{"id":"https://openalex.org/W7225815718","doi":"https://doi.org/10.3389/fphar.2026.1957074","title":"An integrated computational and experimental framework identifies apigenin as a potential therapeutic agent targeting EGFR/STAT3/MMP9 signaling in glioma","display_name":"An integrated computational and experimental framework identifies apigenin as a potential therapeutic agent targeting EGFR/STAT3/MMP9 signaling in glioma","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225815718","doi":"https://doi.org/10.3389/fphar.2026.1957074"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2026.1957074","doi":"https://doi.org/10.3389/fphar.2026.1957074","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1957074","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1957074/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1957074/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100641450","display_name":"Yifei Feng","orcid":"https://orcid.org/0000-0002-7946-446X","observed_orcids":["https://orcid.org/0000-0002-7946-446X"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210129127","display_name":"The First People\u2019s Hospital of Lianyungang","ror":"https://ror.org/03617rq47","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129127"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yifei Feng","raw_affiliation_strings":["Department of Neurosurgery, Institute of Neuroscience, The Affiliated Lianyungang Hospital of Xuzhou Medical University, The First People\u2019s Hospital of Lianyungang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Institute of Neuroscience, The Affiliated Lianyungang Hospital of Xuzhou Medical University, The First People\u2019s Hospital of Lianyungang","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210129127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5149637687","display_name":"Jingshan Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210129127","display_name":"The First People\u2019s Hospital of Lianyungang","ror":"https://ror.org/03617rq47","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129127"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingshan Liang","raw_affiliation_strings":["Department of Neurosurgery, Institute of Neuroscience, Lianyungang Clinical College of Nanjing Medical University, The First People\u2019s Hospital of Lianyungang","Department of Neurosurgery, Institute of Neuroscience, The Affiliated Lianyungang Hospital of Xuzhou Medical University, The First People\u2019s Hospital of Lianyungang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Institute of Neuroscience, Lianyungang Clinical College of Nanjing Medical University, The First People\u2019s Hospital of Lianyungang","institution_ids":["https://openalex.org/I4210129127","https://openalex.org/I83519826"]},{"raw_affiliation_string":"Department of Neurosurgery, Institute of Neuroscience, The Affiliated Lianyungang Hospital of Xuzhou Medical University, The First People\u2019s Hospital of Lianyungang","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210129127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161475032","display_name":"Yili Tian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210129127","display_name":"The First People\u2019s Hospital of Lianyungang","ror":"https://ror.org/03617rq47","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129127"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yili Tian","raw_affiliation_strings":["Department of Neurosurgery, Institute of Neuroscience, The Affiliated Lianyungang Hospital of Xuzhou Medical University, The First People\u2019s Hospital of Lianyungang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Institute of Neuroscience, The Affiliated Lianyungang Hospital of Xuzhou Medical University, The First People\u2019s Hospital of Lianyungang","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210129127"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100345608","display_name":"Yu Liu","orcid":"https://orcid.org/0000-0001-5996-0469","observed_orcids":["https://orcid.org/0000-0001-5996-0469"]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210129127","display_name":"The First People\u2019s Hospital of Lianyungang","ror":"https://ror.org/03617rq47","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129127"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Liu","raw_affiliation_strings":["Department of Neurosurgery, Institute of Neuroscience, The Affiliated Lianyungang Hospital of Xuzhou Medical University, The First People\u2019s Hospital of Lianyungang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Institute of Neuroscience, The Affiliated Lianyungang Hospital of Xuzhou Medical University, The First People\u2019s Hospital of Lianyungang","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210129127"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5043188794","display_name":"Kang Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177388780","display_name":"Xuzhou Medical College","ror":"https://ror.org/04fe7hy80","country_code":"CN","type":"education","lineage":["https://openalex.org/I177388780"]},{"id":"https://openalex.org/I4210129127","display_name":"The First People\u2019s Hospital of Lianyungang","ror":"https://ror.org/03617rq47","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129127"]},{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Kang Xie","raw_affiliation_strings":["Department of Neurosurgery, Institute of Neuroscience, Lianyungang Clinical College of Nanjing Medical University, The First People\u2019s Hospital of Lianyungang","Department of Neurosurgery, Institute of Neuroscience, The Affiliated Lianyungang Hospital of Xuzhou Medical University, The First People\u2019s Hospital of Lianyungang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Institute of Neuroscience, Lianyungang Clinical College of Nanjing Medical University, The First People\u2019s Hospital of Lianyungang","institution_ids":["https://openalex.org/I4210129127","https://openalex.org/I83519826"]},{"raw_affiliation_string":"Department of Neurosurgery, Institute of Neuroscience, The Affiliated Lianyungang Hospital of Xuzhou Medical University, The First People\u2019s Hospital of Lianyungang","institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210129127"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5043188794"],"corresponding_institution_ids":["https://openalex.org/I177388780","https://openalex.org/I4210129127","https://openalex.org/I83519826"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.012500000186264515,"subfield":{"id":"https://openalex.org/subfields/3002","display_name":"Drug Discovery"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.011099999770522118,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2778609962","wikidata":"https://www.wikidata.org/wiki/Q424567","display_name":"Apigenin","level":4,"score":0.6624000072479248},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6345999836921692},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.6248999834060669},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5059999823570251},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4772999882698059},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.4708999991416931},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4672999978065491},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4519999921321869},{"id":"https://openalex.org/C37616216","wikidata":"https://www.wikidata.org/wiki/Q3218363","display_name":"Lasso (programming language)","level":2,"score":0.4025999903678894},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.37720000743865967},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.367900013923645},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.35040000081062317},{"id":"https://openalex.org/C161078062","wikidata":"https://www.wikidata.org/wiki/Q1068690","display_name":"Functional genomics","level":5,"score":0.3416999876499176},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.31949999928474426},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.3066999912261963},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.30000001192092896},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.2750000059604645},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2700999975204468},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.2696000039577484},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.26269999146461487},{"id":"https://openalex.org/C28225019","wikidata":"https://www.wikidata.org/wiki/Q4915005","display_name":"Biological network","level":2,"score":0.2612000107765198},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2563999891281128},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.2551000118255615}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fphar.2026.1957074","doi":"https://doi.org/10.3389/fphar.2026.1957074","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1957074","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1957074/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2026.1957074","doi":"https://doi.org/10.3389/fphar.2026.1957074","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1957074","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1957074/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225815718.pdf","grobid_xml":"https://content.openalex.org/works/W7225815718.grobid-xml"},"referenced_works_count":67,"referenced_works":["https://openalex.org/W2012681969","https://openalex.org/W2070661531","https://openalex.org/W2130410032","https://openalex.org/W2472119419","https://openalex.org/W2482151002","https://openalex.org/W2592397787","https://openalex.org/W2593436234","https://openalex.org/W2765596630","https://openalex.org/W2800469107","https://openalex.org/W2947242709","https://openalex.org/W2964632483","https://openalex.org/W2983179918","https://openalex.org/W3008934493","https://openalex.org/W3074516067","https://openalex.org/W3118914860","https://openalex.org/W3123147918","https://openalex.org/W3128074771","https://openalex.org/W3134580323","https://openalex.org/W3135035839","https://openalex.org/W3216658647","https://openalex.org/W4200045218","https://openalex.org/W4223424947","https://openalex.org/W4223989748","https://openalex.org/W4229079196","https://openalex.org/W4280543735","https://openalex.org/W4281707807","https://openalex.org/W4282841602","https://openalex.org/W4283265567","https://openalex.org/W4283830287","https://openalex.org/W4306850165","https://openalex.org/W4311793622","https://openalex.org/W4319985739","https://openalex.org/W4322504329","https://openalex.org/W4388496485","https://openalex.org/W4390743717","https://openalex.org/W4391994420","https://openalex.org/W4392106645","https://openalex.org/W4392509938","https://openalex.org/W4393936599","https://openalex.org/W4394688967","https://openalex.org/W4395010444","https://openalex.org/W4396519787","https://openalex.org/W4398142513","https://openalex.org/W4400764716","https://openalex.org/W4401672685","https://openalex.org/W4402463684","https://openalex.org/W4403197275","https://openalex.org/W4404054686","https://openalex.org/W4405430206","https://openalex.org/W4406105445","https://openalex.org/W4406225280","https://openalex.org/W4406289485","https://openalex.org/W4407636413","https://openalex.org/W4410869743","https://openalex.org/W4410891331","https://openalex.org/W4412150915","https://openalex.org/W4414222422","https://openalex.org/W4415243585","https://openalex.org/W4416851513","https://openalex.org/W7125399879","https://openalex.org/W7128421515","https://openalex.org/W7134805971","https://openalex.org/W7134935966","https://openalex.org/W7148935507","https://openalex.org/W7172399898","https://openalex.org/W7201958385","https://openalex.org/W7202390319"],"related_works":[],"abstract_inverted_index":{"Background":[0],"Glioma":[1],"is":[2,15],"the":[3,10,48,158,170,300,324],"most":[4],"common":[5],"primary":[6],"malignant":[7],"tumor":[8],"of":[9,86,120,164,232,242,299,327,359],"central":[11],"nervous":[12],"system":[13],"and":[14,23,51,62,75,97,100,110,118,134,151,161,178,190,204,209,228,235,238,260,270,275,287,304,315,344,354,371],"characterized":[16],"by":[17,116,297],"aggressive":[18],"progression,":[19],"high":[20],"recurrence":[21],"rates,":[22],"limited":[24],"therapeutic":[25,49,84,352],"options.":[26],"Apigenin,":[27],"a":[28,121,213,239,362],"naturally":[29],"occurring":[30],"flavonoid,":[31],"exhibits":[32],"promising":[33],"anti-tumor":[34],"properties;":[35],"however,":[36],"its":[37,351],"molecular":[38,52,148,261],"mechanisms":[39,53,321],"in":[40,88,176,336,341,372],"glioma":[41,180,281,337,366],"remain":[42],"insufficiently":[43],"understood.":[44],"To":[45],"systematically":[46],"identify":[47,82],"targets":[50,85],"underlying":[54],"apigenin-mediated":[55],"anti-glioma":[56,325],"activity":[57,326],"through":[58,105,183],"an":[59,312],"integrated":[60,67,313],"computational":[61,314,370],"experimental":[63,316],"approach.":[64],"Methods":[65],"An":[66],"bioinformatics":[68],"framework":[69,317],"combining":[70],"network":[71,128],"pharmacology,":[72],"transcriptomic":[73],"analysis,":[74],"machine":[76],"learning":[77],"algorithms":[78],"was":[79,174],"applied":[80],"to":[81,142,156,211,318],"potential":[83,265,320,353,363],"apigenin":[87,165,269,285,360],"glioma.":[89],"Differentially":[90],"expressed":[91],"genes":[92,102,250],"were":[93,103,140,154,207,251],"screened":[94],"using":[95],"TCGA":[96],"GTEx":[98],"datasets,":[99],"prognostic":[101,123,195,214],"identified":[104,208],"LASSO":[106],"Cox":[107,112],"regression,":[108],"ElasticNet,":[109],"stepwise":[111],"regression":[113],"analyses,":[114],"followed":[115],"construction":[117],"validation":[119],"multigene":[122],"model.":[124],"Weighted":[125],"gene":[126,135],"co-expression":[127],"analysis":[129,132,138],"(WGCNA),":[130],"over-representation":[131],"(ORA),":[133],"set":[136],"enrichment":[137,245],"(GSEA)":[139],"performed":[141],"explore":[143],"functional":[144],"mechanisms.":[145],"Molecular":[146,258],"docking,":[147],"dynamics":[149,262],"simulations,":[150],"ADMET":[152],"prediction":[153],"conducted":[155],"evaluate":[157],"interaction":[159],"stability":[160],"drug-like":[162],"properties":[163],"with":[166,216,225,254,323],"candidate":[167,364],"targets.":[168],"Furthermore,":[169],"predicted":[171,264],"regulatory":[172],"axis":[173],"examined":[175],"LN229":[177],"U87":[179],"cell":[181,184,282],"models":[182],"viability":[185,283],"assays,":[186,189],"colony":[187,289],"formation":[188,290],"Western":[191],"blotting.":[192],"Results":[193],"Six":[194],"genes,":[196],"including":[197],"EGFR,":[198],"MMP9,":[199],"HIF1A,":[200],"STAT3,":[201],"RELA":[202],",":[203,206],"CASP3":[205],"used":[210],"construct":[212],"model":[215,221],"robust":[217],"predictive":[218],"performance.":[219],"The":[220],"achieved":[222],"favorable":[223],"discrimination,":[224],"1-,":[226],"3-,":[227],"5-year":[229],"AUC":[230],"values":[231],"0.840,":[233],"0.876,":[234],"0.817,":[236],"respectively,":[237],"cross-validated":[240],"C-index":[241],"0.78.":[243],"Functional":[244],"analyses":[246],"indicated":[247],"that":[248,332],"these":[249],"primarily":[252],"associated":[253,322],"cancer-related":[255],"signaling":[256,302,343],"pathways.":[257],"docking":[259],"simulations":[263],"stable":[266],"interactions":[267],"between":[268],"key":[271],"targets,":[272],"particularly":[273],"EGFR":[274,292],"STAT3.":[276],"Cellular":[277],"experiments":[278],"showed":[279],"reduced":[280,288],"following":[284],"treatment":[286,367],"after":[291],"or":[293],"MMP9":[294,306,345],"knockdown,":[295],"accompanied":[296],"suppression":[298],"EGFR/STAT3":[301,342],"pathway":[303],"downstream":[305],"expression.":[307],"Conclusion":[308],"This":[309],"study":[310],"established":[311],"investigate":[319],"apigenin.":[328],"Our":[329],"findings":[330],"suggest":[331],"apigenin-associated":[333],"growth":[334],"inhibition":[335],"cells":[338],"involves":[339],"changes":[340],"expression,":[346],"providing":[347],"new":[348],"insights":[349],"into":[350],"supporting":[355],"further":[356],"pre-clinical":[357],"investigation":[358],"as":[361],"for":[365],"based":[368],"on":[369],"vitro":[373],"cellular":[374],"evidence.":[375]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
