{"id":"https://openalex.org/W7225810920","doi":"https://doi.org/10.1186/s12974-026-04118-1","title":"Air pollution exposure interacts with Alzheimer\u2019s genetic susceptibility to reshape microglial epigenomic and transcriptional programs","display_name":"Air pollution exposure interacts with Alzheimer\u2019s genetic susceptibility to reshape microglial epigenomic and transcriptional programs","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225810920","doi":"https://doi.org/10.1186/s12974-026-04118-1"},"language":"en","primary_location":{"id":"doi:10.1186/s12974-026-04118-1","doi":"https://doi.org/10.1186/s12974-026-04118-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12974-026-04118-1","pdf_url":null,"source":{"id":"https://openalex.org/S199572710","display_name":"Journal of Neuroinflammation","issn_l":"1742-2094","issn":["1742-2094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroinflammation","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12974-026-04118-1","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043457272","display_name":"Rengasamy Palanivel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rengasamy Palanivel","raw_affiliation_strings":["Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH, 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH, 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112063632","display_name":"Jean-Eudes Dazard","orcid":"https://orcid.org/0000-0003-4720-3684","observed_orcids":["https://orcid.org/0000-0003-4720-3684"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean-Eudes Dazard","raw_affiliation_strings":["Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH, 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH, 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055495849","display_name":"Armando Vergara-Martel","orcid":"https://orcid.org/0000-0001-7826-2105","observed_orcids":["https://orcid.org/0000-0001-7826-2105"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Armando Vergara-Martel","raw_affiliation_strings":["Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH, 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH, 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161492715","display_name":"Bongsoo Park","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bongsoo Park","raw_affiliation_strings":["Translational Gerontology Branch, National Institute on Aging, National Institute of Health, Baltimore, MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Translational Gerontology Branch, National Institute on Aging, National Institute of Health, Baltimore, MD, USA","institution_ids":["https://openalex.org/I4210136897"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082891135","display_name":"Skanda Moorthy","orcid":"https://orcid.org/0000-0001-9861-8834","observed_orcids":["https://orcid.org/0000-0001-9861-8834"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Skanda Moorthy","raw_affiliation_strings":["Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH, 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH, 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079030782","display_name":"Jonnelle M. Edwards","orcid":"https://orcid.org/0000-0002-1470-6480","observed_orcids":["https://orcid.org/0000-0002-1470-6480"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonnelle Edwards-Glenn","raw_affiliation_strings":["Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH, 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH, 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041734597","display_name":"Elaine Ann Cara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elaine Ann Ebreo Cara","raw_affiliation_strings":["Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH, 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH, 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135956190","display_name":"Kala Mitcham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kala Mitcham","raw_affiliation_strings":["Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH, 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH, 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090536089","display_name":"Edwin V\u00e1zquez\u2010Rosa","orcid":"https://orcid.org/0009-0005-4508-5217","observed_orcids":["https://orcid.org/0009-0005-4508-5217"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I4210110978","display_name":"Louis Stokes Cleveland VA Medical Center","ror":"https://ror.org/01vrybr67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110978","https://openalex.org/I4210127612"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edwin V\u00e1zquez-Rosa","raw_affiliation_strings":["Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA","Department of Psychiatry, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH, 44106, USA","Geriatric Psychiatry, GRECC, Louis Stokes VA Medical Center, Cleveland, OH, USA","Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"raw_affiliation_string":"Department of Psychiatry, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH, 44106, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Geriatric Psychiatry, GRECC, Louis Stokes VA Medical Center, Cleveland, OH, USA","institution_ids":["https://openalex.org/I4210110978"]},{"raw_affiliation_string":"Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031699865","display_name":"Kalyani Chaubey","orcid":"https://orcid.org/0000-0002-6378-6739","observed_orcids":["https://orcid.org/0000-0002-6378-6739"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I4210110978","display_name":"Louis Stokes Cleveland VA Medical Center","ror":"https://ror.org/01vrybr67","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210110978","https://openalex.org/I4210127612"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kalyani Chaubey","raw_affiliation_strings":["Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA","Department of Psychiatry, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH, 44106, USA","Geriatric Psychiatry, GRECC, Louis Stokes VA Medical Center, Cleveland, OH, USA","Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"raw_affiliation_string":"Department of Psychiatry, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH, 44106, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Geriatric Psychiatry, GRECC, Louis Stokes VA Medical Center, Cleveland, OH, USA","institution_ids":["https://openalex.org/I4210110978"]},{"raw_affiliation_string":"Institute for Transformative Molecular Medicine, School of Medicine, Case Western Reserve University, Cleveland, OH, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050799541","display_name":"Francesco Paneni","orcid":"https://orcid.org/0000-0001-6483-7844","observed_orcids":["https://orcid.org/0000-0001-6483-7844"]},"institutions":[{"id":"https://openalex.org/I202697423","display_name":"University of Zurich","ror":"https://ror.org/02crff812","country_code":"CH","type":"education","lineage":["https://openalex.org/I202697423"]},{"id":"https://openalex.org/I4210100468","display_name":"University Hospital Zurich","ror":"https://ror.org/01462r250","country_code":"CH","type":"healthcare","lineage":["https://openalex.org/I4210100468"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Francesco Paneni","raw_affiliation_strings":["Center for Translational and Experimental Cardiology (CTEC), Department of Cardiology, University Hospital Zurich and University of Zurich, Schlieren, Switzerland","University Heart Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Translational and Experimental Cardiology (CTEC), Department of Cardiology, University Hospital Zurich and University of Zurich, Schlieren, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I4210100468"]},{"raw_affiliation_string":"University Heart Center, University Hospital Zurich, University of Zurich, Zurich, Switzerland","institution_ids":["https://openalex.org/I202697423","https://openalex.org/I4210100468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071498567","display_name":"Fulai Jin","orcid":"https://orcid.org/0000-0003-0025-4337","observed_orcids":["https://orcid.org/0000-0003-0025-4337"]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Fulai Jin","raw_affiliation_strings":["Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, 44106-4955, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH, 44106-4955, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5144195108","display_name":"Salil Deo  MD PhD","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Salil Deo","raw_affiliation_strings":["Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA","Department of Surgery, Case School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Health Medicines Center, Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"raw_affiliation_string":"Department of Surgery, Case School of Medicine, Case Western Reserve University, Cleveland, OH, 44106, USA","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070676250","display_name":"Andrew A. Pieper","orcid":"https://orcid.org/0000-0001-6299-6577","observed_orcids":["https://orcid.org/0000-0001-6299-6577"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Andrew A. Pieper","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5022334933","display_name":"Sanjay Rajagopalan","orcid":"https://orcid.org/0000-0001-6669-8163","observed_orcids":["https://orcid.org/0000-0001-6669-8163"]},"institutions":[{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I4210108791","display_name":"University Hospitals Cleveland Medical Center","ror":"https://ror.org/01gc0wp38","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sanjay Rajagopalan","raw_affiliation_strings":["Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH, 44106, USA","Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Research Institute, Department of Medicine, Case Western Reserve University, 2103 Cornell Road, Cleveland, OH, 44106, USA","institution_ids":["https://openalex.org/I58956616"]},{"raw_affiliation_string":"Harrington Heart and Vascular Institute, University Hospitals Cleveland Medical Center, Cleveland, OH, USA","institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210108791"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5022334933","https://openalex.org/A5070676250"],"corresponding_institution_ids":["https://openalex.org/I2799343972","https://openalex.org/I4210108791","https://openalex.org/I58956616"],"apc_list":{"value":4090,"currency":"USD","value_usd":4090},"apc_paid":{"value":4090,"currency":"USD","value_usd":4090},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10190","display_name":"Air Quality and Health Impacts","score":0.6176999807357788,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10190","display_name":"Air Quality and Health Impacts","score":0.6176999807357788,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.2517000138759613,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.08630000054836273,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.599399983882904},{"id":"https://openalex.org/C2779830541","wikidata":"https://www.wikidata.org/wiki/Q1622829","display_name":"Microglia","level":3,"score":0.5903000235557556},{"id":"https://openalex.org/C116567970","wikidata":"https://www.wikidata.org/wiki/Q864217","display_name":"Biobank","level":2,"score":0.5314000248908997},{"id":"https://openalex.org/C67636389","wikidata":"https://www.wikidata.org/wiki/Q784237","display_name":"Genetic predisposition","level":3,"score":0.5281999707221985},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5123000144958496},{"id":"https://openalex.org/C121912465","wikidata":"https://www.wikidata.org/wiki/Q3589153","display_name":"Epigenomics","level":5,"score":0.4819999933242798},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.44290000200271606},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42969998717308044},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.39079999923706055},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.38659998774528503},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.37279999256134033},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.36469998955726624},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.36410000920295715},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.35679998993873596},{"id":"https://openalex.org/C2779777708","wikidata":"https://www.wikidata.org/wiki/Q6033622","display_name":"Inhalation exposure","level":3,"score":0.35370001196861267},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35260000824928284},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.3504999876022339},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.3337000012397766},{"id":"https://openalex.org/C9287583","wikidata":"https://www.wikidata.org/wiki/Q5532883","display_name":"Genetic architecture","level":4,"score":0.3248000144958496},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.32109999656677246},{"id":"https://openalex.org/C87753298","wikidata":"https://www.wikidata.org/wiki/Q17157137","display_name":"Neuroinflammation","level":3,"score":0.3190000057220459},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.31459999084472656},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.313400000333786},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3116999864578247},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.29100000858306885},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.28940001130104065},{"id":"https://openalex.org/C186256576","wikidata":"https://www.wikidata.org/wiki/Q1058294","display_name":"Hormesis","level":3,"score":0.2888999879360199},{"id":"https://openalex.org/C559116025","wikidata":"https://www.wikidata.org/wiki/Q131123","display_name":"Air pollution","level":2,"score":0.28299999237060547},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.2799000144004822},{"id":"https://openalex.org/C2992519594","wikidata":"https://www.wikidata.org/wiki/Q870433","display_name":"Genetic model","level":3,"score":0.27810001373291016},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.27489998936653137},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.271699994802475},{"id":"https://openalex.org/C2776156579","wikidata":"https://www.wikidata.org/wiki/Q417667","display_name":"Amyloid beta","level":3,"score":0.2703999876976013},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2669000029563904},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.2662999927997589},{"id":"https://openalex.org/C125370674","wikidata":"https://www.wikidata.org/wiki/Q1527480","display_name":"Stressor","level":2,"score":0.2660999894142151},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.26579999923706055},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.2632000148296356},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.2612999975681305},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.25929999351501465}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s12974-026-04118-1","doi":"https://doi.org/10.1186/s12974-026-04118-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12974-026-04118-1","pdf_url":null,"source":{"id":"https://openalex.org/S199572710","display_name":"Journal of Neuroinflammation","issn_l":"1742-2094","issn":["1742-2094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroinflammation","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s12974-026-04118-1","doi":"https://doi.org/10.1186/s12974-026-04118-1","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12974-026-04118-1","pdf_url":null,"source":{"id":"https://openalex.org/S199572710","display_name":"Journal of Neuroinflammation","issn_l":"1742-2094","issn":["1742-2094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroinflammation","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Chronic":[0],"exposure":[1,40,135,183],"to":[2,25,122,242],"fine":[3],"particulate":[4],"matter":[5],"air":[6,129],"pollution":[7],"(PM":[8],"2.5":[9,39,62,126,134,224],")":[10],"is":[11],"associated":[12,50],"with":[13,51],"cognitive":[14,160],"decline":[15],"and":[16,41,56,118,152,158,172,188,191,195,209,217,229,245],"neurodegenerative":[17],"disease,":[18],"but":[19,74],"the":[20,26,90,96,100,106,139,143,178,239],"biology":[21],"connecting":[22],"inhaled":[23],"particles":[24],"brain":[27,144],"remains":[28],"incompletely":[29],"defined.":[30],"Among":[31],"475,325":[32],"eligible":[33],"UK":[34],"Biobank":[35],"participants,":[36],"long-term":[37],"PM":[38,61,125,133,223],"Alzheimer":[42],"disease":[43],"(AD)":[44],"polygenic":[45],"risk":[46,53,64],"were":[47],"both":[48,185],"independently":[49],"higher":[52],"of":[54,99,116,174,197],"AD":[55],"related":[57],"dementias":[58],"(ADRD).":[59],"The":[60],"-by-polygenic":[63],"score":[65],"(PRS)":[66],"interaction":[67],"in":[68,215,220],"Cox":[69],"models":[70],"was":[71,93],"statistically":[72],"significant":[73],"sub-multiplicative":[75],"or":[76,127],"below":[77],"unity":[78],"(interaction":[79],"HR":[80],"0.981,":[81],"95%":[82],"CI":[83],"0.965\u20130.998;":[84],"p":[85],"=":[86],"0.026),":[87],"indicating":[88],"that":[89,182,192,193],"combined":[91],"association":[92],"smaller":[94],"than":[95],"simple":[97],"product":[98],"two":[101],"individual":[102],"associations.":[103],"To":[104],"define":[105,230],"underlying":[107],"biology,":[108],"we":[109],"exposed":[110],"5xFAD":[111,163],"mice,":[112],"an":[113,226],"amyloid-based":[114],"model":[115],"AD,":[117],"wild-type":[119],"(WT)":[120],"littermates":[121],"concentrated":[123],"ambient":[124],"filtered":[128],"for":[130,150],"20":[131],"weeks.":[132],"activated":[136],"microglia,":[137],"disrupted":[138],"blood-brain":[140],"barrier,":[141],"depleted":[142],"NAD":[145],"+":[146],"/NADH":[147],"pool":[148],"required":[149],"resilience":[151],"repair,":[153],"impaired":[154],"postnatal":[155],"hippocampal":[156],"neurogenesis,":[157],"caused":[159],"deficits.":[161],"In":[162],"mice":[164],"it":[165],"additionally":[166],"increased":[167],"amyloid":[168],"burden.":[169],"Paired":[170],"RNA-seq":[171],"ATAC-seq":[173],"microglia":[175],"isolated":[176],"from":[177],"same":[179],"animals":[180],"showed":[181],"remodeled":[184],"gene":[186],"expression":[187],"chromatin":[189],"accessibility,":[190],"magnitude":[194],"direction":[196],"this":[198],"response":[199,241],"depended":[200],"on":[201,204],"genotype,":[202],"converging":[203],"inflammatory,":[205],"lysosomal,":[206],"oxidative-stress,":[207],"synaptic,":[208],"amyloid-related":[210],"pathways.\u200b":[211],"\u200bThese":[212],"population-scale":[213],"data":[214,219],"humans":[216],"experimental":[218],"mice\u200b":[221],"support":[222],"as":[225],"environmental":[227],"neurotoxicant":[228],"microglial":[231],"regulatory":[232],"programs":[233],"through":[234],"which":[235],"genetic":[236],"background":[237],"shapes":[238],"biological":[240],"a":[243],"common":[244],"modifiable":[246],"exposure.":[247]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
