{"id":"https://openalex.org/W7225823918","doi":"https://doi.org/10.1126/scitranslmed.aee6618","title":"Osimertinib, platinum, and etoposide for patients with metastatic EGFR / TP53 / RB1 -mutant lung cancers at risk for histological transformation","display_name":"Osimertinib, platinum, and etoposide for patients with metastatic EGFR / TP53 / RB1 -mutant lung cancers at risk for histological transformation","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225823918","doi":"https://doi.org/10.1126/scitranslmed.aee6618"},"language":"en","primary_location":{"id":"doi:10.1126/scitranslmed.aee6618","doi":"https://doi.org/10.1126/scitranslmed.aee6618","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scitranslmed.aee6618","pdf_url":null,"source":{"id":"https://openalex.org/S24207032","display_name":"Science Translational Medicine","issn_l":"1946-6234","issn":["1946-6234","1946-6242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023443732","display_name":"Lena Morrill Gavarr\u00f3","orcid":"https://orcid.org/0000-0002-2242-4010","observed_orcids":["https://orcid.org/0000-0002-2242-4010"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lena Morrill Gavarr\u00f3","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0000-0002-2242-4010","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070865222","display_name":"Monica F. Chen","orcid":"https://orcid.org/0000-0002-7485-2463","observed_orcids":["https://orcid.org/0000-0002-7485-2463"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monica F. Chen","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0000-0002-7485-2463","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026806888","display_name":"\u00c0lvaro Quintanal-Villalonga","orcid":"https://orcid.org/0000-0002-7234-3446","observed_orcids":["https://orcid.org/0000-0002-7234-3446"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"\u00c1lvaro Quintanal Villalonga","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0000-0002-7234-3446","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143232666","display_name":"Yufei Deng","orcid":"https://orcid.org/0009-0000-3352-1126","observed_orcids":["https://orcid.org/0009-0000-3352-1126"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yufei Deng","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0009-0000-3352-1126","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161494635","display_name":"Liancheng Lu","orcid":"https://orcid.org/0009-0003-7914-3230","observed_orcids":["https://orcid.org/0009-0003-7914-3230"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liancheng Lu","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0009-0003-7914-3230","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5117237122","display_name":"Britney Forsyth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Britney Forsyth","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101920851","display_name":"Sahil Sahni","orcid":"https://orcid.org/0009-0006-4678-3903","observed_orcids":["https://orcid.org/0009-0006-4678-3903"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sahil Sahni","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0009-0006-4678-3903","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069418648","display_name":"Eric G. Sun","orcid":"https://orcid.org/0000-0002-9109-1969","observed_orcids":["https://orcid.org/0000-0002-9109-1969"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric G. Sun","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0000-0002-9109-1969","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099071070","display_name":"Swanand Rakhade","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Swanand Rakhade","raw_affiliation_strings":["Columbia University, New York, NY 10027, USA"],"raw_orcid":"https://orcid.org/0000-0002-9321-6999","affiliations":[{"raw_affiliation_string":"Columbia University, New York, NY 10027, USA","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039253933","display_name":"Rania Gaber Mohamed Aly","orcid":"https://orcid.org/0000-0003-1227-6357","observed_orcids":["https://orcid.org/0000-0003-1227-6357"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rania G. Aly","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5132881213","display_name":"Meng Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meng Wang","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082317562","display_name":"Amin H. Sabet","orcid":"https://orcid.org/0000-0001-6010-3632","observed_orcids":["https://orcid.org/0000-0001-6010-3632"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amin Sabet","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0000-0001-6010-3632","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082456906","display_name":"P Solanki","orcid":"https://orcid.org/0000-0002-0064-5656","observed_orcids":["https://orcid.org/0000-0002-0064-5656"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Prithviraj Solanki","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0000-0002-0064-5656","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104158505","display_name":"Christina E. Wilson","orcid":"https://orcid.org/0009-0008-6658-6274","observed_orcids":["https://orcid.org/0009-0008-6658-6274"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Wilson","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0009-0008-6658-6274","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078938585","display_name":"Natasha Rekhtman","orcid":"https://orcid.org/0000-0001-5801-3144","observed_orcids":["https://orcid.org/0000-0001-5801-3144"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natasha Rekhtman","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0000-0001-5801-3144","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077961062","display_name":"Sam E. Tischfield","orcid":"https://orcid.org/0000-0002-5717-3856","observed_orcids":["https://orcid.org/0000-0002-5717-3856"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sam Tischfield","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0000-0002-5717-3856","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053331766","display_name":"Jake June-Koo Lee","orcid":"https://orcid.org/0000-0003-1348-4094","observed_orcids":["https://orcid.org/0000-0003-1348-4094"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jake June-Koo Lee","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0000-0003-1348-4094","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085299610","display_name":"Khadeja A. Moses","orcid":"https://orcid.org/0000-0001-8862-2063","observed_orcids":["https://orcid.org/0000-0001-8862-2063"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Khadeja Moses","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054353657","display_name":"Linda Su Hyun Ahn","orcid":"https://orcid.org/0000-0001-9347-5854","observed_orcids":["https://orcid.org/0000-0001-9347-5854"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda Ahn","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0000-0001-9347-5854","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025520721","display_name":"Clare Wilhelm","orcid":"https://orcid.org/0000-0003-2437-5387","observed_orcids":["https://orcid.org/0000-0003-2437-5387"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Clare Wilhelm","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0000-0003-2437-5387","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076531545","display_name":"Amanda Pupo","orcid":"https://orcid.org/0009-0008-1798-8170","observed_orcids":["https://orcid.org/0009-0008-1798-8170"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda Pupo","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0009-0008-1798-8170","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001711697","display_name":"Christina J. Falcon","orcid":"https://orcid.org/0000-0001-9143-1639","observed_orcids":["https://orcid.org/0000-0001-9143-1639"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christina Falcon","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0000-0001-9143-1639","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057157459","display_name":"Andrea Arf\u00e8","orcid":"https://orcid.org/0000-0003-1534-0609","observed_orcids":["https://orcid.org/0000-0003-1534-0609"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea Arfe","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0000-0003-1534-0609","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002965160","display_name":"Katherine S. Panageas","orcid":"https://orcid.org/0000-0002-6591-604X","observed_orcids":["https://orcid.org/0000-0002-6591-604X"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine Panageas","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0000-0002-6591-604X","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039791495","display_name":"Mark G. Kris","orcid":"https://orcid.org/0000-0002-7317-5341","observed_orcids":["https://orcid.org/0000-0002-7317-5341"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark G. Kris","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059043512","display_name":"Parvathy Manoj","orcid":"https://orcid.org/0000-0002-1121-0121","observed_orcids":["https://orcid.org/0000-0002-1121-0121"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Parvathy Manoj","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039040472","display_name":"Ignas Masilionis","orcid":"https://orcid.org/0000-0001-7937-9014","observed_orcids":["https://orcid.org/0000-0001-7937-9014"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ignas Masilionis","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0000-0001-7937-9014","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059825526","display_name":"Ojasvi Chaudhary","orcid":"https://orcid.org/0000-0003-1434-2506","observed_orcids":["https://orcid.org/0000-0003-1434-2506"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ojasvi Chaudhary","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0000-0003-1434-2506","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082561080","display_name":"Ronan Chalign\u00e9","orcid":"https://orcid.org/0000-0003-4332-3291","observed_orcids":["https://orcid.org/0000-0003-4332-3291"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ronan Chaligne","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0000-0003-4332-3291","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009793829","display_name":"Esther Red\u00edn","orcid":"https://orcid.org/0000-0001-9539-7298","observed_orcids":["https://orcid.org/0000-0001-9539-7298"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Esther Redin","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0000-0001-9539-7298","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014665461","display_name":"Eric E. Gardner","orcid":"https://orcid.org/0000-0002-1552-2675","observed_orcids":["https://orcid.org/0000-0002-1552-2675"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Gardner","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0000-0002-1552-2675","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161419499","display_name":"Xinjun Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinjun Wang","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074451448","display_name":"Dana Pe\u2019er","orcid":"https://orcid.org/0000-0002-9259-8817","observed_orcids":["https://orcid.org/0000-0002-9259-8817"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dana Pe\u2019er","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0000-0002-9259-8817","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049524331","display_name":"Charles M. Rudin","orcid":"https://orcid.org/0000-0001-5204-3465","observed_orcids":["https://orcid.org/0000-0001-5204-3465"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charles M. Rudin","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0000-0001-5204-3465","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016682112","display_name":"Joseph Minhow Chan","orcid":"https://orcid.org/0000-0001-5249-7395","observed_orcids":["https://orcid.org/0000-0001-5249-7395"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph M. Chan","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0000-0001-5249-7395","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014837967","display_name":"Helena Alexandra Yu","orcid":"https://orcid.org/0000-0002-0377-9510","observed_orcids":["https://orcid.org/0000-0002-0377-9510"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Helena A. Yu","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA"],"raw_orcid":"https://orcid.org/0000-0002-0377-9510","affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"Meyer Cancer Center, Weill Cornell Medicine, New York, NY 10065, USA","institution_ids":["https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"875","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2777626846","wikidata":"https://www.wikidata.org/wiki/Q21506464","display_name":"Osimertinib","level":5,"score":0.7192000150680542},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6685000061988831},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5498999953269958},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5123000144958496},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5008000135421753},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.4982999861240387},{"id":"https://openalex.org/C2778119113","wikidata":"https://www.wikidata.org/wiki/Q418817","display_name":"Etoposide","level":3,"score":0.4805999994277954},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.4661000072956085},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.44279998540878296},{"id":"https://openalex.org/C2779438470","wikidata":"https://www.wikidata.org/wiki/Q424401","display_name":"Epidermal growth factor receptor","level":3,"score":0.43959999084472656},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4043000042438507},{"id":"https://openalex.org/C31033888","wikidata":"https://www.wikidata.org/wiki/Q752076","display_name":"Malignant transformation","level":2,"score":0.38359999656677246},{"id":"https://openalex.org/C2780219982","wikidata":"https://www.wikidata.org/wiki/Q17544238","display_name":"YAP1","level":4,"score":0.349700003862381},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.3402999937534332},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3391999900341034},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.33160001039505005},{"id":"https://openalex.org/C113280763","wikidata":"https://www.wikidata.org/wiki/Q2326546","display_name":"Subclinical infection","level":2,"score":0.323199987411499},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.31360000371932983},{"id":"https://openalex.org/C193270364","wikidata":"https://www.wikidata.org/wiki/Q17141925","display_name":"Tissue microarray","level":3,"score":0.3034999966621399},{"id":"https://openalex.org/C76419328","wikidata":"https://www.wikidata.org/wiki/Q74419","display_name":"Epithelial\u2013mesenchymal transition","level":4,"score":0.2953999936580658},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2856000065803528},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.2775999903678894},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.25699999928474426},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.2549000084400177}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1126/scitranslmed.aee6618","doi":"https://doi.org/10.1126/scitranslmed.aee6618","is_oa":false,"landing_page_url":"https://doi.org/10.1126/scitranslmed.aee6618","pdf_url":null,"source":{"id":"https://openalex.org/S24207032","display_name":"Science Translational Medicine","issn_l":"1946-6234","issn":["1946-6234","1946-6242"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science Translational Medicine","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W223909586","https://openalex.org/W1903523058","https://openalex.org/W1979594866","https://openalex.org/W1980497534","https://openalex.org/W1987283660","https://openalex.org/W2023171799","https://openalex.org/W2035114699","https://openalex.org/W2102619694","https://openalex.org/W2103441770","https://openalex.org/W2111292112","https://openalex.org/W2117757143","https://openalex.org/W2130410032","https://openalex.org/W2138207763","https://openalex.org/W2146512944","https://openalex.org/W2154149901","https://openalex.org/W2168342464","https://openalex.org/W2170830174","https://openalex.org/W2179438025","https://openalex.org/W2180481128","https://openalex.org/W2567986926","https://openalex.org/W2603411876","https://openalex.org/W2612786119","https://openalex.org/W2750416916","https://openalex.org/W2770828094","https://openalex.org/W2783337717","https://openalex.org/W2786927525","https://openalex.org/W2810097927","https://openalex.org/W2905529840","https://openalex.org/W2940256315","https://openalex.org/W2943197970","https://openalex.org/W2952339916","https://openalex.org/W2952506496","https://openalex.org/W2999801017","https://openalex.org/W3028669282","https://openalex.org/W3090613431","https://openalex.org/W3099862724","https://openalex.org/W3131055609","https://openalex.org/W3159180476","https://openalex.org/W3168693194","https://openalex.org/W3173930299","https://openalex.org/W3206277552","https://openalex.org/W3206940911","https://openalex.org/W3213253836","https://openalex.org/W4210587306","https://openalex.org/W4280596398","https://openalex.org/W4292229922","https://openalex.org/W4293812614","https://openalex.org/W4295141458","https://openalex.org/W4309944312","https://openalex.org/W4310859551","https://openalex.org/W4327626301","https://openalex.org/W4365997929","https://openalex.org/W4383265707","https://openalex.org/W4385638791","https://openalex.org/W4386741480","https://openalex.org/W4388484248","https://openalex.org/W4389275881","https://openalex.org/W4391657953","https://openalex.org/W4399608272","https://openalex.org/W4407055903","https://openalex.org/W4408881024","https://openalex.org/W6893546887"],"related_works":[],"abstract_inverted_index":{"Although":[0],"EGFR":[1,13,39],"inhibitors":[2],"are":[3],"highly":[4],"effective":[5],"for":[6],"treating":[7],"EGFR-":[8],"mutant":[9],"lung":[10,25],"adenocarcinomas":[11],"(":[12,47],"+":[14,40],"LUADs),":[15],"resistance":[16],"inevitably":[17],"emerges,":[18],"with":[19,38,55,59,79,106],"histologic":[20],"transformation":[21,46,113],"to":[22,114,129,137],"small":[23],"cell":[24],"cancer":[26],"(SCLC)":[27],"representing":[28],"a":[29],"particularly":[30],"aggressive":[31],"mechanism.":[32],"Our":[33],"prospective":[34],"trial":[35],"enrolled":[36],"patients":[37,72],"LUAD":[41],"at":[42],"high":[43],"risk":[44],"of":[45,66,71,74,83,89,97,132,143,163],"TP53":[48,107],"/":[49,108],"RB1":[50,109],"-deficient)":[51],"and":[52,61,86,93,102,120,141,146],"treated":[53],"them":[54],"first-line":[56],"osimertinib":[57,154],"combined":[58],"platinum":[60],"etoposide.":[62],"Despite":[63],"the":[64,133,161],"addition":[65],"SCLC-directed":[67],"chemotherapy,":[68],"nearly":[69],"half":[70],"(5":[73],"11)":[75],"underwent":[76],"SCLC":[77],"transformation,":[78],"median":[80],"progression-free":[81],"survival":[82,88],"11":[84],"months":[85],"overall":[87],"33":[90],"months.":[91],"Genomic":[92],"single-cell":[94],"transcriptomic":[95],"profiling":[96],"patient":[98],"samples":[99],"revealed":[100],"clinical":[101],"subclinical":[103],"plasticity":[104,126,164],"associated":[105],"comutations,":[110],"including":[111],"histological":[112],"SCLC,":[115],"as":[116,118],"well":[117],"mesenchymal":[119],"squamous":[121],"histologies.":[122],"These":[123,156],"changes":[124],"in":[125,165],"were":[127],"linked":[128],"progressive":[130],"disruption":[131],"RB":[134],"pathway,":[135],"leading":[136],"altered":[138],"chromatin":[139],"accessibility":[140],"induction":[142],"neuronal":[144],"differentiation":[145],"epithelial-to-mesenchymal":[147],"transition":[148],"transcriptional":[149],"programs,":[150],"further":[151],"intensified":[152],"by":[153],"treatment.":[155],"findings":[157],"provide":[158],"insights":[159],"into":[160],"role":[162],"mediating":[166],"drug":[167],"tolerance.":[168]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
