{"id":"https://openalex.org/W7225817807","doi":"https://doi.org/10.3389/fnins.2026.1934124","title":"Susceptibility alterations in the hippocampus and subcortical nuclei in hemodialysis patients with end-stage renal disease: an APART-QSM study","display_name":"Susceptibility alterations in the hippocampus and subcortical nuclei in hemodialysis patients with end-stage renal disease: an APART-QSM study","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225817807","doi":"https://doi.org/10.3389/fnins.2026.1934124"},"language":"en","primary_location":{"id":"doi:10.3389/fnins.2026.1934124","doi":"https://doi.org/10.3389/fnins.2026.1934124","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2026.1934124","pdf_url":"https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2026.1934124/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2026.1934124/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5144089530","display_name":"Yuanhui Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099373","display_name":"Second Hospital of Hebei Medical University","ror":"https://ror.org/015ycqv20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099373"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanhui Zhao","raw_affiliation_strings":["Department of Radiology, The Second Hospital of Hebei Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, The Second Hospital of Hebei Medical University","institution_ids":["https://openalex.org/I4210099373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161480280","display_name":"Zhixiang Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099373","display_name":"Second Hospital of Hebei Medical University","ror":"https://ror.org/015ycqv20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099373"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhixiang Yang","raw_affiliation_strings":["Department of Radiology, The Second Hospital of Hebei Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, The Second Hospital of Hebei Medical University","institution_ids":["https://openalex.org/I4210099373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161474029","display_name":"Huiqing Zhang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Huiqing Zhang","raw_affiliation_strings":["The Second Veterans Hospital of Hebei Province"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Veterans Hospital of Hebei Province","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161459716","display_name":"Yang Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yang Li","raw_affiliation_strings":["Wentang Workers\u2019 Sanatorium of Hebei Federation of Trade Unions"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Wentang Workers\u2019 Sanatorium of Hebei Federation of Trade Unions","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102361499","display_name":"Huixiao Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210139529","display_name":"Hebei Eye Hospital","ror":"https://ror.org/033hgw744","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210139529"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huixiao Wang","raw_affiliation_strings":["Hebei Eye Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hebei Eye Hospital","institution_ids":["https://openalex.org/I4210139529"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137547259","display_name":"Shihan Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099373","display_name":"Second Hospital of Hebei Medical University","ror":"https://ror.org/015ycqv20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099373"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shihan Cheng","raw_affiliation_strings":["Department of Radiology, The Second Hospital of Hebei Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, The Second Hospital of Hebei Medical University","institution_ids":["https://openalex.org/I4210099373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161442881","display_name":"Haoyang Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099373","display_name":"Second Hospital of Hebei Medical University","ror":"https://ror.org/015ycqv20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099373"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haoyang Wu","raw_affiliation_strings":["Department of Radiology, The Second Hospital of Hebei Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, The Second Hospital of Hebei Medical University","institution_ids":["https://openalex.org/I4210099373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042070573","display_name":"Zhengnan Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099373","display_name":"Second Hospital of Hebei Medical University","ror":"https://ror.org/015ycqv20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099373"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhengnan Zhang","raw_affiliation_strings":["Department of Radiology, The Second Hospital of Hebei Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, The Second Hospital of Hebei Medical University","institution_ids":["https://openalex.org/I4210099373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161433195","display_name":"Zelin Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099373","display_name":"Second Hospital of Hebei Medical University","ror":"https://ror.org/015ycqv20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099373"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zelin Liu","raw_affiliation_strings":["Department of Radiology, The Second Hospital of Hebei Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, The Second Hospital of Hebei Medical University","institution_ids":["https://openalex.org/I4210099373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082674920","display_name":"Duo Gao","orcid":"https://orcid.org/0000-0003-3691-2119","observed_orcids":["https://orcid.org/0000-0003-3691-2119"]},"institutions":[{"id":"https://openalex.org/I4210099373","display_name":"Second Hospital of Hebei Medical University","ror":"https://ror.org/015ycqv20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099373"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Duo Gao","raw_affiliation_strings":["Department of Radiology, The Second Hospital of Hebei Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, The Second Hospital of Hebei Medical University","institution_ids":["https://openalex.org/I4210099373"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045700877","display_name":"Linghui Meng","orcid":"https://orcid.org/0000-0001-5915-4395","observed_orcids":["https://orcid.org/0000-0001-5915-4395"]},"institutions":[{"id":"https://openalex.org/I4210099373","display_name":"Second Hospital of Hebei Medical University","ror":"https://ror.org/015ycqv20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099373"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Linghui Meng","raw_affiliation_strings":["Department of Radiology, The Second Hospital of Hebei Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, The Second Hospital of Hebei Medical University","institution_ids":["https://openalex.org/I4210099373"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161464535","display_name":"Haiqing Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210099373","display_name":"Second Hospital of Hebei Medical University","ror":"https://ror.org/015ycqv20","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099373"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Haiqing Yang","raw_affiliation_strings":["Department of Radiology, The Second Hospital of Hebei Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, The Second Hospital of Hebei Medical University","institution_ids":["https://openalex.org/I4210099373"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5045700877","https://openalex.org/A5161464535"],"corresponding_institution_ids":["https://openalex.org/I4210099373"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"20","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9916999936103821,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7811999917030334},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.6995999813079834},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.6240000128746033},{"id":"https://openalex.org/C2778063415","wikidata":"https://www.wikidata.org/wiki/Q391744","display_name":"Hemodialysis","level":2,"score":0.6223999857902527},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6025999784469604},{"id":"https://openalex.org/C3019040382","wikidata":"https://www.wikidata.org/wiki/Q476921","display_name":"End stage renal disease","level":3,"score":0.5547999739646912},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5428000092506409},{"id":"https://openalex.org/C2779714222","wikidata":"https://www.wikidata.org/wiki/Q550934","display_name":"Putamen","level":2,"score":0.5169000029563904},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.3849000036716461},{"id":"https://openalex.org/C16246696","wikidata":"https://www.wikidata.org/wiki/Q15282184","display_name":"Susceptibility weighted imaging","level":3,"score":0.36719998717308044},{"id":"https://openalex.org/C65835030","wikidata":"https://www.wikidata.org/wiki/Q1030681","display_name":"Brain size","level":3,"score":0.33809998631477356},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.31940001249313354},{"id":"https://openalex.org/C2779281540","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Central nervous system disease","level":2,"score":0.3174999952316284},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.29580000042915344},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.28619998693466187},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.2669000029563904},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.26510000228881836},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.2632000148296356},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2540000081062317},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2522999942302704},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.25200000405311584}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fnins.2026.1934124","doi":"https://doi.org/10.3389/fnins.2026.1934124","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2026.1934124","pdf_url":"https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2026.1934124/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fnins.2026.1934124","doi":"https://doi.org/10.3389/fnins.2026.1934124","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnins.2026.1934124","pdf_url":"https://www.frontiersin.org/journals/neuroscience/articles/10.3389/fnins.2026.1934124/pdf","source":{"id":"https://openalex.org/S115201632","display_name":"Frontiers in Neuroscience","issn_l":"1662-453X","issn":["1662-453X","1662-4548"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225817807.pdf","grobid_xml":"https://content.openalex.org/works/W7225817807.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1485368148","https://openalex.org/W1486067459","https://openalex.org/W1970928383","https://openalex.org/W2019587683","https://openalex.org/W2021985766","https://openalex.org/W2050900769","https://openalex.org/W2077510921","https://openalex.org/W2125450867","https://openalex.org/W2126681103","https://openalex.org/W2129789527","https://openalex.org/W2152166807","https://openalex.org/W2282280448","https://openalex.org/W2324713866","https://openalex.org/W2412971699","https://openalex.org/W2593271907","https://openalex.org/W2740726467","https://openalex.org/W2895401445","https://openalex.org/W2965654579","https://openalex.org/W2972529806","https://openalex.org/W3094011130","https://openalex.org/W3112745696","https://openalex.org/W4226366125","https://openalex.org/W4241074797","https://openalex.org/W4281898568","https://openalex.org/W4367397297","https://openalex.org/W4384925924","https://openalex.org/W4392777592","https://openalex.org/W4392978048"],"related_works":[],"abstract_inverted_index":{"Objective":[0],"To":[1],"investigate":[2],"APART-QSM-derived":[3],"paramagnetic":[4],"susceptibility":[5,232,250],"(\u03c7para)":[6],"alterations":[7],"in":[8,15,127,217,224,233,267],"hippocampal,":[9,49],"medial":[10,50],"temporal,":[11,51],"and":[12,35,52,65,77,107,117,169,209,228,239,252,273,287],"subcortical":[13,53],"regions":[14],"maintenance":[16,30],"hemodialysis":[17,31,260],"patients":[18,32,109,261],"with":[19,33,110,262],"end-stage":[20],"renal":[21],"disease":[22],"(ESRD).":[23],"Methods":[24],"This":[25],"cross-sectional":[26],"study":[27],"included":[28,73],"55":[29],"ESRD":[34,86,111,263],"39":[36],"healthy":[37],"controls.":[38,123],"\u03c7para,":[39],"the":[40,85,95,128,218,225,234,268],"primary":[41],"imaging":[42],"outcome,":[43],"was":[44,125],"extracted":[45],"from":[46],"FreeSurfer-defined":[47],"bilateral":[48,129,170,226,235,240,269,274],"regions.":[54],"Group":[55],"differences":[56],"across":[57],"20":[58],"prespecified":[59],"ROIs":[60],"were":[61,88,92],"tested":[62],"using":[63,94],"age-":[64],"sex-adjusted":[66],"linear":[67],"models.":[68],"Hippocampal":[69],"sensitivity":[70],"models":[71],"additionally":[72],"ipsilateral":[74,206],"hippocampal":[75,198,207],"volume":[76,81,208],"estimated":[78],"total":[79,231],"intracranial":[80],"(eTIV).":[82],"Correlations":[83],"within":[84],"group":[87],"exploratory.":[89],"Multiple":[90],"comparisons":[91],"controlled":[93],"Benjamini-Hochberg":[96],"false":[97],"discovery":[98],"rate":[99],"(FDR).":[100],"Results":[101],"After":[102],"adjustment":[103,204],"for":[104,205],"age,":[105],"sex,":[106],"education,":[108],"had":[112],"lower":[113,214],"MMSE,":[114],"MoCA":[115,118],"total,":[116],"delayed":[119],"recall":[120],"scores":[121,254],"than":[122],"\u03c7para":[124,199,266],"higher":[126,221,229],"hippocampus":[130],"(left:":[131,173],"\u03b2":[132,144,158,174,186],"=":[133,145,153,159,167,175,183,187,195],"0.002855":[134],"ppm,":[135,139,147,151,161,165,177,181,189,193],"95%":[136,148,162,178,190],"CI:":[137,149,163,179,191],"0.001531\u20130.004179":[138],"q":[140,152,166,182,194],"<":[141],"0.001;":[142],"right:":[143,185],"0.002102":[146],"0.000893\u20130.003312":[150],"0.008),":[154],"left":[155,219,237,271],"putamen":[156],"(":[157],"0.007775":[160],"0.002329\u20130.013222":[164],"0.023),":[168],"ventral":[171],"diencephalon":[172],"0.005427":[176],"0.002029\u20130.008825":[180],"0.014;":[184],"0.004935":[188],"0.001483\u20130.008386":[192],"0.023).":[196],"Bilateral":[197],"remained":[200],"nominally":[201],"significant":[202],"after":[203,242],"eTIV.":[210],"Supplementary":[211,276],"analyses":[212],"showed":[213,264,279],"\u03c7dia":[215,222],"magnitude":[216,223],"hippocampus,":[220,236,270],"caudate,":[227],"APART":[230],"putamen,":[238,272],"VentralDC":[241],"metric-specific":[243],"FDR":[244,256],"correction.":[245,257],"No":[246],"associations":[247],"between":[248],"ROI-wise":[249],"metrics":[251,278],"cognitive":[253],"survived":[255],"Conclusion":[258],"Maintenance":[259],"increased":[265],"VentralDC.":[275],"source-separated":[277],"additional":[280],"regional":[281],"differences,":[282],"but":[283],"their":[284],"algebraic":[285],"relationship":[286],"nonspecific":[288],"biological":[289],"origins":[290],"require":[291],"cautious":[292],"interpretation.":[293]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}