{"id":"https://openalex.org/W7225814602","doi":"https://doi.org/10.1007/s10571-026-01857-w","title":"Effect of Exogenous L-lactate on Post-ischemic Response to Injury in the Neurovascular Unit","display_name":"Effect of Exogenous L-lactate on Post-ischemic Response to Injury in the Neurovascular Unit","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225814602","doi":"https://doi.org/10.1007/s10571-026-01857-w"},"language":"en","primary_location":{"id":"doi:10.1007/s10571-026-01857-w","doi":"https://doi.org/10.1007/s10571-026-01857-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10571-026-01857-w","pdf_url":null,"source":{"id":"https://openalex.org/S33948212","display_name":"Cellular and Molecular Neurobiology","issn_l":"0272-4340","issn":["0272-4340","1573-6830"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Neurobiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1007/s10571-026-01857-w","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059099889","display_name":"Lara Buscemi","orcid":"https://orcid.org/0000-0001-8564-649X","observed_orcids":["https://orcid.org/0000-0001-8564-649X"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Lara Buscemi","raw_affiliation_strings":["Department of Fundamental Neuroscience, University of Lausanne, Rue du Bugnon 9, 1005, Lausanne, Switzerland","Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-8564-649X","affiliations":[{"raw_affiliation_string":"Department of Fundamental Neuroscience, University of Lausanne, Rue du Bugnon 9, 1005, Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]},{"raw_affiliation_string":"Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I97565354"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084034589","display_name":"Lorenz Hirt","orcid":"https://orcid.org/0000-0002-2921-5000","observed_orcids":["https://orcid.org/0000-0002-2921-5000"]},"institutions":[{"id":"https://openalex.org/I2802229882","display_name":"Centre Hospitalier Universitaire Vaudois","ror":"https://ror.org/05a353079","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I2802229882"]},{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Lorenz Hirt","raw_affiliation_strings":["Department of Fundamental Neuroscience, University of Lausanne, Rue du Bugnon 9, 1005, Lausanne, Switzerland","Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-2921-5000","affiliations":[{"raw_affiliation_string":"Department of Fundamental Neuroscience, University of Lausanne, Rue du Bugnon 9, 1005, Lausanne, Switzerland","institution_ids":["https://openalex.org/I97565354"]},{"raw_affiliation_string":"Neurology Service, Department of Clinical Neurosciences, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland","institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I97565354"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5059099889"],"corresponding_institution_ids":["https://openalex.org/I2802229882","https://openalex.org/I97565354"],"apc_list":{"value":4590,"currency":"USD","value_usd":4590},"apc_paid":{"value":4590,"currency":"USD","value_usd":4590},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.25,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.25,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.24570000171661377,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.20200000703334808,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C105572291","wikidata":"https://www.wikidata.org/wiki/Q7002775","display_name":"Neurovascular bundle","level":2,"score":0.9071000218391418},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.5289999842643738},{"id":"https://openalex.org/C2781156865","wikidata":"https://www.wikidata.org/wiki/Q827023","display_name":"Lesion","level":2,"score":0.48899999260902405},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4823000133037567},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.47530001401901245},{"id":"https://openalex.org/C2781458332","wikidata":"https://www.wikidata.org/wiki/Q720026","display_name":"Brain damage","level":2,"score":0.3804999887943268},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.36640000343322754},{"id":"https://openalex.org/C203635412","wikidata":"https://www.wikidata.org/wiki/Q17007432","display_name":"Compartment (ship)","level":2,"score":0.3569999933242798},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3522999882698059},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.34689998626708984},{"id":"https://openalex.org/C2777594495","wikidata":"https://www.wikidata.org/wiki/Q5569540","display_name":"Glial scar","level":4,"score":0.3393000066280365},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.3222000002861023},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31459999084472656},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.314300000667572},{"id":"https://openalex.org/C2777542381","wikidata":"https://www.wikidata.org/wiki/Q502961","display_name":"Astrocyte","level":3,"score":0.31349998712539673},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.31310001015663147},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.30640000104904175},{"id":"https://openalex.org/C2780884517","wikidata":"https://www.wikidata.org/wiki/Q177105","display_name":"Neuroglia","level":3,"score":0.3034999966621399},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.2985000014305115},{"id":"https://openalex.org/C3020199598","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Ischemic stroke","level":3,"score":0.29789999127388},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.296999990940094},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.296099990606308},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.28839999437332153},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.2840999960899353},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.27639999985694885},{"id":"https://openalex.org/C2993714741","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemic injury","level":3,"score":0.2718999981880188},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.26669999957084656},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.2651999890804291},{"id":"https://openalex.org/C2778820722","wikidata":"https://www.wikidata.org/wiki/Q4862390","display_name":"Brain ischemia","level":3,"score":0.25519999861717224},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.2549000084400177},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.25360000133514404},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.25189998745918274},{"id":"https://openalex.org/C74254510","wikidata":"https://www.wikidata.org/wiki/Q7240508","display_name":"Premovement neuronal activity","level":2,"score":0.251800000667572}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/s10571-026-01857-w","doi":"https://doi.org/10.1007/s10571-026-01857-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10571-026-01857-w","pdf_url":null,"source":{"id":"https://openalex.org/S33948212","display_name":"Cellular and Molecular Neurobiology","issn_l":"0272-4340","issn":["0272-4340","1573-6830"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Neurobiology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1007/s10571-026-01857-w","doi":"https://doi.org/10.1007/s10571-026-01857-w","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10571-026-01857-w","pdf_url":null,"source":{"id":"https://openalex.org/S33948212","display_name":"Cellular and Molecular Neurobiology","issn_l":"0272-4340","issn":["0272-4340","1573-6830"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cellular and Molecular Neurobiology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Abstract":[0,169],"L-lactate":[1,53,76,133,170,183],"administration":[2],"enhances":[3],"functional":[4],"recovery":[5,139,174],"in":[6,67,79,115],"several":[7],"preclinical":[8],"animal":[9],"models":[10],"of":[11,31,52,60,63,83,100,146],"acute":[12,69],"brain":[13,42,130],"injury,":[14],"and":[15,37,44,97,106,128,164,177,197,206],"its":[16,24,118,212],"protective":[17],"effects":[18],"have":[19],"been":[20],"mainly":[21],"related":[22],"to":[23,41,58,117,121,137],"metabolic":[25],"functions.":[26],"The":[27],"neurovascular":[28,65,186],"unit,":[29],"consisting":[30],"endothelial":[32],"cells,":[33],"pericytes,":[34],"glial":[35,88,161,203],"cells":[36,89,162,188,204],"neurons,":[38],"is":[39],"central":[40],"metabolism":[43],"post-ischemic":[45,70],"inflammation.":[46],"Here,":[47],"we":[48],"analyzed":[49],"the":[50,56,64,68,80,84,101,107,124,142,157,195,199],"effect":[51],"supplementation":[54,134,171],"on":[55],"response":[57],"injury":[59],"cellular":[61],"components":[62],"unit":[66,187],"phase.":[71],"When":[72],"administered":[73],"at":[74],"reperfusion,":[75],"enhanced":[77],"proliferation":[78,193],"vascular":[81],"compartment":[82],"lesion.":[85],"Furthermore,":[86],"reactive":[87],"from":[90,189],"lactate-treated":[91],"mice":[92],"exhibited":[93],"increased":[94],"morphological":[95],"complexity":[96],"differential":[98],"expression":[99],"gap-junction":[102],"protein":[103,109],"connexin":[104],"30":[105],"lysosomal":[108],"CD68.":[110],"Our":[111],"results":[112],"suggest":[113],"that,":[114],"addition":[116],"presumed":[119],"ability":[120],"help":[122,178],"overcome":[123],"hypoxic":[125],"energy":[126],"crisis":[127],"prevent":[129],"cell":[131],"death,":[132,191],"might":[135],"contribute":[136],"stroke":[138,176],"by":[140,155],"facilitating":[141],"execution":[143],"and/or":[144],"progression":[145],"signaling":[147],"programs":[148],"that":[149],"promote":[150,192],"proliferation,":[151],"as":[152,154],"well":[153],"fine-tuning":[156],"efficiency":[158,200],"with":[159,201],"which":[160,202],"confine":[163,205],"clear":[165,207],"ischemic":[166,208],"damage.":[167],"Graphical":[168],"could":[172,184],"fuel":[173],"after":[175],"mitigate":[179],"damage":[180],"extension":[181],".":[182],"protect":[185],"early":[190],"within":[194],"lesion":[196],"refine":[198],"damage,":[209],"thereby":[210],"preventing":[211],"spread":[213]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
