{"id":"https://openalex.org/W7225819923","doi":"https://doi.org/10.1021/acs.jafc.6c08810","title":"Cyclotides Enable the Oral Activity of Neuroactive Peptides against Lepidopteran Pests","display_name":"Cyclotides Enable the Oral Activity of Neuroactive Peptides against Lepidopteran Pests","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225819923","doi":"https://doi.org/10.1021/acs.jafc.6c08810"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jafc.6c08810","doi":"https://doi.org/10.1021/acs.jafc.6c08810","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jafc.6c08810","pdf_url":null,"source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040937753","display_name":"Yen\u2010Hua Huang","orcid":"https://orcid.org/0000-0001-6937-2660","observed_orcids":["https://orcid.org/0000-0001-6937-2660"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Yen-Hua Huang","raw_affiliation_strings":["The University of Queensland , , , ,"],"raw_orcid":"https://orcid.org/0000-0001-6937-2660","affiliations":[{"raw_affiliation_string":"The University of Queensland , , , ,","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063128380","display_name":"Conan K. L. Wang","orcid":"https://orcid.org/0000-0002-7973-7632","observed_orcids":["https://orcid.org/0000-0002-7973-7632"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Conan K. Wang","raw_affiliation_strings":["The University of Queensland , , , ,"],"raw_orcid":"https://orcid.org/0000-0002-7973-7632","affiliations":[{"raw_affiliation_string":"The University of Queensland , , , ,","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005295954","display_name":"S\u00e9bastien C. Kessler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Se\u0301bastien Kessler","raw_affiliation_strings":["Syngenta Crop Protection AG , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Crop Protection AG , ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077596166","display_name":"Kaat Cappelle","orcid":"https://orcid.org/0000-0002-5248-0005","observed_orcids":["https://orcid.org/0000-0002-5248-0005"]},"institutions":[{"id":"https://openalex.org/I4210087094","display_name":"Syngenta (United Kingdom)","ror":"https://ror.org/000bdn450","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210087094","https://openalex.org/I89199228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kaat Cappelle","raw_affiliation_strings":["Syngenta Crop Protection AG , ,","Syngenta Ltd , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Crop Protection AG , ,","institution_ids":[]},{"raw_affiliation_string":"Syngenta Ltd , ,","institution_ids":["https://openalex.org/I4210087094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001487967","display_name":"Olivier Christiaens","orcid":"https://orcid.org/0000-0001-5850-340X","observed_orcids":["https://orcid.org/0000-0001-5850-340X"]},"institutions":[{"id":"https://openalex.org/I4210087094","display_name":"Syngenta (United Kingdom)","ror":"https://ror.org/000bdn450","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210087094","https://openalex.org/I89199228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Olivier Christiaens","raw_affiliation_strings":["Syngenta Crop Protection AG , ,","Syngenta Ltd , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Crop Protection AG , ,","institution_ids":[]},{"raw_affiliation_string":"Syngenta Ltd , ,","institution_ids":["https://openalex.org/I4210087094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161451036","display_name":"Lisa-Maria Klotz","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lisa-Maria Klotz","raw_affiliation_strings":["Syngenta Crop Protection AG , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Crop Protection AG , ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161476509","display_name":"Heidi Mu\u0308ller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heidi Mu\u0308ller","raw_affiliation_strings":["Syngenta Crop Protection AG , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Crop Protection AG , ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161441472","display_name":"Marisa Eterovic","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marisa Eterovic","raw_affiliation_strings":["Syngenta Crop Protection AG , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Crop Protection AG , ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029676866","display_name":"Mark Schiebler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Schiebler","raw_affiliation_strings":["Syngenta Crop Protection AG , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Crop Protection AG , ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074141704","display_name":"Fides Benfatti","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fides Benfatti","raw_affiliation_strings":["Syngenta Crop Protection AG , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Crop Protection AG , ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161475820","display_name":"Joseph Hawkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087094","display_name":"Syngenta (United Kingdom)","ror":"https://ror.org/000bdn450","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210087094","https://openalex.org/I89199228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Joseph Hawkins","raw_affiliation_strings":["Syngenta Ltd , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Ltd , ,","institution_ids":["https://openalex.org/I4210087094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161444723","display_name":"Jacob Riveron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087094","display_name":"Syngenta (United Kingdom)","ror":"https://ror.org/000bdn450","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210087094","https://openalex.org/I89199228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jacob Riveron","raw_affiliation_strings":["Syngenta Ltd , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Ltd , ,","institution_ids":["https://openalex.org/I4210087094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066400457","display_name":"Keith Ward","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087094","display_name":"Syngenta (United Kingdom)","ror":"https://ror.org/000bdn450","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210087094","https://openalex.org/I89199228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Keith Ward","raw_affiliation_strings":["Syngenta Ltd , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Ltd , ,","institution_ids":["https://openalex.org/I4210087094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075984083","display_name":"Morgan Berrell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087094","display_name":"Syngenta (United Kingdom)","ror":"https://ror.org/000bdn450","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210087094","https://openalex.org/I89199228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Morgan Berrell","raw_affiliation_strings":["Syngenta Ltd , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Ltd , ,","institution_ids":["https://openalex.org/I4210087094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008652291","display_name":"Blandine Rougemont","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087094","display_name":"Syngenta (United Kingdom)","ror":"https://ror.org/000bdn450","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210087094","https://openalex.org/I89199228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Blandine Rougemont","raw_affiliation_strings":["Syngenta Ltd , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Ltd , ,","institution_ids":["https://openalex.org/I4210087094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161489101","display_name":"Iain McGonigal","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087094","display_name":"Syngenta (United Kingdom)","ror":"https://ror.org/000bdn450","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210087094","https://openalex.org/I89199228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Iain McGonigal","raw_affiliation_strings":["Syngenta Ltd , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Ltd , ,","institution_ids":["https://openalex.org/I4210087094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161473838","display_name":"Emily Aldridge","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087094","display_name":"Syngenta (United Kingdom)","ror":"https://ror.org/000bdn450","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210087094","https://openalex.org/I89199228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Emily Aldridge","raw_affiliation_strings":["Syngenta Ltd , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Ltd , ,","institution_ids":["https://openalex.org/I4210087094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090559339","display_name":"Lien De Schrijver","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lien De Schrijver","raw_affiliation_strings":["Syngenta Crop Protection AG , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Crop Protection AG , ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110044682","display_name":"J. Mugnier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087094","display_name":"Syngenta (United Kingdom)","ror":"https://ror.org/000bdn450","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210087094","https://openalex.org/I89199228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jean-Yves Mugnier","raw_affiliation_strings":["Syngenta Ltd , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Ltd , ,","institution_ids":["https://openalex.org/I4210087094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087586299","display_name":"Giovambattista Depietra","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210087094","display_name":"Syngenta (United Kingdom)","ror":"https://ror.org/000bdn450","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210087094","https://openalex.org/I89199228"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Giovambattista Depietra","raw_affiliation_strings":["Syngenta Ltd , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Ltd , ,","institution_ids":["https://openalex.org/I4210087094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073827896","display_name":"Aur\u00e9lien Bigot","orcid":"https://orcid.org/0000-0001-7692-2544","observed_orcids":["https://orcid.org/0000-0001-7692-2544"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Aurelien Bigot","raw_affiliation_strings":["Syngenta Crop Protection AG , ,"],"raw_orcid":"https://orcid.org/0000-0001-7692-2544","affiliations":[{"raw_affiliation_string":"Syngenta Crop Protection AG , ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014444837","display_name":"Quentin Kaas","orcid":"https://orcid.org/0000-0001-9988-6152","observed_orcids":["https://orcid.org/0000-0001-9988-6152"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"Quentin Kaas","raw_affiliation_strings":["Syngenta Crop Protection AG , ,","The University of Queensland , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Syngenta Crop Protection AG , ,","institution_ids":[]},{"raw_affiliation_string":"The University of Queensland , , , ,","institution_ids":["https://openalex.org/I165143802"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079308758","display_name":"David J. Craik","orcid":"https://orcid.org/0000-0003-0007-6796","observed_orcids":["https://orcid.org/0000-0003-0007-6796"]},"institutions":[{"id":"https://openalex.org/I165143802","display_name":"The University of Queensland","ror":"https://ror.org/00rqy9422","country_code":"AU","type":"education","lineage":["https://openalex.org/I165143802"]}],"countries":["AU"],"is_corresponding":false,"raw_author_name":"David J. Craik","raw_affiliation_strings":["The University of Queensland , , , ,"],"raw_orcid":"https://orcid.org/0000-0003-0007-6796","affiliations":[{"raw_affiliation_string":"The University of Queensland , , , ,","institution_ids":["https://openalex.org/I165143802"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11075","display_name":"Insect Resistance and Genetics","score":0.4120999872684479,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11075","display_name":"Insect Resistance and Genetics","score":0.4120999872684479,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11065","display_name":"Insect Pest Control Strategies","score":0.2563000023365021,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11353","display_name":"Venomous Animal Envenomation and Studies","score":0.17990000545978546,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C150149183","wikidata":"https://www.wikidata.org/wiki/Q1940081","display_name":"Midgut","level":3,"score":0.6263999938964844},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.5742999911308289},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.44119998812675476},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.412200003862381},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3968000113964081},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.32919999957084656},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.304500013589859},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.28119999170303345},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.27079999446868896},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2567000091075897},{"id":"https://openalex.org/C2779448229","wikidata":"https://www.wikidata.org/wiki/Q3386847","display_name":"Venom","level":2,"score":0.25609999895095825},{"id":"https://openalex.org/C2780358027","wikidata":"https://www.wikidata.org/wiki/Q407752","display_name":"Neurotoxin","level":2,"score":0.2554999887943268}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acs.jafc.6c08810","doi":"https://doi.org/10.1021/acs.jafc.6c08810","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jafc.6c08810","pdf_url":null,"source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":106,"referenced_works":["https://openalex.org/W334146684","https://openalex.org/W1778363845","https://openalex.org/W1964636816","https://openalex.org/W1975447383","https://openalex.org/W1980253236","https://openalex.org/W1989761771","https://openalex.org/W1990009531","https://openalex.org/W1994656998","https://openalex.org/W1995390287","https://openalex.org/W1996090728","https://openalex.org/W2002804062","https://openalex.org/W2005941282","https://openalex.org/W2006266675","https://openalex.org/W2006767418","https://openalex.org/W2013266935","https://openalex.org/W2016541541","https://openalex.org/W2025405581","https://openalex.org/W2025625871","https://openalex.org/W2027652648","https://openalex.org/W2031172821","https://openalex.org/W2033508868","https://openalex.org/W2036179596","https://openalex.org/W2038703288","https://openalex.org/W2040627229","https://openalex.org/W2041619855","https://openalex.org/W2042558793","https://openalex.org/W2047708956","https://openalex.org/W2049202410","https://openalex.org/W2049398547","https://openalex.org/W2052876027","https://openalex.org/W2057918544","https://openalex.org/W2062688272","https://openalex.org/W2065601090","https://openalex.org/W2070031795","https://openalex.org/W2079760106","https://openalex.org/W2080653832","https://openalex.org/W2084100737","https://openalex.org/W2092336096","https://openalex.org/W2101762911","https://openalex.org/W2103452253","https://openalex.org/W2104412338","https://openalex.org/W2114276539","https://openalex.org/W2120603162","https://openalex.org/W2144105873","https://openalex.org/W2153896272","https://openalex.org/W2166992704","https://openalex.org/W2180091139","https://openalex.org/W2194585050","https://openalex.org/W2314428235","https://openalex.org/W2316572616","https://openalex.org/W2328358728","https://openalex.org/W2332867031","https://openalex.org/W2337044996","https://openalex.org/W2344483017","https://openalex.org/W2466103614","https://openalex.org/W2527785927","https://openalex.org/W2578885445","https://openalex.org/W2759996086","https://openalex.org/W2766078662","https://openalex.org/W2791757849","https://openalex.org/W2801794631","https://openalex.org/W2802911639","https://openalex.org/W2888840670","https://openalex.org/W2898155534","https://openalex.org/W2901321957","https://openalex.org/W2913500366","https://openalex.org/W2940454243","https://openalex.org/W2942919636","https://openalex.org/W2942956896","https://openalex.org/W2944599718","https://openalex.org/W2945869760","https://openalex.org/W2966336292","https://openalex.org/W2982747591","https://openalex.org/W2989805186","https://openalex.org/W3021476227","https://openalex.org/W3022236931","https://openalex.org/W3034454497","https://openalex.org/W3118338975","https://openalex.org/W3162877622","https://openalex.org/W3167784429","https://openalex.org/W3170953318","https://openalex.org/W3193478650","https://openalex.org/W3210046548","https://openalex.org/W4211226929","https://openalex.org/W4214675043","https://openalex.org/W4244736178","https://openalex.org/W4248615091","https://openalex.org/W4307697617","https://openalex.org/W4311214351","https://openalex.org/W4313705693","https://openalex.org/W4318570184","https://openalex.org/W4322502172","https://openalex.org/W4367669884","https://openalex.org/W4377088938","https://openalex.org/W4378229178","https://openalex.org/W4386531270","https://openalex.org/W4387568517","https://openalex.org/W4388024035","https://openalex.org/W4389305879","https://openalex.org/W4390746881","https://openalex.org/W4393388027","https://openalex.org/W4400580139","https://openalex.org/W4403001692","https://openalex.org/W4403064858","https://openalex.org/W4415297716","https://openalex.org/W7122392207"],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Farmers":[1],"face":[2],"shrinking":[3],"crop-protection":[4],"options":[5],"due":[6],"to":[7,81,113],"climate":[8],"change,":[9],"resistance,":[10],"regulations,":[11],"and":[12,18,28,59,85,118,128],"demand":[13],"for":[14],"residue-free":[15],"food.":[16],"Peptides":[17],"proteins":[19],"are":[20,25,75],"attractive":[21],"solutions":[22],"because":[23],"they":[24],"potent,":[26],"specific,":[27],"degrade":[29],"into":[30,115],"harmless":[31],"amino":[32],"acids.":[33],"Venom-derived":[34],"peptide":[35],"neurotoxins":[36,68,112],"show":[37,53],"strong":[38],"potential":[39],"as":[40,145],"bioinsecticides,":[41],"but":[42],"their":[43],"poor":[44],"oral":[45,64],"activity":[46,78],"limits":[47],"use":[48],"in":[49,86],"sprayable":[50],"formulations.":[51],"We":[52],"that":[54],"plant":[55],"cyclotides,":[56],"kalata":[57,132],"B1":[58,133],"B2,":[60],"dramatically":[61],"enhance":[62],"the":[63,107,116,121,129],"efficacy":[65],"of":[66,131,147],"venom-derived":[67],"against":[69,150],"major":[70],"lepidopteran":[71,108],"pests.":[72,154],"Their":[73],"effects":[74],"synergistic,":[76],"increasing":[77],"by":[79],"two":[80],"3-fold":[82],"beyond":[83],"additivity,":[84],"some":[87],"cases,":[88],"enabling":[89],"complete":[90],"mortality":[91],"at":[92],"doses":[93],"where":[94],"either":[95],"component":[96],"alone":[97],"is":[98],"ineffective.":[99],"The":[100],"proposed":[101],"mechanism":[102],"involves":[103],"cyclotides":[104,144],"selectively":[105],"disrupt":[106],"midgut":[109,126],"barrier,":[110],"allowing":[111],"cross":[114],"hemocoel":[117],"act":[119],"on":[120],"nervous":[122],"system.":[123],"Microscopy":[124],"confirms":[125],"damage,":[127],"D-form":[130],"retains":[134],"activity,":[135],"indicating":[136],"an":[137],"achiral,":[138],"lipid-mediated":[139],"interaction.":[140],"These":[141],"results":[142],"establish":[143],"enablers":[146],"peptide-based":[148],"bioinsecticides":[149],"selected":[151],"important":[152],"crop":[153]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}