{"id":"https://openalex.org/W7225818900","doi":"https://doi.org/10.1186/s13099-026-00886-6","title":"The gut microbiota-gut-brain axis in sepsis-associated encephalopathy: pathogenesis and therapeutic potential of probiotics","display_name":"The gut microbiota-gut-brain axis in sepsis-associated encephalopathy: pathogenesis and therapeutic potential of probiotics","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225818900","doi":"https://doi.org/10.1186/s13099-026-00886-6"},"language":"en","primary_location":{"id":"doi:10.1186/s13099-026-00886-6","doi":"https://doi.org/10.1186/s13099-026-00886-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13099-026-00886-6","pdf_url":null,"source":{"id":"https://openalex.org/S116933238","display_name":"Gut Pathogens","issn_l":"1757-4749","issn":["1757-4749"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s13099-026-00886-6","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5138954831","display_name":"Jun Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]},{"id":"https://openalex.org/I4210120169","display_name":"First Affiliated Hospital of Kunming Medical University","ror":"https://ror.org/02g01ht84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120169"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Huang","raw_affiliation_strings":["Department of Critical Care Medicine, Kunming Medical University First Affiliated Hospital, Kunming, 650000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Kunming Medical University First Affiliated Hospital, Kunming, 650000, China","institution_ids":["https://openalex.org/I26080491","https://openalex.org/I4210120169"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010029604","display_name":"Qinfen Gao","orcid":"https://orcid.org/0009-0008-8467-7364","observed_orcids":["https://orcid.org/0009-0008-8467-7364"]},"institutions":[{"id":"https://openalex.org/I10660446","display_name":"Kunming University of Science and Technology","ror":"https://ror.org/00xyeez13","country_code":"CN","type":"education","lineage":["https://openalex.org/I10660446"]},{"id":"https://openalex.org/I4210091044","display_name":"First People's Hospital of Yunnan Province","ror":"https://ror.org/00c099g34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210091044"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qinfen Gao","raw_affiliation_strings":["Department of Emergency, The First People\u2019s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency, The First People\u2019s Hospital of Yunnan Province, Affiliated Hospital of Kunming University of Science and Technology, Kunming, 650000, China","institution_ids":["https://openalex.org/I10660446","https://openalex.org/I4210091044"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161488992","display_name":"Wei Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I26080491","display_name":"Kunming Medical University","ror":"https://ror.org/038c3w259","country_code":"CN","type":"education","lineage":["https://openalex.org/I26080491"]},{"id":"https://openalex.org/I4210120169","display_name":"First Affiliated Hospital of Kunming Medical University","ror":"https://ror.org/02g01ht84","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210120169"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["Department of Critical Care Medicine, Kunming Medical University First Affiliated Hospital, Kunming, 650000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care Medicine, Kunming Medical University First Affiliated Hospital, Kunming, 650000, China","institution_ids":["https://openalex.org/I26080491","https://openalex.org/I4210120169"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5010029604","https://openalex.org/A5161488992"],"corresponding_institution_ids":["https://openalex.org/I10660446","https://openalex.org/I26080491","https://openalex.org/I4210091044","https://openalex.org/I4210120169"],"apc_list":{"value":3390,"currency":"USD","value_usd":3390},"apc_paid":{"value":3390,"currency":"USD","value_usd":3390},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9355000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.03840000182390213,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.005400000140070915,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.703499972820282},{"id":"https://openalex.org/C2777165150","wikidata":"https://www.wikidata.org/wiki/Q269334","display_name":"Dysbiosis","level":3,"score":0.6207000017166138},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5081999897956848},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.5031999945640564},{"id":"https://openalex.org/C2780665704","wikidata":"https://www.wikidata.org/wiki/Q959298","display_name":"Intervention (counseling)","level":2,"score":0.48399999737739563},{"id":"https://openalex.org/C3019978661","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut microbiome","level":3,"score":0.4722999930381775},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.46320000290870667},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.4255000054836273},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.39250001311302185},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.39160001277923584},{"id":"https://openalex.org/C2778621155","wikidata":"https://www.wikidata.org/wiki/Q576349","display_name":"Encephalopathy","level":2,"score":0.38600000739097595},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.3765999972820282},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.36550000309944153},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3361999988555908},{"id":"https://openalex.org/C190139176","wikidata":"https://www.wikidata.org/wiki/Q598976","display_name":"Medical microbiology","level":2,"score":0.3357999920845032},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3255999982357025},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.3199999928474426},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.3158000111579895},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.28679999709129333},{"id":"https://openalex.org/C2986104408","wikidata":"https://www.wikidata.org/wiki/Q179661","display_name":"Clinical treatment","level":2,"score":0.28369998931884766},{"id":"https://openalex.org/C177857423","wikidata":"https://www.wikidata.org/wiki/Q17077315","display_name":"Gut\u2013brain axis","level":3,"score":0.2578999996185303},{"id":"https://openalex.org/C2992053201","wikidata":"https://www.wikidata.org/wiki/Q2585693","display_name":"Clinical efficacy","level":2,"score":0.2500999867916107}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s13099-026-00886-6","doi":"https://doi.org/10.1186/s13099-026-00886-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13099-026-00886-6","pdf_url":null,"source":{"id":"https://openalex.org/S116933238","display_name":"Gut Pathogens","issn_l":"1757-4749","issn":["1757-4749"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut Pathogens","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s13099-026-00886-6","doi":"https://doi.org/10.1186/s13099-026-00886-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13099-026-00886-6","pdf_url":null,"source":{"id":"https://openalex.org/S116933238","display_name":"Gut Pathogens","issn_l":"1757-4749","issn":["1757-4749"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gut Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Sepsis-associated":[0],"encephalopathy":[1],"(SAE)":[2],"represents":[3],"one":[4],"of":[5,10,45,65,82,141],"the":[6,42,60,80,100,119,124,134],"most":[7],"severe":[8],"complications":[9],"sepsis,":[11],"characterized":[12],"by":[13,98],"diffuse":[14],"neurological":[15],"dysfunction.":[16],"It":[17,130],"significantly":[18],"increases":[19],"patient":[20],"mortality":[21],"and":[22,33,53,96,107,137,150],"can":[23],"lead":[24],"to":[25,93,116,160],"long-term":[26],"neuropsychiatric":[27],"sequelae,":[28],"including":[29],"cognitive":[30],"deficits,":[31],"anxiety,":[32],"depression,":[34],"thereby":[35],"imposing":[36],"a":[37,76,90,162],"substantial":[38],"societal":[39],"burden.":[40],"Currently,":[41],"clinical":[43,139],"diagnosis":[44],"SAE":[46,94],"relies":[47],"primarily":[48],"on":[49,123,132],"subjective":[50],"assessment":[51],"scales,":[52],"effective":[54],"specific":[55],"therapies":[56],"are":[57],"lacking,":[58],"underscoring":[59],"need":[61],"for":[62,165,170],"further":[63],"elucidation":[64],"its":[66],"pathological":[67],"mechanisms.":[68],"Recent":[69],"studies":[70,122],"indicate":[71],"that":[72],"gut":[73,101,125],"dysbiosis":[74],"plays":[75],"pivotal":[77],"role":[78],"in":[79,128,154],"development":[81],"SAE.":[83,129,171],"Consequently,":[84],"probiotic-based":[85],"microbiome":[86],"intervention":[87,168],"strategies":[88,169],"offer":[89],"novel":[91],"approach":[92],"prevention":[95],"treatment":[97],"reshaping":[99],"microbiota,":[102],"restoring":[103],"beneficial":[104],"metabolite":[105],"levels,":[106],"inhibiting":[108],"harmful":[109],"immune":[110],"cell":[111],"migration.":[112],"This":[113],"review":[114],"aims":[115],"systematically":[117],"summarize":[118],"latest":[120],"mechanistic":[121],"microbiota-gut-brain":[126],"axis":[127],"focuses":[131],"evaluating":[133],"experimental":[135],"evidence":[136],"potential":[138],"value":[140],"microbiological":[142],"therapies,":[143],"particularly":[144],"probiotics,":[145],"while":[146],"outlining":[147],"future":[148],"challenges":[149],"translational":[151],"research":[152],"directions":[153],"this":[155],"field.":[156],"The":[157],"goal":[158],"is":[159],"provide":[161],"theoretical":[163],"basis":[164],"developing":[166],"precise":[167]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
