{"id":"https://openalex.org/W7225820308","doi":"https://doi.org/10.3389/fvets.2026.1999485","title":"Dietary chitosan modulates immune-related gene expression and improves biochemical parameters and intestinal morphology in broilers","display_name":"Dietary chitosan modulates immune-related gene expression and improves biochemical parameters and intestinal morphology in broilers","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225820308","doi":"https://doi.org/10.3389/fvets.2026.1999485"},"language":"en","primary_location":{"id":"doi:10.3389/fvets.2026.1999485","doi":"https://doi.org/10.3389/fvets.2026.1999485","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2026.1999485","pdf_url":"https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2026.1999485/pdf","source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2026.1999485/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161474350","display_name":"A. R. Keymanesh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I110525433","display_name":"Islamic Azad University, Tehran","ror":"https://ror.org/01kzn7k21","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"A. R. Keymanesh","raw_affiliation_strings":["Department of Veterinary Medicine, Islamic Azad University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterinary Medicine, Islamic Azad University","institution_ids":["https://openalex.org/I110525433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161488467","display_name":"M. Najafi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67388046","display_name":"Gorgan University of Agricultural Sciences and Natural Resources","ror":"https://ror.org/01w6vdf77","country_code":"IR","type":"education","lineage":["https://openalex.org/I67388046"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"M. Najafi","raw_affiliation_strings":["Molecular Genetics Laboratory, Faculty of Animal Sciences, GUASNR"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Genetics Laboratory, Faculty of Animal Sciences, GUASNR","institution_ids":["https://openalex.org/I67388046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008241457","display_name":"Hamid-Reza Aliakbarpour","orcid":"https://orcid.org/0000-0001-7729-4703","observed_orcids":["https://orcid.org/0000-0001-7729-4703"]},"institutions":[{"id":"https://openalex.org/I4400573191","display_name":"Islamic Azad University, Babol","ror":"https://ror.org/00pwbq328","country_code":"IR","type":"education","lineage":["https://openalex.org/I4400573191"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"H. R. Aliakbarpour","raw_affiliation_strings":["Faculty of Veterinary Science, Babol Branch, Islamic Azad University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Veterinary Science, Babol Branch, Islamic Azad University","institution_ids":["https://openalex.org/I4400573191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161484777","display_name":"M. H. Banabazi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I298625061","display_name":"Swedish University of Agricultural Sciences","ror":"https://ror.org/02yy8x990","country_code":"SE","type":"education","lineage":["https://openalex.org/I298625061"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"M. H. Banabazi","raw_affiliation_strings":["Department of Animal Genetics & Breeding, the Swedish University of Agricultural Sciences (SLU)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Animal Genetics & Breeding, the Swedish University of Agricultural Sciences (SLU)","institution_ids":["https://openalex.org/I298625061"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5161484777","https://openalex.org/A5161488467"],"corresponding_institution_ids":["https://openalex.org/I298625061","https://openalex.org/I67388046"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10152","display_name":"Animal Nutrition and Physiology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10152","display_name":"Animal Nutrition and Physiology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10333","display_name":"Meat and Animal Product Quality","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10450","display_name":"Aquaculture Nutrition and Growth","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2780289900","wikidata":"https://www.wikidata.org/wiki/Q326301","display_name":"Broiler","level":2,"score":0.8320000171661377},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.7997000217437744},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.6055999994277954},{"id":"https://openalex.org/C2778024521","wikidata":"https://www.wikidata.org/wiki/Q55639806","display_name":"Basal (medicine)","level":3,"score":0.5792999863624573},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5626000165939331},{"id":"https://openalex.org/C2778345441","wikidata":"https://www.wikidata.org/wiki/Q6460735","display_name":"Meal","level":2,"score":0.48330000042915344},{"id":"https://openalex.org/C22830521","wikidata":"https://www.wikidata.org/wiki/Q649967","display_name":"Feed conversion ratio","level":3,"score":0.4733000099658966},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.4593999981880188},{"id":"https://openalex.org/C66090201","wikidata":"https://www.wikidata.org/wiki/Q15995009","display_name":"Crypt","level":2,"score":0.4219000041484833},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.392300009727478},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.37310001254081726},{"id":"https://openalex.org/C2777226302","wikidata":"https://www.wikidata.org/wiki/Q233345","display_name":"Ileum","level":2,"score":0.3447999954223633},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3377000093460083},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3370000123977661},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3312999904155731},{"id":"https://openalex.org/C3019368612","wikidata":"https://www.wikidata.org/wiki/Q17154506","display_name":"Intestinal mucosa","level":2,"score":0.33070001006126404},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.32199999690055847},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.32170000672340393},{"id":"https://openalex.org/C2777882243","wikidata":"https://www.wikidata.org/wiki/Q11090","display_name":"Small intestine","level":2,"score":0.3084000051021576},{"id":"https://openalex.org/C2776366702","wikidata":"https://www.wikidata.org/wiki/Q185765","display_name":"Jejunum","level":2,"score":0.29019999504089355},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.2847000062465668},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.28040000796318054},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.27709999680519104},{"id":"https://openalex.org/C140793950","wikidata":"https://www.wikidata.org/wiki/Q168091","display_name":"Animal science","level":1,"score":0.27630001306533813},{"id":"https://openalex.org/C499950583","wikidata":"https://www.wikidata.org/wiki/Q183252","display_name":"Morphology (biology)","level":2,"score":0.2628999948501587},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2547000050544739}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fvets.2026.1999485","doi":"https://doi.org/10.3389/fvets.2026.1999485","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2026.1999485","pdf_url":"https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2026.1999485/pdf","source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fvets.2026.1999485","doi":"https://doi.org/10.3389/fvets.2026.1999485","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2026.1999485","pdf_url":"https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2026.1999485/pdf","source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225820308.pdf","grobid_xml":"https://content.openalex.org/works/W7225820308.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W576043361","https://openalex.org/W1650319068","https://openalex.org/W1965069792","https://openalex.org/W1969391744","https://openalex.org/W1980987076","https://openalex.org/W1991025889","https://openalex.org/W1992025440","https://openalex.org/W2031332745","https://openalex.org/W2053152644","https://openalex.org/W2074980407","https://openalex.org/W2101528848","https://openalex.org/W2123483632","https://openalex.org/W2126774025","https://openalex.org/W2167179929","https://openalex.org/W2550882398","https://openalex.org/W2571571791","https://openalex.org/W2585802353","https://openalex.org/W2738982293","https://openalex.org/W2810511316","https://openalex.org/W2964551367","https://openalex.org/W3085243853","https://openalex.org/W3125588722","https://openalex.org/W3140146999","https://openalex.org/W3152747027","https://openalex.org/W3217019599","https://openalex.org/W4213317083","https://openalex.org/W4214946558","https://openalex.org/W4220905002","https://openalex.org/W4281929558","https://openalex.org/W4380204671","https://openalex.org/W4389816014","https://openalex.org/W4401897118","https://openalex.org/W4402541821","https://openalex.org/W4411374544","https://openalex.org/W4412108254","https://openalex.org/W4413751574","https://openalex.org/W7130876667"],"related_works":[],"abstract_inverted_index":{"Introduction":[0],"One":[1],"of":[2,5,24,32,43,51,203,247,270],"the":[3,22,25,30,135,150,158,168,176,268],"benefits":[4],"chitosan":[6,34,98,188,222,254,278,290],"for":[7,99,291],"broilers":[8,54],"is":[9],"positive":[10],"effects":[11,31],"on":[12,35],"growth":[13,36,109],"performance,":[14,37],"intestinal":[15],"morphology":[16,38],"and":[17,39,47,111,124,140,162,166,215,243,260,266],"gene":[18,40],"expression":[19,41,197,269],"profiling.":[20],"Therefore,":[21],"aim":[23],"study":[26],"was":[27,172],"to":[28,58,223,288],"evaluate":[29],"dietary":[33],"profiling":[42],"broiler":[44],"chickens.":[45],"Materials":[46],"methods":[48],"A":[49],"total":[50],"250":[52,74,88,164,178],"one-day-old":[53],"chicken":[55],"were":[56,155,218],"allocated":[57],"five":[59],"experimental":[60],"groups":[61],"including,":[62],"Commercial":[63,163],"corn-soybean":[64],"meal":[65],"basal":[66,71,78,85,92],"diet":[67,72,79,86,93],"(control":[68],"group:":[69],"CON),":[70],"+":[73,80,87,94],"mg/kg":[75,82,89,96,186],"commercial":[76,289],"chitosan,":[77,84,91],"100":[81,185],"local":[83,90,97,187],"400":[95],"a":[100,173,234,284],"42-day":[101],"rearing":[102],"period.":[103],"Results":[104],"Chitosan":[105],"supplementation":[106,255],"numerically":[107],"improved":[108,263],"performance":[110],"feed":[112],"conversion":[113],"ratio":[114,144],"(":[115,130,180,192],"p":[116,131,181,193],">":[117],"0.05)":[118],"but":[119],"significantly":[120,256],"reduced":[121,257],"serum":[122,258],"cholesterol":[123,259],"triglyceride":[125,261],"levels":[126,202],"at":[127],"day":[128],"42":[129],"<":[132,194],"0.05).":[133,195],"In":[134,149],"duodenum,":[136],"crypt":[137],"depth":[138,143],"decreased":[139],"villus":[141],"height-to-crypt":[142],"increased":[145,189,219],"in":[146,175,274,295],"chitosan-fed":[147],"birds.":[148],"jejunum,":[151],"no":[152],"significant":[153,170],"differences":[154],"detected":[156],"among":[157],"CON,":[159],"Local":[160,177],"100,":[161],"groups,":[165],"that":[167,200,230],"only":[169],"effect":[171],"reduction":[174],"group":[179],"=":[182],"0.01).":[183],"Additionally,":[184],"bacterial":[190],"population":[191],"Gene":[196],"analysis":[198,228],"revealed":[199],"mRNA":[201],"TLR2,":[204,239],"IL6,":[205,241],"IL8,":[206],"STAR,":[207],"Cytochrome":[208],"P450,":[209],"TLR4,":[210,240],"IFN,":[211],"TNF\u03b1,":[212,242],"NF\u0199\u03b2,":[213],"BAX":[214],"BCL2":[216],"genes":[217,273],"by":[220],"adding":[221],"diet.":[224],"The":[225],"PPI":[226],"network":[227],"demonstrated":[229],"NF\u0199\u03b2":[231],"acts":[232],"as":[233,283],"central":[235],"hub,":[236],"interacting":[237],"with":[238],"IL1B":[244],"indicating":[245],"activation":[246],"canonical":[248],"TLR/NF\u0199\u03b2":[249],"signaling":[250],"pathway.":[251],"Conclusion":[252],"Dietary":[253],"levels,":[262],"duodenal":[264],"morphology,":[265],"modulated":[267],"selected":[271],"immune-related":[272],"broilers.":[275,296],"Iranian":[276],"ChitoLife":[277],"may":[279],"warrant":[280],"further":[281],"investigation":[282],"potential":[285],"lower-dose":[286],"alternative":[287],"enhancing":[292],"immune":[293],"responses":[294]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}