{"id":"https://openalex.org/W7225806092","doi":"https://doi.org/10.1111/1744-7917.70391","title":"ROS\u2010dependent phosphorylation of insulin receptor and insulin receptor substrate during pupal diapause development in the cotton bollworm, Helicoverpa armigera","display_name":"ROS\u2010dependent phosphorylation of insulin receptor and insulin receptor substrate during pupal diapause development in the cotton bollworm, Helicoverpa armigera","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225806092","doi":"https://doi.org/10.1111/1744-7917.70391","pmid":"https://pubmed.ncbi.nlm.nih.gov/43012655"},"language":"en","primary_location":{"id":"doi:10.1111/1744-7917.70391","doi":"https://doi.org/10.1111/1744-7917.70391","is_oa":false,"landing_page_url":"https://doi.org/10.1111/1744-7917.70391","pdf_url":null,"source":{"id":"https://openalex.org/S77581241","display_name":"Insect Science","issn_l":"1005-295X","issn":["1005-295X","1672-9609","1744-7917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Insect Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161474430","display_name":"Zhiren Su","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiren Su","raw_affiliation_strings":["State Key Laboratory of Biocontrol, School of Life Sciences Sun Yat\u2010sen University  Guangzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biocontrol, School of Life Sciences Sun Yat\u2010sen University  Guangzhou China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161468174","display_name":"Yongpan Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183816158","display_name":"Zhaoqing University","ror":"https://ror.org/025n5kj18","country_code":"CN","type":"education","lineage":["https://openalex.org/I183816158"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongpan Yang","raw_affiliation_strings":["School of Life Science Zhaoqing University  Zhaoqing Guangdong Province China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Science Zhaoqing University  Zhaoqing Guangdong Province China","institution_ids":["https://openalex.org/I183816158"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102701815","display_name":"Yafang Ke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yafang Ke","raw_affiliation_strings":["State Key Laboratory of Biocontrol, School of Life Sciences Sun Yat\u2010sen University  Guangzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biocontrol, School of Life Sciences Sun Yat\u2010sen University  Guangzhou China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078890617","display_name":"\u885b\u83ef \u5f90","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei\u2010Hua Xu","raw_affiliation_strings":["State Key Laboratory of Biocontrol, School of Life Sciences Sun Yat\u2010sen University  Guangzhou China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biocontrol, School of Life Sciences Sun Yat\u2010sen University  Guangzhou China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101658532","display_name":"Songshan Jiang","orcid":"https://orcid.org/0000-0003-4170-5042","observed_orcids":["https://orcid.org/0000-0003-4170-5042"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Songshan Jiang","raw_affiliation_strings":["State Key Laboratory of Biocontrol, School of Life Sciences Sun Yat\u2010sen University  Guangzhou China"],"raw_orcid":"https://orcid.org/0000-0003-4170-5042","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Biocontrol, School of Life Sciences Sun Yat\u2010sen University  Guangzhou China","institution_ids":["https://openalex.org/I157773358"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101658532"],"corresponding_institution_ids":["https://openalex.org/I157773358"],"apc_list":{"value":3400,"currency":"USD","value_usd":3400},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11056","display_name":"Physiological and biochemical adaptations","score":0.6220999956130981,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11056","display_name":"Physiological and biochemical adaptations","score":0.6220999956130981,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.2847000062465668,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.02759999968111515,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C86670359","wikidata":"https://www.wikidata.org/wiki/Q913288","display_name":"Diapause","level":3,"score":0.8237000107765198},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8113999962806702},{"id":"https://openalex.org/C2776712339","wikidata":"https://www.wikidata.org/wiki/Q811652","display_name":"Helicoverpa armigera","level":3,"score":0.7885000109672546},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.6955000162124634},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.6926000118255615},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6345999836921692},{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.6219000220298767},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.609000027179718},{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.4699999988079071},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.45329999923706055},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.453000009059906},{"id":"https://openalex.org/C185967709","wikidata":"https://www.wikidata.org/wiki/Q101433828","display_name":"Insulin receptor substrate","level":5,"score":0.44780001044273376},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.4255000054836273},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.42480000853538513},{"id":"https://openalex.org/C2909831755","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Proto-Oncogene Proteins c-akt","level":4,"score":0.41339999437332153},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3508000075817108},{"id":"https://openalex.org/C175734852","wikidata":"https://www.wikidata.org/wiki/Q170595","display_name":"Pupa","level":3,"score":0.3395000100135803},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3386000096797943},{"id":"https://openalex.org/C201624660","wikidata":"https://www.wikidata.org/wiki/Q15334084","display_name":"IRS1","level":5,"score":0.32010000944137573},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2750000059604645},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.27000001072883606},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.2506999969482422}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1111/1744-7917.70391","doi":"https://doi.org/10.1111/1744-7917.70391","is_oa":false,"landing_page_url":"https://doi.org/10.1111/1744-7917.70391","pdf_url":null,"source":{"id":"https://openalex.org/S77581241","display_name":"Insect Science","issn_l":"1005-295X","issn":["1005-295X","1672-9609","1744-7917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Insect Science","raw_type":"journal-article"},{"id":"pmid:43012655","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43012655","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Insect science","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W15253933","https://openalex.org/W1521905573","https://openalex.org/W1891854262","https://openalex.org/W1964631519","https://openalex.org/W1967216770","https://openalex.org/W1970471141","https://openalex.org/W1974828435","https://openalex.org/W1974999008","https://openalex.org/W1985113364","https://openalex.org/W1998493448","https://openalex.org/W2002088854","https://openalex.org/W2010761126","https://openalex.org/W2011780145","https://openalex.org/W2032172473","https://openalex.org/W2035854501","https://openalex.org/W2040617188","https://openalex.org/W2048440052","https://openalex.org/W2049009766","https://openalex.org/W2056388945","https://openalex.org/W2056673369","https://openalex.org/W2064801081","https://openalex.org/W2072181397","https://openalex.org/W2072253613","https://openalex.org/W2084211225","https://openalex.org/W2084990986","https://openalex.org/W2091944089","https://openalex.org/W2093678284","https://openalex.org/W2103068682","https://openalex.org/W2127108219","https://openalex.org/W2132099317","https://openalex.org/W2142558537","https://openalex.org/W2143621972","https://openalex.org/W2150494200","https://openalex.org/W2339726493","https://openalex.org/W2419494499","https://openalex.org/W2471998062","https://openalex.org/W2496581186","https://openalex.org/W2525470714","https://openalex.org/W2711640537","https://openalex.org/W2735228398","https://openalex.org/W2750561835","https://openalex.org/W2923214423","https://openalex.org/W3006942461","https://openalex.org/W3007767266","https://openalex.org/W3115016325","https://openalex.org/W3164227403","https://openalex.org/W4310102538"],"related_works":[],"abstract_inverted_index":{"Insect":[0],"diapause":[1,35,53,76,186,197,211],"is":[2],"a":[3,85,179,191],"critical":[4],"adaptive":[5],"strategy":[6],"characterized":[7],"by":[8,16],"developmental":[9],"arrest":[10],"and":[11,28,45,70,92,106,118,128,149,153,199,213],"enhanced":[12],"stress":[13,29],"tolerance,":[14],"orchestrated":[15],"intricate":[17],"molecular":[18,216],"networks.":[19],"The":[20],"insulin":[21,42,46],"signaling":[22,193],"pathway,":[23],"which":[24],"governs":[25],"growth,":[26],"metabolism,":[27],"responses,":[30],"has":[31],"been":[32],"implicated":[33],"in":[34,50,58,95,111,151,154,185,202],"regulation.":[36],"However,":[37],"the":[38,59,143],"precise":[39],"roles":[40],"of":[41,88,103,142,145,182,209],"receptor":[43,47],"(InR)":[44],"substrate":[48],"(IRS)":[49],"modulating":[51],"pupal":[52,75,97],"remain":[54],"incompletely":[55],"understood,":[56],"particularly":[57],"economically":[60],"important":[61],"pest":[62],"Helicoverpa":[63,112],"armigera.":[64],"Here,":[65],"we":[66],"show":[67],"that":[68,123,135,166],"InR":[69,90],"IRS":[71,93,124],"are":[72],"associated":[73,170,195],"with":[74,100,171,196],"development":[77,198],"through":[78],"redox-sensitive":[79],"phosphorylation":[80,102,144],"cascades.":[81],"Temporal":[82],"profiling":[83],"revealed":[84,165],"marked":[86],"upregulation":[87],"phosphorylated":[89],"(p-InR)":[91],"(p-IRS)":[94],"diapause-destined":[96],"brains,":[98],"concomitant":[99],"elevated":[101],"Akt":[104,127],"(p-Akt)":[105],"ERK":[107,129,150],"(p-ERK).":[108],"Functional":[109],"validation":[110],"zea":[113],"(HzAm1)":[114],"cells,":[115],"via":[116],"overexpression":[117],"RNA":[119],"interference":[120],"(RNAi),":[121],"showed":[122],"positively":[125],"regulates":[126],"signaling.":[130],"Further":[131,163],"mechanistic":[132],"studies":[133],"indicated":[134],"reactive":[136],"oxygen":[137],"species":[138],"(ROS)":[139],"act":[140],"upstream":[141],"InR,":[146],"IRS,":[147],"Akt,":[148],"vitro":[152],"vivo;":[155],"these":[156],"effects":[157],"were":[158],"reversible":[159],"upon":[160],"ROS":[161],"scavenging.":[162],"investigations":[164],"increased":[167],"p-ERK":[168],"was":[169],"global":[172],"protein":[173],"ubiquitination,":[174],"suggesting":[175],"this":[176],"kinase":[177],"as":[178],"key":[180],"regulator":[181],"proteasomal":[183],"degradation":[184],"development.":[187],"Our":[188],"findings":[189],"delineate":[190],"ROS-InR-IRS-Akt/ERK":[192],"framework":[194],"proteostatic":[200],"regulation":[201],"H.":[203],"armigera,":[204],"thereby":[205],"advancing":[206],"our":[207],"understanding":[208],"insect":[210],"biology":[212],"providing":[214],"candidate":[215],"targets":[217],"for":[218],"future":[219],"pest-management":[220],"interventions.":[221]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
