{"id":"https://openalex.org/W7225815694","doi":"https://doi.org/10.52340/gs.2026.08.04(1).06","title":"THE ROLE OF PCSK9 IN CARDIO-GERIATRIC PATIENTS","display_name":"THE ROLE OF PCSK9 IN CARDIO-GERIATRIC PATIENTS","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225815694","doi":"https://doi.org/10.52340/gs.2026.08.04(1).06"},"language":"en","primary_location":{"id":"doi:10.52340/gs.2026.08.04(1).06","doi":"https://doi.org/10.52340/gs.2026.08.04(1).06","is_oa":true,"landing_page_url":"https://doi.org/10.52340/gs.2026.08.04(1).06","pdf_url":null,"source":{"id":"https://openalex.org/S4210238182","display_name":"GEORGIAN SCIENTISTS","issn_l":"2667-9760","issn":["2667-9760"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4387155489","host_organization_name":"Association for Science","host_organization_lineage":["https://openalex.org/I4387155489"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GEORGIAN SCIENTISTS","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.52340/gs.2026.08.04(1).06","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084941596","display_name":"Nino Khunashvili","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7848551","display_name":"Tbilisi State Medical University","ror":"https://ror.org/020jbrt22","country_code":"GE","type":"education","lineage":["https://openalex.org/I7848551"]}],"countries":["GE"],"is_corresponding":false,"raw_author_name":"Nino Khunashvili","raw_affiliation_strings":["Tbilisi State Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tbilisi State Medical University","institution_ids":["https://openalex.org/I7848551"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024973439","display_name":"L Ratiani","orcid":"https://orcid.org/0009-0002-3255-1811","observed_orcids":["https://orcid.org/0009-0002-3255-1811"]},"institutions":[{"id":"https://openalex.org/I7848551","display_name":"Tbilisi State Medical University","ror":"https://ror.org/020jbrt22","country_code":"GE","type":"education","lineage":["https://openalex.org/I7848551"]}],"countries":["GE"],"is_corresponding":false,"raw_author_name":"Levan Ratiani","raw_affiliation_strings":["Tbilisi State Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tbilisi State Medical University","institution_ids":["https://openalex.org/I7848551"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5072754579","display_name":"Nona Kakauridze","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7848551","display_name":"Tbilisi State Medical University","ror":"https://ror.org/020jbrt22","country_code":"GE","type":"education","lineage":["https://openalex.org/I7848551"]}],"countries":["GE"],"is_corresponding":false,"raw_author_name":"Nona Kakauridze","raw_affiliation_strings":["Tbilisi State Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tbilisi State Medical University","institution_ids":["https://openalex.org/I7848551"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I7848551"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10394","display_name":"Lipoproteins and Cardiovascular Health","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8797000050544739},{"id":"https://openalex.org/C2780948078","wikidata":"https://www.wikidata.org/wiki/Q21130010","display_name":"PCSK9","level":5,"score":0.8726000189781189},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6413000226020813},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6273999810218811},{"id":"https://openalex.org/C500558357","wikidata":"https://www.wikidata.org/wiki/Q12152","display_name":"Myocardial infarction","level":2,"score":0.5888000130653381},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4943000078201294},{"id":"https://openalex.org/C2780072125","wikidata":"https://www.wikidata.org/wiki/Q28350","display_name":"Lipoprotein","level":3,"score":0.48089998960494995},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.46209999918937683},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.41510000824928284},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4009000062942505},{"id":"https://openalex.org/C2778114629","wikidata":"https://www.wikidata.org/wiki/Q15623825","display_name":"Evolocumab","level":5,"score":0.3991999924182892},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.39079999923706055},{"id":"https://openalex.org/C2778096610","wikidata":"https://www.wikidata.org/wiki/Q1476525","display_name":"Dyslipidemia","level":3,"score":0.38519999384880066},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.36959999799728394},{"id":"https://openalex.org/C2778270857","wikidata":"https://www.wikidata.org/wiki/Q2723972","display_name":"Lipid profile","level":3,"score":0.3443000018596649},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.34310001134872437},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.3327000141143799},{"id":"https://openalex.org/C2909478654","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Atherosclerotic cardiovascular disease","level":3,"score":0.32739999890327454},{"id":"https://openalex.org/C2991716557","wikidata":"https://www.wikidata.org/wiki/Q12252367","display_name":"Coronary atherosclerosis","level":3,"score":0.31779998540878296},{"id":"https://openalex.org/C2776839432","wikidata":"https://www.wikidata.org/wiki/Q954845","display_name":"Statin","level":2,"score":0.3151000142097473},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31060001254081726},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2872999906539917},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.2858999967575073},{"id":"https://openalex.org/C2776104379","wikidata":"https://www.wikidata.org/wiki/Q21112670","display_name":"Lipoprotein(a)","level":4,"score":0.2773999869823456},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.2694999873638153},{"id":"https://openalex.org/C2777698277","wikidata":"https://www.wikidata.org/wiki/Q266018","display_name":"Acute coronary syndrome","level":3,"score":0.26080000400543213},{"id":"https://openalex.org/C139572402","wikidata":"https://www.wikidata.org/wiki/Q4927820","display_name":"Blood lipids","level":3,"score":0.258899986743927},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.2540000081062317},{"id":"https://openalex.org/C2779318932","wikidata":"https://www.wikidata.org/wiki/Q1058276","display_name":"Atheroma","level":2,"score":0.2533000111579895},{"id":"https://openalex.org/C2778824825","wikidata":"https://www.wikidata.org/wiki/Q7250439","display_name":"Proprotein convertase","level":5,"score":0.2500999867916107}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.52340/gs.2026.08.04(1).06","doi":"https://doi.org/10.52340/gs.2026.08.04(1).06","is_oa":true,"landing_page_url":"https://doi.org/10.52340/gs.2026.08.04(1).06","pdf_url":null,"source":{"id":"https://openalex.org/S4210238182","display_name":"GEORGIAN SCIENTISTS","issn_l":"2667-9760","issn":["2667-9760"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4387155489","host_organization_name":"Association for Science","host_organization_lineage":["https://openalex.org/I4387155489"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GEORGIAN SCIENTISTS","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.52340/gs.2026.08.04(1).06","doi":"https://doi.org/10.52340/gs.2026.08.04(1).06","is_oa":true,"landing_page_url":"https://doi.org/10.52340/gs.2026.08.04(1).06","pdf_url":null,"source":{"id":"https://openalex.org/S4210238182","display_name":"GEORGIAN SCIENTISTS","issn_l":"2667-9760","issn":["2667-9760"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4387155489","host_organization_name":"Association for Science","host_organization_lineage":["https://openalex.org/I4387155489"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"GEORGIAN SCIENTISTS","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Background:":[0],"Proprotein":[1],"convertase":[2],"subtilisin/kexin":[3],"type":[4],"9":[5],"(PCSK9)":[6],"plays":[7],"a":[8,223,298,326,350],"pivotal":[9],"role":[10],"in":[11,80,245,266,286,312,338],"the":[12,34,107,121,130,138,149,160,202],"progression":[13],"of":[14,72,91,125,135,345],"atherosclerotic":[15],"cardiovascular":[16,192],"disease":[17,260],"(ASCVD)":[18],"by":[19],"regulating":[20],"low-density":[21,39],"lipoprotein":[22,40],"receptor":[23,271],"(LDLR)":[24],"degradation.":[25],"In":[26],"cardio-geriatric":[27,339],"patient":[28],"cohorts":[29],"aged":[30,153,341],"60":[31,154,248],"and":[32,44,67,77,98,115,132,177,186,194,211,234,241,263,283,308,334,372],"older,":[33],"association":[35],"between":[36,110,205,229],"circulating":[37,174,235],"PCSK9,":[38],"cholesterol":[41],"(LDL-C)":[42],"elevation,":[43],"acute":[45,131,240],"myocardial":[46,332],"infarction":[47,333],"(MI)":[48],"phenotypes":[49,262],"is":[50],"highly":[51],"pronounced.":[52],"Emerging":[53],"evidence":[54],"indicates":[55],"that":[56,320],"PCSK9":[57,112,175,207,232,252,273,291,323,359],"actively":[58],"promotes":[59],"systemic":[60],"vascular":[61,281],"inflammation,":[62],"macrophage":[63],"foam":[64],"cell":[65],"formation,":[66],"necrotic":[68],"core":[69],"expansion":[70],"independently":[71],"baseline":[73],"lipid":[74,179],"parameters.":[75],"Diagnosing":[76],"managing":[78],"hypercholesterolemia":[79],"this":[81,103,346],"elderly":[82,314],"population":[83],"remains":[84],"clinically":[85],"challenging":[86],"due":[87],"to":[88,155,159,172,200],"high":[89],"rates":[90,376],"statin":[92],"intolerance,":[93],"age-related":[94],"metabolic":[95],"shifts,":[96],"multi-morbidity,":[97],"advanced":[99,335],"endothelial":[100],"senescence.":[101],"Objective:":[102],"clinical":[104,144,352],"study":[105,318],"evaluates":[106],"specific":[108],"relationship":[109],"plasma":[111,231,322],"levels,":[113],"LDL-C,":[114],"coronary":[116,258,336],"atherosclerosis":[117,337],"progression.":[118],"It":[119],"establishes":[120],"explicit":[122],"biomarker":[123,347],"profile":[124],"geriatric":[126,217,294,379],"patients":[127,150,246,340],"(60+)":[128],"during":[129,238],"subacute":[133,242],"phases":[134,244],"MI":[136,152,243],"within":[137,377],"Georgian":[139],"population.":[140],"Methods:":[141],"A":[142],"rigorous":[143],"evaluation":[145],"was":[146],"performed":[147],"on":[148],"with":[151,256],"85":[156],"years":[157,249],"admitted":[158],"TSMU":[161],"First":[162],"University":[163],"Clinic.":[164],"Fasting":[165],"peripheral":[166],"blood":[167],"samples":[168],"were":[169,198],"systematically":[170],"collected":[171],"quantify":[173],"concentrations":[176],"standard":[178,270],"fractions.":[180],"Comprehensive":[181],"correlation":[182,204,228],"analyses":[183],"tracked":[184],"lipid-dependent":[185],"non-lipid":[187],"dependent":[188],"inflammatory":[189,278],"trends.":[190],"Detailed":[191],"imaging":[193],"multi-variable":[195],"regression":[196],"protocols":[197,296],"deployed":[199],"assess":[201],"direct":[203],"elevated":[206,230,321],"expressions,":[208],"plaque":[209,284],"vulnerability,":[210],"ischemic":[212,309],"recurrence":[213],"risk":[214,307,355],"across":[215],"age-stratified":[216],"brackets.":[218],"Results:":[219],"The":[220],"findings":[221],"demonstrate":[222],"distinct,":[224],"statistically":[225],"significant":[226],"positive":[227],"expressions":[233],"LDL-C":[236,301],"fractions":[237],"both":[239],"over":[247],"old.":[250],"High":[251],"titers":[253],"strongly":[254],"correlate":[255],"aggressive":[257],"artery":[259],"(CAD)":[261],"accelerated":[264],"atherogenesis":[265],"older":[267],"adults.":[268],"Beyond":[269],"degradation,":[272],"acts":[274],"as":[275,325],"an":[276,363],"autonomous":[277],"mediator,":[279],"accelerating":[280],"remodeling":[282],"destabilization":[285],"aging":[287],"vessels.":[288],"Incorporating":[289],"targeted":[290],"inhibitors":[292],"into":[293],"triage":[295],"achieves":[297],"profound,":[299],"sustained":[300],"reduction,":[302],"drastically":[303],"minimizing":[304],"residual":[305],"atherothrombotic":[306],"stroke":[310],"occurrence":[311],"these":[313],"cohorts.":[315],"Conclusion:":[316],"This":[317],"confirms":[319],"serves":[324],"vital":[327],"prognostic":[328],"indicator":[329],"for":[330,354],"early":[331],"60+.":[342],"Early":[343],"screening":[344],"matrix":[348],"provides":[349],"powerful":[351],"mechanism":[353],"stratification.":[356],"Implementing":[357],"personalized":[358],"targeting":[360],"therapies":[361],"offers":[362],"exceptionally":[364],"effective,":[365],"well-tolerated":[366],"lipid-lowering":[367],"strategy,":[368],"optimizing":[369],"therapeutic":[370],"adherence":[371],"long-term":[373],"functional":[374],"survival":[375],"vulnerable":[378],"populations.":[380]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
