty of Medicine, Mohammed IV University of Sciences and Health","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044470246","display_name":"Abdallah Badou","orcid":"https://orcid.org/0000-0003-4849-9085","observed_orcids":["https://orcid.org/0000-0003-4849-9085"]},"institutions":[{"id":"https://openalex.org/I99297268","display_name":"University of Hassan II Casablanca","ror":"https://ror.org/001q4kn48","country_code":"MA","type":"education","lineage":["https://openalex.org/I99297268"]}],"countries":["MA"],"is_corresponding":true,"raw_author_name":"Abdallah Badou","raw_affiliation_strings":["Immunogenetics and Human Pathology Laboratory, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University of Casablanca","The City of Innovation and Technology Transfer, Hassan II University of Casablanca"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunogenetics and Human Pathology Laboratory, Faculty of Medicine and Pharmacy of Casablanca, Hassan II University of Casablanca","institution_ids":["https://openalex.org/I99297268"]},{"raw_affiliation_string":"The City of Innovation and Technology Transfer, Hassan II University of Casablanca","institution_ids":["https://openalex.org/I99297268"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5044470246"],"corresponding_institution_ids":["https://openalex.org/I99297268"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.5938000082969666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.5938000082969666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.23890000581741333,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.043699998408555984,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.7689999938011169},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6854000091552734},{"id":"https://openalex.org/C24586158","wikidata":"https://www.wikidata.org/wiki/Q27075","display_name":"Mitochondrial DNA","level":3,"score":0.6395000219345093},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6365000009536743},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5641000270843506},{"id":"https://openalex.org/C111491248","wikidata":"https://www.wikidata.org/wiki/Q18033821","display_name":"DNAJA3","level":5,"score":0.5299000144004822},{"id":"https://openalex.org/C163950672","wikidata":"https://www.wikidata.org/wiki/Q14905375","display_name":"mitochondrial fusion","level":4,"score":0.4058000147342682},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3905999958515167},{"id":"https://openalex.org/C100206155","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Bioenergetics","level":3,"score":0.37880000472068787},{"id":"https://openalex.org/C2778175917","wikidata":"https://www.wikidata.org/wiki/Q17125553","display_name":"Mitochondrial ROS","level":3,"score":0.37779998779296875},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3587999939918518},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.3452000021934509},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.3427000045776367},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.3199000060558319},{"id":"https://openalex.org/C2991704936","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Cell metabolism","level":3,"score":0.3165000081062317},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.31299999356269836},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.3091000020503998},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.30379998683929443},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.30000001192092896},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.28859999775886536},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.2842999994754791},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.27959999442100525},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.26930001378059387},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.26350000500679016},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2565999925136566}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fimmu.2026.1952347","doi":"https://doi.org/10.3389/fimmu.2026.1952347","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1952347","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1952347","doi":"https://doi.org/10.3389/fimmu.2026.1952347","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1952347","pdf_url":null,"source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":135,"referenced_works":["https://openalex.org/W1458147944","https://openalex.org/W1910012553","https://openalex.org/W1987604182","https://openalex.org/W2005853038","https://openalex.org/W2064876347","https://openalex.org/W2073300038","https://openalex.org/W2095987251","https://openalex.org/W2097637096","https://openalex.org/W2098906695","https://openalex.org/W2100039832","https://openalex.org/W2105137332","https://openalex.org/W2113729748","https://openalex.org/W2117692326","https://openalex.org/W2121330845","https://openalex.org/W2149437353","https://openalex.org/W2156160154","https://openalex.org/W2159475512","https://openalex.org/W2160551785","https://openalex.org/W2164340825","https://openalex.org/W2183934252","https://openalex.org/W2223535266","https://openalex.org/W2234115940","https://openalex.org/W2279311208","https://openalex.org/W2397077488","https://openalex.org/W2503407514","https://openalex.org/W2521327281","https://openalex.org/W2558729727","https://openalex.org/W2593337891","https://openalex.org/W2606811642","https://openalex.org/W2607103422","https://openalex.org/W2625418525","https://openalex.org/W2714470490","https://openalex.org/W2734141593","https://openalex.org/W2753148939","https://openalex.org/W2789892520","https://openalex.org/W2790553047","https://openalex.org/W2793902970","https://openalex.org/W2795915709","https://openalex.org/W2883221432","https://openalex.org/W2883721603","https://openalex.org/W2888230031","https://openalex.org/W2909858565","https://openalex.org/W2913788177","https://openalex.org/W2927282330","https://openalex.org/W2946700301","https://openalex.org/W2946765582","https://openalex.org/W2952254903","https://openalex.org/W2955084980","https://openalex.org/W2971445256","https://openalex.org/W2972170432","https://openalex.org/W2978810474","https://openalex.org/W2981274839","https://openalex.org/W2994421311","https://openalex.org/W3002808620","https://openalex.org/W3006349318","https://openalex.org/W3008361765","https://openalex.org/W3010473434","https://openalex.org/W3020254217","https://openalex.org/W3030503581","https://openalex.org/W3043469221","https://openalex.org/W3046833950","https://openalex.org/W3048511092","https://openalex.org/W3082015854","https://openalex.org/W3082205604","https://openalex.org/W3089985411","https://openalex.org/W3092690010","https://openalex.org/W3095331736","https://openalex.org/W3108887271","https://openalex.org/W3111339501","https://openalex.org/W3126505600","https://openalex.org/W3127051356","https://openalex.org/W3128879566","https://openalex.org/W3143118498","https://openalex.org/W3159430513","https://openalex.org/W3163347686","https://openalex.org/W3173639056","https://openalex.org/W3173665490","https://openalex.org/W3188002297","https://openalex.org/W3201702469","https://openalex.org/W3202508672","https://openalex.org/W3205804972","https://openalex.org/W3217249110","https://openalex.org/W4220751331","https://openalex.org/W4281483346","https://openalex.org/W4281776892","https://openalex.org/W4284879360","https://openalex.org/W4285730243","https://openalex.org/W4286515290","https://openalex.org/W4297198373","https://openalex.org/W4307380321","https://openalex.org/W4319778034","https://openalex.org/W4321014029","https://openalex.org/W4322758128","https://openalex.org/W4360852432","https://openalex.org/W4372291488","https://openalex.org/W4376113304","https://openalex.org/W4379376255","https://openalex.org/W4381165982","https://openalex.org/W4381597608","https://openalex.org/W4384282302","https://openalex.org/W4385415243","https://openalex.org/W4386624401","https://openalex.org/W4386699775","https://openalex.org/W4388820167","https://openalex.org/W4390611686","https://openalex.org/W4390791132","https://openalex.org/W4391809047","https://openalex.org/W4392108967","https://openalex.org/W4392931591","https://openalex.org/W4393338106","https://openalex.org/W4394997002","https://openalex.org/W4401539632","https://openalex.org/W4403203191","https://openalex.org/W4403221233","https://openalex.org/W4403342813","https://openalex.org/W4403510075","https://openalex.org/W4404171708","https://openalex.org/W4404259631","https://openalex.org/W4404487488","https://openalex.org/W4404523054","https://openalex.org/W4405463476","https://openalex.org/W4405517005","https://openalex.org/W4406731670","https://openalex.org/W4407203151","https://openalex.org/W4408276525","https://openalex.org/W4408548219","https://openalex.org/W4411929908","https://openalex.org/W4412376303","https://openalex.org/W4412877884","https://openalex.org/W4416204601","https://openalex.org/W4417107349","https://openalex.org/W7125824042","https://openalex.org/W7134079188","https://openalex.org/W7170162634","https://openalex.org/W7170198886"],"related_works":[],"abstract_inverted_index":{"Mitochondria":[0],"are":[1,64],"now":[2],"recognized":[3],"as":[4,124,126,147],"central":[5,142],"regulators":[6],"of":[7,78,174,212],"tumor":[8,51,85,91,111,152],"biology,":[9],"extending":[10],"beyond":[11],"their":[12],"traditional":[13],"role":[14],"in":[15,35,83],"bioenergetics":[16],"to":[17,27,53,55,67,116,118,127,129,180,232],"control":[18,48],"cell":[19,81],"survival,":[20],"stress":[21],"responses,":[22],"immune":[23,80,93,108,121,154],"signaling,":[24,43],"and":[25,46,58,76,92,110,132,156,177,195,203,215,234],"adaptation":[26],"therapeutic":[28,157],"pressures.":[29],"In":[30],"cancers,":[31],"mitochondrial":[32,41,44,74,104,144,162,175,182,191,213,230,236],"plasticity":[33,145],"encompasses,":[34],"particular,":[36],"metabolic":[37,96],"reprogramming,":[38],"redox":[39],"regulation,":[40],"DNA":[42],"dynamics,":[45],"quality":[47],"mechanisms,":[49],"enabling":[50],"cells":[52],"adapt":[54],"a":[56,141,148,226],"heterogeneous":[57],"challenging":[59],"microenvironment.":[60,86],"However,":[61],"these":[62,138,220],"alterations":[63],"not":[65],"limited":[66],"malignant":[68],"cells:":[69],"they":[70],"also":[71,160],"influence":[72],"the":[73,84,170,178,223],"state":[75],"functions":[77,183],"various":[79],"populations":[82],"The":[87],"reciprocal":[88],"interactions":[89],"between":[90],"mitochondria,":[94],"involving":[95],"competition,":[97],"mitochondrial-derived":[98],"signals,":[99],"and,":[100],"more":[101,209],"recently,":[102],"intercellular":[103],"transfer,":[105],"can":[106],"promote":[107],"dysfunction":[109],"escape.":[112],"These":[113],"mechanisms":[114,139],"contribute":[115],"resistance":[117,128],"immunotherapies,":[119],"particularly":[120],"checkpoint":[122],"blockade,":[123],"well":[125],"certain":[130],"chemotherapies":[131],"targeted":[133],"therapies.":[134],"This":[135],"review":[136],"integrates":[137],"around":[140],"concept:":[143],"serves":[146],"functional":[149],"interface":[150],"linking":[151],"adaptation,":[153],"suppression,":[155],"resistance.":[158],"We":[159],"examine":[161],"vulnerabilities":[163,214],"that":[164],"could":[165,207],"be":[166],"exploited":[167],"therapeutically,":[168],"emphasizing":[169],"highly":[171],"context-dependent":[172],"nature":[173],"targeting":[176,231],"need":[179],"preserve":[181],"essential":[184],"for":[185,225],"antitumor":[186],"immunity.":[187],"Finally,":[188],"we":[189],"discuss":[190],"heterogeneity,":[192],"potential":[193],"biomarkers,":[194],"emerging":[196],"approaches":[197],"based":[198],"on":[199],"single-cell,":[200],"spatial,":[201],"CRISPR,":[202],"multi-omics":[204],"technologies,":[205],"which":[206],"enable":[208],"precise":[210],"identification":[211],"improved":[216],"patient":[217],"stratification.":[218],"Together,":[219],"advances":[221],"pave":[222],"way":[224],"transition":[227],"from":[228],"nonspecific":[229],"context-specific":[233],"precision":[235],"immunotherapy.":[237]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
