{"id":"https://openalex.org/W7225808149","doi":"https://doi.org/10.18413/rrpharmacology.12.1272","title":"Haloperidol for modelling osteoporosis in rats","display_name":"Haloperidol for modelling osteoporosis in rats","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225808149","doi":"https://doi.org/10.18413/rrpharmacology.12.1272"},"language":"en","primary_location":{"id":"doi:10.18413/rrpharmacology.12.1272","doi":"https://doi.org/10.18413/rrpharmacology.12.1272","is_oa":true,"landing_page_url":"https://doi.org/10.18413/rrpharmacology.12.1272","pdf_url":null,"source":{"id":"https://openalex.org/S4210169204","display_name":"Research Results in Pharmacology","issn_l":"2588-0535","issn":["2588-0535","2658-381X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310321056","host_organization_name":"Pensoft Publishers","host_organization_lineage":["https://openalex.org/P4310321056"],"host_organization_lineage_names":["Pensoft Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research Results in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.18413/rrpharmacology.12.1272","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5082626292","display_name":"Roza Yu. Ilyina","orcid":"https://orcid.org/0000-0001-8534-1282","observed_orcids":["https://orcid.org/0000-0001-8534-1282"]},"institutions":[{"id":"https://openalex.org/I4210127959","display_name":"Kazan State Medical Academy","ror":"https://ror.org/02ct1m089","country_code":"RU","type":"education","lineage":["https://openalex.org/I4210127959"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Roza Ju. Ilyina","raw_affiliation_strings":["Kazan State Medical Academy"],"raw_orcid":"https://orcid.org/0000-0001-8534-1282","affiliations":[{"raw_affiliation_string":"Kazan State Medical Academy","institution_ids":["https://openalex.org/I4210127959"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113530128","display_name":"\u041b\u0438\u043b\u0438\u044f \u0415\u0432\u0433\u0435\u043d\u044c\u0435\u0432\u043d\u0430 \u0417\u0438\u0433\u0430\u043d\u0448\u0438\u043d\u0430","orcid":"https://orcid.org/0000-0003-1999-0705","observed_orcids":["https://orcid.org/0000-0003-1999-0705"]},"institutions":[{"id":"https://openalex.org/I186356647","display_name":"Kazan State Medical University","ror":"https://ror.org/013pk4y14","country_code":"RU","type":"education","lineage":["https://openalex.org/I186356647"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Liliya E. Ziganshina","raw_affiliation_strings":["Kazan State Medical University"],"raw_orcid":"https://orcid.org/0000-0003-1999-0705","affiliations":[{"raw_affiliation_string":"Kazan State Medical University","institution_ids":["https://openalex.org/I186356647"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"12","issue":"4","first_page":"1","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.7925000190734863,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10071","display_name":"Bone health and osteoporosis research","score":0.7925000190734863,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.19099999964237213,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11221","display_name":"Bone health and treatments","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2776541429","wikidata":"https://www.wikidata.org/wiki/Q165328","display_name":"Osteoporosis","level":2,"score":0.8152999877929688},{"id":"https://openalex.org/C2780948584","wikidata":"https://www.wikidata.org/wiki/Q251347","display_name":"Haloperidol","level":3,"score":0.7741000056266785},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6068999767303467},{"id":"https://openalex.org/C2780026642","wikidata":"https://www.wikidata.org/wiki/Q40924","display_name":"Urine","level":2,"score":0.5787000060081482},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5745999813079834},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5382999777793884},{"id":"https://openalex.org/C2777397205","wikidata":"https://www.wikidata.org/wiki/Q275792","display_name":"Saline","level":2,"score":0.5012999773025513},{"id":"https://openalex.org/C2781451080","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Cortical bone","level":2,"score":0.498199999332428},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.48750001192092896},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.4860000014305115},{"id":"https://openalex.org/C10146269","wikidata":"https://www.wikidata.org/wiki/Q185557","display_name":"Excretion","level":2,"score":0.4090999960899353},{"id":"https://openalex.org/C170033053","wikidata":"https://www.wikidata.org/wiki/Q952019","display_name":"Bone remodeling","level":2,"score":0.4016999900341034},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.37619999051094055},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.3199999928474426},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30390000343322754},{"id":"https://openalex.org/C3019114686","wikidata":"https://www.wikidata.org/wiki/Q3089676","display_name":"Rat model","level":2,"score":0.290800005197525},{"id":"https://openalex.org/C2909674915","wikidata":"https://www.wikidata.org/wiki/Q1851434","display_name":"Bone histomorphometry","level":4,"score":0.27320000529289246},{"id":"https://openalex.org/C2778606738","wikidata":"https://www.wikidata.org/wiki/Q265868","display_name":"Bone tissue","level":2,"score":0.2694000005722046},{"id":"https://openalex.org/C21547065","wikidata":"https://www.wikidata.org/wiki/Q418243","display_name":"Acid phosphatase","level":3,"score":0.25690001249313354},{"id":"https://openalex.org/C2781413609","wikidata":"https://www.wikidata.org/wiki/Q7308373","display_name":"Regimen","level":2,"score":0.25589999556541443}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.18413/rrpharmacology.12.1272","doi":"https://doi.org/10.18413/rrpharmacology.12.1272","is_oa":true,"landing_page_url":"https://doi.org/10.18413/rrpharmacology.12.1272","pdf_url":null,"source":{"id":"https://openalex.org/S4210169204","display_name":"Research Results in Pharmacology","issn_l":"2588-0535","issn":["2588-0535","2658-381X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310321056","host_organization_name":"Pensoft Publishers","host_organization_lineage":["https://openalex.org/P4310321056"],"host_organization_lineage_names":["Pensoft Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research Results in Pharmacology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.18413/rrpharmacology.12.1272","doi":"https://doi.org/10.18413/rrpharmacology.12.1272","is_oa":true,"landing_page_url":"https://doi.org/10.18413/rrpharmacology.12.1272","pdf_url":null,"source":{"id":"https://openalex.org/S4210169204","display_name":"Research Results in Pharmacology","issn_l":"2588-0535","issn":["2588-0535","2658-381X"],"is_oa":true,"is_in_doaj":true,"is_core":false,"listed_in":["doaj","poland-20","russia-white-list-1"],"host_organization":"https://openalex.org/P4310321056","host_organization_name":"Pensoft Publishers","host_organization_lineage":["https://openalex.org/P4310321056"],"host_organization_lineage_names":["Pensoft Publishers"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Research Results in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Introduction:":[0],"Various":[1],"experimental":[2,72,326],"models":[3],"of":[4,24,27,37,47,97,101,145,149,155,161,168,192,223,231,243,255,266,279,305,315,338],"osteoporosis":[5,32,48,327],"are":[6],"well-known":[7],"and":[8,49,57,71,116,140,165,174,198,228,258,260,312,318,328],"presented":[9],"in":[10,20,33,54,104,127,189,204,209,211,219,240,252,263,272],"the":[11,21,25,38,83,138,146,156,159,162,166,169,190,205,212,220,229,232,241,244,253,264,273,289,298,329],"literature,":[12],"yet":[13],"we":[14,136],"did":[15],"not":[16],"find":[17],"a":[18,44,142,187,217,250],"description":[19],"available":[22],"literature":[23],"possibility":[26],"using":[28],"antipsychotics":[29],"to":[30,42,50,82,88,121,281,288,294,324,335],"induce":[31],"rats.":[34,55],"The":[35],"aim":[36],"study:":[39],"We":[40,107,182],"aimed":[41],"develop":[43],"\u201chaloperidol":[45,330],"model\u201d":[46,331],"evaluate":[51],"its":[52],"efficiency":[53],"Materials":[56],"Methods:":[58],"Wistar":[59],"rats":[60,128,282],"were":[61,129,172],"divided":[62],"into":[63],"2":[64,236,248],"groups":[65],"(20":[66],"animals":[67],"each):":[68],"control":[69,274],"(saline)":[70],"(haloperidol).":[73],"Haloperidol":[74,320],"was":[75],"administered":[76],"intraperitoneally":[77,283],"for":[78,111,119,284],"90":[79,134,285],"days":[80,286],"according":[81,287],"regimen":[84,290],"from":[85,291],"15":[86,292],"mg/kg/day":[87,90,293,296],"5":[89,295],"as":[91,268],"1":[92],"mL":[93],"per":[94],"100":[95],"mg":[96],"rat":[98],"body":[99],"weight":[100],"saline":[102],"solutions":[103],"corresponding":[105],"concentrations.":[106],"performed":[108,141],"blood":[109],"tests":[110,118],"total":[112,193],"calcium,":[113],"alkaline":[114,199],"phosphatase,":[115],"urine":[117,213],"oxyproline":[120,210],"demonstrate":[122],"that":[123,184],"bone":[124,147,299,306,316],"metabolism":[125,300],"changes":[126,301],"consistent":[130],"with":[131,270,302],"osteoporosis.":[132],"After":[133],"days,":[135],"finalized":[137],"experiment":[139],"histomorphometry":[143,311],"assessment":[144],"tissue":[148,317],"rats\u2019":[150],"vertebrae":[151],"(the":[152],"average":[153,221],"diameter":[154,222],"spongy":[157],"trabecula,":[158],"thickness":[160,230],"cortical":[163,233],"plate":[164],"area":[167,242],"intertrabecular":[170,245],"space":[171,246],"evaluated)":[173],"microelement":[175,313],"analysis":[176],"(Ca,":[177],"Sr,":[178,267],"Zn,":[179],"Cu).":[180],"Results:":[181],"found":[183],"haloperidol":[185,280],"induced":[186],"decrease":[188],"level":[191],"calcium":[194],"by":[195,201,214,225,235,247,309],"2.2":[196,226],"times":[197,203,227],"phosphatase":[200],"1.6":[202],"blood,":[206],"an":[207,238,261],"increase":[208,239,262],"1.7":[215],"times;":[216,249],"reduction":[218],"trabeculae":[224],"layer":[234],"times,":[237],"deficiency":[251],"content":[254,265],"Ca,":[256],"Zn":[257],"Cu,":[259],"compared":[269],"such":[271],"group.":[275],"Conclusion:":[276],"Prolonged":[277],"administration":[278],"causes":[297],"all":[303],"characteristics":[304],"destruction,":[307],"detected":[308],"biochemical,":[310],"analyses":[314],"blood.":[319],"could":[321,332],"be":[322,333],"used":[323,334],"model":[325],"study":[336],"potential":[337],"new":[339],"antiresorptive":[340],"agents.":[341]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}