{"id":"https://openalex.org/W7225804593","doi":"https://doi.org/10.1002/rcm.70203","title":"Identification of Geographical Chemical Markers in Neolitsea pallens Using UHPLC\u2010Q\u2010TOF\u2010MS/MS and Multivariate Analysis","display_name":"Identification of Geographical Chemical Markers in Neolitsea pallens Using UHPLC\u2010Q\u2010TOF\u2010MS/MS and Multivariate Analysis","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225804593","doi":"https://doi.org/10.1002/rcm.70203","pmid":"https://pubmed.ncbi.nlm.nih.gov/43012638"},"language":"en","primary_location":{"id":"doi:10.1002/rcm.70203","doi":"https://doi.org/10.1002/rcm.70203","is_oa":false,"landing_page_url":"https://doi.org/10.1002/rcm.70203","pdf_url":null,"source":{"id":"https://openalex.org/S89689683","display_name":"Rapid Communications in Mass Spectrometry","issn_l":"0951-4198","issn":["0951-4198","1097-0231"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rapid Communications in Mass Spectrometry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5105473242","display_name":"VK Varshney","orcid":"https://orcid.org/0009-0008-2761-9600","observed_orcids":["https://orcid.org/0009-0008-2761-9600"]},"institutions":[{"id":"https://openalex.org/I128076159","display_name":"Forest Research Institute","ror":"https://ror.org/00tqkxb21","country_code":"IN","type":"facility","lineage":["https://openalex.org/I128076159","https://openalex.org/I1286922834"]},{"id":"https://openalex.org/I1286922834","display_name":"Indian Council of Forestry Research and Education","ror":"https://ror.org/04r2bgz73","country_code":"IN","type":"government","lineage":["https://openalex.org/I1286922834"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Nisha Thakur","raw_affiliation_strings":["Chemistry and Bio\u2010prospecting Division Forest Research Institute, ICFRE\u2010Dehradun  India"],"raw_orcid":"https://orcid.org/0009-0008-2761-9600","affiliations":[{"raw_affiliation_string":"Chemistry and Bio\u2010prospecting Division Forest Research Institute, ICFRE\u2010Dehradun  India","institution_ids":["https://openalex.org/I128076159","https://openalex.org/I1286922834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007534322","display_name":"Murali Kondeboina","orcid":"https://orcid.org/0000-0001-7876-7410","observed_orcids":["https://orcid.org/0000-0001-7876-7410"]},"institutions":[{"id":"https://openalex.org/I128076159","display_name":"Forest Research Institute","ror":"https://ror.org/00tqkxb21","country_code":"IN","type":"facility","lineage":["https://openalex.org/I128076159","https://openalex.org/I1286922834"]},{"id":"https://openalex.org/I1286922834","display_name":"Indian Council of Forestry Research and Education","ror":"https://ror.org/04r2bgz73","country_code":"IN","type":"government","lineage":["https://openalex.org/I1286922834"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Kondeboina Murali","raw_affiliation_strings":["Chemistry and Bio\u2010prospecting Division Forest Research Institute, ICFRE\u2010Dehradun  India"],"raw_orcid":"https://orcid.org/0000-0001-7876-7410","affiliations":[{"raw_affiliation_string":"Chemistry and Bio\u2010prospecting Division Forest Research Institute, ICFRE\u2010Dehradun  India","institution_ids":["https://openalex.org/I128076159","https://openalex.org/I1286922834"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053310106","display_name":"Y. C. Tripathi","orcid":"https://orcid.org/0000-0003-1367-5122","observed_orcids":["https://orcid.org/0000-0003-1367-5122"]},"institutions":[{"id":"https://openalex.org/I128076159","display_name":"Forest Research Institute","ror":"https://ror.org/00tqkxb21","country_code":"IN","type":"facility","lineage":["https://openalex.org/I128076159","https://openalex.org/I1286922834"]},{"id":"https://openalex.org/I1286922834","display_name":"Indian Council of Forestry Research and Education","ror":"https://ror.org/04r2bgz73","country_code":"IN","type":"government","lineage":["https://openalex.org/I1286922834"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Yogesh Chandra Tripathi","raw_affiliation_strings":["Chemistry and Bio\u2010prospecting Division Forest Research Institute, ICFRE\u2010Dehradun  India"],"raw_orcid":"https://orcid.org/0000-0003-1367-5122","affiliations":[{"raw_affiliation_string":"Chemistry and Bio\u2010prospecting Division Forest Research Institute, ICFRE\u2010Dehradun  India","institution_ids":["https://openalex.org/I128076159","https://openalex.org/I1286922834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061554072","display_name":"Vinay Kumar Varshney","orcid":"https://orcid.org/0000-0003-3662-1063","observed_orcids":["https://orcid.org/0000-0003-3662-1063"]},"institutions":[{"id":"https://openalex.org/I128076159","display_name":"Forest Research Institute","ror":"https://ror.org/00tqkxb21","country_code":"IN","type":"facility","lineage":["https://openalex.org/I128076159","https://openalex.org/I1286922834"]},{"id":"https://openalex.org/I1286922834","display_name":"Indian Council of Forestry Research and Education","ror":"https://ror.org/04r2bgz73","country_code":"IN","type":"government","lineage":["https://openalex.org/I1286922834"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Vinay Kumar Varshney","raw_affiliation_strings":["Chemistry and Bio\u2010prospecting Division Forest Research Institute, ICFRE\u2010Dehradun  India"],"raw_orcid":"https://orcid.org/0000-0003-3662-1063","affiliations":[{"raw_affiliation_string":"Chemistry and Bio\u2010prospecting Division Forest Research Institute, ICFRE\u2010Dehradun  India","institution_ids":["https://openalex.org/I128076159","https://openalex.org/I1286922834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5061554072"],"corresponding_institution_ids":["https://openalex.org/I128076159","https://openalex.org/I1286922834"],"apc_list":{"value":4840,"currency":"USD","value_usd":4840},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"41","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.5835000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.5835000276565552,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11709","display_name":"Traditional Chinese Medicine Analysis","score":0.19480000436306,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11613","display_name":"Phytochemistry and Biological Activities","score":0.03629999980330467,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C21565614","wikidata":"https://www.wikidata.org/wiki/Q12149006","display_name":"Metabolomics","level":2,"score":0.8324000239372253},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.6628000140190125},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6572999954223633},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5065000057220459},{"id":"https://openalex.org/C135870905","wikidata":"https://www.wikidata.org/wiki/Q903667","display_name":"Metabolome","level":3,"score":0.4878999888896942},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.4334000051021576},{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.4081000089645386},{"id":"https://openalex.org/C92835128","wikidata":"https://www.wikidata.org/wiki/Q1277447","display_name":"Hierarchical clustering","level":3,"score":0.4036000072956085},{"id":"https://openalex.org/C31827203","wikidata":"https://www.wikidata.org/wiki/Q874296","display_name":"Tandem mass spectrometry","level":3,"score":0.3889999985694885},{"id":"https://openalex.org/C2777477808","wikidata":"https://www.wikidata.org/wiki/Q407595","display_name":"Metabolite","level":2,"score":0.38600000739097595},{"id":"https://openalex.org/C162356407","wikidata":"https://www.wikidata.org/wiki/Q180809","display_name":"Mass spectrometry","level":2,"score":0.33469998836517334},{"id":"https://openalex.org/C151304367","wikidata":"https://www.wikidata.org/wiki/Q910067","display_name":"Chemometrics","level":2,"score":0.3197999894618988},{"id":"https://openalex.org/C64489805","wikidata":"https://www.wikidata.org/wiki/Q873864","display_name":"Liquid chromatography\u2013mass spectrometry","level":3,"score":0.3027999997138977},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28540000319480896},{"id":"https://openalex.org/C2776441662","wikidata":"https://www.wikidata.org/wiki/Q2823314","display_name":"Tricarboxylic acid","level":4,"score":0.2709999978542328},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.2632000148296356},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2623000144958496},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.2621000111103058}],"mesh":[{"descriptor_ui":"D000097922","descriptor_name":"Liquid Chromatography-Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015999","descriptor_name":"Multivariate Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018515","descriptor_name":"Plant Leaves","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018515","descriptor_name":"Plant Leaves","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D025341","descriptor_name":"Principal Component Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053719","descriptor_name":"Tandem Mass Spectrometry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D055442","descriptor_name":"Metabolome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/rcm.70203","doi":"https://doi.org/10.1002/rcm.70203","is_oa":false,"landing_page_url":"https://doi.org/10.1002/rcm.70203","pdf_url":null,"source":{"id":"https://openalex.org/S89689683","display_name":"Rapid Communications in Mass Spectrometry","issn_l":"0951-4198","issn":["0951-4198","1097-0231"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rapid Communications in Mass Spectrometry","raw_type":"journal-article"},{"id":"pmid:43012638","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43012638","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Rapid communications in mass spectrometry : RCM","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1562179743","https://openalex.org/W1968430975","https://openalex.org/W1998881190","https://openalex.org/W2019429489","https://openalex.org/W2031825920","https://openalex.org/W2039807203","https://openalex.org/W2041874267","https://openalex.org/W2055072891","https://openalex.org/W2066172476","https://openalex.org/W2085914326","https://openalex.org/W2106857639","https://openalex.org/W2121833999","https://openalex.org/W2141786835","https://openalex.org/W2143283561","https://openalex.org/W2148032599","https://openalex.org/W2151144822","https://openalex.org/W2152875701","https://openalex.org/W2328125159","https://openalex.org/W2619860499","https://openalex.org/W3095291331","https://openalex.org/W3108864475","https://openalex.org/W3141693773","https://openalex.org/W3181660183","https://openalex.org/W3214190594","https://openalex.org/W4211254291","https://openalex.org/W4323313289","https://openalex.org/W4392911915","https://openalex.org/W4393527849","https://openalex.org/W4405627932","https://openalex.org/W4409290393","https://openalex.org/W4411669863","https://openalex.org/W4412633253","https://openalex.org/W4416371458"],"related_works":[],"abstract_inverted_index":{"RATIONALE:":[0],"Comprehensive":[1],"characterization":[2],"of":[3,21,47,130,144,154,246],"plant":[4,263,288],"metabolomes":[5,264],"is":[6],"essential":[7],"for":[8,260,277],"understanding":[9],"phytochemical":[10,279],"diversity":[11],"and":[12,36,99,119,132,160,168,197,214,225,253,265,283],"identifying":[13,266],"location-specific":[14],"metabolic":[15,203,228,237,269,281],"signatures.":[16],"However,":[17],"the":[18,44,110,141,145,152,207],"high":[19],"complexity":[20],"untargeted":[22,58,247],"metabolomics":[23,60],"datasets":[24],"requires":[25],"robust":[26,258],"analytical":[27],"workflows":[28],"that":[29,175,185],"integrate":[30],"high-resolution":[31],"mass":[32,84,97],"spectrometry":[33,85],"with":[34,80,166,191,195,240],"chemometric":[35,251],"pathway-based":[37],"analyses.":[38],"This":[39,271],"study":[40],"aimed":[41],"to":[42,108,124,139],"characterize":[43],"metabolomic":[45],"landscape":[46],"Neolitsea":[48],"pallens":[49,179],"leaves":[50],"collected":[51,65],"from":[52,66],"diverse":[53,158],"Himalayan":[54,70],"locations":[55],"using":[56,74,95],"an":[57],"UHPLC-QTOF-MS/MS":[59,149,248],"approach.":[61],"METHODS:":[62],"Leaf":[63],"samples":[64],"13":[67],"geographically":[68],"distinct":[69],"populations":[71],"were":[72,93,188],"analyzed":[73],"ultra-high":[75],"performance":[76],"liquid":[77],"chromatography":[78],"coupled":[79],"quadrupole":[81],"time-of-flight":[82],"tandem":[83],"(UHPLC-QTOF-MS/MS)":[86],"in":[87,286],"negative":[88],"electrospray":[89],"ionization":[90],"mode.":[91],"Metabolites":[92],"annotated":[94],"accurate":[96],"measurements":[98],"MS/MS":[100],"fragmentation":[101],"patterns.":[102],"Frequency-based":[103,163],"feature":[104],"filtering":[105,164],"was":[106,137],"applied":[107],"refine":[109],"metabolite":[111],"dataset,":[112],"followed":[113],"by":[114],"principal":[115],"component":[116],"analysis":[117,122,150,183],"(PCA)":[118],"hierarchical":[120],"clustering":[121],"(HCA)":[123],"identify":[125],"discriminant":[126,172],"metabolites.":[127,162],"Kyoto":[128],"Encyclopedia":[129],"Genes":[131],"Genomes":[133],"(KEGG)-based":[134],"pathway":[135,182],"mapping":[136],"performed":[138],"investigate":[140],"biological":[142],"significance":[143],"selected":[146],"biomarkers.":[147,270],"RESULTS:":[148],"enabled":[151],"annotation":[153],"56":[155],"metabolites":[156,174,234],"encompassing":[157],"primary":[159],"secondary":[161],"combined":[165],"PCA":[167],"HCA":[169],"identified":[170],"10":[171],"biomarker":[173,284],"effectively":[176],"differentiated":[177],"N.":[178],"populations.":[180],"KEGG":[181],"revealed":[184],"these":[186],"biomarkers":[187],"predominantly":[189],"associated":[190,239],"central":[192],"carbon":[193],"metabolism,":[194],"propanoate":[196],"butanoate":[198],"metabolism":[199],"serving":[200],"as":[201],"key":[202],"hubs":[204],"linking":[205],"glycolysis,":[206],"tricarboxylic":[208],"acid":[209,212,216],"cycle,":[210],"amino":[211],"degradation,":[213],"fatty":[215],"metabolism.":[217],"Conserved":[218],"metabolites,":[219],"including":[220],"citric":[221],"acid,":[222,224],"succinic":[223],"\u03b2-alanine,":[226],"reflected":[227],"stability":[229],"across":[230],"populations,":[231],"whereas":[232],"low-frequency":[233],"represented":[235],"adaptive":[236],"variation":[238],"geographical":[241],"diversity.":[242],"CONCLUSION:":[243],"The":[244],"integration":[245],"metabolomics,":[249],"multivariate":[250],"analysis,":[252],"pathway-level":[254],"interpretation":[255],"provides":[256],"a":[257,274],"strategy":[259],"resolving":[261],"complex":[262],"biologically":[267],"relevant":[268],"workflow":[272],"offers":[273],"comprehensive":[275],"framework":[276],"investigating":[278],"diversity,":[280],"adaptation,":[282],"discovery":[285],"medicinal":[287],"species.":[289]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}