{"id":"https://openalex.org/W7225815252","doi":"https://doi.org/10.3389/fphar.2026.1988214","title":"Bisphenol a is associated with ovarian cancer chemoresistance via ecmCAF-mediated stromal remodeling: an integrative multi-omics study","display_name":"Bisphenol a is associated with ovarian cancer chemoresistance via ecmCAF-mediated stromal remodeling: an integrative multi-omics study","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225815252","doi":"https://doi.org/10.3389/fphar.2026.1988214"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2026.1988214","doi":"https://doi.org/10.3389/fphar.2026.1988214","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1988214","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1988214/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1988214/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018601741","display_name":"Siqi Guan","orcid":"https://orcid.org/0000-0002-4844-145X","observed_orcids":["https://orcid.org/0000-0002-4844-145X"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210087691","display_name":"Beijing Tian Tan Hospital","ror":"https://ror.org/003regz62","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087691"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siqi Guan","raw_affiliation_strings":["Department of Gynecology and Obstetrics, Beijing Tiantan Hospital, Capital Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, Beijing Tiantan Hospital, Capital Medical University","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210087691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085383229","display_name":"Miaoran Xia","orcid":"https://orcid.org/0000-0003-4461-359X","observed_orcids":["https://orcid.org/0000-0003-4461-359X"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Miaoran Xia","raw_affiliation_strings":["Department of Immunology, School of Basic Medical Sciences, Capital Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology, School of Basic Medical Sciences, Capital Medical University","institution_ids":["https://openalex.org/I183519381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103019310","display_name":"Yue He","orcid":"https://orcid.org/0000-0003-4041-9271","observed_orcids":["https://orcid.org/0000-0003-4041-9271","https://orcid.org/0000-0003-2105-5249"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210163952","display_name":"Beijing Obstetrics and Gynecology Hospital","ror":"https://ror.org/05787my06","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163952"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue He","raw_affiliation_strings":["Laboratory for Clinical Medicine, Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Clinical Medicine, Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210163952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100553556","display_name":"Limin Feng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210087691","display_name":"Beijing Tian Tan Hospital","ror":"https://ror.org/003regz62","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087691"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Limin Feng","raw_affiliation_strings":["Department of Gynecology and Obstetrics, Beijing Tiantan Hospital, Capital Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gynecology and Obstetrics, Beijing Tiantan Hospital, Capital Medical University","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210087691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161465544","display_name":"Yumei Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210163952","display_name":"Beijing Obstetrics and Gynecology Hospital","ror":"https://ror.org/05787my06","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163952"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yumei Wu","raw_affiliation_strings":["Laboratory for Clinical Medicine, Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Clinical Medicine, Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210163952"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161450971","display_name":"Ming Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210163952","display_name":"Beijing Obstetrics and Gynecology Hospital","ror":"https://ror.org/05787my06","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163952"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ming Wang","raw_affiliation_strings":["Laboratory for Clinical Medicine, Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory for Clinical Medicine, Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210163952"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100553556","https://openalex.org/A5161450971","https://openalex.org/A5161465544"],"corresponding_institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210087691","https://openalex.org/I4210163952"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.4154999852180481,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10686","display_name":"Effects and risks of endocrine disrupting chemicals","score":0.4154999852180481,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.41110000014305115,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.05270000174641609,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.7263000011444092},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.6349999904632568},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6323999762535095},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.513700008392334},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4018000066280365},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.3935000002384186},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.37439998984336853},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3734999895095825},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.364300012588501},{"id":"https://openalex.org/C2780862370","wikidata":"https://www.wikidata.org/wiki/Q1138899","display_name":"Endocrine disruptor","level":4,"score":0.36399999260902405},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.3635999858379364},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.35519999265670776},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.32829999923706055},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.32109999656677246},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3167000114917755},{"id":"https://openalex.org/C2909706936","wikidata":"https://www.wikidata.org/wiki/Q42417562","display_name":"Cancer-Associated Fibroblasts","level":4,"score":0.30970001220703125},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3066999912261963},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.3046000003814697},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.302700012922287},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3001999855041504},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.2980000078678131},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2872999906539917},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.2849999964237213},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2757999897003174},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.26429998874664307},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.2614000141620636},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.25360000133514404}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fphar.2026.1988214","doi":"https://doi.org/10.3389/fphar.2026.1988214","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1988214","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1988214/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2026.1988214","doi":"https://doi.org/10.3389/fphar.2026.1988214","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1988214","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1988214/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225815252.pdf","grobid_xml":"https://content.openalex.org/works/W7225815252.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1965498876","https://openalex.org/W1967211742","https://openalex.org/W1970358298","https://openalex.org/W2001085078","https://openalex.org/W2005334224","https://openalex.org/W2021296110","https://openalex.org/W2031982698","https://openalex.org/W2060934232","https://openalex.org/W2106864345","https://openalex.org/W2116554142","https://openalex.org/W2149573463","https://openalex.org/W2154589460","https://openalex.org/W2512899508","https://openalex.org/W2618851150","https://openalex.org/W2732492274","https://openalex.org/W2770300603","https://openalex.org/W2900166571","https://openalex.org/W2902447942","https://openalex.org/W2942537534","https://openalex.org/W3003058300","https://openalex.org/W3132661792","https://openalex.org/W3135822722","https://openalex.org/W3158218790","https://openalex.org/W3201437718","https://openalex.org/W4212863656","https://openalex.org/W4286560117","https://openalex.org/W4309013952","https://openalex.org/W4315754639","https://openalex.org/W4392896322","https://openalex.org/W4408137176","https://openalex.org/W4409307859","https://openalex.org/W4413118488","https://openalex.org/W4414096826","https://openalex.org/W4415269418","https://openalex.org/W4415898515","https://openalex.org/W7136106232","https://openalex.org/W7155556719"],"related_works":[],"abstract_inverted_index":{"Background":[0],"BPA":[1,29,58,78,135,139,154,184,243],"is":[2,17,31],"a":[3,210],"ubiquitous":[4],"endocrine":[5],"disruptor":[6],"linked":[7],"to":[8,74,156,203,216,244],"ovarian":[9,46,217],"cancer,":[10],"yet":[11],"its":[12],"effect":[13],"on":[14,45],"chemotherapy":[15],"efficacy":[16],"unknown.":[18],"CAFs":[19,192,199],"drive":[20],"drug":[21],"resistance":[22,202],"via":[23,35],"microenvironment":[24,221],"remodeling.":[25,222],"We":[26,40],"investigated":[27],"whether":[28],"exposure":[30,215,230],"associated":[32],"with":[33,86,149],"chemoresistance":[34,103,219],"CAF-mediated":[36],"stromal":[37],"reprogramming.":[38],"Methods":[39],"performed":[41],"single-cell":[42],"RNA":[43],"sequencing":[44],"cancer":[47,218,246],"samples":[48],"across":[49,65],"treatment-naive,":[50],"post-chemotherapy,":[51],"and":[52,94,105,143,161,170,188,193,232],"recurrent":[53,176],"states":[54],"(n":[55],"=":[56],"10).":[57],"target":[59,79],"gene":[60],"set":[61],"activity":[62,122],"was":[63,109],"quantified":[64],"cell":[66],"types":[67],"using":[68],"AUCell":[69],"scoring.":[70],"Fibroblasts":[71,117],"were":[72,81,100],"re-clustered":[73],"characterize":[75],"CAF":[76,130],"subtypes.":[77],"genes":[80],"integrated":[82],"from":[83,197],"public":[84],"databases,":[85],"core":[87],"targets":[88],"prioritized":[89],"through":[90,220],"protein-protein":[91],"interaction":[92],"networks":[93],"molecular":[95,150],"docking.":[96],"Machine":[97],"learning":[98],"models":[99],"built":[101],"for":[102],"prediction,":[104],"in":[106,174,191],"vitro":[107,179],"validation":[108,180],"performed;":[110],"CellChat":[111,165],"inferred":[112],"intercellular":[113],"communication":[114],"dynamics.":[115],"Results":[116],"exhibited":[118],"the":[119,175,240],"highest":[120],"BPA-driven":[121],"among":[123],"all":[124],"tumor":[125],"cells.":[126],"The":[127,206],"extracellular":[128],"matrix":[129],"(ecmCAF)":[131],"subtype":[132],"showed":[133,182],"elevated":[134],"scores.":[136],"Integration":[137],"of":[138,242],"targets,":[140],"ecmCAF":[141,226],"markers,":[142],"recurrence":[144],"signatures":[145],"yielded":[146],"hub":[147],"genes,":[148],"docking":[151],"predicting":[152],"favorable":[153],"binding":[155],"PTGS2":[157],"(\u22127.7),":[158],"MMP2":[159],"(\u22127.6),":[160],"SERPINE1":[162],"(\u22127.5":[163],"kcal/mol).":[164],"revealed":[166],"heightened":[167],"CAF-to-epithelial":[168],"pro-EMT":[169],"CAF-to-immune":[171],"suppressive":[172],"signaling":[173],"sample.":[177],"In":[178],"further":[181],"that":[183,194,234],"treatment":[185,247],"increased":[186],"ACTA2":[187],"COL1A1":[189],"expression":[190],"conditioned":[195],"medium":[196],"BPA-treated":[198],"enhanced":[200],"SKOV3":[201],"cisplatin.":[204],"Conclusion":[205],"BPA-ecmCAF":[207],"axis":[208],"represents":[209],"novel":[211],"mechanism":[212],"linking":[213],"environmental":[214,235],"These":[223],"findings":[224],"identify":[225],"effectors":[227],"as":[228],"candidate":[229],"biomarkers":[231],"suggest":[233],"risk":[236],"assessment":[237],"should":[238],"consider":[239],"potential":[241],"compromise":[245],"outcomes.":[248]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}