{"id":"https://openalex.org/W7225808304","doi":"https://doi.org/10.14525/jjd.96","title":"Chronic Alcohol and Combination Antiretroviral Therapy Exacerbate Mandibular Bone Deterioration via Cytokine Dysregulation in Male Diabetic Sprague DawleyRats","display_name":"Chronic Alcohol and Combination Antiretroviral Therapy Exacerbate Mandibular Bone Deterioration via Cytokine Dysregulation in Male Diabetic Sprague DawleyRats","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225808304","doi":"https://doi.org/10.14525/jjd.96"},"language":"en","primary_location":{"id":"doi:10.14525/jjd.96","doi":"https://doi.org/10.14525/jjd.96","is_oa":true,"landing_page_url":"https://doi.org/10.14525/jjd.96","pdf_url":null,"source":{"id":"https://openalex.org/S4404677258","display_name":"Jordan journal of dentistry.","issn_l":"0258-4638","issn":["0258-4638","3007-536X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310319221","host_organization_name":"Jordan University of Science and Technology","host_organization_lineage":["https://openalex.org/P4310319221"],"host_organization_lineage_names":["Jordan University of Science and Technology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jordan Journal of dentistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.14525/jjd.96","any_repository_has_fulltext":false},"authorships":[],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.926800012588501,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.042399998754262924,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8902999758720398},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.6399999856948853},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6378999948501587},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5462999939918518},{"id":"https://openalex.org/C673006","wikidata":"https://www.wikidata.org/wiki/Q4941581","display_name":"Bone resorption","level":2,"score":0.5289999842643738},{"id":"https://openalex.org/C2779280383","wikidata":"https://www.wikidata.org/wiki/Q257331","display_name":"Streptozotocin","level":3,"score":0.4819999933242798},{"id":"https://openalex.org/C2776033226","wikidata":"https://www.wikidata.org/wiki/Q828410","display_name":"Osteoclast","level":3,"score":0.4101000130176544},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.3977000117301941},{"id":"https://openalex.org/C2777275308","wikidata":"https://www.wikidata.org/wiki/Q234668","display_name":"Cart","level":2,"score":0.39719998836517334},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.39649999141693115},{"id":"https://openalex.org/C2779624480","wikidata":"https://www.wikidata.org/wiki/Q635195","display_name":"Polydipsia","level":3,"score":0.38370001316070557},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.3790000081062317},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.3319000005722046},{"id":"https://openalex.org/C2779329777","wikidata":"https://www.wikidata.org/wiki/Q2304401","display_name":"Bone density","level":3,"score":0.30169999599456787},{"id":"https://openalex.org/C2780973866","wikidata":"https://www.wikidata.org/wiki/Q913236","display_name":"Osteocyte","level":4,"score":0.2937000095844269},{"id":"https://openalex.org/C2776919888","wikidata":"https://www.wikidata.org/wiki/Q1146112","display_name":"Haematoxylin","level":3,"score":0.28929999470710754},{"id":"https://openalex.org/C2780551157","wikidata":"https://www.wikidata.org/wiki/Q938983","display_name":"Osteomyelitis","level":2,"score":0.2816999852657318},{"id":"https://openalex.org/C2781282405","wikidata":"https://www.wikidata.org/wiki/Q2035084","display_name":"Osteolysis","level":2,"score":0.2676999866962433},{"id":"https://openalex.org/C151279780","wikidata":"https://www.wikidata.org/wiki/Q143588","display_name":"Dental alveolus","level":2,"score":0.265500009059906},{"id":"https://openalex.org/C2781184567","wikidata":"https://www.wikidata.org/wiki/Q107244","display_name":"Monocyte","level":2,"score":0.259799987077713},{"id":"https://openalex.org/C2776169692","wikidata":"https://www.wikidata.org/wiki/Q4941552","display_name":"Bone disease","level":3,"score":0.25619998574256897}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.14525/jjd.96","doi":"https://doi.org/10.14525/jjd.96","is_oa":true,"landing_page_url":"https://doi.org/10.14525/jjd.96","pdf_url":null,"source":{"id":"https://openalex.org/S4404677258","display_name":"Jordan journal of dentistry.","issn_l":"0258-4638","issn":["0258-4638","3007-536X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310319221","host_organization_name":"Jordan University of Science and Technology","host_organization_lineage":["https://openalex.org/P4310319221"],"host_organization_lineage_names":["Jordan University of Science and Technology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jordan Journal of dentistry","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.14525/jjd.96","doi":"https://doi.org/10.14525/jjd.96","is_oa":true,"landing_page_url":"https://doi.org/10.14525/jjd.96","pdf_url":null,"source":{"id":"https://openalex.org/S4404677258","display_name":"Jordan journal of dentistry.","issn_l":"0258-4638","issn":["0258-4638","3007-536X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj"],"host_organization":"https://openalex.org/P4310319221","host_organization_name":"Jordan University of Science and Technology","host_organization_lineage":["https://openalex.org/P4310319221"],"host_organization_lineage_names":["Jordan University of Science and Technology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Jordan Journal of dentistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Objectives:":[0],"Diabetes":[1,82],"mellitus":[2],"(DBT),":[3],"chronic":[4],"alcohol":[5,169],"(ALC)":[6],"consumption,":[7],"and":[8,25,41,62,73,90,105,112,115,120,124,133,139,170,181,200,205],"combination":[9],"antiretroviral":[10,214],"therapy":[11],"(cART)":[12],"can":[13],"impair":[14],"bone":[15,23,130,149,174,203,217],"turnover,":[16],"but":[17],"their":[18,146],"combined":[19,197],"effects":[20,34,195],"on":[21,202],"mandibular":[22],"cells":[24],"osteogenic":[26],"cytokines":[27],"remain":[28],"unclear.":[29],"This":[30],"study":[31],"evaluated":[32],"these":[33],"in":[35],"male":[36,45],"diabetic":[37],"Sprague-Dawley":[38],"rats.":[39],"Materials":[40],"Methods:":[42],"Fifty-eight":[43],"10-week-old":[44],"rats":[46],"were":[47],"assigned":[48],"to":[49],"ten":[50],"groups:":[51],"control,":[52],"ALC,":[53,142,199],"DBT,":[54,144,198],"cART,":[55,143],"ALC+cART,":[56],"DBT+ALC,":[57],"DBT+cART,":[58],"DBT+ALC+cART,":[59],"gelatin":[60],"(GEL),":[61],"buffered":[63],"citrate":[64],"(CB).":[65],"ALC":[66],"was":[67,83],"administered":[68],"as":[69],"10%":[70],"v/v":[71],"ethanol,":[72],"cART":[74,171,201],"at":[75],"0.023":[76],"mg/kg":[77],"daily":[78],"for":[79,126,190],"12":[80],"weeks.":[81],"induced":[84],"with":[85],"a":[86,187],"20%":[87],"fructose":[88],"diet":[89],"one":[91],"Streptozotocin":[92],"(STZ)":[93],"injection":[94],"(40":[95],"mg/kg),":[96],"then":[97],"confirmed":[98],"by":[99,168],"fasting":[100],"blood":[101],"glucose":[102],"(>250":[103],"mg/dL)":[104],"serum":[106],"insulin.":[107],"We":[108],"collected":[109],"mandibles,":[110],"fixed":[111],"decalcified":[113],"them,":[114],"assessed":[116],"them":[117],"using":[118],"haematoxylin":[119],"eosin":[121],"(H&E)":[122],"staining":[123],"immunohistochemistry":[125],"tartrate-resistant":[127],"acid":[128],"phosphatase,":[129],"morphogenetic":[131],"protein3,":[132],"transforming":[134],"growth":[135],"factor-\u03b21":[136],"(TRAP,":[137],"BMP-3,":[138],"TGF-\u03b21).":[140],"Results:":[141],"or":[145],"combinations":[147],"increased":[148,177],"marrow":[150],"adiposity.":[151],"BMP-3":[152],"inhibition":[153],"reduced":[154,179],"osteocyte":[155],"numbers":[156],"(TRAP-positive":[157],"cells)":[158],"without":[159],"significantly":[160],"changing":[161],"TGF-\u03b21":[162],"expression.":[163],"Conclusions:":[164],"Diabetic":[165],"conditions":[166],"compounded":[167],"exposure":[172],"exacerbate":[173],"deterioration":[175],"through":[176],"adipogenesis,":[178],"osteoblastogenesis,":[180],"enhanced":[182],"osteolysis.":[183],"These":[184],"findings":[185],"provide":[186],"biological":[188],"basis":[189],"further":[191],"investigating":[192],"the":[193],"oral":[194],"of":[196],"healing":[204],"implant":[206],"osseointegration.":[207],"Keywords:":[208],"Type-2":[209],"diabetes":[210],"mellitus,":[211],"Alcoholism,":[212],"Combination":[213],"therapy,":[215],"Mandibular":[216],"cells,":[218],"Cytokines,":[219],"Osteoblastogenesis,":[220],"Osteolysis":[221]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
