{"id":"https://openalex.org/W7225816152","doi":"https://doi.org/10.1021/acsomega.6c09154","title":"Biodegradable Cu/Sr Co-Doped Hydroxyapatite Composite for Bone Defect Reconstruction: An In Vivo Study","display_name":"Biodegradable Cu/Sr Co-Doped Hydroxyapatite Composite for Bone Defect Reconstruction: An In Vivo Study","publication_year":2026,"publication_date":"2026-11-12","ids":{"openalex":"https://openalex.org/W7225816152","doi":"https://doi.org/10.1021/acsomega.6c09154"},"language":"en","primary_location":{"id":"doi:10.1021/acsomega.6c09154","doi":"https://doi.org/10.1021/acsomega.6c09154","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.6c09154","pdf_url":null,"source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1021/acsomega.6c09154","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101851889","display_name":"Zhengqing Zhu","orcid":"https://orcid.org/0000-0002-0109-1771","observed_orcids":["https://orcid.org/0000-0002-0109-1771"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Zhengqing Zhu","raw_affiliation_strings":["University Medical Center Utrecht , , ,"],"raw_orcid":"https://orcid.org/0000-0002-0109-1771","affiliations":[{"raw_affiliation_string":"University Medical Center Utrecht , , ,","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001413689","display_name":"Azin Khodaei","orcid":"https://orcid.org/0000-0001-8729-3296","observed_orcids":["https://orcid.org/0000-0001-8729-3296"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Azin Khodaei","raw_affiliation_strings":["University Medical Center Utrecht , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Medical Center Utrecht , , ,","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101582435","display_name":"Liwei Zhu","orcid":"https://orcid.org/0009-0009-9057-7527","observed_orcids":["https://orcid.org/0009-0009-9057-7527"]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liwei Zhu","raw_affiliation_strings":["The Second Hospital of Jilin University , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Hospital of Jilin University , , , ,","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122295502","display_name":"Youbin Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Youbin Li","raw_affiliation_strings":["The Second Hospital of Jilin University , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Hospital of Jilin University , , , ,","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147226966","display_name":"Xudong Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xudong Li","raw_affiliation_strings":["The Second Hospital of Jilin University , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Hospital of Jilin University , , , ,","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015290220","display_name":"Moyo C. Kruyt","orcid":"https://orcid.org/0000-0002-5983-5251","observed_orcids":["https://orcid.org/0000-0002-5983-5251"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Moyo C. Kruyt","raw_affiliation_strings":["University Medical Center Utrecht , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University Medical Center Utrecht , , ,","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055954923","display_name":"S. Amir Kamali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Seyed Amir Kamali","raw_affiliation_strings":["Utrecht University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Utrecht University , , ,","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077676327","display_name":"Harrie Weinans","orcid":"https://orcid.org/0000-0002-2275-6170","observed_orcids":["https://orcid.org/0000-0002-2275-6170"]},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Harrie Weinans","raw_affiliation_strings":["University Medical Center Utrecht , , ,"],"raw_orcid":"https://orcid.org/0000-0002-2275-6170","affiliations":[{"raw_affiliation_string":"University Medical Center Utrecht , , ,","institution_ids":["https://openalex.org/I3018483916"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161450065","display_name":"Lanfeng Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210142484","display_name":"Second Affiliated Hospital of Jilin University","ror":"https://ror.org/03x6hbh34","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210142484"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lanfeng Huang","raw_affiliation_strings":["The Second Hospital of Jilin University , , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Hospital of Jilin University , , , ,","institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210142484"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5027118553","display_name":"Saber Amin Yavari","orcid":"https://orcid.org/0000-0003-1677-5751","observed_orcids":["https://orcid.org/0000-0003-1677-5751"]},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I3018483916"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Saber Amin Yavari","raw_affiliation_strings":["Regenerative Medicine Centre Utrecht, Utrecht University , ,","University Medical Center Utrecht , , ,"],"raw_orcid":"https://orcid.org/0000-0003-1677-5751","affiliations":[{"raw_affiliation_string":"Regenerative Medicine Centre Utrecht, Utrecht University , ,","institution_ids":["https://openalex.org/I193662353"]},{"raw_affiliation_string":"University Medical Center Utrecht , , ,","institution_ids":["https://openalex.org/I3018483916"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":1935,"currency":"USD","value_usd":1935},"apc_paid":{"value":1935,"currency":"USD","value_usd":1935},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13470","display_name":"Surface Treatment and Coatings","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2210","display_name":"Mechanical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.6746000051498413},{"id":"https://openalex.org/C8337478","wikidata":"https://www.wikidata.org/wiki/Q1777289","display_name":"Bone healing","level":2,"score":0.6298999786376953},{"id":"https://openalex.org/C104779481","wikidata":"https://www.wikidata.org/wiki/Q50707","display_name":"Composite number","level":2,"score":0.6220999956130981},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.6220999956130981},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.46860000491142273},{"id":"https://openalex.org/C2778606738","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Bone tissue","level":2,"score":0.38670000433921814},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.3756999969482422},{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.3553999960422516},{"id":"https://openalex.org/C136948725","wikidata":"https://www.wikidata.org/wiki/Q1458306","display_name":"Soft tissue","level":2,"score":0.3197999894618988},{"id":"https://openalex.org/C2777663904","wikidata":"https://www.wikidata.org/wiki/Q988343","display_name":"Blood vessel","level":2,"score":0.3075999915599823},{"id":"https://openalex.org/C518915863","wikidata":"https://www.wikidata.org/wiki/Q938","display_name":"Strontium","level":2,"score":0.30649998784065247},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30250000953674316},{"id":"https://openalex.org/C199343813","wikidata":"https://www.wikidata.org/wiki/Q12128","display_name":"Dentistry","level":1,"score":0.2851000130176544},{"id":"https://openalex.org/C2779772531","wikidata":"https://www.wikidata.org/wiki/Q19689164","display_name":"Void (composites)","level":2,"score":0.2824999988079071},{"id":"https://openalex.org/C2993291840","wikidata":"https://www.wikidata.org/wiki/Q1121544","display_name":"Bone formation","level":2,"score":0.27619999647140503},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.2531999945640564}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acsomega.6c09154","doi":"https://doi.org/10.1021/acsomega.6c09154","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.6c09154","pdf_url":null,"source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1021/acsomega.6c09154","doi":"https://doi.org/10.1021/acsomega.6c09154","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acsomega.6c09154","pdf_url":null,"source":{"id":"https://openalex.org/S4210239500","display_name":"ACS Omega","issn_l":"2470-1343","issn":["2470-1343"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Omega","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W1550396184","https://openalex.org/W1984911535","https://openalex.org/W1987546158","https://openalex.org/W2056818359","https://openalex.org/W2109673760","https://openalex.org/W2143245418","https://openalex.org/W2160935729","https://openalex.org/W2221356237","https://openalex.org/W2727722511","https://openalex.org/W2756086046","https://openalex.org/W2956049423","https://openalex.org/W2976567064","https://openalex.org/W2981336571","https://openalex.org/W3120222545","https://openalex.org/W3189146210","https://openalex.org/W3210007659","https://openalex.org/W4281781654","https://openalex.org/W4293900678","https://openalex.org/W4308695713","https://openalex.org/W4309498003","https://openalex.org/W4323262359","https://openalex.org/W4365504964","https://openalex.org/W4378983159","https://openalex.org/W4385615343","https://openalex.org/W4386084852","https://openalex.org/W4386141795","https://openalex.org/W4387008318","https://openalex.org/W4391605073","https://openalex.org/W4394958885","https://openalex.org/W4400622079","https://openalex.org/W4404147251","https://openalex.org/W4404568587","https://openalex.org/W4404647815","https://openalex.org/W4405251788","https://openalex.org/W4408944302","https://openalex.org/W4408960088","https://openalex.org/W4410759428","https://openalex.org/W4413998765","https://openalex.org/W4415547512","https://openalex.org/W4416716473","https://openalex.org/W4416726568","https://openalex.org/W7130580804","https://openalex.org/W7161042640"],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Bone":[1,122],"defect":[2,23,115,160],"repair":[3,161],"remains":[4],"a":[5,43,52,93,111,190],"significant":[6],"challenge":[7],"in":[8,12,31,149],"the":[9,148,154],"clinic,":[10],"particularly":[11],"complex":[13,195],"ischemic":[14],"situations.":[15],"Conventional":[16],"bone":[17,35,46,159,171,184,196],"substitutes":[18],"typically":[19],"fail":[20],"due":[21],"to":[22],"geometries,":[24],"impaired":[25],"blood":[26],"supply,":[27],"or":[28],"unbalanced":[29],"degradation":[30],"coordination":[32],"with":[33,59,66,74],"new":[34],"formation.":[36],"To":[37],"address":[38],"these":[39],"limitations,":[40],"we":[41],"developed":[42],"bioactive,":[44],"injectable":[45],"void":[47],"filler.":[48],"It":[49],"consists":[50],"of":[51,100,147],"poly(vinyl":[53],"alcohol)/sodium":[54],"alginate":[55],"(PVA/SA)":[56],"composite":[57,102,138,157],"loaded":[58],"copper":[60],"(Cu),":[61],"strontium":[62],"(Sr),":[63],"and":[64,79,90,119,124,130,144,170,186],"codoped":[65,73,156],"low-crystallinity":[67],"hydroxyapatite":[68],"(HA)":[69],"granules.":[70],"Specifically,":[71],"HA":[72],"1":[75],"mol":[76,81],"%":[77,82],"Cu":[78],"4":[80,118],"Sr":[83],"was":[84,103],"hydrothermally":[85],"synthesized":[86],"at":[87],"120":[88],"\u00b0C":[89],"incorporated":[91],"into":[92,110],"double-network":[94],"PVA/SA":[95],"hydrogel.":[96],"The":[97],"regenerative":[98],"capacity":[99],"this":[101,137],"then":[104],"evaluated":[105],"by":[106,141,163,182],"implanting":[107],"preformed":[108],"cylinders":[109],"nonload-bearing":[112],"rat":[113],"femoral":[114],"model":[116],"for":[117,193],"8":[120],"weeks.":[121],"regeneration":[123],"neovascularization":[125],"were":[126],"assessed":[127],"using":[128],"micro-CT":[129],"immunohistology.":[131],"In":[132],"vivo":[133,150],"tests":[134],"demonstrated":[135],"that":[136,153],"is":[139],"replaced":[140],"bone.":[142],"Micro-CT":[143],"histological":[145,175],"evaluations":[146],"results":[151],"showed":[152],"Cu/Sr":[155],"enhanced":[158,164],"accompanied":[162],"early":[165],"neovascularization,":[166],"supporting":[167],"coordinated":[168],"vascular":[169],"tissue":[172],"regeneration.":[173],"Lastly,":[174],"staining":[176],"revealed":[177],"unique":[178],"healing":[179],"patterns":[180],"characterized":[181],"\u201cbridge-like\u201d":[183],"restoration":[185],"\u201cisland-like\u201d":[187],"regeneration,":[188],"offering":[189],"promising":[191],"option":[192],"treating":[194],"defects.":[197]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
