{"id":"https://openalex.org/W7225819744","doi":"https://doi.org/10.1007/s00262-026-04628-0","title":"Prognostic value of systemic inflammatory biomarkers in advanced gastroesophageal adenocarcinoma patients undergoing chemoimmunotherapy","display_name":"Prognostic value of systemic inflammatory biomarkers in advanced gastroesophageal adenocarcinoma patients undergoing chemoimmunotherapy","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225819744","doi":"https://doi.org/10.1007/s00262-026-04628-0"},"language":"en","primary_location":{"id":"doi:10.1007/s00262-026-04628-0","doi":"https://doi.org/10.1007/s00262-026-04628-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00262-026-04628-0","pdf_url":null,"source":{"id":"https://openalex.org/S203303425","display_name":"Cancer Immunology Immunotherapy","issn_l":"0340-7004","issn":["0340-7004","1432-0851"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology, Immunotherapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1007/s00262-026-04628-0","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5133979973","display_name":"Martin Korpan","orcid":"https://orcid.org/0009-0005-8508-1640","observed_orcids":["https://orcid.org/0009-0005-8508-1640"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Martin Korpan","raw_affiliation_strings":["Christian Doppler Laboratory for Personalized Immunotherapy, Department of Medicine I, Medical University of Vienna, Vienna, Austria","Division of Oncology, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Christian Doppler Laboratory for Personalized Immunotherapy, Department of Medicine I, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Division of Oncology, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052934588","display_name":"Daniel Nothdurfter","orcid":"https://orcid.org/0009-0007-9690-2293","observed_orcids":["https://orcid.org/0009-0007-9690-2293"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Daniel Nothdurfter","raw_affiliation_strings":["Department of Internal Medicine I for Hematology With Stem Cell Transplantation, Hemostaseology, and Medical Oncology, Ordensklinikum Linz, Linz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I for Hematology With Stem Cell Transplantation, Hemostaseology, and Medical Oncology, Ordensklinikum Linz, Linz, Austria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011711845","display_name":"Bernhard Doleschal","orcid":"https://orcid.org/0009-0004-4813-4435","observed_orcids":["https://orcid.org/0009-0004-4813-4435"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bernhard Doleschal","raw_affiliation_strings":["Department of Internal Medicine I for Hematology With Stem Cell Transplantation, Hemostaseology, and Medical Oncology, Ordensklinikum Linz, Linz, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine I for Hematology With Stem Cell Transplantation, Hemostaseology, and Medical Oncology, Ordensklinikum Linz, Linz, Austria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077525995","display_name":"Patrick Reimann","orcid":"https://orcid.org/0000-0001-8387-3357","observed_orcids":["https://orcid.org/0000-0001-8387-3357"]},"institutions":[{"id":"https://openalex.org/I4210087533","display_name":"Landeskrankenhaus Feldkirch","ror":"https://ror.org/004gqpt18","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210087533"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Patrick Reimann","raw_affiliation_strings":["Department of Internal Medicine II, Academic Teaching Hospital Feldkirch, 6800, Feldkirch, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine II, Academic Teaching Hospital Feldkirch, 6800, Feldkirch, Austria","institution_ids":["https://openalex.org/I4210087533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063566935","display_name":"Thomas L. Winder","orcid":"https://orcid.org/0000-0002-4216-2994","observed_orcids":["https://orcid.org/0000-0002-4216-2994"]},"institutions":[{"id":"https://openalex.org/I4210087533","display_name":"Landeskrankenhaus Feldkirch","ror":"https://ror.org/004gqpt18","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4210087533"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Thomas Winder","raw_affiliation_strings":["Department of Internal Medicine II, Academic Teaching Hospital Feldkirch, 6800, Feldkirch, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine II, Academic Teaching Hospital Feldkirch, 6800, Feldkirch, Austria","institution_ids":["https://openalex.org/I4210087533"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036764789","display_name":"Florian Huemer","orcid":"https://orcid.org/0000-0001-9184-4038","observed_orcids":["https://orcid.org/0000-0001-9184-4038"]},"institutions":[{"id":"https://openalex.org/I27945538","display_name":"Paracelsus Medical University","ror":"https://ror.org/03z3mg085","country_code":"AT","type":"education","lineage":["https://openalex.org/I27945538"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Florian Huemer","raw_affiliation_strings":["Cancer Research Laboratory of the Department of Internal Medicine III, Paracelsus Medical University, Salzburg, Austria","Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Paracelsus Medical University, Salzburg, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Laboratory of the Department of Internal Medicine III, Paracelsus Medical University, Salzburg, Austria","institution_ids":["https://openalex.org/I27945538"]},{"raw_affiliation_string":"Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Paracelsus Medical University, Salzburg, Austria","institution_ids":["https://openalex.org/I27945538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006219111","display_name":"Lukas Wei\u00df","orcid":"https://orcid.org/0000-0002-2174-5613","observed_orcids":["https://orcid.org/0000-0002-2174-5613"]},"institutions":[{"id":"https://openalex.org/I27945538","display_name":"Paracelsus Medical University","ror":"https://ror.org/03z3mg085","country_code":"AT","type":"education","lineage":["https://openalex.org/I27945538"]},{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["AT","DE"],"is_corresponding":false,"raw_author_name":"Lukas Weiss","raw_affiliation_strings":["Cancer Research Laboratory of the Department of Internal Medicine III, Paracelsus Medical University, Salzburg, Austria","Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Paracelsus Medical University, Salzburg, Austria","Department of Medicine III and Comprehensive Cancer Center (CCC Munich LMU), University Hospital, LMU Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Laboratory of the Department of Internal Medicine III, Paracelsus Medical University, Salzburg, Austria","institution_ids":["https://openalex.org/I27945538"]},{"raw_affiliation_string":"Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Paracelsus Medical University, Salzburg, Austria","institution_ids":["https://openalex.org/I27945538"]},{"raw_affiliation_string":"Department of Medicine III and Comprehensive Cancer Center (CCC Munich LMU), University Hospital, LMU Munich, Munich, Germany","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008248378","display_name":"Sophie Roider\u2010Schur","orcid":"https://orcid.org/0000-0002-3797-0268","observed_orcids":["https://orcid.org/0000-0002-3797-0268"]},"institutions":[{"id":"https://openalex.org/I4387153558","display_name":"St. Josef-Krankenhaus Wien","ror":"https://ror.org/03pmpje25","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4387153558"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Sophie Roider-Schur","raw_affiliation_strings":["Department of Medicine I, Oncology, St. Josef Krankenhaus, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine I, Oncology, St. Josef Krankenhaus, Vienna, Austria","institution_ids":["https://openalex.org/I4387153558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111775850","display_name":"Leopold \u00d6hler","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153558","display_name":"St. Josef-Krankenhaus Wien","ror":"https://ror.org/03pmpje25","country_code":"AT","type":"healthcare","lineage":["https://openalex.org/I4387153558"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Leopold \u00d6hler","raw_affiliation_strings":["Department of Medicine I, Oncology, St. Josef Krankenhaus, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine I, Oncology, St. Josef Krankenhaus, Vienna, Austria","institution_ids":["https://openalex.org/I4387153558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069334269","display_name":"Ewald W\u00f6ll","orcid":"https://orcid.org/0000-0002-1285-8691","observed_orcids":["https://orcid.org/0000-0002-1285-8691"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ewald W\u00f6ll","raw_affiliation_strings":["Department of Internal Medicine, St. Vinzenz Hospital Zams, Zams, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, St. Vinzenz Hospital Zams, Zams, Austria","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082451703","display_name":"Karina Borbil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karina Borbil","raw_affiliation_strings":["Department of Medicine III and Comprehensive Cancer Center (CCC Munich LMU), University Hospital, LMU Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine III and Comprehensive Cancer Center (CCC Munich LMU), University Hospital, LMU Munich, Munich, Germany","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161446920","display_name":"Lena Weiss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27945538","display_name":"Paracelsus Medical University","ror":"https://ror.org/03z3mg085","country_code":"AT","type":"education","lineage":["https://openalex.org/I27945538"]},{"id":"https://openalex.org/I3018771216","display_name":"LMU Klinikum","ror":"https://ror.org/02jet3w32","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]},{"id":"https://openalex.org/I8204097","display_name":"Ludwig-Maximilians-Universit\u00e4t M\u00fcnchen","ror":"https://ror.org/05591te55","country_code":"DE","type":"education","lineage":["https://openalex.org/I8204097"]}],"countries":["AT","DE"],"is_corresponding":false,"raw_author_name":"Lena Weiss","raw_affiliation_strings":["Cancer Research Laboratory of the Department of Internal Medicine III, Paracelsus Medical University, Salzburg, Austria","Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Paracelsus Medical University, Salzburg, Austria","Department of Medicine III and Comprehensive Cancer Center (CCC Munich LMU), University Hospital, LMU Munich, Munich, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Laboratory of the Department of Internal Medicine III, Paracelsus Medical University, Salzburg, Austria","institution_ids":["https://openalex.org/I27945538"]},{"raw_affiliation_string":"Department of Internal Medicine III with Haematology, Medical Oncology, Haemostaseology, Infectiology and Rheumatology, Paracelsus Medical University, Salzburg, Austria","institution_ids":["https://openalex.org/I27945538"]},{"raw_affiliation_string":"Department of Medicine III and Comprehensive Cancer Center (CCC Munich LMU), University Hospital, LMU Munich, Munich, Germany","institution_ids":["https://openalex.org/I3018771216","https://openalex.org/I8204097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061724888","display_name":"Fabienne I. Nocera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]},{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Fabienne Nocera","raw_affiliation_strings":["Department of Hematology and Oncology, Comprehensive Cancer Center Innsbruck, Medical University of Innsbruck, Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Comprehensive Cancer Center Innsbruck, Medical University of Innsbruck, Innsbruck, Austria","institution_ids":["https://openalex.org/I143397708","https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061589425","display_name":"Arno Amann","orcid":"https://orcid.org/0000-0002-9358-8389","observed_orcids":["https://orcid.org/0000-0002-9358-8389"]},"institutions":[{"id":"https://openalex.org/I143397708","display_name":"Innsbruck Medical University","ror":"https://ror.org/03pt86f80","country_code":"AT","type":"education","lineage":["https://openalex.org/I143397708"]},{"id":"https://openalex.org/I190249584","display_name":"Universit\u00e4t Innsbruck","ror":"https://ror.org/054pv6659","country_code":"AT","type":"education","lineage":["https://openalex.org/I190249584"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Arno Amann","raw_affiliation_strings":["Department of Hematology and Oncology, Comprehensive Cancer Center Innsbruck, Medical University of Innsbruck, Innsbruck, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Comprehensive Cancer Center Innsbruck, Medical University of Innsbruck, Innsbruck, Austria","institution_ids":["https://openalex.org/I143397708","https://openalex.org/I190249584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158276668","display_name":"Nadine Bosbach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098738","display_name":"Klinik Hirslanden","ror":"https://ror.org/014c2qb55","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210098738","https://openalex.org/I4210110334"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nadine Bosbach","raw_affiliation_strings":["Clinical Trial Unit, Hirslanden Zurich AG, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trial Unit, Hirslanden Zurich AG, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210098738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108949519","display_name":"Alexander Reinhard Siebenh\u00fcner","orcid":"https://orcid.org/0000-0002-5404-2383","observed_orcids":["https://orcid.org/0000-0002-5404-2383"]},"institutions":[{"id":"https://openalex.org/I4210098738","display_name":"Klinik Hirslanden","ror":"https://ror.org/014c2qb55","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210098738","https://openalex.org/I4210110334"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Alexander Siebenh\u00fcner","raw_affiliation_strings":["Klinik f\u00fcr H\u00e4matologie und Onkologie, Hirslanden Zurich AG, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinik f\u00fcr H\u00e4matologie und Onkologie, Hirslanden Zurich AG, Zurich, Switzerland","institution_ids":["https://openalex.org/I4210098738"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034847353","display_name":"Gerald W. Prager","orcid":"https://orcid.org/0000-0002-7854-7781","observed_orcids":["https://orcid.org/0000-0002-7854-7781"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Gerald W. Prager","raw_affiliation_strings":["Division of Oncology, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025877193","display_name":"Anna Sophie Berghoff","orcid":"https://orcid.org/0000-0001-9379-6797","observed_orcids":["https://orcid.org/0000-0001-9379-6797","https://orcid.org/0000-0003-0767-6241"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Anna S. Berghoff","raw_affiliation_strings":["Christian Doppler Laboratory for Personalized Immunotherapy, Department of Medicine I, Medical University of Vienna, Vienna, Austria","Division of Oncology, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Christian Doppler Laboratory for Personalized Immunotherapy, Department of Medicine I, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Division of Oncology, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057141936","display_name":"Matthias Preusser","orcid":"https://orcid.org/0000-0003-3541-2315","observed_orcids":["https://orcid.org/0000-0003-3541-2315"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Matthias Preusser","raw_affiliation_strings":["Christian Doppler Laboratory for Personalized Immunotherapy, Department of Medicine I, Medical University of Vienna, Vienna, Austria","Division of Oncology, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Christian Doppler Laboratory for Personalized Immunotherapy, Department of Medicine I, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Division of Oncology, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091089536","display_name":"Hannah Christina Puhr","orcid":"https://orcid.org/0000-0002-7203-8732","observed_orcids":["https://orcid.org/0000-0002-7203-8732"]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Hannah C. Puhr","raw_affiliation_strings":["Christian Doppler Laboratory for Personalized Immunotherapy, Department of Medicine I, Medical University of Vienna, Vienna, Austria","Division of Oncology, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Christian Doppler Laboratory for Personalized Immunotherapy, Department of Medicine I, Medical University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]},{"raw_affiliation_string":"Division of Oncology, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161430390","display_name":"Ayseg\u00fcl Ilhan-Mutlu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76134821","display_name":"Medical University of Vienna","ror":"https://ror.org/05n3x4p02","country_code":"AT","type":"education","lineage":["https://openalex.org/I76134821"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Ayseg\u00fcl Ilhan-Mutlu","raw_affiliation_strings":["Division of Oncology, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Department of Medicine I, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria","institution_ids":["https://openalex.org/I76134821"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5091089536"],"corresponding_institution_ids":["https://openalex.org/I76134821"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":{"value":4590,"currency":"USD","value_usd":4590},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10696","display_name":"Gastric Cancer Management and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2780790343","wikidata":"https://www.wikidata.org/wiki/Q5090610","display_name":"Chemoimmunotherapy","level":4,"score":0.9610999822616577},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8937000036239624},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7784000039100647},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6013000011444092},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.5011000037193298},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.49950000643730164},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.46160000562667847},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4020000100135803},{"id":"https://openalex.org/C2779984678","wikidata":"https://www.wikidata.org/wiki/Q2145898","display_name":"Response Evaluation Criteria in Solid Tumors","level":4,"score":0.3653999865055084},{"id":"https://openalex.org/C185926286","wikidata":"https://www.wikidata.org/wiki/Q1929812","display_name":"Systemic therapy","level":4,"score":0.36239999532699585},{"id":"https://openalex.org/C2780739268","wikidata":"https://www.wikidata.org/wiki/Q2112244","display_name":"Progression-free survival","level":3,"score":0.3499999940395355},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.34310001134872437},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.30799999833106995},{"id":"https://openalex.org/C2776907518","wikidata":"https://www.wikidata.org/wiki/Q1734165","display_name":"Performance status","level":3,"score":0.2948000133037567},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.2946999967098236},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.289000004529953},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.2849000096321106},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2768999934196472},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.273499995470047},{"id":"https://openalex.org/C3019894029","wikidata":"https://www.wikidata.org/wiki/Q332823","display_name":"Overall survival","level":2,"score":0.25940001010894775},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.25360000133514404}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s00262-026-04628-0","doi":"https://doi.org/10.1007/s00262-026-04628-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00262-026-04628-0","pdf_url":null,"source":{"id":"https://openalex.org/S203303425","display_name":"Cancer Immunology Immunotherapy","issn_l":"0340-7004","issn":["0340-7004","1432-0851"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology, Immunotherapy","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1007/s00262-026-04628-0","doi":"https://doi.org/10.1007/s00262-026-04628-0","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s00262-026-04628-0","pdf_url":null,"source":{"id":"https://openalex.org/S203303425","display_name":"Cancer Immunology Immunotherapy","issn_l":"0340-7004","issn":["0340-7004","1432-0851"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Immunology, Immunotherapy","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Systemic":[2,67],"inflammation":[3],"is":[4],"a":[5],"key":[6],"driver":[7],"of":[8,271],"cancer":[9,65],"progression":[10],"across":[11,61],"solid":[12],"tumors,":[13],"including":[14],"gastroesophageal":[15],"adenocarcinoma":[16],"(GEA).":[17],"Evidence":[18],"on":[19,109],"inflammatory":[20,68,88,150,281,298],"biomarkers":[21,69,282,299],"in":[22,182,287],"advanced":[23,54,135,272],"GEA":[24,55,273],"remains":[25],"largely":[26,236],"Asian":[27],"cohort\u2013based,":[28],"while":[29],"European":[30,64,268],"real-world":[31,49,269],"data":[32,255],"are":[33],"limited":[34],"and":[35,92,106,112,137,152,158,173,198,227,247,249,256,318],"pivotal":[36],"chemoimmunotherapy":[37,59],"trials":[38],"did":[39],"not":[40],"report":[41],"these":[42],"markers.":[43],"Methods":[44],"This":[45],"exploratory,":[46],"retrospective,":[47],"multicenter,":[48],"study":[50],"included":[51],"patients":[52,122,132,207,274],"with":[53,134,140,163,190,209,216,285,313],"receiving":[56,275],"1st-line":[57],"palliative":[58],"treated":[60],"9":[62],"Central":[63],"centers.":[66],"[neutrophil-to-lymphocyte":[70],"ratio":[71,74,77,80],"(NLR),":[72],"platelet-to-lymphocyte":[73],"(PLR),":[75],"leucocyte-to-lymphocyte":[76],"(LLR),":[78],"lymphocyte-to-monocyte":[79],"(LMR),":[81],"modified":[82],"Glasgow":[83],"Prognostic":[84],"Score":[85],"(mGPS),":[86],"systemic":[87,93,149,280],"response":[89],"index":[90,95],"(SIRI)":[91],"immune-inflammation":[94],"(SII)]":[96],"were":[97,214,235,260,283],"analyzed":[98,239],"according":[99],"to":[100,253,262],"median":[101,125],"values":[102],"before":[103],"treatment":[104],"initiation":[105],"the":[107,120,146,293],"impact":[108],"progression-free":[110],"(PFS)":[111],"overall":[113],"survival":[114,286],"(OS)":[115],"was":[116,188],"assessed.":[117],"Results":[118],"Of":[119],"182":[121],"(79%":[123],"male,":[124],"age:":[126],"66":[127],"years)":[128],"included,":[129],"146":[130],"(80%)":[131],"presented":[133],"disease":[136],"36":[138],"(20%)":[139],"recurrent":[141],"disease.":[142],"When":[143],"dichotomized":[144,291],"at":[145,292],"median,":[147],"all":[148,169,178,278],"ratios":[151],"indices":[153],"(NLR,":[154],"PLR,":[155],"LLR,":[156],"SIRI":[157,245],"SII)":[159],"showed":[160],"significant":[161],"association":[162],"shorter":[164,217],"PFS":[165,192,218],"(HR":[166,175,193,200,229],"range":[167,176],"1.43\u20131.70,":[168],"p":[170,179,195,202],"<":[171,180,196,203],"0.05)":[172,181,197],"OS":[174,199,228],"1.87\u20132.09,":[177],"univariable":[183,263,288],"analysis,":[184],"whereas":[185],"higher":[186,212],"LMR":[187,250],"associated":[189,215,284],"longer":[191],"0.64,":[194],"0.47,":[201],"0.05).":[204],"In":[205,266],"118":[206],"(65%)":[208],"available":[210,302],"mGPS,":[211],"scores":[213],"(per":[219],"one":[220],"point":[221],"increase\u2014HR":[222],"1.72,":[223],"95%":[224,231],"CI":[225,232],"1.25\u20132.37)":[226],"1.77,":[230],"1.26\u20132.49).":[233],"Associations":[234],"consistent":[237],"when":[238,290],"as":[240,300],"continuous":[241],"variables,":[242],"except":[243],"for":[244],"(PFS":[246],"OS)":[248],"(PFS).":[251],"Due":[252],"missing":[254],"overlapping":[257],"indices,":[258],"analyses":[259,289],"restricted":[261],"associations.":[264],"Conclusion":[265],"this":[267],"cohort":[270],"first-line":[276],"chemoimmunotherapy,":[277],"investigated":[279],"median.":[294],"These":[295],"findings":[296],"support":[297],"readily":[301],"prognostic":[303,316,321],"markers":[304],"but":[305],"warrant":[306],"further":[307],"validation,":[308],"particularly":[309],"regarding":[310],"their":[311,319],"associations":[312],"established":[314],"clinical":[315],"factors":[317],"independent":[320],"value.":[322]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
