{"id":"https://openalex.org/W7225820836","doi":"https://doi.org/10.21203/rs.3.rs-11043700/v1","title":"A dominant antigen is necessary but not sufficient for effective neoantigen vaccination in murine mesothelioma","display_name":"A dominant antigen is necessary but not sufficient for effective neoantigen vaccination in murine mesothelioma","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225820836","doi":"https://doi.org/10.21203/rs.3.rs-11043700/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-11043700/v1","doi":"https://doi.org/10.21203/rs.3.rs-11043700/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11043700/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.21203/rs.3.rs-11043700/v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004095879","display_name":"Jessica Boulter","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148584","display_name":"Institute for Respiratory Health","ror":"https://ror.org/04n4wd093","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210148584"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Jessica Boulter","raw_affiliation_strings":["National Centre for Asbestos Related Diseases, Institute for Respiratory Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Asbestos Related Diseases, Institute for Respiratory Health","institution_ids":["https://openalex.org/I4210148584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161481479","display_name":"Shaokang Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148584","display_name":"Institute for Respiratory Health","ror":"https://ror.org/04n4wd093","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210148584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Shaokang Ma","raw_affiliation_strings":["National Centre for Asbestos Related Diseases, Institute for Respiratory Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Asbestos Related Diseases, Institute for Respiratory Health","institution_ids":["https://openalex.org/I4210148584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161436014","display_name":"Wen-Shuz Yeow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148584","display_name":"Institute for Respiratory Health","ror":"https://ror.org/04n4wd093","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210148584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Wen-Shuz Yeow","raw_affiliation_strings":["National Centre for Asbestos Related Diseases, Institute for Respiratory Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Asbestos Related Diseases, Institute for Respiratory Health","institution_ids":["https://openalex.org/I4210148584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161438610","display_name":"Georgia Hosking","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148584","display_name":"Institute for Respiratory Health","ror":"https://ror.org/04n4wd093","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210148584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Georgia Hosking","raw_affiliation_strings":["National Centre for Asbestos Related Diseases, Institute for Respiratory Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Asbestos Related Diseases, Institute for Respiratory Health","institution_ids":["https://openalex.org/I4210148584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072802117","display_name":"Ian M. Dick","orcid":"https://orcid.org/0000-0003-1902-9033","observed_orcids":["https://orcid.org/0000-0003-1902-9033"]},"institutions":[{"id":"https://openalex.org/I4210148584","display_name":"Institute for Respiratory Health","ror":"https://ror.org/04n4wd093","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210148584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ian M. Dick","raw_affiliation_strings":["National Centre for Asbestos Related Diseases, Institute for Respiratory Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Asbestos Related Diseases, Institute for Respiratory Health","institution_ids":["https://openalex.org/I4210148584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112713929","display_name":"Peter Chiang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148584","display_name":"Institute for Respiratory Health","ror":"https://ror.org/04n4wd093","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210148584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Peter Chiang","raw_affiliation_strings":["National Centre for Asbestos Related Diseases, Institute for Respiratory Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Asbestos Related Diseases, Institute for Respiratory Health","institution_ids":["https://openalex.org/I4210148584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161458109","display_name":"Nandini Makwana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148584","display_name":"Institute for Respiratory Health","ror":"https://ror.org/04n4wd093","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210148584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Nandini Makwana","raw_affiliation_strings":["National Centre for Asbestos Related Diseases, Institute for Respiratory Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Asbestos Related Diseases, Institute for Respiratory Health","institution_ids":["https://openalex.org/I4210148584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161427100","display_name":"Samuel C. Neeve","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148584","display_name":"Institute for Respiratory Health","ror":"https://ror.org/04n4wd093","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210148584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Samuel C. Neeve","raw_affiliation_strings":["National Centre for Asbestos Related Diseases, Institute for Respiratory Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Asbestos Related Diseases, Institute for Respiratory Health","institution_ids":["https://openalex.org/I4210148584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050434858","display_name":"Ebony J. Rouse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148584","display_name":"Institute for Respiratory Health","ror":"https://ror.org/04n4wd093","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210148584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Ebony J. Rouse","raw_affiliation_strings":["National Centre for Asbestos Related Diseases, Institute for Respiratory Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Asbestos Related Diseases, Institute for Respiratory Health","institution_ids":["https://openalex.org/I4210148584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161429643","display_name":"Chloe Choi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148584","display_name":"Institute for Respiratory Health","ror":"https://ror.org/04n4wd093","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210148584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Chloe Choi","raw_affiliation_strings":["National Centre for Asbestos Related Diseases, Institute for Respiratory Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Asbestos Related Diseases, Institute for Respiratory Health","institution_ids":["https://openalex.org/I4210148584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076907829","display_name":"Francois Xavier Rwandamuriye","orcid":"https://orcid.org/0000-0002-3456-3931","observed_orcids":["https://orcid.org/0000-0002-3456-3931"]},"institutions":[{"id":"https://openalex.org/I4210148584","display_name":"Institute for Respiratory Health","ror":"https://ror.org/04n4wd093","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210148584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Francois Xavier Rwandamuriye","raw_affiliation_strings":["National Centre for Asbestos Related Diseases, Institute for Respiratory Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Asbestos Related Diseases, Institute for Respiratory Health","institution_ids":["https://openalex.org/I4210148584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161445526","display_name":"Bruce W. S. Robinson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210148584","display_name":"Institute for Respiratory Health","ror":"https://ror.org/04n4wd093","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210148584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Bruce W. S. Robinson","raw_affiliation_strings":["National Centre for Asbestos Related Diseases, Institute for Respiratory Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Asbestos Related Diseases, Institute for Respiratory Health","institution_ids":["https://openalex.org/I4210148584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121273230","display_name":"Jenette Creaney","orcid":"https://orcid.org/0000-0002-9391-9395","observed_orcids":["https://orcid.org/0000-0002-9391-9395"]},"institutions":[{"id":"https://openalex.org/I4210148584","display_name":"Institute for Respiratory Health","ror":"https://ror.org/04n4wd093","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210148584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Jenette Creaney","raw_affiliation_strings":["National Centre for Asbestos Related Diseases, Institute for Respiratory Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Asbestos Related Diseases, Institute for Respiratory Health","institution_ids":["https://openalex.org/I4210148584"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073547034","display_name":"Alec Redwood","orcid":"https://orcid.org/0000-0001-8601-8292","observed_orcids":["https://orcid.org/0000-0001-8601-8292"]},"institutions":[{"id":"https://openalex.org/I4210148584","display_name":"Institute for Respiratory Health","ror":"https://ror.org/04n4wd093","country_code":"AU","type":"facility","lineage":["https://openalex.org/I4210148584"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Alec J. Redwood","raw_affiliation_strings":["National Centre for Asbestos Related Diseases, Institute for Respiratory Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Centre for Asbestos Related Diseases, Institute for Respiratory Health","institution_ids":["https://openalex.org/I4210148584"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5004095879"],"corresponding_institution_ids":["https://openalex.org/I4210148584"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.02199999988079071,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2780480104","wikidata":"https://www.wikidata.org/wiki/Q18351145","display_name":"Immunoediting","level":4,"score":0.7868000268936157},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6047999858856201},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5993000268936157},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.569599986076355},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5565000176429749},{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.5070000290870667},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4205000102519989},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.39899998903274536},{"id":"https://openalex.org/C2780441014","wikidata":"https://www.wikidata.org/wiki/Q7907952","display_name":"Vaccine efficacy","level":3,"score":0.33809998631477356},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3294000029563904},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.32710000872612},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2883000075817108},{"id":"https://openalex.org/C167508917","wikidata":"https://www.wikidata.org/wiki/Q578537","display_name":"DNA vaccination","level":4,"score":0.28700000047683716},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.2863999903202057},{"id":"https://openalex.org/C151913843","wikidata":"https://www.wikidata.org/wiki/Q3454555","display_name":"Dominance (genetics)","level":3,"score":0.27000001072883606},{"id":"https://openalex.org/C2778378633","wikidata":"https://www.wikidata.org/wiki/Q2378309","display_name":"Cancer vaccine","level":4,"score":0.2687000036239624}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-11043700/v1","doi":"https://doi.org/10.21203/rs.3.rs-11043700/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11043700/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-11043700/v1","doi":"https://doi.org/10.21203/rs.3.rs-11043700/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11043700/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1534871424","https://openalex.org/W1576462372","https://openalex.org/W1711559113","https://openalex.org/W1973555453","https://openalex.org/W2006759360","https://openalex.org/W2009720434","https://openalex.org/W2011458181","https://openalex.org/W2079018735","https://openalex.org/W2079696222","https://openalex.org/W2102278945","https://openalex.org/W2108706633","https://openalex.org/W2115094537","https://openalex.org/W2140235037","https://openalex.org/W2151794156","https://openalex.org/W2155943701","https://openalex.org/W2172170289","https://openalex.org/W2201214180","https://openalex.org/W2282550179","https://openalex.org/W2514996992","https://openalex.org/W2616155686","https://openalex.org/W2724264513","https://openalex.org/W2728365508","https://openalex.org/W2799790632","https://openalex.org/W2888266297","https://openalex.org/W2904210127","https://openalex.org/W2908301499","https://openalex.org/W2979330780","https://openalex.org/W2988519437","https://openalex.org/W2990871782","https://openalex.org/W2999923306","https://openalex.org/W3025076282","https://openalex.org/W3093383535","https://openalex.org/W3122627530","https://openalex.org/W3151427897","https://openalex.org/W3195059440","https://openalex.org/W3201015884","https://openalex.org/W4213332617","https://openalex.org/W4247053599","https://openalex.org/W4293043553","https://openalex.org/W4313454538","https://openalex.org/W4365446410","https://openalex.org/W4376133743","https://openalex.org/W4385620081","https://openalex.org/W4387935658","https://openalex.org/W4391067309","https://openalex.org/W4392230251","https://openalex.org/W4401422221","https://openalex.org/W4404200254","https://openalex.org/W4405983094","https://openalex.org/W4406104381","https://openalex.org/W4413984685","https://openalex.org/W7134966475"],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Neoantigen":[1],"vaccines":[2,18,44,93,140],"have":[3],"emerged":[4],"as":[5],"a":[6,75,83,96],"promising":[7],"strategy":[8],"for":[9,30,119,146],"personalised":[10],"cancer":[11,90],"treatment,":[12],"however":[13,110],"the":[14,68,87,114,136],"features":[15],"of":[16,70,86,112,138],"neoantigen":[17,71,139],"that":[19,43,55,66,94,129],"confer":[20],"effective":[21],"tumour":[22,32],"protection":[23,52],"remain":[24],"poorly":[25],"defined.":[26],"Further,":[27],"their":[28],"application":[29],"low":[31,88,148],"mutation":[33],"burden":[34],"(TMB)":[35],"cancers":[36],"has":[37],"been":[38],"largely":[39],"unexplored.":[40],"We":[41,63],"hypothesised":[42,65],"targeting":[45],"spontaneously":[46,99],"immunogenic":[47],"neoantigens":[48,54,103],"would":[49,78],"provide":[50],"superior":[51],"to":[53],"induce":[56],"de":[57],"novo":[58],"T-cell":[59,106],"responses":[60,107],"post":[61],"vaccination.":[62],"also":[64],"increasing":[67],"breadth":[69],"targets":[72],"or":[73],"including":[74],"dominant":[76,97,115],"antigen":[77,116,126],"enhance":[79],"vaccine":[80,120,132],"efficacy.":[81],"In":[82],"mouse":[84],"model":[85],"TMB":[89,149],"mesothelioma,":[91,142],"only":[92,113],"combine":[95],"antigen,":[98],"recognised":[100],"antigens,":[101],"and":[102,134],"with":[104,143],"vaccine-inducible":[105],"conferred":[108],"protection,":[109],"immunoediting":[111],"was":[117],"sufficient":[118],"failure.":[121],"This":[122],"study":[123],"highlights":[124],"potential":[125,144],"dominance":[127],"hierarchies":[128],"can":[130],"influence":[131],"efficacy":[133],"demonstrates":[135],"feasibility":[137],"in":[141],"implications":[145],"other":[147],"tumours.":[150]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}