{"id":"https://openalex.org/W7225820989","doi":"https://doi.org/10.7554/elife.96385.2","title":"FoxO factors preserve airway epithelial homeostasis by coordinating adaptive stress responses","display_name":"FoxO factors preserve airway epithelial homeostasis by coordinating adaptive stress responses","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225820989","doi":"https://doi.org/10.7554/elife.96385.2"},"language":"en","primary_location":{"id":"doi:10.7554/elife.96385.2","doi":"https://doi.org/10.7554/elife.96385.2","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.96385.2","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.7554/elife.96385.2","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067691526","display_name":"Karin Uliczka","orcid":"https://orcid.org/0009-0008-2114-6179","observed_orcids":["https://orcid.org/0009-0008-2114-6179"]},"institutions":[{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]},{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karin Uliczka","raw_affiliation_strings":["Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL)","Division of Innate Immunity, Priority Research Area Chronic Lung Diseases, Research Center Borstel \u2013 Leibniz Lung Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL)","institution_ids":["https://openalex.org/I4210129183"]},{"raw_affiliation_string":"Division of Innate Immunity, Priority Research Area Chronic Lung Diseases, Research Center Borstel \u2013 Leibniz Lung Center","institution_ids":["https://openalex.org/I4210128097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035986364","display_name":"Judith Bossen","orcid":"https://orcid.org/0000-0002-6604-4570","observed_orcids":["https://orcid.org/0000-0002-6604-4570"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]},{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Judith Bossen","raw_affiliation_strings":["Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL)","Department of Molecular Physiology, Zoology, Kiel University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL)","institution_ids":["https://openalex.org/I4210129183"]},{"raw_affiliation_string":"Department of Molecular Physiology, Zoology, Kiel University","institution_ids":["https://openalex.org/I32021983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053343387","display_name":"Ulrich M. Zissler","orcid":"https://orcid.org/0000-0003-4826-3419","observed_orcids":["https://orcid.org/0000-0003-4826-3419"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]},{"id":"https://openalex.org/I268975460","display_name":"Universit\u00e4tsklinikum Gie\u00dfen und Marburg","ror":"https://ror.org/032nzv584","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I268975460"]},{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210131615","display_name":"Universities of Giessen and Marburg Lung Center","ror":"https://ror.org/045f0ws19","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210131615"]},{"id":"https://openalex.org/I4210142109","display_name":"Rosenheim Technical University of Applied Sciences","ror":"https://ror.org/03hbmgt12","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210142109"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulrich M Zissler","raw_affiliation_strings":["CPC-M, Member of the German Center for Lung Research (DZL)","Center of Allergy and Environment (ZAUM), Technical University Munich and Helmholtz Center Munich, German Research Center for Environmental Health","Medical Faculty, University Medical Center Giessen and Marburg, Philipps-Universit\u00e4t Marburg","Technology Transfer Center for Building Biology, Airway and Indoor Health, Technical University of Applied Sciences Rosenheim","UGMLC, Member of the German Center for Lung Research (DZL)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CPC-M, Member of the German Center for Lung Research (DZL)","institution_ids":["https://openalex.org/I4210129183"]},{"raw_affiliation_string":"Center of Allergy and Environment (ZAUM), Technical University Munich and Helmholtz Center Munich, German Research Center for Environmental Health","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I62916508"]},{"raw_affiliation_string":"Medical Faculty, University Medical Center Giessen and Marburg, Philipps-Universit\u00e4t Marburg","institution_ids":["https://openalex.org/I161103922","https://openalex.org/I268975460"]},{"raw_affiliation_string":"Technology Transfer Center for Building Biology, Airway and Indoor Health, Technical University of Applied Sciences Rosenheim","institution_ids":["https://openalex.org/I4210142109"]},{"raw_affiliation_string":"UGMLC, Member of the German Center for Lung Research (DZL)","institution_ids":["https://openalex.org/I4210129183","https://openalex.org/I4210131615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021251489","display_name":"Christine Fink","orcid":"https://orcid.org/0000-0003-0083-2168","observed_orcids":["https://orcid.org/0000-0003-0083-2168"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christine Fink","raw_affiliation_strings":["Department of Molecular Physiology, Zoology, Kiel University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology, Zoology, Kiel University","institution_ids":["https://openalex.org/I32021983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019265776","display_name":"Xiao Niu","orcid":"https://orcid.org/0000-0001-5246-1376","observed_orcids":["https://orcid.org/0000-0001-5246-1376"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Xiao Niu","raw_affiliation_strings":["Department of Molecular Physiology, Zoology, Kiel University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology, Zoology, Kiel University","institution_ids":["https://openalex.org/I32021983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040099244","display_name":"Mario Pieper","orcid":"https://orcid.org/0000-0003-2589-6782","observed_orcids":["https://orcid.org/0000-0003-2589-6782"]},"institutions":[{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mario Pieper","raw_affiliation_strings":["Anatomical Institute, L\u00fcbeck University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Anatomical Institute, L\u00fcbeck University","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013464458","display_name":"Ruben D. Prange","orcid":"https://orcid.org/0000-0001-6941-4509","observed_orcids":["https://orcid.org/0000-0001-6941-4509"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ruben D Prange","raw_affiliation_strings":["Department of Molecular Physiology, Zoology, Kiel University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology, Zoology, Kiel University","institution_ids":["https://openalex.org/I32021983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084901270","display_name":"Christina Vock","orcid":"https://orcid.org/0000-0003-3936-3426","observed_orcids":["https://orcid.org/0000-0003-3936-3426"]},"institutions":[{"id":"https://openalex.org/I161103922","display_name":"Philipps University of Marburg","ror":"https://ror.org/01rdrb571","country_code":"DE","type":"education","lineage":["https://openalex.org/I161103922"]},{"id":"https://openalex.org/I268975460","display_name":"Universit\u00e4tsklinikum Gie\u00dfen und Marburg","ror":"https://ror.org/032nzv584","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I268975460"]},{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christina Vock","raw_affiliation_strings":["Division of Experimental Pneumology, Priority Research Area Chronic Lung diseases, Research Center Borstel \u2013 Leibniz Lung Center","Medical Faculty, University Medical Center Giessen and Marburg, Philipps-Universit\u00e4t Marburg"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Experimental Pneumology, Priority Research Area Chronic Lung diseases, Research Center Borstel \u2013 Leibniz Lung Center","institution_ids":["https://openalex.org/I4210128097"]},{"raw_affiliation_string":"Medical Faculty, University Medical Center Giessen and Marburg, Philipps-Universit\u00e4t Marburg","institution_ids":["https://openalex.org/I161103922","https://openalex.org/I268975460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008966909","display_name":"Christina Wagner","orcid":"https://orcid.org/0009-0005-8121-0046","observed_orcids":["https://orcid.org/0009-0005-8121-0046"]},"institutions":[{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christina Wagner","raw_affiliation_strings":["Division of Invertebrate Models, Priority Research Area Chronic Lung diseases, Research Center Borstel \u2013 Leibniz Lung Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Invertebrate Models, Priority Research Area Chronic Lung diseases, Research Center Borstel \u2013 Leibniz Lung Center","institution_ids":["https://openalex.org/I4210128097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086652070","display_name":"Mirjam Knop","orcid":"https://orcid.org/0009-0002-2530-9701","observed_orcids":["https://orcid.org/0009-0002-2530-9701"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mirjam Knop","raw_affiliation_strings":["Department of Molecular Physiology, Zoology, Kiel University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Physiology, Zoology, Kiel University","institution_ids":["https://openalex.org/I32021983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007913924","display_name":"Ahmed Abdelsadik","orcid":"https://orcid.org/0000-0002-4782-6681","observed_orcids":["https://orcid.org/0000-0002-4782-6681"]},"institutions":[{"id":"https://openalex.org/I86310350","display_name":"Aswan University","ror":"https://ror.org/048qnr849","country_code":"EG","type":"education","lineage":["https://openalex.org/I86310350"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ahmed Abdelsadik","raw_affiliation_strings":["Zoology Department, Faculty of Science, Aswan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zoology Department, Faculty of Science, Aswan University","institution_ids":["https://openalex.org/I86310350"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159168949","display_name":"Soren Franzenburg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"S\u00f6ren Franzenburg","raw_affiliation_strings":["IKMB, Kiel University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IKMB, Kiel University","institution_ids":["https://openalex.org/I32021983"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047320258","display_name":"Iris Bruchhaus","orcid":"https://orcid.org/0000-0002-3363-7409","observed_orcids":["https://orcid.org/0000-0002-3363-7409"]},"institutions":[{"id":"https://openalex.org/I94402716","display_name":"Bernhard Nocht Institute for Tropical Medicine","ror":"https://ror.org/01evwfd48","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I94402716"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Iris Bruchhaus","raw_affiliation_strings":["Bernhard Nocht Institute for Tropical Medicine"],"raw_orcid":"https://orcid.org/0000-0002-3363-7409","affiliations":[{"raw_affiliation_string":"Bernhard Nocht Institute for Tropical Medicine","institution_ids":["https://openalex.org/I94402716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072405396","display_name":"Michael Wegmann","orcid":"https://orcid.org/0000-0002-1658-1554","observed_orcids":["https://orcid.org/0000-0002-1658-1554"]},"institutions":[{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]},{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Michael Wegmann","raw_affiliation_strings":["Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL)","Division of Lung Immunology, Priority Research Area Chronic Lung diseases, Research Center Borstel \u2013 Leibniz Lung Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL)","institution_ids":["https://openalex.org/I4210129183"]},{"raw_affiliation_string":"Division of Lung Immunology, Priority Research Area Chronic Lung diseases, Research Center Borstel \u2013 Leibniz Lung Center","institution_ids":["https://openalex.org/I4210128097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086064578","display_name":"Carsten B. Schmidt\u2010Weber","orcid":"https://orcid.org/0000-0002-3203-8084","observed_orcids":["https://orcid.org/0000-0002-3203-8084"]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Carsten B Schmidt-Weber","raw_affiliation_strings":["CPC-M, Member of the German Center for Lung Research (DZL)","Center of Allergy and Environment (ZAUM), Technical University Munich and Helmholtz Center Munich, German Research Center for Environmental Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CPC-M, Member of the German Center for Lung Research (DZL)","institution_ids":["https://openalex.org/I4210129183"]},{"raw_affiliation_string":"Center of Allergy and Environment (ZAUM), Technical University Munich and Helmholtz Center Munich, German Research Center for Environmental Health","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101759993","display_name":"Peter K\u00f6nig","orcid":"https://orcid.org/0009-0000-7637-7451","observed_orcids":["https://orcid.org/0009-0000-7637-7451","https://orcid.org/0000-0002-8155-7948"]},"institutions":[{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I9341345","display_name":"University of L\u00fcbeck","ror":"https://ror.org/00t3r8h32","country_code":"DE","type":"education","lineage":["https://openalex.org/I9341345"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Peter K\u00f6nig","raw_affiliation_strings":["Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL)","Anatomical Institute, L\u00fcbeck University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL)","institution_ids":["https://openalex.org/I4210129183"]},{"raw_affiliation_string":"Anatomical Institute, L\u00fcbeck University","institution_ids":["https://openalex.org/I9341345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161451058","display_name":"Petra Pfefferle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]},{"id":"https://openalex.org/I4210131615","display_name":"Universities of Giessen and Marburg Lung Center","ror":"https://ror.org/045f0ws19","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210131615"]},{"id":"https://openalex.org/I4210142109","display_name":"Rosenheim Technical University of Applied Sciences","ror":"https://ror.org/03hbmgt12","country_code":"DE","type":"education","lineage":["https://openalex.org/I4210142109"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Petra Pfefferle","raw_affiliation_strings":["Technology Transfer Center for Building Biology, Airway and Indoor Health, Technical University of Applied Sciences Rosenheim","UGMLC, Member of the German Center for Lung Research (DZL)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Technology Transfer Center for Building Biology, Airway and Indoor Health, Technical University of Applied Sciences Rosenheim","institution_ids":["https://openalex.org/I4210142109"]},{"raw_affiliation_string":"UGMLC, Member of the German Center for Lung Research (DZL)","institution_ids":["https://openalex.org/I4210129183","https://openalex.org/I4210131615"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037957303","display_name":"Holger Heine","orcid":"https://orcid.org/0000-0001-8128-5068","observed_orcids":["https://orcid.org/0000-0001-8128-5068"]},"institutions":[{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]},{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Holger Heine","raw_affiliation_strings":["Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL)","Division of Innate Immunity, Priority Research Area Chronic Lung Diseases, Research Center Borstel \u2013 Leibniz Lung Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL)","institution_ids":["https://openalex.org/I4210129183"]},{"raw_affiliation_string":"Division of Innate Immunity, Priority Research Area Chronic Lung Diseases, Research Center Borstel \u2013 Leibniz Lung Center","institution_ids":["https://openalex.org/I4210128097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069123854","display_name":"Thomas Roeder","orcid":"https://orcid.org/0000-0002-3489-3834","observed_orcids":["https://orcid.org/0000-0002-3489-3834"]},"institutions":[{"id":"https://openalex.org/I32021983","display_name":"Christian-Albrechts-Universit\u00e4t zu Kiel","ror":"https://ror.org/04v76ef78","country_code":"DE","type":"education","lineage":["https://openalex.org/I32021983"]},{"id":"https://openalex.org/I4210129183","display_name":"German Center for Lung Research","ror":"https://ror.org/03dx11k66","country_code":"DE","type":"facility","lineage":["https://openalex.org/I4210129183","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Thomas Roeder","raw_affiliation_strings":["Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL)","Department of Molecular Physiology, Zoology, Kiel University"],"raw_orcid":"https://orcid.org/0000-0002-3489-3834","affiliations":[{"raw_affiliation_string":"Airway Research Center North (ARCN), Member of the German Center for Lung Research (DZL)","institution_ids":["https://openalex.org/I4210129183"]},{"raw_affiliation_string":"Department of Molecular Physiology, Zoology, Kiel University","institution_ids":["https://openalex.org/I32021983"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":12,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3000,"currency":"USD","value_usd":2500},"apc_paid":{"value":3000,"currency":"USD","value_usd":2500},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12835","display_name":"FOXO transcription factor regulation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12835","display_name":"FOXO transcription factor regulation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11884","display_name":"Redox biology and oxidative stress","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.675599992275238},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6486999988555908},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6198999881744385},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6141999959945679},{"id":"https://openalex.org/C105922876","wikidata":"https://www.wikidata.org/wiki/Q1423981","display_name":"Airway","level":2,"score":0.553600013256073},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.49050000309944153},{"id":"https://openalex.org/C125370674","wikidata":"https://www.wikidata.org/wiki/Q1527480","display_name":"Stressor","level":2,"score":0.4586000144481659},{"id":"https://openalex.org/C87568996","wikidata":"https://www.wikidata.org/wiki/Q1428754","display_name":"Respiratory epithelium","level":3,"score":0.448199987411499},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4431000053882599},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.42419999837875366},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.41200000047683716},{"id":"https://openalex.org/C7836513","wikidata":"https://www.wikidata.org/wiki/Q1641506","display_name":"Hypoxia (environmental)","level":3,"score":0.39959999918937683},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.326200008392334},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.3221000134944916},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.30469998717308044},{"id":"https://openalex.org/C168003608","wikidata":"https://www.wikidata.org/wiki/Q21101484","display_name":"FOXO3","level":4,"score":0.2976999878883362},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.28299999237060547},{"id":"https://openalex.org/C140149449","wikidata":"https://www.wikidata.org/wiki/Q17928793","display_name":"FOXO1","level":4,"score":0.27880001068115234},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2752000093460083},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.26910001039505005},{"id":"https://openalex.org/C2491326","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy homeostasis","level":3,"score":0.263700008392334},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.2612999975681305},{"id":"https://openalex.org/C78604142","wikidata":"https://www.wikidata.org/wiki/Q1640582","display_name":"Fight-or-flight response","level":3,"score":0.25769999623298645},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.25519999861717224},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2547999918460846},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.2524999976158142}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.7554/elife.96385.2","doi":"https://doi.org/10.7554/elife.96385.2","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.96385.2","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.7554/elife.96385.2","doi":"https://doi.org/10.7554/elife.96385.2","is_oa":true,"landing_page_url":"https://doi.org/10.7554/elife.96385.2","pdf_url":null,"source":{"id":"https://openalex.org/S1336409049","display_name":"eLife","issn_l":"2050-084X","issn":["2050-084X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311710","host_organization_name":"eLife Sciences Publications Ltd","host_organization_lineage":["https://openalex.org/P4310311710"],"host_organization_lineage_names":["eLife Sciences Publications Ltd"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"eLife","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":84,"referenced_works":["https://openalex.org/W1511506873","https://openalex.org/W1526749616","https://openalex.org/W1697235441","https://openalex.org/W1928868997","https://openalex.org/W1965684670","https://openalex.org/W1981539810","https://openalex.org/W1996129013","https://openalex.org/W1998100955","https://openalex.org/W1999966127","https://openalex.org/W2001604240","https://openalex.org/W2004268699","https://openalex.org/W2005331723","https://openalex.org/W2018260002","https://openalex.org/W2032427485","https://openalex.org/W2038053724","https://openalex.org/W2064490246","https://openalex.org/W2069306070","https://openalex.org/W2075798702","https://openalex.org/W2078314973","https://openalex.org/W2082852887","https://openalex.org/W2090760489","https://openalex.org/W2092790181","https://openalex.org/W2099261625","https://openalex.org/W2100103802","https://openalex.org/W2100393234","https://openalex.org/W2110643873","https://openalex.org/W2115494902","https://openalex.org/W2130723383","https://openalex.org/W2136123560","https://openalex.org/W2149846303","https://openalex.org/W2153736795","https://openalex.org/W2156208878","https://openalex.org/W2157409103","https://openalex.org/W2160324372","https://openalex.org/W2161681967","https://openalex.org/W2164298308","https://openalex.org/W2164438840","https://openalex.org/W2164833592","https://openalex.org/W2166208596","https://openalex.org/W2189863592","https://openalex.org/W2299931861","https://openalex.org/W2395236684","https://openalex.org/W2476703789","https://openalex.org/W2513165392","https://openalex.org/W2606278826","https://openalex.org/W2745650866","https://openalex.org/W2768795275","https://openalex.org/W2769153103","https://openalex.org/W2769400169","https://openalex.org/W2773754711","https://openalex.org/W2842304560","https://openalex.org/W2889475609","https://openalex.org/W2895001016","https://openalex.org/W2898864613","https://openalex.org/W2903445736","https://openalex.org/W2941021319","https://openalex.org/W2944545583","https://openalex.org/W2950891712","https://openalex.org/W2951703547","https://openalex.org/W2952014247","https://openalex.org/W2969381424","https://openalex.org/W2990660417","https://openalex.org/W2994365379","https://openalex.org/W3000661016","https://openalex.org/W3023457686","https://openalex.org/W3028573631","https://openalex.org/W3030890563","https://openalex.org/W3033558602","https://openalex.org/W3033954215","https://openalex.org/W3120354465","https://openalex.org/W3120576609","https://openalex.org/W3135924594","https://openalex.org/W3152264894","https://openalex.org/W3204845221","https://openalex.org/W3205710586","https://openalex.org/W4224980296","https://openalex.org/W4226056698","https://openalex.org/W4288050944","https://openalex.org/W4290975643","https://openalex.org/W4306967032","https://openalex.org/W4384154735","https://openalex.org/W4386741078","https://openalex.org/W4387975817","https://openalex.org/W7014948526"],"related_works":[],"abstract_inverted_index":{"Airway":[0],"epithelia":[1],"must":[2],"maintain":[3,186],"functional":[4],"and":[5,30,45,61,128],"structural":[6],"homeostasis":[7,188],"despite":[8],"exposure":[9],"to":[10,20,56],"diverse":[11],"environmental":[12,190],"stressors.":[13],"FoxO":[14,40,100,118,142,179],"transcription":[15],"factors":[16,41,72],"are":[17,164],"well":[18],"suited":[19],"this":[21],"task,":[22],"acting":[23],"as":[24],"integration":[25],"hubs":[26],"that":[27,39,88,106,152,160,185],"translate":[28],"extrinsic":[29],"intrinsic":[31],"signals":[32],"into":[33],"appropriate":[34],"physiological":[35],"responses.":[36],"We":[37],"show":[38,73],"in":[42,54,113,123,129,144,166,177],"Drosophila,":[43,79],"mouse,":[44],"human":[46,65],"airway":[47,66,115,130,187],"epithelial":[48,67,182],"cells":[49],"(AECs)":[50],"undergo":[51],"nuclear":[52],"translocation":[53],"response":[55],"stressors":[57],"including":[58],"hypoxia,":[59],"temperature,":[60],"oxidative":[62],"stress.":[63],"In":[64,78],"cell":[68],"lines,":[69],"individual":[70],"hFOXO":[71],"distinct,":[74],"cell-type-specific":[75],"activation":[76],"patterns.":[77],"hypoxia":[80],"was":[81,120],"the":[82,114,136],"only":[83],"stressor":[84],"among":[85],"those":[86],"tested":[87],"triggered":[89],"a":[90,98,175],"dfoxo-dependent":[91],"innate":[92],"immune":[93],"response.":[94],"Because":[95],"Drosophila":[96],"possesses":[97],"single":[99],"ortholog,":[101],"loss-of-function":[102],"analysis":[103],"directly":[104],"demonstrated":[105],"dfoxo":[107],"is":[108],"required":[109],"for":[110],"stress":[111,138,162,183],"resistance":[112],"epithelium.":[116],"Reduced":[117],"expression":[119],"similarly":[121],"observed":[122],"mouse":[124],"models":[125],"of":[126],"asthma":[127,133],"samples":[131],"from":[132],"patients,":[134],"paralleling":[135],"increased":[137],"sensitivity":[139],"seen":[140],"upon":[141],"loss":[143],"flies.":[145],"While":[146],"our":[147],"data":[148],"do":[149],"not":[150],"establish":[151],"reduced":[153],"FOXO":[154],"levels":[155],"cause":[156],"asthma,":[157],"they":[158],"indicate":[159],"FoxO-dependent":[161],"pathways":[163],"altered":[165],"diseased":[167],"airways":[168],"across":[169],"species.":[170],"Together,":[171],"these":[172],"findings":[173],"support":[174],"model":[176],"which":[178],"coordinates":[180],"adaptive":[181],"responses":[184],"under":[189],"challenge.":[191]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}