{"id":"https://openalex.org/W7225818149","doi":"https://doi.org/10.52340/gs.2026.08.04(1).04","title":"HETEROCHROMATIN AND NOR ALTERATIONS IN DUCTAL BREAST CANCER","display_name":"HETEROCHROMATIN AND NOR ALTERATIONS IN DUCTAL BREAST CANCER","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225818149","doi":"https://doi.org/10.52340/gs.2026.08.04(1).04"},"language":"en","primary_location":{"id":"doi:10.52340/gs.2026.08.04(1).04","doi":"https://doi.org/10.52340/gs.2026.08.04(1).04","is_oa":true,"landing_page_url":"https://doi.org/10.52340/gs.2026.08.04(1).04","pdf_url":null,"source":{"id":"https://openalex.org/S4210238182","display_name":"GEORGIAN SCIENTISTS","issn_l":"2667-9760","issn":["2667-9760"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4387155489","host_organization_name":"Association for Science","host_organization_lineage":["https://openalex.org/I4387155489"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GEORGIAN SCIENTISTS","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.52340/gs.2026.08.04(1).04","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001816349","display_name":"T Lezhava","orcid":"https://orcid.org/0000-0002-8727-5693","observed_orcids":["https://orcid.org/0000-0002-8727-5693"]},"institutions":[{"id":"https://openalex.org/I102808428","display_name":"Tbilisi State University","ror":"https://ror.org/05fd1hd85","country_code":"GE","type":"education","lineage":["https://openalex.org/I102808428"]}],"countries":["GE"],"is_corresponding":true,"raw_author_name":"Teimuraz Lezhava","raw_affiliation_strings":["Tbilisi State University, Tbilisi"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tbilisi State University, Tbilisi","institution_ids":["https://openalex.org/I102808428"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5001816349"],"corresponding_institution_ids":["https://openalex.org/I102808428"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.24289999902248383,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.24289999902248383,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.19349999725818634,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.09130000323057175,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C103435993","wikidata":"https://www.wikidata.org/wiki/Q837783","display_name":"Heterochromatin","level":4,"score":0.7982000112533569},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6564000248908997},{"id":"https://openalex.org/C73397532","wikidata":"https://www.wikidata.org/wiki/Q623749","display_name":"Chromatid","level":4,"score":0.6442999839782715},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.45590001344680786},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.4271000027656555},{"id":"https://openalex.org/C207812311","wikidata":"https://www.wikidata.org/wiki/Q426560","display_name":"Ribosomal DNA","level":4,"score":0.39629998803138733},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.37940001487731934},{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.37119999527931213},{"id":"https://openalex.org/C174475383","wikidata":"https://www.wikidata.org/wiki/Q246128","display_name":"Cytogenetics","level":4,"score":0.3662000000476837},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.364300012588501},{"id":"https://openalex.org/C63491729","wikidata":"https://www.wikidata.org/wiki/Q14762596","display_name":"Centromere","level":4,"score":0.3474999964237213},{"id":"https://openalex.org/C140367098","wikidata":"https://www.wikidata.org/wiki/Q425319","display_name":"Satellite DNA","level":4,"score":0.29170000553131104},{"id":"https://openalex.org/C2777761686","wikidata":"https://www.wikidata.org/wiki/Q715347","display_name":"Lymphocyte","level":2,"score":0.2678000032901764},{"id":"https://openalex.org/C93304396","wikidata":"https://www.wikidata.org/wiki/Q14763008","display_name":"Mitosis","level":2,"score":0.25699999928474426}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.52340/gs.2026.08.04(1).04","doi":"https://doi.org/10.52340/gs.2026.08.04(1).04","is_oa":true,"landing_page_url":"https://doi.org/10.52340/gs.2026.08.04(1).04","pdf_url":null,"source":{"id":"https://openalex.org/S4210238182","display_name":"GEORGIAN SCIENTISTS","issn_l":"2667-9760","issn":["2667-9760"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4387155489","host_organization_name":"Association for Science","host_organization_lineage":["https://openalex.org/I4387155489"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GEORGIAN SCIENTISTS","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.52340/gs.2026.08.04(1).04","doi":"https://doi.org/10.52340/gs.2026.08.04(1).04","is_oa":true,"landing_page_url":"https://doi.org/10.52340/gs.2026.08.04(1).04","pdf_url":null,"source":{"id":"https://openalex.org/S4210238182","display_name":"GEORGIAN SCIENTISTS","issn_l":"2667-9760","issn":["2667-9760"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4387155489","host_organization_name":"Association for Science","host_organization_lineage":["https://openalex.org/I4387155489"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GEORGIAN SCIENTISTS","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"After":[0],"the":[1,4,8,67,86,113,122,139,147,154,169,178,204,229,239,255,263,283,290,302,316,327],"completion":[2],"of":[3,11,23,37,44,78,89,96,99,133,136,156,206,233,241,257,266,269,271,295,304,318],"Human":[5],"Genome":[6],"Project,":[7],"strategic":[9],"direction":[10,312],"modern":[12],"genetics":[13],"shifted":[14],"towards":[15],"functional":[16],"genomics,":[17],"which":[18,249],"also":[19,215],"includes":[20],"non-coding":[21,26],"regions":[22],"DNA.":[24],"Total":[25],"DNA":[27],"and":[28,56,70,112,119,124,238,280,320],"satellite":[29,101,144],"stalk":[30],"with":[31,61,66,117,121,174,213,225,254,276,282,298],"ribosomal":[32,97,134,202,231,267,305],"cystrons,":[33],"comprising":[34],"repetitive":[35],"sequences":[36],"nucleotides":[38],"localized":[39],"in":[40,59,105,143,146,185,211,223,252,274,287,301,307,313,326],"heterochromatin.":[41],"The":[42,48,76,131,200,293],"functions":[43],"heterochromatin":[45,55,58,80,90],"remain":[46],"unclear.":[47],"present":[49],"study":[50,294],"aims":[51],"to":[52,153,177,188,289],"investigate":[53],"total":[54,79],"NOR":[57],"patients":[60,116,173,212,224,275],"Ductal":[62],"Breast":[63],"Cancer":[64],"(DBC)":[65],"bioregulator":[68,123],"Livagen":[69],"a":[71,125,310,322],"heavy":[72,126],"metal":[73,127],"(CoCl2)":[74],"(LCo).":[75],"level":[77],"by":[81],"differential":[82,264],"scanning":[83],"microcalorimetry":[84],"showed":[85],"melting":[87],"point":[88],"indicating":[91,315],"slight":[92],"chromatin":[93],"heterochromatinization.":[94],"Intensity":[95],"cystrons":[98,135,268],"chromatid":[100,137],"stalks":[102],"(NOR":[103],"heterochromatin)":[104],"32":[106],"lymphocyte":[107],"cultures":[108],"from":[109,115],"healthy":[110],"individuals":[111],"18":[114],"DBC,":[118,175],"DBC":[120,214,226,277,281],"have":[128],"been":[129],"studied.":[130],"activity":[132,155,183,201,230,265,303],"on":[138,208,235],"15":[140,171,237,273],"chromosomes":[141,209],"included":[142],"associations":[145,186],"control":[148,179,291],"group":[149,180],"was":[150,216,244,250],"reduced":[151,245],"compared":[152,176],"other":[157],"chromatids":[158,170,234,270,297],"(14":[159],"=":[160,162,195],"21":[161],"22":[163],">":[164,166,192],"13":[165,194],"15).":[167],"But,":[168],"chromosome":[172,236,272],"had":[181],"high":[182],"inclusion":[184],"corresponded":[187],"order":[189],":":[190],"(15":[191],"21>22=":[193],"14)":[196],"(p":[197,219,246],"<":[198,220,247],"0.001).":[199,221],"cistrons":[203,232],"type":[205],"association":[207,242],"15:15":[210,243],"significantly":[217],"increased":[218],"However":[222],"+":[227],"LCo,":[228],"frequency":[240],"0.001),":[248],"mainly":[251],"line":[253],"data":[256],"middle":[258],"age.":[259],"Our":[260],"results":[261],"indicated":[262],"(significantly":[278,285],"increased)":[279],"LCo":[284],"reduced)":[286],"contrast":[288],"group.":[292],"acrocentric":[296],"epigenetic":[299],"variability":[300],"genes":[306],"pathology":[308],"is":[309],"new":[311,323],"medicine,":[314],"diagnosis":[317],"diseases":[319],"defining":[321],"treatment":[324],"strategy":[325],"future.":[328]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
