{"id":"https://openalex.org/W7225815223","doi":"https://doi.org/10.5281/zenodo.24137609","title":"Premature Computation: The Relationship Between Neuroinflammation and Cognitive Performance","display_name":"Premature Computation: The Relationship Between Neuroinflammation and Cognitive Performance","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225815223","doi":"https://doi.org/10.5281/zenodo.24137609"},"language":"en","primary_location":{"id":"doi:10.5281/zenodo.24137609","doi":"https://doi.org/10.5281/zenodo.24137609","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24137609","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.5281/zenodo.24137609","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038574926","display_name":"Filip Roth","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Roth, Filip","raw_affiliation_strings":["Independent Researcher"],"raw_orcid":"https://orcid.org/0009-0005-7203-9697","affiliations":[{"raw_affiliation_string":"Independent Researcher","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5038574926"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10258","display_name":"Philosophy and Theoretical Science","score":0.5536999702453613,"subfield":{"id":"https://openalex.org/subfields/1211","display_name":"Philosophy"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T10258","display_name":"Philosophy and Theoretical Science","score":0.5536999702453613,"subfield":{"id":"https://openalex.org/subfields/1211","display_name":"Philosophy"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T13044","display_name":"Biofield Effects and Biophysics","score":0.12070000171661377,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.046799998730421066,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6564000248908997},{"id":"https://openalex.org/C122527463","wikidata":"https://www.wikidata.org/wiki/Q578430","display_name":"Quantum decoherence","level":3,"score":0.5730999708175659},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.5446000099182129},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.40459999442100525},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3828999996185303},{"id":"https://openalex.org/C2781181686","wikidata":"https://www.wikidata.org/wiki/Q4226068","display_name":"Coherence (philosophical gambling strategy)","level":2,"score":0.3785000145435333},{"id":"https://openalex.org/C176777502","wikidata":"https://www.wikidata.org/wiki/Q4774623","display_name":"Anticipation (artificial intelligence)","level":2,"score":0.36640000343322754},{"id":"https://openalex.org/C117717151","wikidata":"https://www.wikidata.org/wiki/Q3589155","display_name":"Epigenome","level":5,"score":0.36309999227523804},{"id":"https://openalex.org/C84114770","wikidata":"https://www.wikidata.org/wiki/Q46344","display_name":"Quantum","level":2,"score":0.33169999718666077},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.32190001010894775},{"id":"https://openalex.org/C66024118","wikidata":"https://www.wikidata.org/wiki/Q1122506","display_name":"Computational model","level":2,"score":0.3034000098705292},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.3021000027656555},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2858000099658966},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.2802000045776367},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.2761000096797943},{"id":"https://openalex.org/C159762639","wikidata":"https://www.wikidata.org/wiki/Q2273845","display_name":"Seesaw molecular geometry","level":3,"score":0.26339998841285706},{"id":"https://openalex.org/C2781012912","wikidata":"https://www.wikidata.org/wiki/Q901117","display_name":"Excitotoxicity","level":4,"score":0.2565000057220459}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.5281/zenodo.24137609","doi":"https://doi.org/10.5281/zenodo.24137609","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24137609","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},{"id":"doi:10.5281/zenodo.24137610","doi":"https://doi.org/10.5281/zenodo.24137610","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24137610","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"}],"best_oa_location":{"id":"doi:10.5281/zenodo.24137609","doi":"https://doi.org/10.5281/zenodo.24137609","is_oa":true,"landing_page_url":"https://doi.org/10.5281/zenodo.24137609","pdf_url":null,"source":{"id":"https://openalex.org/S4306400562","display_name":"Zenodo (CERN European Organization for Nuclear Research)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67311998","host_organization_name":"European Organization for Nuclear Research","host_organization_lineage":["https://openalex.org/I67311998"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Preprint"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Contemporary":[0],"neuroscience":[1],"increasingly":[2],"confronts":[3],"the":[4,25,38,46,98,103,152,158,169,188,214,234,242,260,294,321],"explanatory":[5],"boundaries":[6],"of":[7,18,28,50,222,237,244,314],"classical":[8,179,304],"computationalism,":[9],"which":[10],"models":[11,307],"conscious":[12,64,215],"awareness":[13],"as":[14,97,143,207,213],"an":[15,192,339],"emergent":[16],"byproduct":[17],"deterministic":[19],"synaptic":[20],"firing":[21],"rates":[22],"while":[23],"leaving":[24],"hard":[26],"problem":[27],"consciousness,":[29],"sensory":[30],"binding,":[31],"and":[32,76,84,93,116,123,133,147,167,255,271,289,292,337],"non-algorithmic":[33,183,309],"mathematical":[34],"insight":[35],"unresolved.":[36],"Extending":[37],"Penrose-Hameroff":[39],"Orchestrated":[40,160],"Objective":[41,161],"Reduction":[42,162],"(Orch-OR)":[43],"framework":[44],"within":[45],"overarching":[47],"companion":[48],"perspective":[49],"The":[51],"Bad":[52],"Trip":[53],"Hypothesis,":[54],"this":[55,201,238],"paper":[56],"introduces":[57],"a":[58,144,208,219],"quantum":[59,69,174,223,310],"biological":[60],"model":[61,104],"demonstrating":[62,264,325],"that":[63,265,299,326],"cognition":[65],"relies":[66],"on":[67],"macroscopic":[68,145],"coherence":[70,154],"across":[71,107],"neuronal":[72],"cytoskeletal":[73,335],"tubulin":[74],"lattices,":[75],"formalizes":[77],"how":[78],"chronic":[79],"neuroinflammation":[80],"drives":[81],"phase":[82,153],"decoherence":[83,149],"computational":[85,224],"collapse.":[86],"While":[87],"dietary":[88],"cereal":[89],"antigens":[90],"(Amylase-Trypsin":[91],"Inhibitors":[92],"gliadin":[94],"peptides)":[95],"serve":[96],"primary":[99,209],"post-Neolithic":[100],"historical":[101],"exemplar,":[102],"holds":[105],"autonomously":[106],"diverse":[108],"neuroinflammatory":[109,140],"etiologies":[110],"driving":[111],"intestinal":[112],"hyperpermeability,":[113],"systemic":[114],"endotoxemia,":[115],"basolateral":[117],"amygdala":[118],"microgliosis.":[119],"Downstream":[120],"cytokine":[121],"signaling":[122,218],"quinolinic":[124],"acid":[125],"excitotoxicity":[126],"downregulate":[127],"SETD2-mediated":[128],"\u03b1-tubulin":[129],"Lysine":[130],"40":[131],"trimethylation":[132],"hyperphosphorylate":[134],"Microtubule-Associated":[135],"Protein":[136],"2":[137],"(MAP2).":[138],"This":[139],"noise":[141],"acts":[142],"thermal":[146],"chemical":[148],"engine,":[150],"shortening":[151],"lifetime":[155],"(\u03c4\u03d5)":[156],"below":[157],"Penrose":[159],"threshold":[163],"(\u03c4Orch":[164],"\u2248":[165],"\u210f/EG)":[166],"depleting":[168],"entangled":[170],"qubit":[171],"register.":[172],"Consequently,":[173],"superpositions":[175,283],"collapse":[176],"prematurely":[177],"into":[178,191,268],"pointer":[180],"states":[181],"before":[182],"self-reduction":[184],"can":[185],"occur,":[186],"forcing":[187],"nervous":[189],"system":[190],"algorithmic":[193],"fallback":[194],"characterized":[195],"by":[196],"rigid,":[197],"defensive":[198],"heuristics.":[199],"Within":[200],"framework,":[202],"anxiety":[203],"is":[204],"formalized":[205],"not":[206],"psychological":[210],"defect,":[211],"but":[212],"affective":[216],"telemetry":[217],"catastrophic":[220],"loss":[221],"bandwidth":[225],"under":[226],"Karl":[227],"Friston\u2019s":[228],"Free":[229],"Energy":[230],"Principle.":[231],"We":[232],"trace":[233],"multi-scale":[235],"consequences":[236],"premature":[239],"collapse:":[240],"(i)":[241],"dissolution":[243],"somatic":[245],"social":[246],"resonance,":[247],"compelling":[248],"human":[249,301],"populations":[250],"to":[251],"construct":[252],"externalized":[253],"bureaucratic":[254],"legal":[256],"protocol":[257],"wrappers;":[258],"(ii)":[259],"macroeconomic":[261],"productivity":[262],"paradox,":[263],"partitioning":[266],"employees":[267],"isolated":[269],"cubicles":[270],"enforcing":[272],"continuous":[273],"surveillance":[274],"(an":[275],"organizational":[276,290],"Quantum":[277],"Zeno":[278],"effect)":[279],"destroys":[280],"collaborative":[281],"team":[282],"(\u223c":[284],"2^K),":[285],"causing":[286],"widespread":[287],"alienation":[288],"stagnation;":[291],"(iii)":[293],"cognitive":[295,341],"automation":[296],"fallacy,":[297],"proving":[298],"replacing":[300],"workers":[302],"with":[303],"silicon":[305],"language":[306],"liquidates":[308],"capacity":[311],"in":[312],"favor":[313],"derivative":[315],"statistical":[316],"interpolation.":[317],"Finally,":[318],"we":[319],"formulate":[320],"Antigenic":[322],"Decoupling":[323],"Protocol,":[324],"eliminating":[327],"immunogenic":[328],"cereals":[329],"de-primes":[330],"microglial":[331],"alarms,":[332],"restores":[333],"native":[334],"coherence,":[336],"unlocks":[338],"asymmetric":[340],"upgrade.":[342]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
