{"id":"https://openalex.org/W7225817531","doi":"https://doi.org/10.64898/2026.11.09.765508","title":"TREM2-stimulated, PDGF-dependent macrophage-fibroblast crosstalk induces beneficial plaque remodeling in clonal hematopoiesis","display_name":"TREM2-stimulated, PDGF-dependent macrophage-fibroblast crosstalk induces beneficial plaque remodeling in clonal hematopoiesis","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225817531","doi":"https://doi.org/10.64898/2026.11.09.765508"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.09.765508","doi":"https://doi.org/10.64898/2026.11.09.765508","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.09.765508","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.11.09.765508","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100665061","display_name":"Wenli Liu","orcid":"https://orcid.org/0000-0002-1981-611X","observed_orcids":["https://orcid.org/0000-0002-1981-611X","https://orcid.org/0009-0006-8009-6103"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wenli Liu","raw_affiliation_strings":["New York-Presbyterian/Columbia University Irving Medical Center, UNITED STATES;"],"raw_orcid":"https://orcid.org/0000-0002-1981-611X","affiliations":[{"raw_affiliation_string":"New York-Presbyterian/Columbia University Irving Medical Center, UNITED STATES;","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022420096","display_name":"Chenyi Xue","orcid":"https://orcid.org/0000-0002-8829-7659","observed_orcids":["https://orcid.org/0000-0002-8829-7659"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chenyi Xue","raw_affiliation_strings":["Columbia University, UNITED STATES;"],"raw_orcid":"https://orcid.org/0000-0002-8829-7659","affiliations":[{"raw_affiliation_string":"Columbia University, UNITED STATES;","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070353655","display_name":"Malgorzata Olszewska","orcid":"https://orcid.org/0009-0004-3416-1635","observed_orcids":["https://orcid.org/0009-0004-3416-1635"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Malgorzata Olszewska","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai, UNITED STATES;"],"raw_orcid":"https://orcid.org/0009-0004-3416-1635","affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, UNITED STATES;","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051421168","display_name":"Cheng-Chieh Hsu","orcid":"https://orcid.org/0000-0002-3423-7159","observed_orcids":["https://orcid.org/0000-0002-3423-7159"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheng-Chieh Hsu","raw_affiliation_strings":["New York-Presbyterian/Columbia University Irving Medical Center, UNITED STATES;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"New York-Presbyterian/Columbia University Irving Medical Center, UNITED STATES;","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085540599","display_name":"Mustafa Yal\u00e7\u0131nkaya","orcid":"https://orcid.org/0000-0003-2199-0886","observed_orcids":["https://orcid.org/0000-0003-2199-0886"]},"institutions":[{"id":"https://openalex.org/I4390039230","display_name":"Herbert Irving Comprehensive Cancer Center","ror":"https://ror.org/051kc1939","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039230"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mustafa Yalcinkaya","raw_affiliation_strings":["Columbia University Herbert Irving Comprehensive Cancer Center, UNITED STATES;"],"raw_orcid":"https://orcid.org/0000-0003-2199-0886","affiliations":[{"raw_affiliation_string":"Columbia University Herbert Irving Comprehensive Cancer Center, UNITED STATES;","institution_ids":["https://openalex.org/I4390039230"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088332182","display_name":"Tong Xiao","orcid":"https://orcid.org/0000-0003-1462-4650","observed_orcids":["https://orcid.org/0000-0003-1462-4650"]},"institutions":[{"id":"https://openalex.org/I81020160","display_name":"Louisiana State University Health Sciences Center Shreveport","ror":"https://ror.org/03151rh82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121820613","https://openalex.org/I81020160"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tong Xiao","raw_affiliation_strings":["LSU Health Shreveport Department of Pathology & Translational Pathobiology, UNITED STATES;"],"raw_orcid":"https://orcid.org/0000-0003-1462-4650","affiliations":[{"raw_affiliation_string":"LSU Health Shreveport Department of Pathology & Translational Pathobiology, UNITED STATES;","institution_ids":["https://openalex.org/I81020160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006121966","display_name":"Kai Schlepckow","orcid":"https://orcid.org/0000-0002-1119-2293","observed_orcids":["https://orcid.org/0000-0002-1119-2293"]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kai Schlepckow","raw_affiliation_strings":["German Center for Neurodegenerative Diseases (DZNE), UNITED STATES;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Neurodegenerative Diseases (DZNE), UNITED STATES;","institution_ids":["https://openalex.org/I2801533059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065084452","display_name":"Christian Haass","orcid":"https://orcid.org/0000-0002-4869-1627","observed_orcids":["https://orcid.org/0000-0002-4869-1627"]},"institutions":[{"id":"https://openalex.org/I2801533059","display_name":"German Center for Neurodegenerative Diseases","ror":"https://ror.org/043j0f473","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I2801533059","https://openalex.org/I4405256427"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Haass","raw_affiliation_strings":["German Center for Neurodegenerative Diseases, GERMANY;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"German Center for Neurodegenerative Diseases, GERMANY;","institution_ids":["https://openalex.org/I2801533059"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061840849","display_name":"Eirini P. Papapetrou","orcid":"https://orcid.org/0000-0001-7002-417X","observed_orcids":["https://orcid.org/0000-0001-7002-417X"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eirini P Papapetrou","raw_affiliation_strings":["Icahn School of Medicine at Mount Sinai, UNITED STATES;"],"raw_orcid":"https://orcid.org/0000-0001-7002-417X","affiliations":[{"raw_affiliation_string":"Icahn School of Medicine at Mount Sinai, UNITED STATES;","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005881707","display_name":"Kathryn M. Monroe","orcid":"https://orcid.org/0000-0002-6901-1176","observed_orcids":["https://orcid.org/0000-0002-6901-1176"]},"institutions":[{"id":"https://openalex.org/I4210097160","display_name":"Denali Therapeutics (United States)","ror":"https://ror.org/00pprn321","country_code":"US","type":"company","lineage":["https://openalex.org/I4210097160"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kathryn M. Monroe","raw_affiliation_strings":["Denali Therapeutics Inc"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Denali Therapeutics Inc","institution_ids":["https://openalex.org/I4210097160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058393037","display_name":"Nan Wang","orcid":"https://orcid.org/0000-0001-9976-0859","observed_orcids":["https://orcid.org/0000-0001-9976-0859"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nan Wang","raw_affiliation_strings":["New York-Presbyterian/Columbia University Irving Medical Center, UNITED STATES;"],"raw_orcid":"https://orcid.org/0000-0001-9976-0859","affiliations":[{"raw_affiliation_string":"New York-Presbyterian/Columbia University Irving Medical Center, UNITED STATES;","institution_ids":["https://openalex.org/I2799503643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026776682","display_name":"Muredach P. Reilly","orcid":"https://orcid.org/0000-0002-3035-9386","observed_orcids":["https://orcid.org/0000-0002-3035-9386"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Muredach Reilly","raw_affiliation_strings":["Columbia University, UNITED STATES;"],"raw_orcid":"https://orcid.org/0000-0002-3035-9386","affiliations":[{"raw_affiliation_string":"Columbia University, UNITED STATES;","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018642661","display_name":"Alan R. Tall","orcid":"https://orcid.org/0000-0002-7708-2417","observed_orcids":["https://orcid.org/0000-0002-7708-2417"]},"institutions":[{"id":"https://openalex.org/I2799503643","display_name":"Columbia University Irving Medical Center","ror":"https://ror.org/01esghr10","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799503643"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan R. Tall","raw_affiliation_strings":["New York-Presbyterian/Columbia University Irving Medical Center, UNITED STATES;"],"raw_orcid":"https://orcid.org/0000-0002-7708-2417","affiliations":[{"raw_affiliation_string":"New York-Presbyterian/Columbia University Irving Medical Center, UNITED STATES;","institution_ids":["https://openalex.org/I2799503643"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11628","display_name":"Myeloproliferative Neoplasms: Diagnosis and Treatment","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.7717999815940857},{"id":"https://openalex.org/C2780545995","wikidata":"https://www.wikidata.org/wiki/Q18030421","display_name":"PDGFB","level":5,"score":0.7224000096321106},{"id":"https://openalex.org/C37307934","wikidata":"https://www.wikidata.org/wiki/Q18030422","display_name":"PDGFRA","level":4,"score":0.7102000117301941},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.6032000184059143},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5760999917984009},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5135999917984009},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.4950999915599823},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4708999991416931},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.45210000872612},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.44350001215934753},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.42289999127388},{"id":"https://openalex.org/C170932241","wikidata":"https://www.wikidata.org/wiki/Q411610","display_name":"Neurofibromin 1","level":3,"score":0.36090001463890076},{"id":"https://openalex.org/C101666144","wikidata":"https://www.wikidata.org/wiki/Q2587862","display_name":"CCL2","level":4,"score":0.3582000136375427},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3580999970436096},{"id":"https://openalex.org/C137738243","wikidata":"https://www.wikidata.org/wiki/Q189092","display_name":"Cell migration","level":3,"score":0.3578000068664551},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.35260000824928284},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.34769999980926514},{"id":"https://openalex.org/C54166955","wikidata":"https://www.wikidata.org/wiki/Q658145","display_name":"Chemotaxis","level":3,"score":0.3066999912261963},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29600000381469727},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.28769999742507935},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.2867000102996826},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.2757999897003174},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.27379998564720154},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2732999920845032},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.26420000195503235},{"id":"https://openalex.org/C160448771","wikidata":"https://www.wikidata.org/wiki/Q184726","display_name":"Phagocytosis","level":2,"score":0.25760000944137573},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2565000057220459}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.09.765508","doi":"https://doi.org/10.64898/2026.11.09.765508","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.09.765508","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.09.765508","doi":"https://doi.org/10.64898/2026.11.09.765508","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.09.765508","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Background:":[0],"In":[1,246],"Jak2V617F":[2,48,113],"clonal":[3],"hematopoiesis,":[4],"inflammatory":[5,251,292],"signaling":[6,39],"suppresses":[7],"macrophage":[8,103,216,232,257,277],"TREM2":[9,18,73,98,253],"and":[10,26,35,80,89,106,130,169,195,203,219,242,264,268,291],"promotes":[11,255],"features":[12],"of":[13,116,250],"plaque":[14,21],"instability,":[15],"while":[16],"therapeutic":[17],"agonism":[19],"reverses":[20],"instability":[22],"by":[23,201,205,231],"increasing":[24],"fibroblasts":[25,178,186,225,275],"fibrous":[27,108,127,152,270],"cap":[28,109,128,153,271],"formation.":[29,273],"We":[30],"tested":[31],"whether":[32],"macrophage-derived":[33,135],"PDGFB":[34,104,136],"stromal":[36,66,82,143,209,236],"cell":[37,83,164,293],"PDGFR?":[38,259],"mediate":[40],"this":[41],"response.":[42,144],"Methods:":[43],"Low":[44],"allele":[45],"burden":[46],"(LAB)":[47],"atherosclerosis":[49],"models":[50],"were":[51,69,85,93,199],"combined":[52],"with":[53,71,100,174,214],"inducible":[54],"Pdgfb":[55,117],"deletion":[56,62,148,238],"in":[57,63,111,118,126,279,295],"CX3CR1-lineage":[58,119],"monocytes/macrophages":[59],"or":[60,159],"Pdgfra":[61,147,206,237],"Col1a2-lineage":[64,146],"fibroblast-enriched":[65],"cells.":[67],"Mice":[68],"treated":[70],"the":[72,123,142,150,296],"agonist":[74],"4D9.":[75],"Plaque":[76],"composition,":[77],"macrophage-fibroblast":[78,285],"interactions,":[79],"aortic":[81],"populations":[84,172,267],"analyzed.":[86],"Human":[87],"WT":[88],"JAK2V617F":[90],"iPSC-derived":[91],"macrophages":[92,227],"used":[94],"for":[95,141],"validation.":[96],"Results:":[97],"activation":[99,254],"4D9":[101,175,202],"increased":[102,167,239],"production":[105],"promoted":[107],"formation":[110],"LAB":[112],"atherosclerosis.":[114],"Deletion":[115],"cells":[120],"markedly":[121],"attenuated":[122,204],"4D9-mediated":[124],"increase":[125],"area":[129],"lesional":[131,240],"PDGFR?+":[132],"cells,":[133],"establishing":[134],"as":[137],"a":[138,247,256,280],"key":[139],"signal":[140],"Consistently,":[145],"abolished":[149],"4D9-induced":[151],"response":[154,210],"without":[155],"significantly":[156],"altering":[157],"lesion":[158],"necrotic":[160],"core":[161],"area.":[162],"Single":[163],"RNA-seq":[165],"identified":[166],"Fmod+":[168,177,263],"CD26/Dpp4+":[170],"fibroblast":[171,266],"associated":[173,213],"treatment.":[176],"represented":[179],"an":[180],"abundant":[181],"matrix-associated":[182],"population,":[183],"whereas":[184],"CD26+":[185,224,265,274],"showed":[187],"greatest":[188],"enrichment,":[189],"prominent":[190],"extracellular":[191],"matrix,":[192],"collagen":[193],"organization,":[194],"matrix-remodeling":[196],"programs":[197,218],"that":[198,261,287],"enhanced":[200],"deletion.":[207],"The":[208],"was":[211,229],"also":[212],"reduced":[215],"migration-related":[217],"predicted":[220],"chemokine":[221],"communication":[222,286],"from":[223],"to":[226],"which":[228],"verified":[230],"migration":[233],"studies.":[234],"Moreover,":[235],"CCR2+":[241],"CCR5+":[243],"macrophages.":[244],"Conclusions:":[245],"CH":[248],"model":[249],"atherosclerosis,":[252],"PDGFB-stromal":[258],"pathway":[260],"expands":[262],"increases":[269],"matrix":[272,289],"impair":[276],"chemotaxis":[278],"DPP4-dependent":[281],"manner,":[282],"suggesting":[283],"reciprocal":[284],"coordinates":[288],"remodeling":[290],"trafficking":[294],"plaque.":[297]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
