{"id":"https://openalex.org/W7225814467","doi":"https://doi.org/10.3389/fmicb.2026.1991208","title":"Lineage-aware evaluation of machine learning for observed cross-genus occurrence of IncC plasmids in public databases","display_name":"Lineage-aware evaluation of machine learning for observed cross-genus occurrence of IncC plasmids in public databases","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225814467","doi":"https://doi.org/10.3389/fmicb.2026.1991208"},"language":"en","primary_location":{"id":"doi:10.3389/fmicb.2026.1991208","doi":"https://doi.org/10.3389/fmicb.2026.1991208","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2026.1991208","pdf_url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1991208/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1991208/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100318951","display_name":"Yao Wang","orcid":"https://orcid.org/0000-0001-5433-7360","observed_orcids":["https://orcid.org/0000-0001-5433-7360","https://orcid.org/0009-0006-2566-6492"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuli Wang","raw_affiliation_strings":["Department of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161439331","display_name":"Xuechun Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuechun Zhou","raw_affiliation_strings":["Department of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161423095","display_name":"Yanhao Shen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yanhao Shen","raw_affiliation_strings":["Zhengzhou Medical College"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zhengzhou Medical College","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135244759","display_name":"Yuanyuan Jia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuanyuan Jia","raw_affiliation_strings":["Department of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020176677","display_name":"Zhaoli Liu","orcid":"https://orcid.org/0000-0002-3641-4470","observed_orcids":["https://orcid.org/0000-0002-3641-4470"]},"institutions":[{"id":"https://openalex.org/I38877650","display_name":"Zhengzhou University","ror":"https://ror.org/04ypx8c21","country_code":"CN","type":"education","lineage":["https://openalex.org/I38877650"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhaoli Liu","raw_affiliation_strings":["National Health Commission Key Laboratory of Cardiovascular Regenerative Medicine, Central China Subcenter of National Center for Cardiovascular Diseases, Henan Cardiovascular Disease Center, Fuwai Central-China Cardiovascular Hospital, Central China Fuwai Hospital of Zhengzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Health Commission Key Laboratory of Cardiovascular Regenerative Medicine, Central China Subcenter of National Center for Cardiovascular Diseases, Henan Cardiovascular Disease Center, Fuwai Central-China Cardiovascular Hospital, Central China Fuwai Hospital of Zhengzhou University","institution_ids":["https://openalex.org/I38877650"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161481266","display_name":"Lei Fang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lei Fang","raw_affiliation_strings":["Puyang Oilfield General Hospital, Puyang"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Puyang Oilfield General Hospital, Puyang","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101431046","display_name":"Ruyan Chen","orcid":"https://orcid.org/0000-0003-0018-405X","observed_orcids":["https://orcid.org/0000-0003-0018-405X"]},"institutions":[{"id":"https://openalex.org/I167383011","display_name":"Henan University of Science and Technology","ror":"https://ror.org/05d80kz58","country_code":"CN","type":"education","lineage":["https://openalex.org/I167383011"]},{"id":"https://openalex.org/I4210134906","display_name":"First Affiliated Hospital of Henan University of Science and Technology","ror":"https://ror.org/035zbbv42","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210134906"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruyan Chen","raw_affiliation_strings":["Department of Clinical Laboratory, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology","institution_ids":["https://openalex.org/I167383011","https://openalex.org/I4210134906"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100298158","display_name":"Jingjing Sun","orcid":"https://orcid.org/0009-0009-2397-4469","observed_orcids":["https://orcid.org/0009-0009-2397-4469","https://orcid.org/0009-0001-2867-3253"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingjing Sun","raw_affiliation_strings":["Department of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110370736","display_name":"Nan Yi","orcid":"https://orcid.org/0009-0001-1355-6505","observed_orcids":["https://orcid.org/0009-0001-1355-6505"]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Nan Yi","raw_affiliation_strings":["Department of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University","institution_ids":["https://openalex.org/I4210156804"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100527881","display_name":"Xiaobing Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156804","display_name":"First Affiliated Hospital of Zhengzhou University","ror":"https://ror.org/056swr059","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156804"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaobing Guo","raw_affiliation_strings":["Department of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, The First Affiliated Hospital of Zhengzhou University","institution_ids":["https://openalex.org/I4210156804"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100527881"],"corresponding_institution_ids":["https://openalex.org/I4210156804"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12167","display_name":"Bacterial Identification and Susceptibility Testing","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.567799985408783},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5494999885559082},{"id":"https://openalex.org/C151810110","wikidata":"https://www.wikidata.org/wiki/Q7307074","display_name":"RefSeq","level":4,"score":0.5378000140190125},{"id":"https://openalex.org/C185798385","wikidata":"https://www.wikidata.org/wiki/Q1161707","display_name":"Benchmark (surveying)","level":2,"score":0.5350000262260437},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5102999806404114},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5002999901771545},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.4697999954223633},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.44029998779296875},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.35190001130104065},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.32190001010894775},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.31459999084472656},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.30329999327659607},{"id":"https://openalex.org/C64869954","wikidata":"https://www.wikidata.org/wiki/Q1859747","display_name":"False positive paradox","level":2,"score":0.30079999566078186},{"id":"https://openalex.org/C21200559","wikidata":"https://www.wikidata.org/wiki/Q7451068","display_name":"Sensitivity (control systems)","level":2,"score":0.2786000072956085},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.2743000090122223},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.2578999996185303},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.25690001249313354},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25440001487731934},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.2515000104904175}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fmicb.2026.1991208","doi":"https://doi.org/10.3389/fmicb.2026.1991208","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2026.1991208","pdf_url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1991208/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fmicb.2026.1991208","doi":"https://doi.org/10.3389/fmicb.2026.1991208","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmicb.2026.1991208","pdf_url":"https://www.frontiersin.org/journals/microbiology/articles/10.3389/fmicb.2026.1991208/pdf","source":{"id":"https://openalex.org/S2484704948","display_name":"Frontiers in Microbiology","issn_l":"1664-302X","issn":["1664-302X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Microbiology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225814467.pdf","grobid_xml":"https://content.openalex.org/works/W7225814467.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W28412257","https://openalex.org/W1542735222","https://openalex.org/W1562379206","https://openalex.org/W1678356000","https://openalex.org/W1966716734","https://openalex.org/W1970782126","https://openalex.org/W1991884276","https://openalex.org/W2056132907","https://openalex.org/W2082290707","https://openalex.org/W2082521980","https://openalex.org/W2084007633","https://openalex.org/W2084759112","https://openalex.org/W2092939357","https://openalex.org/W2099533874","https://openalex.org/W2110065044","https://openalex.org/W2114725566","https://openalex.org/W2114850508","https://openalex.org/W2118836230","https://openalex.org/W2140647036","https://openalex.org/W2140848003","https://openalex.org/W2142678478","https://openalex.org/W2143325926","https://openalex.org/W2147839609","https://openalex.org/W2152575748","https://openalex.org/W2173732482","https://openalex.org/W2295598076","https://openalex.org/W2346485333","https://openalex.org/W2750953301","https://openalex.org/W2771835478","https://openalex.org/W2803474517","https://openalex.org/W2883838322","https://openalex.org/W2886632764","https://openalex.org/W2909601828","https://openalex.org/W2911964244","https://openalex.org/W2950150251","https://openalex.org/W2977770083","https://openalex.org/W3024222188","https://openalex.org/W3036187761","https://openalex.org/W3043497582","https://openalex.org/W3048090444","https://openalex.org/W3049128840","https://openalex.org/W3093718851","https://openalex.org/W3170689505","https://openalex.org/W3179598697","https://openalex.org/W3189243975","https://openalex.org/W3215940488","https://openalex.org/W3217314753","https://openalex.org/W4225845191","https://openalex.org/W4229443239","https://openalex.org/W4307838425","https://openalex.org/W4309310674","https://openalex.org/W4310893902","https://openalex.org/W4360860759","https://openalex.org/W4381470613","https://openalex.org/W4381620211","https://openalex.org/W4388380062","https://openalex.org/W4390704263","https://openalex.org/W4393949536","https://openalex.org/W4396509133","https://openalex.org/W4399139567","https://openalex.org/W4400653000","https://openalex.org/W4401557561","https://openalex.org/W4401954669","https://openalex.org/W4402557213","https://openalex.org/W4403447969","https://openalex.org/W4403870935","https://openalex.org/W4404458588","https://openalex.org/W4404531745","https://openalex.org/W4407364366","https://openalex.org/W4407369465","https://openalex.org/W4407637664","https://openalex.org/W4409257324","https://openalex.org/W4412396715","https://openalex.org/W7134979027"],"related_works":[],"abstract_inverted_index":{"Introduction":[0],"IncC":[1],"plasmids":[2,20,50,234],"contribute":[3],"to":[4,18,22,117,126],"the":[5,135,171,175,191,242],"dissemination":[6],"of":[7,90,151,156,160,170],"antimicrobial":[8],"resistance":[9],"across":[10],"bacterial":[11],"hosts.":[12],"We":[13],"developed":[14],"an":[15,149,154,209],"IncC-specific":[16],"model":[17,193,230],"classify":[19],"belonging":[21],"highly":[23],"similar":[24,203],"cross-genus":[25,216],"pairs":[26],"observed":[27],"in":[28,67],"public":[29],"databases":[30,68],"and":[31,53,106,112,119,125,128,142,153,174,197,199,218,223],"evaluated":[32],"its":[33],"performance":[34],"when":[35],"related":[36],"lineages":[37],"were":[38,110],"kept":[39],"together":[40],"during":[41],"validation.":[42],"Methods":[43],"The":[44,62,229],"development":[45,172],"cohort":[46,58,173],"comprised":[47],"988":[48],"PLSDB":[49],"(266":[51],"label-positive),":[52],"a":[54,87,247],"separately":[55],"sourced":[56],"RefSeq":[57],"contained":[59],"250":[60],"plasmids.":[61],"operational":[63],"label":[64],"denotes":[65],"occurrence":[66,217],"rather":[69],"than":[70],"experimentally":[71],"measured":[72],"transfer.":[73],"Among":[74],"five":[75],"standalone":[76],"learners,":[77],"LightGBM":[78],"with":[79,86,121,130],"100":[80],"foldwise-selected":[81],"4-mers":[82],"(LightGBM-100)":[83],"was":[84,140],"retained,":[85],"fixed":[88],"threshold":[89],"0.306":[91],"derived":[92],"via":[93],"nested":[94],"random-CV":[95],"Youden-index":[96],"selection.":[97],"Results":[98],"Under":[99],"random":[100],"five-fold":[101],"cross-validation,":[102],"pooled":[103],"out-of-fold":[104],"AUROC":[105,150],"average":[107],"precision":[108],"(AP)":[109],"0.960":[111],"0.928,":[113],"respectively,":[114],"but":[115],"fell":[116],"0.742":[118],"0.498":[120],"primary":[122],"Mash-component":[123],"blocking":[124],"0.712":[127],"0.412":[129],"more":[131],"permissive":[132],"blocking.":[133],"At":[134],"random-CV-derived":[136],"threshold,":[137],"blocked":[138],"sensitivity":[139],"0.259":[141],"0.162,":[143],"respectively.":[144],"In":[145],"RefSeq,":[146],"LightGBM-100":[147],"achieved":[148],"0.937":[152],"AP":[155],"0.894,":[157],"although":[158],"81":[159],"84":[161],"positives":[162],"lay":[163],"within":[164,235],"Mash":[165],"distance":[166],"d":[167],"<":[168],"0.00124":[169],"labels":[176],"partly":[177],"relied":[178],"on":[179],"pair":[180],"evidence":[181],"from":[182],"both":[183],"databases.":[184],"Biological":[185],"features":[186],"did":[187],"not":[188],"reproducibly":[189],"improve":[190],"4-mer":[192],"after":[194],"lineage":[195,221],"blocking,":[196],"family-":[198],"order-crossing":[200],"outcomes":[201],"showed":[202],"limitations.":[204],"Discussion":[205],"This":[206],"study":[207],"establishes":[208],"IncC-specific,":[210],"lineage-aware":[211],"benchmark":[212],"for":[213,239,249],"predicting":[214],"database-observed":[215],"demonstrates":[219],"how":[220],"relatedness":[222],"database":[224],"representation":[225],"shape":[226],"predictive":[227],"performance.":[228],"may":[231],"help":[232],"prioritize":[233],"represented":[236],"sequence":[237],"backgrounds":[238],"follow-up,":[240],"while":[241],"integrated":[243],"biological":[244],"analyses":[245],"provide":[246],"basis":[248],"targeted":[250],"experimental":[251],"investigation.":[252]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}