{"id":"https://openalex.org/W7225808771","doi":"https://doi.org/10.64898/2026.11.06.764966","title":"Serum extracellular vesicle proteomics reveals treatment\u2013associated biomarkers in pancreatic ductal adenocarcinoma","display_name":"Serum extracellular vesicle proteomics reveals treatment\u2013associated biomarkers in pancreatic ductal adenocarcinoma","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225808771","doi":"https://doi.org/10.64898/2026.11.06.764966"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.06.764966","doi":"https://doi.org/10.64898/2026.11.06.764966","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.11.06.764966","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5141063257","display_name":"Sehong Min","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sehong Min","raw_affiliation_strings":["Pacific Northwest National Laboratory;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pacific Northwest National Laboratory;","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002232583","display_name":"Komal K. Abhange","orcid":"https://orcid.org/0009-0001-6834-928X","observed_orcids":["https://orcid.org/0009-0001-6834-928X"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Komal Abhange","raw_affiliation_strings":["University of Michigan Medical Center;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan Medical Center;","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112726544","display_name":"Tai\u2010Tu Lin","orcid":"https://orcid.org/0000-0002-8985-0364","observed_orcids":["https://orcid.org/0000-0002-8985-0364"]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tai-Tu Lin","raw_affiliation_strings":["Pacific Northwest National Laboratory;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pacific Northwest National Laboratory;","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5135154178","display_name":"Jianliang Dai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jianliang Dai","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018160871","display_name":"Isaac Kwame Attah","orcid":"https://orcid.org/0000-0002-9626-2069","observed_orcids":["https://orcid.org/0000-0002-9626-2069"]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Isaac K. Attah","raw_affiliation_strings":["Pacific Northwest National Laboratory;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pacific Northwest National Laboratory;","institution_ids":["https://openalex.org/I142606810"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152883775","display_name":"Anders Bogard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anders Bogard","raw_affiliation_strings":["University of Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076767039","display_name":"Vaibhav Sahai","orcid":"https://orcid.org/0000-0003-1892-1548","observed_orcids":["https://orcid.org/0000-0003-1892-1548"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Vaibhav Sahai","raw_affiliation_strings":["University of Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082821643","display_name":"Kyle Clifford Cuneo","orcid":"https://orcid.org/0000-0002-8264-6483","observed_orcids":["https://orcid.org/0000-0002-8264-6483"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kyle C. Cuneo","raw_affiliation_strings":["University of Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161422999","display_name":"Suyu Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suyu Liu","raw_affiliation_strings":["University of Texas MD Anderson Cancer Center;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas MD Anderson Cancer Center;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074120071","display_name":"David M. Lubman","orcid":"https://orcid.org/0000-0001-7731-0232","observed_orcids":["https://orcid.org/0000-0001-7731-0232"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David M. Lubman","raw_affiliation_strings":["University of Michigan Medical Center;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Michigan Medical Center;","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074663242","display_name":"Tujin Shi","orcid":"https://orcid.org/0000-0002-5592-3588","observed_orcids":["https://orcid.org/0000-0002-5592-3588"]},"institutions":[{"id":"https://openalex.org/I142606810","display_name":"Pacific Northwest National Laboratory","ror":"https://ror.org/05h992307","country_code":"US","type":"facility","lineage":["https://openalex.org/I1325736334","https://openalex.org/I1330989302","https://openalex.org/I142606810","https://openalex.org/I39565521"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tujin Shi","raw_affiliation_strings":["Pacific Northwest National Laboratory;"],"raw_orcid":"https://orcid.org/0000-0002-5592-3588","affiliations":[{"raw_affiliation_string":"Pacific Northwest National Laboratory;","institution_ids":["https://openalex.org/I142606810"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10231","display_name":"Pancreatic and Hepatic Oncology Research","score":0.009700000286102295,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10519","display_name":"Advanced Proteomics Techniques and Applications","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.6349999904632568},{"id":"https://openalex.org/C80311884","wikidata":"https://www.wikidata.org/wiki/Q7268939","display_name":"Quantitative proteomics","level":4,"score":0.5659000277519226},{"id":"https://openalex.org/C2777148230","wikidata":"https://www.wikidata.org/wiki/Q17144959","display_name":"FOLFIRINOX","level":5,"score":0.5638999938964844},{"id":"https://openalex.org/C2908689518","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicle","level":5,"score":0.5414000153541565},{"id":"https://openalex.org/C2781261824","wikidata":"https://www.wikidata.org/wiki/Q903634","display_name":"Exosome","level":5,"score":0.4805999994277954},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4496999979019165},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.4496999979019165},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.400299996137619},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.38830000162124634},{"id":"https://openalex.org/C2780210213","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic cancer","level":3,"score":0.3865000009536743},{"id":"https://openalex.org/C2780258809","wikidata":"https://www.wikidata.org/wiki/Q414143","display_name":"Gemcitabine","level":3,"score":0.38199999928474426},{"id":"https://openalex.org/C125965507","wikidata":"https://www.wikidata.org/wiki/Q1516595","display_name":"Laser capture microdissection","level":4,"score":0.37139999866485596},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.33719998598098755},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.33660000562667847},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3343999981880188},{"id":"https://openalex.org/C146543888","wikidata":"https://www.wikidata.org/wiki/Q425056","display_name":"Blood proteins","level":2,"score":0.32910001277923584},{"id":"https://openalex.org/C121157162","wikidata":"https://www.wikidata.org/wiki/Q419999","display_name":"Transthyretin","level":2,"score":0.32089999318122864},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31200000643730164},{"id":"https://openalex.org/C2992026798","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic ductal adenocarcinoma","level":4,"score":0.2847000062465668},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2728999853134155},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.272599995136261},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.27129998803138733},{"id":"https://openalex.org/C195580219","wikidata":"https://www.wikidata.org/wiki/Q7251511","display_name":"Protein turnover","level":3,"score":0.2574000060558319},{"id":"https://openalex.org/C3020076753","wikidata":"https://www.wikidata.org/wiki/Q212961","display_name":"Pancreatic carcinoma","level":4,"score":0.25459998846054077},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.25369998812675476},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.25130000710487366}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.06.764966","doi":"https://doi.org/10.64898/2026.11.06.764966","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.11.06.764966","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Background":[0],"Longitudinal":[1,300],"biomarkers":[2],"of":[3,121,130,215],"treatment":[4,151,167],"response":[5,314],"in":[6,109,182,186,199,233,254,293,308,340],"pancreatic":[7,45],"ductal":[8],"adenocarcinoma":[9],"(PDAC)":[10],"are":[11,335],"needed.":[12],"Extracellular":[13],"vesicle":[14],"(EV)-enriched":[15],"serum":[16,37,301],"proteomics":[17,303],"may":[18],"provide":[19],"a":[20,311],"minimally":[21],"invasive":[22],"approach":[23],"for":[24,82,248],"monitoring":[25],"systemic":[26],"and":[27,35,52,65,76,84,90,104,144,159,175,201,210,219,250,322,330,337,349],"tumor-associated":[28],"responses":[29],"to":[30,97,111,155],"therapy.":[31,57],"Methods":[32],"Paired":[33,87],"pre-treatment":[34],"post-treatment":[36],"samples":[38],"were":[39,59,80,95,107,125,152,168,179,190],"analyzed":[40],"from":[41],"51":[42],"patients":[43],"with":[44,50,55,127,170,265,286],"cancer,":[46],"including":[47,204,310],"25":[48],"treated":[49,54],"FOLFIRINOX":[51,184,193,245],"20":[53],"gemcitabine-based":[56],"EVs":[58],"enriched":[60],"using":[61,115],"the":[62,137,183,229,234,251],"Mag-Net":[63],"method":[64],"profiled":[66],"by":[67,196,213],"data":[68],"independent":[69,342],"acquisition":[70],"mass":[71],"spectrometry.":[72],"After":[73],"batch":[74],"correction":[75,270],"filtering,":[77],"941":[78],"proteins":[79,124,132,140,163,189,227],"retained":[81],"differential":[83],"pathway":[85],"analyses.":[86],"linear":[88],"models":[89],"gene":[91],"set":[92],"enrichment":[93,214],"analyses":[94],"used":[96],"assess":[98],"treatment-associated":[99,280,305],"changes.":[100],"Baseline":[101,319],"protein":[102],"abundance":[103,262,321],"longitudinal":[105,323],"changes":[106,178,307,325],"evaluated":[108],"relation":[110],"overall":[112],"survival":[113],"(OS)":[114],"Cox":[116],"models.":[117],"Results":[118],"A":[119,237],"total":[120],"2,089":[122],"EV-associated":[123],"identified,":[126],"an":[128],"average":[129],"1,186":[131],"quantified":[133],"per":[134,290],"sample.":[135],"Across":[136],"cohort,":[138],"26":[139],"differed":[141],"between":[142],"post-":[143],"pretreatment":[145,260],"samples.":[146],"Proteins":[147],"that":[148,164],"increased":[149],"after":[150,166,244,268,317],"primarily":[153],"related":[154],"extracellular":[156],"matrix":[157],"organization":[158],"cell":[160],"adhesion,":[161],"whereas":[162],"decreased":[165,242],"associated":[169,264,285],"actin":[171],"cytoskeletal":[172],"organization,":[173],"coagulation,":[174,218],"hemostasis.":[176],"Treatment-associated":[177],"more":[180],"pronounced":[181],"group,":[185],"which":[187],"32":[188],"differentially":[191],"expressed.":[192],"was":[194,257,263,283],"characterized":[195],"coordinated":[197,312],"reductions":[198],"platelet-":[200],"coagulation-associated":[202],"proteins,":[203],"PF4,":[205],"PF4V1,":[206],"PPBP,":[207],"GP5,":[208],"ITGA2B,":[209],"ITGB3,":[211],"accompanied":[212],"platelet":[216,240,345],"activation,":[217],"hemostasis":[220],"pathways":[221],"among":[222],"down-regulated":[223],"processes.":[224],"No":[225],"individual":[226],"met":[228],"same":[230],"significance":[231],"threshold":[232],"gemcitabine":[235],"group.":[236],"composite":[238],"seven-protein":[239],"score":[241,255],"significantly":[243],"but":[246],"not":[247],"gemcitabine,":[249],"between-regimen":[252],"difference":[253],"change":[256],"significant.":[258],"Higher":[259],"ITGB1":[261,320],"longer":[266],"OS":[267,288],"multiple-testing":[269],"(HR,":[271],"0.112;":[272],"BH-FDR":[273],"=":[274,297],"0.0063).":[275],"In":[276],"multivariable":[277],"analysis,":[278],"greater":[279],"platelet-score":[281,324],"depletion":[282],"independently":[284],"shorter":[287],"(HR":[289],"unit":[291],"increase":[292],"\u0394score,":[294],"0.56;":[295],"P":[296],"0.030).":[298],"Conclusions":[299],"EV-enriched":[302],"identified":[304],"biological":[306],"PDAC,":[309],"platelet-related":[313],"predominantly":[315],"observed":[316],"FOLFIRINOX.":[318],"represent":[326],"potentially":[327],"complementary":[328],"prognostic":[329],"pharmacodynamic":[331],"markers.":[332],"These":[333],"findings":[334],"exploratory":[336],"require":[338],"validation":[339],"larger,":[341],"cohorts":[343],"incorporating":[344],"counts,":[346],"coagulation":[347],"measurements,":[348],"targeted":[350],"proteomic":[351],"assays.":[352]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
