{"id":"https://openalex.org/W7225812674","doi":"https://doi.org/10.1002/adhm.71964","title":"Establishment of a Responsive Tooth\u2010on\u2010a\u2010Chip Platform for the Assessment of Regenerative Factors in Dental Tissue Regeneration","display_name":"Establishment of a Responsive Tooth\u2010on\u2010a\u2010Chip Platform for the Assessment of Regenerative Factors in Dental Tissue Regeneration","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225812674","doi":"https://doi.org/10.1002/adhm.71964","pmid":"https://pubmed.ncbi.nlm.nih.gov/43012452"},"language":"en","primary_location":{"id":"doi:10.1002/adhm.71964","doi":"https://doi.org/10.1002/adhm.71964","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adhm.71964","pdf_url":null,"source":{"id":"https://openalex.org/S2500736452","display_name":"Advanced Healthcare Materials","issn_l":"2192-2640","issn":["2192-2640","2192-2659"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Healthcare Materials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1002/adhm.71964","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5001573772","display_name":"Chong Huang","orcid":"https://orcid.org/0000-0002-0392-9398","observed_orcids":["https://orcid.org/0000-0002-0392-9398","https://orcid.org/0000-0003-0779-8214","https://orcid.org/0000-0002-4312-0382","https://orcid.org/0009-0002-3701-541X","https://orcid.org/0009-0004-3693-3141","https://orcid.org/0009-0004-7614-1763"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802934949"]},{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN","NL"],"is_corresponding":false,"raw_author_name":"Chong Huang","raw_affiliation_strings":["Department of Dentistry \u2013 Regenerative Biomaterials Research Institute for Medical Innovation Radboud University Medical Center  Nijmegen The Netherlands","The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology Wuhan University Wuhan China"],"raw_orcid":"https://orcid.org/0000-0002-9351-5921","affiliations":[{"raw_affiliation_string":"Department of Dentistry \u2013 Regenerative Biomaterials Research Institute for Medical Innovation Radboud University Medical Center  Nijmegen The Netherlands","institution_ids":["https://openalex.org/I2802934949"]},{"raw_affiliation_string":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology Wuhan University Wuhan China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079207853","display_name":"Wei Ji","orcid":"https://orcid.org/0000-0002-1473-5222","observed_orcids":["https://orcid.org/0000-0002-1473-5222"]},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Ji","raw_affiliation_strings":["Department of Implantology School & Hospital of Stomatology Wuhan University Wuhan China","The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology Wuhan University Wuhan China"],"raw_orcid":"https://orcid.org/0000-0002-1473-5222","affiliations":[{"raw_affiliation_string":"Department of Implantology School & Hospital of Stomatology Wuhan University Wuhan China","institution_ids":["https://openalex.org/I37461747"]},{"raw_affiliation_string":"The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei\u2010MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology Wuhan University Wuhan China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064267835","display_name":"Fang Yang","orcid":"https://orcid.org/0000-0002-4022-7643","observed_orcids":["https://orcid.org/0000-0002-4022-7643"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Fang Yang","raw_affiliation_strings":["Department of Dentistry \u2013 Regenerative Biomaterials Research Institute for Medical Innovation Radboud University Medical Center  Nijmegen The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-4022-7643","affiliations":[{"raw_affiliation_string":"Department of Dentistry \u2013 Regenerative Biomaterials Research Institute for Medical Innovation Radboud University Medical Center  Nijmegen The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058252244","display_name":"X. Frank Walboomers","orcid":"https://orcid.org/0000-0001-5742-9826","observed_orcids":["https://orcid.org/0000-0001-5742-9826"]},"institutions":[{"id":"https://openalex.org/I2802934949","display_name":"Radboud University Medical Center","ror":"https://ror.org/05wg1m734","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2802934949"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"X. Frank Walboomers","raw_affiliation_strings":["Department of Dentistry \u2013 Regenerative Biomaterials Research Institute for Medical Innovation Radboud University Medical Center  Nijmegen The Netherlands"],"raw_orcid":"https://orcid.org/0000-0001-5742-9826","affiliations":[{"raw_affiliation_string":"Department of Dentistry \u2013 Regenerative Biomaterials Research Institute for Medical Innovation Radboud University Medical Center  Nijmegen The Netherlands","institution_ids":["https://openalex.org/I2802934949"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5058252244"],"corresponding_institution_ids":["https://openalex.org/I2802934949"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":{"value":4880,"currency":"USD","value_usd":4880},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11919","display_name":"dental development and anomalies","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11919","display_name":"dental development and anomalies","score":0.7041000127792358,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.07900000363588333,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.05220000073313713,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C171056886","wikidata":"https://www.wikidata.org/wiki/Q193119","display_name":"Regeneration (biology)","level":2,"score":0.6209999918937683},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.5515999794006348},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5343000292778015},{"id":"https://openalex.org/C2778185831","wikidata":"https://www.wikidata.org/wiki/Q5375195","display_name":"Enamel matrix derivative","level":3,"score":0.5328999757766724},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.5203999876976013},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.43380001187324524},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.40849998593330383},{"id":"https://openalex.org/C151279780","wikidata":"https://www.wikidata.org/wiki/Q143588","display_name":"Dental alveolus","level":2,"score":0.40389999747276306},{"id":"https://openalex.org/C2780171871","wikidata":"https://www.wikidata.org/wiki/Q6804676","display_name":"Mechanobiology","level":2,"score":0.38659998774528503},{"id":"https://openalex.org/C74373430","wikidata":"https://www.wikidata.org/wiki/Q24727126","display_name":"Fibroblast growth factor","level":3,"score":0.37779998779296875},{"id":"https://openalex.org/C2778414984","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biomaterial","level":2,"score":0.3529999852180481},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.34389999508857727},{"id":"https://openalex.org/C2780381497","wikidata":"https://www.wikidata.org/wiki/Q463418","display_name":"Fibroblast","level":3,"score":0.33570000529289246},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.32350000739097595},{"id":"https://openalex.org/C113843644","wikidata":"https://www.wikidata.org/wiki/Q901882","display_name":"Interface (matter)","level":4,"score":0.31189998984336853},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.30300000309944153},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.2888999879360199},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2849000096321106},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2849000096321106},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.27880001068115234},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.2680000066757202},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.2556999921798706}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/adhm.71964","doi":"https://doi.org/10.1002/adhm.71964","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adhm.71964","pdf_url":null,"source":{"id":"https://openalex.org/S2500736452","display_name":"Advanced Healthcare Materials","issn_l":"2192-2640","issn":["2192-2640","2192-2659"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Healthcare Materials","raw_type":"journal-article"},{"id":"pmid:43012452","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43012452","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced healthcare materials","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/adhm.71964","doi":"https://doi.org/10.1002/adhm.71964","is_oa":true,"landing_page_url":"https://doi.org/10.1002/adhm.71964","pdf_url":null,"source":{"id":"https://openalex.org/S2500736452","display_name":"Advanced Healthcare Materials","issn_l":"2192-2640","issn":["2192-2640","2192-2659"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Healthcare Materials","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W1970750249","https://openalex.org/W1973004999","https://openalex.org/W2013520568","https://openalex.org/W2018092590","https://openalex.org/W2021550972","https://openalex.org/W2039848988","https://openalex.org/W2040702795","https://openalex.org/W2066194444","https://openalex.org/W2075924400","https://openalex.org/W2085638402","https://openalex.org/W2104209550","https://openalex.org/W2122982898","https://openalex.org/W2134257943","https://openalex.org/W2146886646","https://openalex.org/W2151371698","https://openalex.org/W2163149880","https://openalex.org/W2580122461","https://openalex.org/W2621842261","https://openalex.org/W2626725994","https://openalex.org/W2806168560","https://openalex.org/W2944494372","https://openalex.org/W2954261203","https://openalex.org/W2995076723","https://openalex.org/W3002612078","https://openalex.org/W3010864892","https://openalex.org/W3019982879","https://openalex.org/W3111015203","https://openalex.org/W3128117134","https://openalex.org/W3167340540","https://openalex.org/W3197954209","https://openalex.org/W3215480816","https://openalex.org/W4214707326","https://openalex.org/W4229442068","https://openalex.org/W4280537476","https://openalex.org/W4280540675","https://openalex.org/W4281679148","https://openalex.org/W4285732868","https://openalex.org/W4285744455","https://openalex.org/W4294584679","https://openalex.org/W4318071539","https://openalex.org/W4366520907","https://openalex.org/W4384945168","https://openalex.org/W4385813866","https://openalex.org/W4385834891","https://openalex.org/W4386629716","https://openalex.org/W4386861564","https://openalex.org/W4392055707","https://openalex.org/W4392926443","https://openalex.org/W4399260307","https://openalex.org/W4399594331","https://openalex.org/W4399652440","https://openalex.org/W4401823515","https://openalex.org/W4402464141","https://openalex.org/W4402497885","https://openalex.org/W4402540250","https://openalex.org/W4405847612","https://openalex.org/W4406478661","https://openalex.org/W4406639379","https://openalex.org/W4408369475","https://openalex.org/W4408683653","https://openalex.org/W4409310794","https://openalex.org/W4409456707","https://openalex.org/W4412372938","https://openalex.org/W4412595027","https://openalex.org/W4413373875","https://openalex.org/W4414982452","https://openalex.org/W4415535905"],"related_works":[],"abstract_inverted_index":{"Tooth":[0],"formation":[1,17,125],"relies":[2],"on":[3],"reciprocal":[4],"signaling":[5],"between":[6],"embryological":[7],"dental":[8,189],"epithelial":[9,81],"(DE)":[10],"and":[11,21,42,97,103,126,184],"mesenchymal":[12,76],"(DM)":[13],"cells,":[14],"orchestrating":[15],"the":[16,108,165,186],"of":[18,45,149,188],"enamel,":[19],"dentin,":[20],"vascularized":[22],"pulp.":[23],"Current":[24],"regenerative":[25,182,190],"strategies":[26],"aim":[27],"to":[28,87,115],"recreate":[29],"DE-DM":[30,56],"signaling,":[31],"yet":[32],"responsive":[33],"in":[34,64,172],"vitro":[35,173],"platforms":[36],"that":[37,152],"faithfully":[38],"reconstruct":[39],"this":[40],"interface":[41,57,124],"enable":[43],"benchmarking":[44,181],"candidate":[46],"cues":[47,183],"are":[48],"unavailable.":[49],"Herein,":[50],"a":[51,54,69,74,143,150,169,177],"tooth-on-a-chip":[52,166],"with":[53,78,131],"reconstructed":[55],"was":[58,85],"tested":[59],"for":[60,157,180],"cue-specific":[61,128],"tissue":[62],"maturation":[63,129],"vitro.":[65],"The":[66,83,120],"platform":[67,121],"comprises":[68],"polydimethylsiloxane":[70],"microfluidic":[71],"device":[72],"integrating":[73],"fibrin-based":[75],"compartment":[77],"an":[79],"overlying":[80],"layer.":[82],"system":[84,167],"exposed":[86],"two":[88],"developmental":[89],"inducers,":[90],"sequential":[91],"fibroblast":[92],"growth":[93],"factor":[94],"10":[95],"(FGF10)":[96],"bone":[98],"morphogenetic":[99],"protein":[100],"4":[101],"(BMP4),":[102],"BMP2,":[104],"as":[105,107,168],"well":[106],"clinically":[109,156],"used":[110,155],"enamel":[111,138],"matrix":[112],"derivative":[113],"Emdogain,":[114],"emulate":[116],"distinct":[117],"inductive":[118],"environments.":[119],"robustly":[122],"supported":[123],"revealed":[127],"trajectories":[130],"high":[132],"experimental":[133],"reproducibility.":[134],"Notably,":[135],"Emdogain":[136],"induced":[137],"organ-like":[139],"structural":[140],"maturation,":[141],"revealing":[142],"previously":[144],"unrecognized":[145],"pro-enamel":[146],"(amelogenic)":[147],"activity":[148],"biomaterial":[151],"has":[153],"been":[154],"over":[158],"three":[159],"decades.":[160],"Together,":[161],"these":[162],"findings":[163],"validated":[164],"biologically":[170],"relevant":[171],"test":[174],"platform,":[175],"providing":[176],"translational":[178],"framework":[179],"guiding":[185],"development":[187],"therapies.":[191]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
