{"id":"https://openalex.org/W7225817924","doi":"https://doi.org/10.1371/journal.pntd.0014811","title":"Immunogenicity of Hantavirus and evaluation of vaccine protective efficacy: A comparative neutralizing antibody study of vaccine strains and representative epidemic strains from selected provinces in China","display_name":"Immunogenicity of Hantavirus and evaluation of vaccine protective efficacy: A comparative neutralizing antibody study of vaccine strains and representative epidemic strains from selected provinces in China","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225817924","doi":"https://doi.org/10.1371/journal.pntd.0014811"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pntd.0014811","doi":"https://doi.org/10.1371/journal.pntd.0014811","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0014811","pdf_url":null,"source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Neglected Tropical Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pntd.0014811","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082805505","display_name":"Xiaoxia Huang","orcid":"https://orcid.org/0009-0009-1212-8232","observed_orcids":["https://orcid.org/0009-0009-1212-8232"]},"institutions":[{"id":"https://openalex.org/I184490438","display_name":"Chinese Center For Disease Control and Prevention","ror":"https://ror.org/04wktzw65","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210140986","display_name":"National Institute for Viral Disease Control and Prevention","ror":"https://ror.org/04b1sh213","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210140986","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoxia Huang","raw_affiliation_strings":["National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention","National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases"],"raw_orcid":"https://orcid.org/0009-0009-1212-8232","affiliations":[{"raw_affiliation_string":"National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986"]},{"raw_affiliation_string":"National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161445597","display_name":"Zhangqi Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184490438","display_name":"Chinese Center For Disease Control and Prevention","ror":"https://ror.org/04wktzw65","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210140986","display_name":"National Institute for Viral Disease Control and Prevention","ror":"https://ror.org/04b1sh213","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210140986","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhangqi Zheng","raw_affiliation_strings":["National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110934421","display_name":"Shanshan Du","orcid":"https://orcid.org/0009-0003-2340-9394","observed_orcids":["https://orcid.org/0009-0003-2340-9394"]},"institutions":[{"id":"https://openalex.org/I184490438","display_name":"Chinese Center For Disease Control and Prevention","ror":"https://ror.org/04wktzw65","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210140986","display_name":"National Institute for Viral Disease Control and Prevention","ror":"https://ror.org/04b1sh213","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210140986","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shanshan Du","raw_affiliation_strings":["National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention","National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986"]},{"raw_affiliation_string":"National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109461624","display_name":"Aqian Li","orcid":"https://orcid.org/0000-0003-3640-6961","observed_orcids":["https://orcid.org/0000-0003-3640-6961"]},"institutions":[{"id":"https://openalex.org/I184490438","display_name":"Chinese Center For Disease Control and Prevention","ror":"https://ror.org/04wktzw65","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210140986","display_name":"National Institute for Viral Disease Control and Prevention","ror":"https://ror.org/04b1sh213","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210140986","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Aqian Li","raw_affiliation_strings":["National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention","National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986"]},{"raw_affiliation_string":"National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161432159","display_name":"Fangzhen Tian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149137203","display_name":"Guiyang Medical University","ror":"https://ror.org/035y7a716","country_code":"CN","type":"education","lineage":["https://openalex.org/I149137203"]},{"id":"https://openalex.org/I184490438","display_name":"Chinese Center For Disease Control and Prevention","ror":"https://ror.org/04wktzw65","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210140986","display_name":"National Institute for Viral Disease Control and Prevention","ror":"https://ror.org/04b1sh213","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210140986","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fangzhen Tian","raw_affiliation_strings":["Ministry of Education, Guizhou Medical University","National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ministry of Education, Guizhou Medical University","institution_ids":["https://openalex.org/I149137203"]},{"raw_affiliation_string":"National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161466453","display_name":"Tianmeng Gu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184490438","display_name":"Chinese Center For Disease Control and Prevention","ror":"https://ror.org/04wktzw65","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210140986","display_name":"National Institute for Viral Disease Control and Prevention","ror":"https://ror.org/04b1sh213","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210140986","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianmeng Gu","raw_affiliation_strings":["National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118838179","display_name":"Zheng Lanling","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I149137203","display_name":"Guiyang Medical University","ror":"https://ror.org/035y7a716","country_code":"CN","type":"education","lineage":["https://openalex.org/I149137203"]},{"id":"https://openalex.org/I184490438","display_name":"Chinese Center For Disease Control and Prevention","ror":"https://ror.org/04wktzw65","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210140986","display_name":"National Institute for Viral Disease Control and Prevention","ror":"https://ror.org/04b1sh213","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210140986","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lanling Zheng","raw_affiliation_strings":["Ministry of Education, Guizhou Medical University","National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Ministry of Education, Guizhou Medical University","institution_ids":["https://openalex.org/I149137203"]},{"raw_affiliation_string":"National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100307049","display_name":"Li Chuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184490438","display_name":"Chinese Center For Disease Control and Prevention","ror":"https://ror.org/04wktzw65","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210140986","display_name":"National Institute for Viral Disease Control and Prevention","ror":"https://ror.org/04b1sh213","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210140986","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Chuan","raw_affiliation_strings":["National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention","National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986"]},{"raw_affiliation_string":"National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100422797","display_name":"Qin Wang","orcid":"https://orcid.org/0000-0001-6070-8148","observed_orcids":["https://orcid.org/0000-0001-6070-8148"]},"institutions":[{"id":"https://openalex.org/I184490438","display_name":"Chinese Center For Disease Control and Prevention","ror":"https://ror.org/04wktzw65","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210140986","display_name":"National Institute for Viral Disease Control and Prevention","ror":"https://ror.org/04b1sh213","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210140986","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qin Wang","raw_affiliation_strings":["National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention","National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986"]},{"raw_affiliation_string":"National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161490713","display_name":"Li Yuan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184490438","display_name":"Chinese Center For Disease Control and Prevention","ror":"https://ror.org/04wktzw65","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210140986","display_name":"National Institute for Viral Disease Control and Prevention","ror":"https://ror.org/04b1sh213","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210140986","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Yuan","raw_affiliation_strings":["National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5123088838","display_name":"Jiandong Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184490438","display_name":"Chinese Center For Disease Control and Prevention","ror":"https://ror.org/04wktzw65","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210151987"]},{"id":"https://openalex.org/I4210140986","display_name":"National Institute for Viral Disease Control and Prevention","ror":"https://ror.org/04b1sh213","country_code":"CN","type":"government","lineage":["https://openalex.org/I184490438","https://openalex.org/I4210127390","https://openalex.org/I4210140986","https://openalex.org/I4210151987"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiandong Li","raw_affiliation_strings":["National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention","National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention","institution_ids":["https://openalex.org/I184490438","https://openalex.org/I4210140986"]},{"raw_affiliation_string":"National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2670,"currency":"USD","value_usd":2670},"apc_paid":{"value":2670,"currency":"USD","value_usd":2670},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":"11","first_page":"e0014811","last_page":"e0014811"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12047","display_name":"Viral Infections and Vectors","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11581","display_name":"Viral Infections and Outbreaks Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2780868878","wikidata":"https://www.wikidata.org/wiki/Q1660197","display_name":"Immunogenicity","level":3,"score":0.8267999887466431},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.8195000290870667},{"id":"https://openalex.org/C2911215419","wikidata":"https://www.wikidata.org/wiki/Q9002005","display_name":"Hantaan virus","level":4,"score":0.7688999772071838},{"id":"https://openalex.org/C2775992772","wikidata":"https://www.wikidata.org/wiki/Q29001073","display_name":"Hantavirus","level":3,"score":0.7085999846458435},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.6751000285148621},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.527899980545044},{"id":"https://openalex.org/C32611913","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Titer","level":3,"score":0.498199999332428},{"id":"https://openalex.org/C2776872762","wikidata":"https://www.wikidata.org/wiki/Q3560939","display_name":"Inactivated vaccine","level":3,"score":0.46810001134872437},{"id":"https://openalex.org/C2780801004","wikidata":"https://www.wikidata.org/wiki/Q1415366","display_name":"Immunization","level":3,"score":0.46709999442100525},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4374000132083893},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.42480000853538513},{"id":"https://openalex.org/C138894074","wikidata":"https://www.wikidata.org/wiki/Q7201694","display_name":"Plaque reduction neutralization test","level":4,"score":0.41830000281333923},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4154999852180481},{"id":"https://openalex.org/C22889606","wikidata":"https://www.wikidata.org/wiki/Q2166189","display_name":"Antibody titer","level":4,"score":0.3659000098705292},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.35109999775886536},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.3330000042915344},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.31690001487731934},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.290800005197525},{"id":"https://openalex.org/C3018913218","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody response","level":3,"score":0.2718999981880188}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1371/journal.pntd.0014811","doi":"https://doi.org/10.1371/journal.pntd.0014811","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0014811","pdf_url":null,"source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Neglected Tropical Diseases","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1371/journal.pntd.0014811","doi":"https://doi.org/10.1371/journal.pntd.0014811","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pntd.0014811","pdf_url":null,"source":{"id":"https://openalex.org/S46544255","display_name":"PLoS neglected tropical diseases","issn_l":"1935-2727","issn":["1935-2727","1935-2735"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Neglected Tropical Diseases","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":11,"referenced_works":["https://openalex.org/W2083971727","https://openalex.org/W2110758620","https://openalex.org/W2288658137","https://openalex.org/W2768582733","https://openalex.org/W2882971445","https://openalex.org/W3003165035","https://openalex.org/W3024428639","https://openalex.org/W3035099895","https://openalex.org/W3089077341","https://openalex.org/W4388599930","https://openalex.org/W4411528001"],"related_works":[],"abstract_inverted_index":{"Background":[0],"Hemorrhagic":[1],"fever":[2],"with":[3,25,153,214],"renal":[4],"syndrome":[5],"(HFRS)":[6],"caused":[7],"by":[8,136,358],"Hantavirus":[9],"(HV)":[10],"remains":[11],"a":[12,65,224],"significant":[13,225],"public":[14],"health":[15],"burden":[16],"in":[17,41,46,72,90,227,240,378],"the":[18,75,79,96,101,105,108,124,197,228,241,385,403,416,429],"world.":[19],"HFRS":[20,43,49,62,141,202,439],"bivalent":[21],"inactivated":[22],"vaccine":[23,160,164,234,259,289,420],"(HFRSbiv)":[24],"Hantaan":[26],"virus":[27,31,80,106],"(HTNV)":[28],"and":[29,59,93,107,121,146,167,179,217,236,248,303,333,339,394,423,427,431,436,441,444],"Seoul":[30],"(SEOV)":[32],"strains":[33,171,235,238,331,393],"isolated":[34],"20":[35],"years":[36],"ago":[37],"have":[38,346],"been":[39],"used":[40,377],"key":[42],"endemic":[44],"provinces":[45],"China":[47,379],"for":[48],"prevention.":[50],"After":[51],"decades":[52],"of":[53,56,67,78,95,104,111,123,126,132,230,341,353,360,398,405,408,434],"effective":[54],"implementation":[55],"comprehensive":[57],"prevention":[58,440],"control":[60,442],"measures,":[61],"has":[63],"entered":[64],"stage":[66],"epidemic":[68,170,237,264,294,314,330,424],"fluctuation":[69],"at":[70,143],"low-level":[71],"China.":[73],"However,":[74],"continuous":[76],"transmission":[77,430],"among":[81],"rodent":[82],"host":[83],"animals":[84],"may":[85,99,365],"lead":[86],"to":[87,116,401],"dynamic":[88],"changes":[89],"genetic":[91,337,406],"diversity":[92,338],"immunogenicity":[94,125,324,340],"virus,":[97],"which":[98,343],"affect":[100],"pathogenic":[102,432],"mechanism":[103],"protective":[109],"effect":[110],"vaccines.":[112],"It":[113,396],"is":[114,223,397],"necessary":[115],"carry":[117],"out":[118],"timely":[119,437],"monitoring":[120,404],"evaluation":[122],"HV.":[127],"Methodology/principal":[128],"findings":[129],"A":[130],"panel":[131],"sera":[133,250,283,305],"was":[134,326],"established":[135],"screening":[137],"serum":[138,199,242],"samples":[139],"from":[140,172,195,362],"patients":[142],"convalescent":[144],"phase":[145],"individuals":[147],"who":[148],"had":[149],"received":[150],"standardized":[151],"immunization":[152],"HFRSbiv.":[154],"Neutralizing":[155],"antibody":[156],"titers":[157,229],"against":[158,233,258,263,288,293,310,313,390],"HTNV":[159,209],"strain":[161,165,260,265,290,295,315],"84FLi,":[162],"SEOV":[163,215,329],"L99,":[166],"three":[168],"representative":[169],"different":[173,363,391],"genotypes":[174,364],"(HTNV:":[175],"SX26,":[176],"SEOV:":[177],"LN03":[178,296,332],"FJ-17)":[180],"were":[181,193,206,213,220],"measured":[182],"using":[183],"an":[184],"enzyme-linked":[185],"immunosorbent":[186],"assay-based":[187],"microneutralization":[188],"test":[189],"(MN-ELISA).":[190],"HV-neutralizing":[191],"antibodies":[192,232,356],"detected":[194,239],"all":[196],"selected":[198],"samples.":[200,243],"Among":[201],"patients,":[203],"47.92%":[204],"(23/48)":[205],"identified":[207],"as":[208],"infection,":[210,216],"27.08%":[211],"(13/48)":[212],"25%":[218],"(12/48)":[219],"untypable.":[221],"There":[222],"difference":[226],"neutralizing":[231,355,383],"For":[244,280],"HTNV,":[245],"both":[246],"patient":[247,282],"vaccinee":[249,304],"exhibited":[251],"significantly":[252,285,307],"higher":[253],"geometric":[254],"mean":[255],"titer":[256],"(GMT)":[257],"84FLi":[261],"than":[262,292,312],"SX26":[266],"(1:386.08":[267],"vs.":[268,274,298,318],"1:223.04,":[269],"\ud835\udc43":[270,276,300,320],"<":[271,277,301,321],"0.001;":[272],"1:137.94":[273],"1:110.37,":[275],"0.05,":[278],"respectively).":[279],"SEOV,":[281],"showed":[284,306],"lower":[286,308],"GMT":[287,309],"L99":[291,311],"(1:177.02":[297],"1:297.71,":[299],"0.01),":[302],"FJ-17":[316],"(1:97.52":[317],"1:243.71,":[319],"0.001).":[322],"Significant":[323],"heterogeneity":[325],"observed":[327],"between":[328,419],"FJ-17.":[334],"Conclusions/significance":[335],"The":[336,351,374],"HV,":[342,435],"causes":[344],"HFRS,":[345],"certain":[347],"geographical":[348],"regional":[349,409],"characteristics.":[350],"levels":[352],"cross":[354,372],"induced":[357],"infection":[359],"HV":[361],"vary":[366,389],"significantly,":[367],"but":[368],"still":[369],"provide":[370],"sufficient":[371],"protection.":[373],"HFRSbiv":[375],"currently":[376],"could":[380],"induce":[381],"broad":[382],"antibody,":[384],"cross-protective":[386],"efficacy":[387],"might":[388],"circulating":[392,411],"genotypes.":[395],"great":[399],"significance":[400],"strengthen":[402],"characteristics":[407],"specific":[410],"viral":[412],"strains,":[413,425],"regularly":[414],"evaluate":[415,428],"matching":[417],"degree":[418],"protection":[421],"effectiveness":[422],"predict":[426],"risks":[433],"optimize":[438],"strategies":[443],"measures.":[445]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
