{"id":"https://openalex.org/W7225821097","doi":"https://doi.org/10.6084/m9.figshare.34987876","title":"Phytochemistry and multi-target pharmacological mechanisms of Abelmoschus manihot (L.) Medicus in diabetic nephropathy","display_name":"Phytochemistry and multi-target pharmacological mechanisms of Abelmoschus manihot (L.) Medicus in diabetic nephropathy","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225821097","doi":"https://doi.org/10.6084/m9.figshare.34987876"},"language":"en","primary_location":{"id":"doi:10.6084/m9.figshare.34987876","doi":"https://doi.org/10.6084/m9.figshare.34987876","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.34987876","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.6084/m9.figshare.34987876","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161439239","display_name":"Wenbo Zhu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wenbo Zhu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158026366","display_name":"Fazhi Su","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fazhi Su","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161456188","display_name":"Mingyang Zhao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mingyang Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074506356","display_name":"Mengfei Tian","orcid":"https://orcid.org/0000-0002-7901-6149","observed_orcids":["https://orcid.org/0000-0002-7901-6149"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mengfei Tian","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5161465802","display_name":"Lei Tang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lei Tang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.29350000619888306,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.29350000619888306,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.23849999904632568,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13919","display_name":"Medicinal plant effects and applications","score":0.11379999667406082,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8319000005722046},{"id":"https://openalex.org/C195475562","wikidata":"https://www.wikidata.org/wiki/Q1639139","display_name":"Phytochemical","level":2,"score":0.717199981212616},{"id":"https://openalex.org/C2779922275","wikidata":"https://www.wikidata.org/wiki/Q1129105","display_name":"Diabetic nephropathy","level":3,"score":0.6972000002861023},{"id":"https://openalex.org/C523307889","wikidata":"https://www.wikidata.org/wiki/Q640068","display_name":"Phytochemistry","level":2,"score":0.6689000129699707},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.5580000281333923},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5013999938964844},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.4449999928474426},{"id":"https://openalex.org/C188947578","wikidata":"https://www.wikidata.org/wiki/Q200253","display_name":"Traditional Chinese medicine","level":3,"score":0.42489999532699585},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.38260000944137573},{"id":"https://openalex.org/C2781184683","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Nephropathy","level":3,"score":0.37220001220703125},{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.34220001101493835},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.29269999265670776},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.29109999537467957},{"id":"https://openalex.org/C2779158651","wikidata":"https://www.wikidata.org/wiki/Q188840","display_name":"Medicinal plants","level":2,"score":0.26420000195503235},{"id":"https://openalex.org/C3018601027","wikidata":"https://www.wikidata.org/wiki/Q83124","display_name":"Manihot esculenta","level":2,"score":0.25760000944137573},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.2549000084400177}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.6084/m9.figshare.34987876","doi":"https://doi.org/10.6084/m9.figshare.34987876","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.34987876","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.6084/m9.figshare.34987876.v1","doi":"https://doi.org/10.6084/m9.figshare.34987876.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.34987876.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.6084/m9.figshare.34987876","doi":"https://doi.org/10.6084/m9.figshare.34987876","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.34987876","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Diabetic":[0],"nephropathy":[1],"is":[2],"a":[3,55,98],"leading":[4],"cause":[5],"of":[6,58,62,89,104],"end-stage":[7],"renal":[8],"disease,":[9],"but":[10],"current":[11],"therapies":[12],"remain":[13],"limited":[14],"in":[15,27,76,94],"efficacy":[16],"and":[17,45,69,82],"safety.":[18],"Abelmoschus":[19],"manihot":[20],"(L.)":[21],"Medicus":[22],"possess":[23],"kidney":[24,43],"protecting":[25],"effects":[26],"traditional":[28],"Chinese":[29],"medicine.":[30],"Modern":[31],"clinical":[32],"practice":[33],"has":[34],"used":[35],"its":[36],"standard":[37],"preparation":[38],"Huangkui":[39],"capsules":[40],"to":[41],"treat":[42],"diseases":[44],"confirmed":[46],"flavonoids":[47],"are":[48],"main":[49],"active":[50],"ingredients.":[51],"This":[52],"review":[53],"provides":[54],"comprehensive":[56],"overview":[57],"the":[59,86,90,102],"phytochemical":[60],"profile":[61],"A.":[63],"manihot,":[64],"with":[65],"emphasis":[66],"on":[67],"flavonoids,":[68],"systematically":[70],"summarises":[71],"their":[72],"multi-target":[73],"pharmacological":[74],"mechanisms":[75],"DN,":[77],"including":[78],"anti-inflammatory,":[79],"anti-oxidant,":[80],"anti-fibrosis":[81],"cytoprotective":[83],"effects.":[84],"Additionally,":[85],"structural":[87],"characteristics":[88],"compounds":[91],"also":[92],"describe":[93],"this":[95,108],"article,":[96],"providing":[97],"chemical":[99],"rationale":[100],"for":[101],"development":[103],"flavonoid-based":[105],"therapeutics":[106],"against":[107],"complex":[109],"disease.":[110]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}