{"id":"https://openalex.org/W7225812802","doi":"https://doi.org/10.21203/rs.3.rs-11190753/v1","title":"Dose-Dependent Neuroprotective Effect of Hesperidin Against Vincristine-Induced Neuropathy","display_name":"Dose-Dependent Neuroprotective Effect of Hesperidin Against Vincristine-Induced Neuropathy","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225812802","doi":"https://doi.org/10.21203/rs.3.rs-11190753/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-11190753/v1","doi":"https://doi.org/10.21203/rs.3.rs-11190753/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11190753/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.21203/rs.3.rs-11190753/v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161449719","display_name":"Sana amjadi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163205636","display_name":"Tabriz University of Medical Sciences","ror":"https://ror.org/04krpx645","country_code":"IR","type":"education","lineage":["https://openalex.org/I163205636"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Sana amjadi","raw_affiliation_strings":["Tabriz University of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tabriz University of Medical Sciences","institution_ids":["https://openalex.org/I163205636"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046009147","display_name":"Javad Khalili Fard","orcid":"https://orcid.org/0000-0002-0353-1806","observed_orcids":["https://orcid.org/0000-0002-0353-1806"]},"institutions":[{"id":"https://openalex.org/I163205636","display_name":"Tabriz University of Medical Sciences","ror":"https://ror.org/04krpx645","country_code":"IR","type":"education","lineage":["https://openalex.org/I163205636"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Javad Khalili Fard","raw_affiliation_strings":["Tabriz University of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tabriz University of Medical Sciences","institution_ids":["https://openalex.org/I163205636"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5099184163","display_name":"Adel Mahmoudi Gharehbaba","orcid":"https://orcid.org/0009-0000-9172-4829","observed_orcids":["https://orcid.org/0009-0000-9172-4829"]},"institutions":[{"id":"https://openalex.org/I163205636","display_name":"Tabriz University of Medical Sciences","ror":"https://ror.org/04krpx645","country_code":"IR","type":"education","lineage":["https://openalex.org/I163205636"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Adel Mahmoudi Gharehbaba","raw_affiliation_strings":["Tabriz University of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tabriz University of Medical Sciences","institution_ids":["https://openalex.org/I163205636"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5161455612","display_name":"Bohloul Habibi Asl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I163205636","display_name":"Tabriz University of Medical Sciences","ror":"https://ror.org/04krpx645","country_code":"IR","type":"education","lineage":["https://openalex.org/I163205636"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Bohloul Habibi Asl","raw_affiliation_strings":["Tabriz University of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tabriz University of Medical Sciences","institution_ids":["https://openalex.org/I163205636"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I163205636"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12429","display_name":"Chemotherapy-induced organ toxicity mitigation","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2776128092","wikidata":"https://www.wikidata.org/wiki/Q385937","display_name":"Hesperidin","level":3,"score":0.9365000128746033},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.7208999991416931},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.6787999868392944},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.671500027179718},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.6596999764442444},{"id":"https://openalex.org/C2779901536","wikidata":"https://www.wikidata.org/wiki/Q945238","display_name":"Peripheral neuropathy","level":3,"score":0.5468999743461609},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.5307999849319458},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5020999908447266},{"id":"https://openalex.org/C25498285","wikidata":"https://www.wikidata.org/wiki/Q1981368","display_name":"Neuroprotection","level":2,"score":0.47029998898506165},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4616999924182892},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.43950000405311584},{"id":"https://openalex.org/C2777883359","wikidata":"https://www.wikidata.org/wiki/Q1888634","display_name":"Allodynia","level":5,"score":0.42170000076293945},{"id":"https://openalex.org/C2779429289","wikidata":"https://www.wikidata.org/wiki/Q408977","display_name":"Vincristine","level":4,"score":0.4196999967098236},{"id":"https://openalex.org/C2779054382","wikidata":"https://www.wikidata.org/wiki/Q72185287","display_name":"Flavonoid","level":3,"score":0.35989999771118164},{"id":"https://openalex.org/C197711040","wikidata":"https://www.wikidata.org/wiki/Q5910791","display_name":"Hot plate test","level":4,"score":0.31349998712539673},{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.27799999713897705},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2671000063419342},{"id":"https://openalex.org/C2780051329","wikidata":"https://www.wikidata.org/wiki/Q273169","display_name":"Capsaicin","level":3,"score":0.26499998569488525},{"id":"https://openalex.org/C149857219","wikidata":"https://www.wikidata.org/wiki/Q5239054","display_name":"Effective dose (radiation)","level":2,"score":0.257999986410141}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-11190753/v1","doi":"https://doi.org/10.21203/rs.3.rs-11190753/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11190753/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-11190753/v1","doi":"https://doi.org/10.21203/rs.3.rs-11190753/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11190753/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":51,"referenced_works":["https://openalex.org/W178270209","https://openalex.org/W1732832561","https://openalex.org/W1736515909","https://openalex.org/W2070032192","https://openalex.org/W2111443510","https://openalex.org/W2114458368","https://openalex.org/W2125289626","https://openalex.org/W2146682857","https://openalex.org/W2593697738","https://openalex.org/W2613929012","https://openalex.org/W2620036274","https://openalex.org/W2637410905","https://openalex.org/W2738754795","https://openalex.org/W2802277418","https://openalex.org/W2913856862","https://openalex.org/W2923697933","https://openalex.org/W2952941462","https://openalex.org/W2967533411","https://openalex.org/W3034361113","https://openalex.org/W3040700551","https://openalex.org/W3089064573","https://openalex.org/W3092435124","https://openalex.org/W3135024925","https://openalex.org/W3156899852","https://openalex.org/W3157329682","https://openalex.org/W3187419526","https://openalex.org/W3196486841","https://openalex.org/W3206349719","https://openalex.org/W3207388101","https://openalex.org/W3210606870","https://openalex.org/W4210395111","https://openalex.org/W4213240312","https://openalex.org/W4221040717","https://openalex.org/W4282595930","https://openalex.org/W4286008242","https://openalex.org/W4288686153","https://openalex.org/W4312205224","https://openalex.org/W4318479370","https://openalex.org/W4318942344","https://openalex.org/W4386303373","https://openalex.org/W4389489475","https://openalex.org/W4389736651","https://openalex.org/W4400801425","https://openalex.org/W4401456288","https://openalex.org/W4402815827","https://openalex.org/W4404006380","https://openalex.org/W4407077530","https://openalex.org/W4407482857","https://openalex.org/W4408144676","https://openalex.org/W4414852277","https://openalex.org/W4415585303"],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Vincristine-induced":[2],"peripheral":[3,235,268],"neuropathy":[4],"(VIPN)":[5],"is":[6,23],"a":[7,24,32,42,229,260],"common,":[8],"dose-limiting":[9],"complication":[10],"of":[11,56,140,249,257,266],"chemotherapy":[12],"for":[13,45,263],"which":[14],"no":[15],"effective":[16,243],"preventive":[17,54],"treatment":[18],"currently":[19],"exists.":[20],"Oxidative":[21],"stress":[22,70],"key":[25],"mechanism":[26],"underlying":[27],"vincristine":[28,90,97],"neurotoxicity,":[29],"and":[30,38,67,96,119,125,130,143,166,179,197,201],"hesperidin,":[31],"citrus-derived":[33],"flavonoid":[34],"with":[35,99,170,237],"well-documented":[36],"antioxidant":[37,132],"neuroprotective":[39],"properties,":[40],"represents":[41],"promising":[43],"candidate":[44,261],"its":[46],"prevention.":[47],"Objective":[48],"This":[49],"study":[50],"evaluated":[51],"the":[52,113,138,141,206,223,241,264],"dose-dependent":[53,230],"effects":[55],"hesperidin":[57,100,189,258],"on":[58,120],"VIPN":[59],"in":[60,216],"mice,":[61],"assessed":[62,111],"through":[63,247],"thermal":[64,154],"nociceptive":[65,108,195],"behavior":[66],"serum":[68,164,199],"oxidative":[69,250],"biomarkers.":[71],"Methods":[72],"Fifty":[73],"male":[74],"mice":[75],"were":[76,135,220],"randomly":[77],"divided":[78],"into":[79],"five":[80],"groups":[81],"(n":[82],"=":[83],"10/group):":[84],"vehicle":[85,88],"+":[86,89],"saline,":[87],"(0.1":[91],"mg/kg/day,":[92,105],"i.p.,":[93],"10":[94,158],"days),":[95],"co-administered":[98],"(25,":[101],"50,":[102],"or":[103],"100":[104,191,238],"i.p.).":[106],"Thermal":[107],"latency":[109,196],"was":[110,146],"using":[112],"Hot":[114],"Plate":[115],"test":[116],"at":[117,137,177,190],"baseline":[118],"days":[121],"6,":[122],"10,":[123],"15,":[124],"19.":[126],"Serum":[127],"malondialdehyde":[128],"(MDA)":[129],"total":[131],"capacity":[133],"(TAC)":[134],"measured":[136],"end":[139],"protocol,":[142],"body":[144,217],"weight":[145,218],"monitored":[147],"throughout.":[148],"Results":[149],"Vincristine":[150],"administration":[151],"induced":[152],"significant":[153,214],"hyperalgesia":[155],"from":[156],"day":[157],"onward,":[159],"accompanied":[160],"by":[161],"significantly":[162,184,193],"elevated":[163],"MDA":[165,200],"reduced":[167],"TAC":[168,202],"compared":[169],"controls":[171],"(":[172,209],"P":[173,210],"<":[174,211],"0.001).":[175,212],"Hesperidin":[176,227],"25":[178],"50":[180],"mg/kg":[181,192,239],"did":[182],"not":[183],"modify":[185],"these":[186],"outcomes;":[187],"however,":[188],"preserved":[194],"normalized":[198],"levels":[203],"relative":[204],"to":[205],"vincristine-only":[207],"group":[208],"No":[213],"differences":[215],"gain":[219],"observed":[221],"among":[222],"experimental":[224],"groups.":[225],"Conclusion":[226],"exerts":[228],"protective":[231],"effect":[232],"against":[233],"vincristine-induced":[234],"neuropathy,":[236],"being":[240],"most":[242],"dose,":[244],"likely":[245],"mediated":[246],"attenuation":[248],"stress.":[251],"These":[252],"findings":[253],"support":[254],"further":[255],"investigation":[256],"as":[259],"adjunct":[262],"prevention":[265],"chemotherapy-induced":[267],"neuropathy.":[269]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
