{"id":"https://openalex.org/W7225810422","doi":"https://doi.org/10.64898/2026.11.10.26367720","title":"Spatiotemporal mapping of ex vivo myometrial contractions in adenomyosis","display_name":"Spatiotemporal mapping of ex vivo myometrial contractions in adenomyosis","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225810422","doi":"https://doi.org/10.64898/2026.11.10.26367720"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.10.26367720","doi":"https://doi.org/10.64898/2026.11.10.26367720","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.10.26367720","pdf_url":null,"source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.64898/2026.11.10.26367720","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5158525933","display_name":"Emilie Huon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127056","display_name":"Laboratoire Mati\u00e8re et Syst\u00e8mes Complexes","ror":"https://ror.org/032w6q449","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4210095849","https://openalex.org/I4210127056"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Emilie Huon","raw_affiliation_strings":["Laboratoire Matiere et Systemes Complexes;"],"raw_orcid":"https://orcid.org/0009-0003-3522-2965","affiliations":[{"raw_affiliation_string":"Laboratoire Matiere et Systemes Complexes;","institution_ids":["https://openalex.org/I4210127056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033410737","display_name":"L\u00e9na Zig","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127056","display_name":"Laboratoire Mati\u00e8re et Syst\u00e8mes Complexes","ror":"https://ror.org/032w6q449","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4210095849","https://openalex.org/I4210127056"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lena Zig","raw_affiliation_strings":["Laboratoire Matiere et Systemes Complexes;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Matiere et Systemes Complexes;","institution_ids":["https://openalex.org/I4210127056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161456308","display_name":"Olympe Seguard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127056","display_name":"Laboratoire Mati\u00e8re et Syst\u00e8mes Complexes","ror":"https://ror.org/032w6q449","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4210095849","https://openalex.org/I4210127056"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Olympe Seguard","raw_affiliation_strings":["Laboratoire Matiere et Systemes Complexes;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Matiere et Systemes Complexes;","institution_ids":["https://openalex.org/I4210127056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5093112864","display_name":"Marine Plancke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127056","display_name":"Laboratoire Mati\u00e8re et Syst\u00e8mes Complexes","ror":"https://ror.org/032w6q449","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4210095849","https://openalex.org/I4210127056"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marine Plancke","raw_affiliation_strings":["Laboratoire Matiere et Systemes Complexes;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratoire Matiere et Systemes Complexes;","institution_ids":["https://openalex.org/I4210127056"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035992529","display_name":"Carole Abo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120939","display_name":"H\u00f4pital Marie Lannelongue","ror":"https://ror.org/02ndr3r66","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210120939","https://openalex.org/I4405287512"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Carole Abo","raw_affiliation_strings":["Hopitaux Paris Saint-Joseph Marie Lannelongue"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hopitaux Paris Saint-Joseph Marie Lannelongue","institution_ids":["https://openalex.org/I4210120939"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112318372","display_name":"M.-C. Lamau","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120939","display_name":"H\u00f4pital Marie Lannelongue","ror":"https://ror.org/02ndr3r66","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210120939","https://openalex.org/I4405287512"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Marie-Charlotte Lamau","raw_affiliation_strings":["Hopitaux Paris Saint-Joseph Marie Lannelongue"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hopitaux Paris Saint-Joseph Marie Lannelongue","institution_ids":["https://openalex.org/I4210120939"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026925259","display_name":"Gauthier Dietrich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120939","display_name":"H\u00f4pital Marie Lannelongue","ror":"https://ror.org/02ndr3r66","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210120939","https://openalex.org/I4405287512"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Gauthier Dietrich","raw_affiliation_strings":["Hopitaux Paris Saint-Joseph Marie Lannelongue"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hopitaux Paris Saint-Joseph Marie Lannelongue","institution_ids":["https://openalex.org/I4210120939"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021221113","display_name":"Ylann Abrahami","orcid":"https://orcid.org/0000-0002-3057-6890","observed_orcids":["https://orcid.org/0000-0002-3057-6890"]},"institutions":[{"id":"https://openalex.org/I4210120939","display_name":"H\u00f4pital Marie Lannelongue","ror":"https://ror.org/02ndr3r66","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210120939","https://openalex.org/I4405287512"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ylann Abrahami","raw_affiliation_strings":["Hopitaux Paris Saint-Joseph Marie Lannelongue"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hopitaux Paris Saint-Joseph Marie Lannelongue","institution_ids":["https://openalex.org/I4210120939"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158470683","display_name":"Jordan Kouby","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210120939","display_name":"H\u00f4pital Marie Lannelongue","ror":"https://ror.org/02ndr3r66","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210120939","https://openalex.org/I4405287512"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jordan Kouby","raw_affiliation_strings":["Hopitaux Paris Saint-Joseph Marie Lannelongue"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hopitaux Paris Saint-Joseph Marie Lannelongue","institution_ids":["https://openalex.org/I4210120939"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006476106","display_name":"Julien Adam","orcid":"https://orcid.org/0000-0001-7556-9101","observed_orcids":["https://orcid.org/0000-0001-7556-9101"]},"institutions":[{"id":"https://openalex.org/I4210120939","display_name":"H\u00f4pital Marie Lannelongue","ror":"https://ror.org/02ndr3r66","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210120939","https://openalex.org/I4405287512"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Julien Adam","raw_affiliation_strings":["Hopitaux Paris Saint-Joseph Marie Lannelongue"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hopitaux Paris Saint-Joseph Marie Lannelongue","institution_ids":["https://openalex.org/I4210120939"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081906663","display_name":"Nicolas R. Chevalier","orcid":"https://orcid.org/0000-0002-9713-1511","observed_orcids":["https://orcid.org/0000-0002-9713-1511","https://orcid.org/0000-0001-7160-4301"]},"institutions":[{"id":"https://openalex.org/I4210127056","display_name":"Laboratoire Mati\u00e8re et Syst\u00e8mes Complexes","ror":"https://ror.org/032w6q449","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I204730241","https://openalex.org/I4210095849","https://openalex.org/I4210127056"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Nicolas R Chevalier","raw_affiliation_strings":["Laboratoire Matiere et Systemes Complexes;"],"raw_orcid":"https://orcid.org/0000-0002-9713-1511","affiliations":[{"raw_affiliation_string":"Laboratoire Matiere et Systemes Complexes;","institution_ids":["https://openalex.org/I4210127056"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10935","display_name":"Endometriosis Research and Treatment","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10935","display_name":"Endometriosis Research and Treatment","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10989","display_name":"Uterine Myomas and Treatments","score":0.0026000000070780516,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11589","display_name":"Gynecological conditions and treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2729","display_name":"Obstetrics and Gynecology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2778164554","wikidata":"https://www.wikidata.org/wiki/Q2562472","display_name":"Myometrium","level":3,"score":0.892300009727478},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.8342000246047974},{"id":"https://openalex.org/C2779166600","wikidata":"https://www.wikidata.org/wiki/Q2012569","display_name":"Adenomyosis","level":3,"score":0.7537000179290771},{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.7366999983787537},{"id":"https://openalex.org/C2776176026","wikidata":"https://www.wikidata.org/wiki/Q169960","display_name":"Oxytocin","level":2,"score":0.6895999908447266},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.636900007724762},{"id":"https://openalex.org/C2776766599","wikidata":"https://www.wikidata.org/wiki/Q1751296","display_name":"Uterine contraction","level":3,"score":0.6287000179290771},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5656999945640564},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49230000376701355},{"id":"https://openalex.org/C181612422","wikidata":"https://www.wikidata.org/wiki/Q14908140","display_name":"Oxytocin receptor","level":3,"score":0.39579999446868896},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3912999927997589},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.37380000948905945},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3643999993801117},{"id":"https://openalex.org/C2776050358","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Muscle contraction","level":2,"score":0.32670000195503235},{"id":"https://openalex.org/C2779066055","wikidata":"https://www.wikidata.org/wiki/Q9612","display_name":"Uterus","level":2,"score":0.3176000118255615},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.28600001335144043},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.26109999418258667},{"id":"https://openalex.org/C58207958","wikidata":"https://www.wikidata.org/wiki/Q33596","display_name":"Motility","level":2,"score":0.25130000710487366}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.10.26367720","doi":"https://doi.org/10.64898/2026.11.10.26367720","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.10.26367720","pdf_url":null,"source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.10.26367720","doi":"https://doi.org/10.64898/2026.11.10.26367720","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.10.26367720","pdf_url":null,"source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Objective:":[0],"Uterine":[1],"dyscontractility":[2],"plays":[3],"a":[4,210,217,289],"major":[5],"role":[6],"in":[7,18,28,48,103,192,203,221,258,260],"pain":[8],"sensation,":[9],"infertility,":[10],"and":[11,22,45,56,74,118,126,140,153,159,165,172,179,181,305],"adenomyosis":[12,57,70,173,266],"pathogenesis.":[13],"In":[14,195,295],"vivo,":[15,242],"contractility":[16,44,268],"occurs":[17],"the":[19,33,104,122,135,151,189,204,227,245,261,308],"inner":[20,154,190,205,246],"myometrium":[21,191,239,276],"junctional":[23,34],"zone,":[24],"which":[25],"is":[26,254,314],"thickened":[27],"adenomyosis.":[29],"We":[30,94,108,129,225],"examined":[31],"whether":[32],"zone":[35],"presents":[36],"particular":[37],"contractile":[38,147,184,291,300,319],"features":[39],"ex":[40,61,229,241],"vivo":[41,62,146,230,259,265],"by":[42,138],"measuring":[43],"oxytocin":[46,131,198,213,278,298],"response":[47,292],"full-thickness":[49],"serosa-to-endometrium":[50,123,136],"myometrial":[51,235],"slices":[52],"retrieved":[53],"from":[54,307],"control":[55,171],"patients.":[58,90],"Design:":[59],"Prospective":[60],"case-control":[63],"study.":[64],"Subjects:":[65],"Premenopausal":[66],"women":[67],"following":[68],"hysterectomy:":[69],"(n":[71,76],"=":[72,77],"16)":[73],"controls":[75],"12).":[78],"Contractility:":[79],"57":[80],"strips":[81],"(11":[82],"vs":[83,88],"8":[84],"patients),":[85],"immunofluorescence:":[86],"10":[87],"9":[89],"Main":[91],"Outcome":[92],"Measures:":[93],"resorted":[95],"to":[96,186,271,281,293,302],"spatiotemporal":[97,231],"mapping,":[98],"time-lapse":[99,232],"video-based":[100],"techniques":[101],"used":[102],"field":[105],"of":[106,116,234,273],"gastroenterology.":[107],"measured":[109,130],"contraction":[110,177,222],"frequency,":[111,162],"amplitude,":[112,163],"duration,":[113,164],"velocity,":[114],"site":[115],"origin,":[117],"propagation":[119],"direction":[120,321],"along":[121,134],"axis,":[124],"before":[125],"after":[127],"oxytocin.":[128,294],"receptor":[132,199,214,312],"density":[133,200,313],"axis":[137],"immunofluorescence":[139],"machine":[141],"learning-assisted":[142],"segmentation.":[143],"Results:":[144],"Ex":[145,264],"waves":[148,185,301],"propagated":[149],"throughout":[150],"outer":[152,262],"myometrium,":[155,310],"with":[156],"similar":[157,270],"amplitude":[158],"frequency.":[160,223],"Contraction":[161],"velocity":[166,180],"did":[167,285],"not":[168,243,286],"differ":[169],"between":[170],"uteri.":[174],"Oxytocin":[175],"increased":[176],"frequency":[178],"systematically":[182],"caused":[183,299],"originate":[187,303],"at":[188,304],"both":[193,196,296],"groups.":[194],"groups,":[197,297],"was":[201,269],"highest":[202],"myometrium.":[206,263],"Adenomyosis":[207],"patients":[208],"had":[209],"1.8-fold":[211],"higher":[212],"density,":[215],"but":[216,283],"smaller":[218],"oxytocin-induced":[219],"increase":[220],"Conclusion:":[224],"provide":[226],"first":[228],"analysis":[233],"contractions.":[236],"The":[237],"whole":[238],"contracts":[240],"just":[244],"part":[247],"(junctional":[248],"zone).":[249],"This":[250,316],"uniform":[251],"myogenic":[252],"motility":[253],"presumably":[255],"inhibited":[256],"neurally":[257],"basal":[267],"that":[272,318],"controls.":[274],"Adenomyotic":[275],"overexpressed":[277],"receptors":[279],"compared":[280],"controls,":[282],"this":[284],"translate":[287],"into":[288],"stronger":[290],"propagate":[306],"sub-endometrial":[309],"where":[311],"higher.":[315],"demonstrates":[317],"wave":[320],"can":[322],"be":[323],"controlled":[324],"hormonally.":[325]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
