{"id":"https://openalex.org/W7225823384","doi":"https://doi.org/10.1007/s40005-026-00841-2","title":"Polymeric nanoparticles for chronic wound therapy: integrating polymer bioactivity, semisolid formulation, and the wound microenvironment","display_name":"Polymeric nanoparticles for chronic wound therapy: integrating polymer bioactivity, semisolid formulation, and the wound microenvironment","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225823384","doi":"https://doi.org/10.1007/s40005-026-00841-2"},"language":"en","primary_location":{"id":"doi:10.1007/s40005-026-00841-2","doi":"https://doi.org/10.1007/s40005-026-00841-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40005-026-00841-2","pdf_url":null,"source":{"id":"https://openalex.org/S70884739","display_name":"Journal of Pharmaceutical Investigation","issn_l":"2093-5552","issn":["2093-5552","2093-6214"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","kci-registered","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1007/s40005-026-00841-2","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063019167","display_name":"Monica Sakla","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]},{"id":"https://openalex.org/I96823368","display_name":"German University in Cairo","ror":"https://ror.org/03rjt0z37","country_code":"EG","type":"education","lineage":["https://openalex.org/I96823368"]}],"countries":["DE","EG"],"is_corresponding":false,"raw_author_name":"Monica Sakla","raw_affiliation_strings":["Department of Pharmaceutical Technology, Faculty of Pharmacy, German University in Cairo (GUC), Cairo, Egypt","Pharmaceutical Materials and Processing, Department of Pharmacy, Saarland University, Saarbr\u00fccken, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Technology, Faculty of Pharmacy, German University in Cairo (GUC), Cairo, Egypt","institution_ids":["https://openalex.org/I96823368"]},{"raw_affiliation_string":"Pharmaceutical Materials and Processing, Department of Pharmacy, Saarland University, Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161481243","display_name":"Shahir Aziz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I96823368","display_name":"German University in Cairo","ror":"https://ror.org/03rjt0z37","country_code":"EG","type":"education","lineage":["https://openalex.org/I96823368"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Shahir Aziz","raw_affiliation_strings":["Department of Pharmaceutical Technology, Faculty of Pharmacy, German University in Cairo (GUC), Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Technology, Faculty of Pharmacy, German University in Cairo (GUC), Cairo, Egypt","institution_ids":["https://openalex.org/I96823368"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109635642","display_name":"Samar Mansour","orcid":"https://orcid.org/0000-0002-3033-164X","observed_orcids":["https://orcid.org/0000-0002-3033-164X"]},"institutions":[{"id":"https://openalex.org/I4405266782","display_name":"German International University","ror":"https://ror.org/05j3zem39","country_code":"EG","type":"education","lineage":["https://openalex.org/I4405266782"]},{"id":"https://openalex.org/I96823368","display_name":"German University in Cairo","ror":"https://ror.org/03rjt0z37","country_code":"EG","type":"education","lineage":["https://openalex.org/I96823368"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Samar Mansour","raw_affiliation_strings":["Department of Pharmaceutical Technology, Faculty of Pharmacy, German University in Cairo (GUC), Cairo, Egypt","Faculty of Pharmaceutical Engineering and Technology, German International University (GIU), Cairo, Egypt"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Technology, Faculty of Pharmacy, German University in Cairo (GUC), Cairo, Egypt","institution_ids":["https://openalex.org/I96823368"]},{"raw_affiliation_string":"Faculty of Pharmaceutical Engineering and Technology, German International University (GIU), Cairo, Egypt","institution_ids":["https://openalex.org/I4405266782"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086057683","display_name":"Sangeun Lee","orcid":"https://orcid.org/0000-0001-8716-0637","observed_orcids":["https://orcid.org/0000-0001-8716-0637"]},"institutions":[{"id":"https://openalex.org/I4210124929","display_name":"Helmholtz Centre for Infection Research","ror":"https://ror.org/03d0p2685","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929"]},{"id":"https://openalex.org/I4210142777","display_name":"Helmholtz Institute for Pharmaceutical Research Saarland","ror":"https://ror.org/042dsac10","country_code":"DE","type":"government","lineage":["https://openalex.org/I1305996414","https://openalex.org/I4210124929","https://openalex.org/I4210142777"]},{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Sangeun Lee","raw_affiliation_strings":["Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarbr\u00fccken, Germany","Pharmaceutical Materials and Processing, Department of Pharmacy, Saarland University, Saarbr\u00fccken, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8716-0637","affiliations":[{"raw_affiliation_string":"Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I4210124929","https://openalex.org/I4210142777"]},{"raw_affiliation_string":"Pharmaceutical Materials and Processing, Department of Pharmacy, Saarland University, Saarbr\u00fccken, Germany","institution_ids":["https://openalex.org/I91712215"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5086057683"],"corresponding_institution_ids":["https://openalex.org/I4210124929","https://openalex.org/I4210142777","https://openalex.org/I91712215"],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":{"value":3890,"currency":"USD","value_usd":3890},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.6930999755859375},{"id":"https://openalex.org/C2781051411","wikidata":"https://www.wikidata.org/wiki/Q2078852","display_name":"Chronic wound","level":3,"score":0.5791000127792358},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.5044999718666077},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4916999936103821},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.44699999690055847},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.43160000443458557},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.34290000796318054},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32179999351501465},{"id":"https://openalex.org/C3020296196","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative damage","level":3,"score":0.31940001249313354},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.3012000024318695},{"id":"https://openalex.org/C3020610862","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue repair","level":2,"score":0.2964000105857849},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.2784999907016754},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.2777000069618225},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.2773999869823456},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2667999863624573},{"id":"https://openalex.org/C2776714187","wikidata":"https://www.wikidata.org/wiki/Q212410","display_name":"Protease","level":3,"score":0.2522999942302704}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s40005-026-00841-2","doi":"https://doi.org/10.1007/s40005-026-00841-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40005-026-00841-2","pdf_url":null,"source":{"id":"https://openalex.org/S70884739","display_name":"Journal of Pharmaceutical Investigation","issn_l":"2093-5552","issn":["2093-5552","2093-6214"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","kci-registered","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Investigation","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1007/s40005-026-00841-2","doi":"https://doi.org/10.1007/s40005-026-00841-2","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s40005-026-00841-2","pdf_url":null,"source":{"id":"https://openalex.org/S70884739","display_name":"Journal of Pharmaceutical Investigation","issn_l":"2093-5552","issn":["2093-5552","2093-6214"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","kci-registered","norway-1","poland-40","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmaceutical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":227,"referenced_works":["https://openalex.org/W1809035786","https://openalex.org/W1819622007","https://openalex.org/W1843302206","https://openalex.org/W1949832432","https://openalex.org/W1967401897","https://openalex.org/W1968179926","https://openalex.org/W1971500643","https://openalex.org/W1972129160","https://openalex.org/W1974933131","https://openalex.org/W1975088956","https://openalex.org/W1987825791","https://openalex.org/W1988223511","https://openalex.org/W1998624315","https://openalex.org/W2001143650","https://openalex.org/W2011569383","https://openalex.org/W2012727362","https://openalex.org/W2015530052","https://openalex.org/W2020398834","https://openalex.org/W2024306244","https://openalex.org/W2025292917","https://openalex.org/W2050877797","https://openalex.org/W2052116137","https://openalex.org/W2055037957","https://openalex.org/W2062440390","https://openalex.org/W2065181822","https://openalex.org/W2069165747","https://openalex.org/W2074630757","https://openalex.org/W2087417066","https://openalex.org/W2088895766","https://openalex.org/W2095395900","https://openalex.org/W2100767817","https://openalex.org/W2101312385","https://openalex.org/W2107660675","https://openalex.org/W2113972541","https://openalex.org/W2121511326","https://openalex.org/W2126890281","https://openalex.org/W2131945662","https://openalex.org/W2144874527","https://openalex.org/W2145496621","https://openalex.org/W2147038478","https://openalex.org/W2153186862","https://openalex.org/W2156492800","https://openalex.org/W2159115452","https://openalex.org/W2164841185","https://openalex.org/W2170101626","https://openalex.org/W2171416093","https://openalex.org/W2176823143","https://openalex.org/W2229086138","https://openalex.org/W2296196708","https://openalex.org/W2344598639","https://openalex.org/W2345127954","https://openalex.org/W2589067428","https://openalex.org/W2701973945","https://openalex.org/W2795652485","https://openalex.org/W2799932713","https://openalex.org/W2809295976","https://openalex.org/W2886853896","https://openalex.org/W2887467147","https://openalex.org/W2888517593","https://openalex.org/W2892397780","https://openalex.org/W2898522810","https://openalex.org/W2901273961","https://openalex.org/W2924085198","https://openalex.org/W2947075584","https://openalex.org/W2955670821","https://openalex.org/W2962904682","https://openalex.org/W2972344267","https://openalex.org/W2973942010","https://openalex.org/W2977432665","https://openalex.org/W2977448327","https://openalex.org/W2983618915","https://openalex.org/W2990283565","https://openalex.org/W2999307392","https://openalex.org/W3003657535","https://openalex.org/W3006454610","https://openalex.org/W3015114136","https://openalex.org/W3020058005","https://openalex.org/W3030674895","https://openalex.org/W3033475116","https://openalex.org/W3036106325","https://openalex.org/W3036924121","https://openalex.org/W3041256382","https://openalex.org/W3047875984","https://openalex.org/W3087208630","https://openalex.org/W3087896330","https://openalex.org/W3113083839","https://openalex.org/W3125201854","https://openalex.org/W3131555792","https://openalex.org/W3138572009","https://openalex.org/W3148353015","https://openalex.org/W3149202180","https://openalex.org/W3157057024","https://openalex.org/W3159065861","https://openalex.org/W3160349886","https://openalex.org/W3171498185","https://openalex.org/W3175377719","https://openalex.org/W3177756681","https://openalex.org/W3196662301","https://openalex.org/W3200379753","https://openalex.org/W3211109061","https://openalex.org/W3212033179","https://openalex.org/W3216967779","https://openalex.org/W4200280317","https://openalex.org/W4200394740","https://openalex.org/W4221104975","https://openalex.org/W4221109530","https://openalex.org/W4229332568","https://openalex.org/W4280492050","https://openalex.org/W4281770502","https://openalex.org/W4282029199","https://openalex.org/W4294783133","https://openalex.org/W4297998362","https://openalex.org/W4306803502","https://openalex.org/W4308957056","https://openalex.org/W4310597404","https://openalex.org/W4311931865","https://openalex.org/W4311964451","https://openalex.org/W4312039235","https://openalex.org/W4313414730","https://openalex.org/W4313458514","https://openalex.org/W4313479033","https://openalex.org/W4318046678","https://openalex.org/W4318677147","https://openalex.org/W4319063493","https://openalex.org/W4327739331","https://openalex.org/W4360616834","https://openalex.org/W4362576246","https://openalex.org/W4377092492","https://openalex.org/W4379233503","https://openalex.org/W4383371965","https://openalex.org/W4385577666","https://openalex.org/W4385955701","https://openalex.org/W4386438984","https://openalex.org/W4386811600","https://openalex.org/W4387661160","https://openalex.org/W4388578352","https://openalex.org/W4389108769","https://openalex.org/W4390789956","https://openalex.org/W4391463581","https://openalex.org/W4391783344","https://openalex.org/W4391814110","https://openalex.org/W4392698269","https://openalex.org/W4393144087","https://openalex.org/W4394687120","https://openalex.org/W4394812826","https://openalex.org/W4394857483","https://openalex.org/W4398242665","https://openalex.org/W4399360398","https://openalex.org/W4399697775","https://openalex.org/W4399732076","https://openalex.org/W4400485270","https://openalex.org/W4400814502","https://openalex.org/W4400889181","https://openalex.org/W4401015406","https://openalex.org/W4401595897","https://openalex.org/W4402830370","https://openalex.org/W4403117317","https://openalex.org/W4403781908","https://openalex.org/W4405986983","https://openalex.org/W4407095669","https://openalex.org/W4407566209","https://openalex.org/W4407814202","https://openalex.org/W4408721591","https://openalex.org/W4409187177","https://openalex.org/W4409266144","https://openalex.org/W4409855533","https://openalex.org/W4410015682","https://openalex.org/W4410282176","https://openalex.org/W4410459466","https://openalex.org/W4410722666","https://openalex.org/W4410989227","https://openalex.org/W4411165782","https://openalex.org/W4411437122","https://openalex.org/W4411441116","https://openalex.org/W4411893415","https://openalex.org/W4412429005","https://openalex.org/W4413038283","https://openalex.org/W4413137938","https://openalex.org/W4413294690","https://openalex.org/W4413309353","https://openalex.org/W4413353694","https://openalex.org/W4414130206","https://openalex.org/W4414161949","https://openalex.org/W4414942947","https://openalex.org/W4415207061","https://openalex.org/W4415278237","https://openalex.org/W4415543047","https://openalex.org/W4415623454","https://openalex.org/W4415646767","https://openalex.org/W4415762445","https://openalex.org/W4415855207","https://openalex.org/W4416067713","https://openalex.org/W4416202096","https://openalex.org/W4416382661","https://openalex.org/W4416763108","https://openalex.org/W4416911961","https://openalex.org/W4417126390","https://openalex.org/W4417416303","https://openalex.org/W4417422933","https://openalex.org/W7115059487","https://openalex.org/W7123688253","https://openalex.org/W7124542750","https://openalex.org/W7126381195","https://openalex.org/W7127188300","https://openalex.org/W7128293269","https://openalex.org/W7128588945","https://openalex.org/W7128951226","https://openalex.org/W7128994843","https://openalex.org/W7129021080","https://openalex.org/W7129649084","https://openalex.org/W7130531826","https://openalex.org/W7131354982","https://openalex.org/W7133906455","https://openalex.org/W7141613998","https://openalex.org/W7148379829","https://openalex.org/W7149670633","https://openalex.org/W7154681616","https://openalex.org/W7155350995","https://openalex.org/W7159158984","https://openalex.org/W7160188046","https://openalex.org/W7160285667","https://openalex.org/W7162549682","https://openalex.org/W7163920376","https://openalex.org/W7163959222","https://openalex.org/W7164053340","https://openalex.org/W7164573749","https://openalex.org/W7204457284"],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Wound":[2],"healing":[3],"is":[4,138],"governed":[5],"by":[6],"the":[7,12,84,91,102,108,127,141,224],"wound":[8,57,110,149,183,203],"microenvironment,":[9],"which":[10,145,194],"coordinates":[11],"cellular":[13],"and":[14,33,46,67,104,112,133,157,174,202,221,231,236,248],"molecular":[15],"processes":[16],"required":[17],"for":[18,82,170,244,252],"tissue":[19,44],"repair.":[20],"In":[21],"chronic":[22,109,253],"wounds,":[23],"persistent":[24],"inflammation,":[25],"oxidative":[26],"stress,":[27],"infection,":[28],"hypoxia,":[29],"excessive":[30],"protease":[31],"activity,":[32],"impaired":[34,116],"angiogenesis":[35],"become":[36],"closely":[37],"interconnected,":[38],"creating":[39],"pathological":[40,105,179],"conditions":[41,205],"that":[42,63],"sustain":[43],"damage":[45],"delay":[47],"regeneration.":[48],"Although":[49],"topical":[50,88],"semisolid":[51,73,122,125,199,225],"formulations":[52,89],"are":[53,206],"widely":[54],"used":[55],"in":[56,193],"management,":[58],"they":[59],"often":[60],"exhibit":[61],"limitations":[62],"reduce":[64],"local":[65],"bioavailability":[66],"efficacy.":[68],"Incorporating":[69],"polymeric":[70,131],"nanoparticles":[71,213],"into":[72],"matrices":[74],"has":[75],"therefore":[76],"emerged":[77],"as":[78,163,208],"a":[79,168,190,241],"promising":[80],"strategy":[81],"combining":[83],"practical":[85],"advantages":[86],"of":[87,94,107,130,143],"with":[90],"multifunctional":[92],"capabilities":[93],"nanodelivery":[95],"systems.":[96],"Area":[97],"covered":[98],"This":[99,234],"review":[100],"examines":[101],"biochemical":[103],"features":[106],"microenvironment":[111],"their":[113,161],"impact":[114],"on":[115,140],"healing.":[117],"It":[118],"then":[119],"discusses":[120],"nanoparticle-loaded":[121],"platforms,":[123],"including":[124],"formulations,":[126],"therapeutic":[128,215],"benefits":[129],"nanoparticles,":[132],"nanoparticle-forming":[134],"polymers.":[135],"Particular":[136],"emphasis":[137],"placed":[139],"bioactivity":[142],"polymers,":[144],"can":[146],"actively":[147],"support":[148],"repair":[150],"through":[151],"anti-inflammatory,":[152],"antimicrobial,":[153],"hemostatic,":[154],"regenerative,":[155],"antioxidant,":[156],"stimuli-responsive":[158],"functions":[159],"beyond":[160],"role":[162],"carriers.":[164],"These":[165],"properties":[166],"provide":[167,240],"basis":[169],"matching":[171],"polymer":[172,195],"chemistry":[173],"nanoparticle":[175,197],"functionality":[176],"to":[177],"dominant":[178],"barriers":[180],"within":[181],"specific":[182],"microenvironments.":[184],"Expert":[185],"opinion":[186],"Finally,":[187],"we":[188],"advance":[189],"formulation-system":[191],"perspective":[192],"chemistry,":[196],"functionality,":[198],"matrix":[200,226],"behavior,":[201],"microenvironmental":[204],"treated":[207],"interdependent":[209],"design":[210],"variables.":[211],"Polymeric":[212],"offer":[214],"protection,":[216],"targeted":[217],"delivery,":[218],"controlled":[219],"release,":[220],"bioactivity,":[222],"while":[223],"regulates":[227],"applicability,":[228],"retention,":[229],"dispersion,":[230],"release":[232],"behavior.":[233],"microenvironment-matched":[235],"matrix-integrated":[237],"framework":[238],"may":[239],"rational":[242],"foundation":[243],"developing":[245],"precise,":[246],"multifunctional,":[247],"effective":[249],"next-generation":[250],"therapies":[251],"wounds.":[254]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}