{"id":"https://openalex.org/W7225813825","doi":"https://doi.org/10.1186/s12967-026-09193-9","title":"Neural pathway\u2013informed unsupervised learning for cross-resolution transcriptomic profiling of Alzheimer\u2019s disease heterogeneity","display_name":"Neural pathway\u2013informed unsupervised learning for cross-resolution transcriptomic profiling of Alzheimer\u2019s disease heterogeneity","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225813825","doi":"https://doi.org/10.1186/s12967-026-09193-9"},"language":"en","primary_location":{"id":"doi:10.1186/s12967-026-09193-9","doi":"https://doi.org/10.1186/s12967-026-09193-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12967-026-09193-9","pdf_url":null,"source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12967-026-09193-9","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017283709","display_name":"Xiaosheng Wang","orcid":"https://orcid.org/0000-0002-7199-7093","observed_orcids":["https://orcid.org/0000-0002-7199-7093"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiaosheng Wang","raw_affiliation_strings":["Center for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA"],"raw_orcid":"https://orcid.org/0000-0002-7199-7093","affiliations":[{"raw_affiliation_string":"Center for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023266250","display_name":"Chia-Hao Tung","orcid":"https://orcid.org/0000-0001-5638-4216","observed_orcids":["https://orcid.org/0000-0001-5638-4216"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chia-Hao Tung","raw_affiliation_strings":["Center for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I919571938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006688612","display_name":"Zhongming Zhao","orcid":"https://orcid.org/0000-0002-3477-0914","observed_orcids":["https://orcid.org/0000-0002-3477-0914"]},"institutions":[{"id":"https://openalex.org/I919571938","display_name":"The University of Texas Health Science Center at Houston","ror":"https://ror.org/03gds6c39","country_code":"US","type":"education","lineage":["https://openalex.org/I919571938"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhongming Zhao","raw_affiliation_strings":["Center for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA","Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, 77054, USA"],"raw_orcid":"https://orcid.org/0000-0002-3477-0914","affiliations":[{"raw_affiliation_string":"Center for Precision Health, McWilliams School of Biomedical Informatics, The University of Texas Health Science Center at Houston, Houston, TX, 77030, USA","institution_ids":["https://openalex.org/I919571938"]},{"raw_affiliation_string":"Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, TX, 77054, USA","institution_ids":["https://openalex.org/I919571938"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5006688612"],"corresponding_institution_ids":["https://openalex.org/I919571938"],"apc_list":{"value":3890,"currency":"USD","value_usd":3890},"apc_paid":{"value":3890,"currency":"USD","value_usd":3890},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.7300000190734863,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.7300000190734863,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.17149999737739563,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.0771000012755394,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.8022000193595886},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6182000041007996},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6107000112533569},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.4287000000476837},{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.421099990606308},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.3587000072002411},{"id":"https://openalex.org/C8038995","wikidata":"https://www.wikidata.org/wiki/Q1152135","display_name":"Unsupervised learning","level":2,"score":0.3513999879360199},{"id":"https://openalex.org/C2985665543","wikidata":"https://www.wikidata.org/wiki/Q3560550","display_name":"Spatial learning","level":3,"score":0.3167000114917755},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.30219998955726624},{"id":"https://openalex.org/C189206191","wikidata":"https://www.wikidata.org/wiki/Q222046","display_name":"Genomics","level":4,"score":0.29109999537467957},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2824999988079071},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.27900001406669617},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2773999869823456},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.274399995803833},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.2632000148296356},{"id":"https://openalex.org/C95371953","wikidata":"https://www.wikidata.org/wiki/Q591745","display_name":"DNA microarray","level":4,"score":0.26080000400543213},{"id":"https://openalex.org/C2984127161","wikidata":"https://www.wikidata.org/wiki/Q969316","display_name":"Neural activity","level":2,"score":0.2549999952316284}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s12967-026-09193-9","doi":"https://doi.org/10.1186/s12967-026-09193-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12967-026-09193-9","pdf_url":null,"source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s12967-026-09193-9","doi":"https://doi.org/10.1186/s12967-026-09193-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12967-026-09193-9","pdf_url":null,"source":{"id":"https://openalex.org/S142026636","display_name":"Journal of Translational Medicine","issn_l":"1479-5876","issn":["1479-5876"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Translational Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Alzheimer\u2019s":[0],"disease":[1],"(AD)":[2],"is":[3],"a":[4,26,50,58,84,90,231],"heterogeneous":[5],"neurodegenerative":[6],"disorder,":[7],"yet":[8],"the":[9,66,139,235],"molecular":[10,28,228],"and":[11,45,89,99,123,134,149,156,166,195,202,206,226,243,252,272,293,303,307,323,327,339,353,363,369],"cellular":[12,119,159,232],"mechanisms":[13],"underlying":[14],"its":[15],"heterogeneity":[16,41,349],"remain":[17],"poorly":[18],"understood.":[19],"Previous":[20],"studies":[21],"have":[22],"largely":[23],"relied":[24],"on":[25,65,234],"single":[27],"modality,":[29],"limiting":[30],"comprehensive":[31],"characterization":[32],"of":[33,68,186,278,320],"AD":[34,40,177,259,315,340,348],"heterogeneity.":[35],"We":[36,56,106],"aimed":[37],"to":[38,78,94],"characterize":[39],"across":[42,104,138],"bulk,":[43],"single-nucleus,":[44],"spatial":[46,91,124,354],"transcriptomic":[47,82,92,142],"data":[48],"using":[49],"common":[51,127],"neural":[52,59,71,96,136,181,223,343,359],"pathway\u2013informed":[53,344],"analytical":[54],"framework.":[55],"developed":[57],"pathway-informed":[60],"unsupervised":[61],"learning":[62],"framework":[63,74,346],"based":[64],"activities":[67],"25":[69],"curated":[70],"pathways.":[72],"The":[73],"was":[75,167],"applied":[76],"separately":[77],"six":[79,187],"bulk":[80,141,188,214,239],"brain":[81],"datasets,":[83,189],"single-nucleus":[85],"RNA":[86],"sequencing":[87],"dataset,":[88],"dataset":[93],"identify":[95],"pathway\u2013associated":[97],"subgroups":[98,220,264],"compare":[100],"their":[101],"biological":[102],"characteristics":[103,165],"resolutions.":[105],"comprehensively":[107],"characterized":[108,130],"subgroup-specific":[109],"clinical":[110,172],"features,":[111],"DNA":[112,150,253,267,364],"repair":[113,151,268,365],"capacity,":[114,152,269],"metabolic":[115,147,203,328,362],"activity,":[116],"immune":[117,154,208,367],"signatures,":[118,155,366,368],"heterogeneity,":[120,160,271],"cell-cell":[121],"communication,":[122],"distributions.":[125],"A":[126],"three-subgroup":[128],"partition":[129],"relatively":[131],"high,":[132],"intermediate,":[133],"low":[135],"enrichment":[137,183,197,205,225,330],"analyzed":[140],"datasets.":[143,215],"Neu-H":[144,241,287],"exhibited":[145,265],"enhanced":[146],"function":[148],"lower":[153,180,266,324],"reduced":[157],"tissue-level":[158],"whereas":[161,296],"Neu-L":[162,256,297,321],"showed":[163,179,317],"opposite":[164],"associated":[168,227],"with":[169,175,221,313],"more":[170,247],"severe":[171],"pathology.":[173,341],"Compared":[174,312],"controls,":[176,314],"samples":[178],"gene-set":[182,204,329],"in":[184,193,198,212,238,261,285,291,300],"four":[185],"no":[190],"significant":[191],"difference":[192],"ROSMAP,":[194],"higher":[196,207],"GSE5281.":[199],"Lower":[200],"DNA-repair":[201],"signatures":[209],"were":[210,246,289],"observed":[211,237],"most":[213],"Single-nucleus":[216],"analyses":[217],"identified":[218],"neuronal":[219],"differing":[222],"pathway":[224,360],"characteristics,":[229],"providing":[230],"perspective":[233],"patterns":[236,284,338],"tissues.":[240],"excitatory":[242],"inhibitory":[244],"neurons":[245,260,292],"diverse,":[248],"differentiated,":[249],"metabolically":[250],"active,":[251],"repair\u2013competent":[254],"than":[255,276],"neurons,":[257],"but":[258],"all":[262],"three":[263],"increased":[270,305],"weakened":[273],"cell\u2013cell":[274],"communication":[275],"those":[277],"controls.":[279],"Spatial":[280],"transcriptomics":[281],"recapitulated":[282],"these":[283,336],"situ:":[286],"spots":[288,298,322],"enriched":[290],"gray":[294],"matter,":[295],"predominated":[299],"white":[301],"matter":[302],"had":[304],"microglial":[306],"oligodendrocyte":[308],"precursor":[309],"cell":[310],"representation.":[311],"tissues":[316],"greater":[318],"representation":[319],"neural,":[325],"DNA-repair,":[326],"scores,":[331],"suggesting":[332],"an":[333],"association":[334],"between":[335],"transcriptional":[337],"Our":[342],"cross-resolution":[345],"characterizes":[347],"at":[350],"tissue,":[351],"cellular,":[352],"levels,":[355],"highlighting":[356],"associations":[357],"among":[358],"expression,":[361],"tissue":[370],"organization.":[371]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}