{"id":"https://openalex.org/W7225804196","doi":"https://doi.org/10.1002/adhm.71963","title":"Engineered Milk\u2010Derived Extracellular Vesicles Integrate PCSK9 Silencing and Inflammation Modulation for Hyperlipidemia Therapy","display_name":"Engineered Milk\u2010Derived Extracellular Vesicles Integrate PCSK9 Silencing and Inflammation Modulation for Hyperlipidemia Therapy","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225804196","doi":"https://doi.org/10.1002/adhm.71963","pmid":"https://pubmed.ncbi.nlm.nih.gov/43012445"},"language":"en","primary_location":{"id":"doi:10.1002/adhm.71963","doi":"https://doi.org/10.1002/adhm.71963","is_oa":false,"landing_page_url":"https://doi.org/10.1002/adhm.71963","pdf_url":null,"source":{"id":"https://openalex.org/S2500736452","display_name":"Advanced Healthcare Materials","issn_l":"2192-2640","issn":["2192-2640","2192-2659"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Healthcare Materials","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5152860034","display_name":"Qinyu Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]},{"id":"https://openalex.org/I4391767758","display_name":"State Key Laboratory of Drug Research","ror":"https://ror.org/058t7w767","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qinyu Li","raw_affiliation_strings":["School of Chinese Materia Medica Nanjing University of Chinese Medicine  Nanjing China","State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chinese Materia Medica Nanjing University of Chinese Medicine  Nanjing China","institution_ids":["https://openalex.org/I131434179"]},{"raw_affiliation_string":"State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101978328","display_name":"Xiang L\u00fc","orcid":"https://orcid.org/0000-0002-8671-5554","observed_orcids":["https://orcid.org/0000-0002-8671-5554"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]},{"id":"https://openalex.org/I4391767758","display_name":"State Key Laboratory of Drug Research","ror":"https://ror.org/058t7w767","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang Lu","raw_affiliation_strings":["School of Chinese Materia Medica Nanjing University of Chinese Medicine  Nanjing China","State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China"],"raw_orcid":"https://orcid.org/0009-0002-8384-6126","affiliations":[{"raw_affiliation_string":"School of Chinese Materia Medica Nanjing University of Chinese Medicine  Nanjing China","institution_ids":["https://openalex.org/I131434179"]},{"raw_affiliation_string":"State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161472181","display_name":"Qing Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I141649914","display_name":"Nanchang University","ror":"https://ror.org/042v6xz23","country_code":"CN","type":"education","lineage":["https://openalex.org/I141649914"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]},{"id":"https://openalex.org/I4391767758","display_name":"State Key Laboratory of Drug Research","ror":"https://ror.org/058t7w767","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qing Liu","raw_affiliation_strings":["Department of Pharmacy Medical College of Nanchang University  Nanchang China","State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy Medical College of Nanchang University  Nanchang China","institution_ids":["https://openalex.org/I141649914"]},{"raw_affiliation_string":"State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161494732","display_name":"Hongyu Liu","orcid":"https://orcid.org/0009-0002-9127-7074","observed_orcids":["https://orcid.org/0009-0002-9127-7074"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]},{"id":"https://openalex.org/I4391767758","display_name":"State Key Laboratory of Drug Research","ror":"https://ror.org/058t7w767","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongyu Liu","raw_affiliation_strings":["School of Chinese Materia Medica Nanjing University of Chinese Medicine  Nanjing China","State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China"],"raw_orcid":"https://orcid.org/0009-0002-9127-7074","affiliations":[{"raw_affiliation_string":"School of Chinese Materia Medica Nanjing University of Chinese Medicine  Nanjing China","institution_ids":["https://openalex.org/I131434179"]},{"raw_affiliation_string":"State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113067436","display_name":"Yangyuan Ye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]},{"id":"https://openalex.org/I4391767758","display_name":"State Key Laboratory of Drug Research","ror":"https://ror.org/058t7w767","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yangyuan Ye","raw_affiliation_strings":["School of Chinese Materia Medica Nanjing University of Chinese Medicine  Nanjing China","State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chinese Materia Medica Nanjing University of Chinese Medicine  Nanjing China","institution_ids":["https://openalex.org/I131434179"]},{"raw_affiliation_string":"State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101685835","display_name":"Ye Cui","orcid":"https://orcid.org/0000-0001-9428-1429","observed_orcids":["https://orcid.org/0000-0001-9428-1429"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4391767758","display_name":"State Key Laboratory of Drug Research","ror":"https://ror.org/058t7w767","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ye Cui","raw_affiliation_strings":["State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China","University of Chinese Academy of Sciences  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences  Beijing China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161428592","display_name":"Chang Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4391767758","display_name":"State Key Laboratory of Drug Research","ror":"https://ror.org/058t7w767","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chang Liu","raw_affiliation_strings":["State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China","University of Chinese Academy of Sciences  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences  Beijing China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5153611522","display_name":"Gulixian Aili","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4391767758","display_name":"State Key Laboratory of Drug Research","ror":"https://ror.org/058t7w767","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gulixian Aili","raw_affiliation_strings":["State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China","University of Chinese Academy of Sciences  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences  Beijing China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161422045","display_name":"Yi Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]},{"id":"https://openalex.org/I4391767758","display_name":"State Key Laboratory of Drug Research","ror":"https://ror.org/058t7w767","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Liu","raw_affiliation_strings":["School of Chinese Materia Medica Nanjing University of Chinese Medicine  Nanjing China","State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chinese Materia Medica Nanjing University of Chinese Medicine  Nanjing China","institution_ids":["https://openalex.org/I131434179"]},{"raw_affiliation_string":"State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042235039","display_name":"Hao Feng","orcid":"https://orcid.org/0000-0003-4066-8104","observed_orcids":["https://orcid.org/0000-0003-4066-8104"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]},{"id":"https://openalex.org/I4391767758","display_name":"State Key Laboratory of Drug Research","ror":"https://ror.org/058t7w767","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Feng","raw_affiliation_strings":["School of Chinese Materia Medica Nanjing University of Chinese Medicine  Nanjing China","State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chinese Materia Medica Nanjing University of Chinese Medicine  Nanjing China","institution_ids":["https://openalex.org/I131434179"]},{"raw_affiliation_string":"State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5152787242","display_name":"Anqi Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4391767758","display_name":"State Key Laboratory of Drug Research","ror":"https://ror.org/058t7w767","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Anqi Xu","raw_affiliation_strings":["State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China","University of Chinese Academy of Sciences  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences  Beijing China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161492156","display_name":"Li Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]},{"id":"https://openalex.org/I4391767758","display_name":"State Key Laboratory of Drug Research","ror":"https://ror.org/058t7w767","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Liang","raw_affiliation_strings":["School of Chinese Materia Medica Nanjing University of Chinese Medicine  Nanjing China","State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Chinese Materia Medica Nanjing University of Chinese Medicine  Nanjing China","institution_ids":["https://openalex.org/I131434179"]},{"raw_affiliation_string":"State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069851034","display_name":"Miaorong Yu","orcid":"https://orcid.org/0000-0002-0474-5339","observed_orcids":["https://orcid.org/0000-0002-0474-5339"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4391767758","display_name":"State Key Laboratory of Drug Research","ror":"https://ror.org/058t7w767","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Miaorong Yu","raw_affiliation_strings":["State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China","University of Chinese Academy of Sciences  Beijing China"],"raw_orcid":"https://orcid.org/0000-0002-0474-5339","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences  Beijing China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025180836","display_name":"Di Nie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4391767758","display_name":"State Key Laboratory of Drug Research","ror":"https://ror.org/058t7w767","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Di Nie","raw_affiliation_strings":["State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China","University of Chinese Academy of Sciences  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences  Beijing China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050475714","display_name":"Yong Gan","orcid":"https://orcid.org/0000-0002-4579-994X","observed_orcids":["https://orcid.org/0000-0002-4579-994X"]},"institutions":[{"id":"https://openalex.org/I131434179","display_name":"Nanjing University of Chinese Medicine","ror":"https://ror.org/04523zj19","country_code":"CN","type":"education","lineage":["https://openalex.org/I131434179"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I223893228","display_name":"National Medical Products Administration","ror":"https://ror.org/002k3wk88","country_code":"CN","type":"government","lineage":["https://openalex.org/I223893228","https://openalex.org/I4405258220"]},{"id":"https://openalex.org/I4210112820","display_name":"Shanghai Institute of Materia Medica","ror":"https://ror.org/022syn853","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820"]},{"id":"https://openalex.org/I4210136676","display_name":"National Institutes for Food and Drug Control","ror":"https://ror.org/041rdq190","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210136676"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I4391767758","display_name":"State Key Laboratory of Drug Research","ror":"https://ror.org/058t7w767","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yong Gan","raw_affiliation_strings":["NMPA Key Laboratory For Quality Research and Evaluation of Pharmaceutical Excipients National Institutes for Food and Drug Control  Beijing China","School of Chinese Materia Medica Nanjing University of Chinese Medicine  Nanjing China","State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China","University of Chinese Academy of Sciences  Beijing China"],"raw_orcid":"https://orcid.org/0000-0002-4579-994X","affiliations":[{"raw_affiliation_string":"NMPA Key Laboratory For Quality Research and Evaluation of Pharmaceutical Excipients National Institutes for Food and Drug Control  Beijing China","institution_ids":["https://openalex.org/I223893228","https://openalex.org/I4210136676"]},{"raw_affiliation_string":"School of Chinese Materia Medica Nanjing University of Chinese Medicine  Nanjing China","institution_ids":["https://openalex.org/I131434179"]},{"raw_affiliation_string":"State Key Laboratory of Drug Research & Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210112820","https://openalex.org/I4391767758"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences  Beijing China","institution_ids":["https://openalex.org/I4210165038"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5025180836","https://openalex.org/A5050475714"],"corresponding_institution_ids":["https://openalex.org/I131434179","https://openalex.org/I19820366","https://openalex.org/I223893228","https://openalex.org/I4210112820","https://openalex.org/I4210136676","https://openalex.org/I4210165038","https://openalex.org/I4391767758"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.5268999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.5268999934196472,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.4490000009536743,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.01510000042617321,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2780948078","wikidata":"https://www.wikidata.org/wiki/Q21130010","display_name":"PCSK9","level":5,"score":0.7760999798774719},{"id":"https://openalex.org/C102747710","wikidata":"https://www.wikidata.org/wiki/Q824237","display_name":"Endosome","level":3,"score":0.7235000133514404},{"id":"https://openalex.org/C2779091943","wikidata":"https://www.wikidata.org/wiki/Q1079120","display_name":"Hyperlipidemia","level":3,"score":0.6403999924659729},{"id":"https://openalex.org/C119056186","wikidata":"https://www.wikidata.org/wiki/Q1431332","display_name":"Gene silencing","level":3,"score":0.6327999830245972},{"id":"https://openalex.org/C79747257","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytic cycle","level":4,"score":0.5864999890327454},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5260000228881836},{"id":"https://openalex.org/C18150654","wikidata":"https://www.wikidata.org/wiki/Q17153796","display_name":"Nanocarriers","level":3,"score":0.515999972820282},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4991999864578247},{"id":"https://openalex.org/C2778824825","wikidata":"https://www.wikidata.org/wiki/Q7250439","display_name":"Proprotein convertase","level":5,"score":0.4814000129699707},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4713999927043915},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.45750001072883606},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.43720000982284546},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.4140999913215637},{"id":"https://openalex.org/C25938499","wikidata":"https://www.wikidata.org/wiki/Q7663812","display_name":"Systemic administration","level":3,"score":0.3871999979019165},{"id":"https://openalex.org/C62746215","wikidata":"https://www.wikidata.org/wiki/Q14890615","display_name":"Apolipoprotein B","level":3,"score":0.3666999936103821},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.34040001034736633},{"id":"https://openalex.org/C43554185","wikidata":"https://www.wikidata.org/wiki/Q425649","display_name":"LDL receptor","level":4,"score":0.3221000134944916},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.32199999690055847},{"id":"https://openalex.org/C28005876","wikidata":"https://www.wikidata.org/wiki/Q189814","display_name":"Endocytosis","level":3,"score":0.3138999938964844},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.3102000057697296},{"id":"https://openalex.org/C2908627167","wikidata":"https://www.wikidata.org/wiki/Q7250439","display_name":"Proprotein Convertases","level":5,"score":0.3066999912261963},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2831000089645386},{"id":"https://openalex.org/C2776252253","wikidata":"https://www.wikidata.org/wiki/Q7663815","display_name":"Systemic inflammation","level":3,"score":0.2800999879837036},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27950000762939453},{"id":"https://openalex.org/C64863464","wikidata":"https://www.wikidata.org/wiki/Q3190616","display_name":"Juxtacrine signalling","level":4,"score":0.27630001306533813},{"id":"https://openalex.org/C2778849439","wikidata":"https://www.wikidata.org/wiki/Q6397985","display_name":"Kexin","level":5,"score":0.27549999952316284},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.2750000059604645},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2694000005722046},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.2500999867916107}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1002/adhm.71963","doi":"https://doi.org/10.1002/adhm.71963","is_oa":false,"landing_page_url":"https://doi.org/10.1002/adhm.71963","pdf_url":null,"source":{"id":"https://openalex.org/S2500736452","display_name":"Advanced Healthcare Materials","issn_l":"2192-2640","issn":["2192-2640","2192-2659"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced Healthcare Materials","raw_type":"journal-article"},{"id":"pmid:43012445","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43012445","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Advanced healthcare materials","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1483024467","https://openalex.org/W1926076964","https://openalex.org/W2015790286","https://openalex.org/W2054472394","https://openalex.org/W2103764669","https://openalex.org/W2155239981","https://openalex.org/W2288512038","https://openalex.org/W2605610684","https://openalex.org/W2765769920","https://openalex.org/W2782685575","https://openalex.org/W2795137969","https://openalex.org/W2911290113","https://openalex.org/W2914770902","https://openalex.org/W2955889508","https://openalex.org/W2975259971","https://openalex.org/W3007154337","https://openalex.org/W3022639545","https://openalex.org/W3035222954","https://openalex.org/W3046619106","https://openalex.org/W3183532060","https://openalex.org/W3188940990","https://openalex.org/W3215724670","https://openalex.org/W3216299442","https://openalex.org/W3217355073","https://openalex.org/W4200094286","https://openalex.org/W4210840666","https://openalex.org/W4220671681","https://openalex.org/W4308679511","https://openalex.org/W4313554841","https://openalex.org/W4323306903","https://openalex.org/W4380992275","https://openalex.org/W4384924850","https://openalex.org/W4386863589","https://openalex.org/W4389608707","https://openalex.org/W4389849095","https://openalex.org/W4390012023","https://openalex.org/W4391882866","https://openalex.org/W4392367035","https://openalex.org/W4393314184","https://openalex.org/W4396805516","https://openalex.org/W4399774939","https://openalex.org/W4399889576","https://openalex.org/W4401899591","https://openalex.org/W4402356257","https://openalex.org/W4402619355","https://openalex.org/W4403104998","https://openalex.org/W4403679654","https://openalex.org/W4404723298","https://openalex.org/W4405187423","https://openalex.org/W4405398259","https://openalex.org/W4405532758","https://openalex.org/W4406757111","https://openalex.org/W4407227047","https://openalex.org/W4407803685","https://openalex.org/W4412493515"],"related_works":[],"abstract_inverted_index":{"Hyperlipidemia":[0],"is":[1],"a":[2,37,129,165,177],"systemic":[3,148,161],"metabolic":[4],"disorder":[5],"closely":[6],"associated":[7],"with":[8,88,122],"chronic":[9],"inflammation.":[10,23],"Effective":[11],"management":[12],"requires":[13],"integrated":[14],"strategies":[15],"that":[16,73],"simultaneously":[17],"lower":[18],"lipid":[19,61,155,158],"level":[20],"and":[21,142,160,163,194],"attenuate":[22],"Nucleic":[24],"acid":[25,180],"therapeutics,":[26],"such":[27,59],"as":[28,60,69],"proprotein":[29],"convertase":[30],"subtilisin/kexin":[31],"type":[32],"9":[33],"(PCSK9)":[34],"siRNA,":[35,124],"represent":[36],"breakthrough":[38],"in":[39,80],"lipid-lowering":[40,193],"therapy.":[41],"However,":[42,82],"they":[43],"either":[44],"lack":[45],"direct":[46],"anti-inflammatory":[47,71,195],"effects":[48],"(GalNAc-siRNA)":[49],"or":[50],"are":[51],"prone":[52],"to":[53,115],"triggering":[54],"unintended":[55],"inflammatory":[56],"responses":[57],"themselves":[58],"nanoparticles":[62],"(LNPs).":[63],"Milk-derived":[64],"extracellular":[65],"vesicles":[66],"(MDEs)":[67],"emerge":[68],"naturally":[70],"nanocarriers":[72],"suppress":[74],"key":[75],"pro-inflammatory":[76],"cytokines":[77],"by":[78,106],"30.0%-96.5%":[79],"vitro.":[81],"MDEs":[83,105,127,141,152,186],"predominantly":[84],"undergo":[85],"endocytic":[86],"trafficking":[87],"substantial":[89],"endosomal/lysosomal":[90],"sequestration,":[91],"which":[92],"can":[93],"limit":[94],"productive":[95],"cytosolic":[96],"siRNA":[97],"delivery.":[98],"To":[99],"address":[100],"this,":[101],"we":[102],"developed":[103],"engineered":[104,126,151,185],"incorporating":[107],"30.0%":[108],"(w/w)":[109],"probiotic-derived":[110],"glycolipids":[111],"into":[112],"their":[113],"membranes":[114],"facilitate":[116],"early":[117],"endosomal":[118],"escape.":[119],"When":[120],"loaded":[121],"PCSK9":[123],"the":[125,170],"achieved":[128],"remarkable":[130],"silencing":[131],"efficiency":[132],"of":[133,150],"90.2":[134],"\u00b1":[135],"0.2%,":[136],"significantly":[137],"outperforming":[138],"both":[139],"unmodified":[140],"conventional":[143],"LNPs.":[144],"In":[145],"hyperlipidemic":[146],"mice,":[147],"administration":[149],"improved":[153],"serum":[154],"profiles,":[156],"reduced":[157],"accumulation":[159],"inflammation,":[162],"showed":[164],"favorable":[166],"safety":[167],"profile":[168],"under":[169],"conditions":[171],"examined.":[172],"Collectively,":[173],"this":[174],"work":[175],"provides":[176],"promising":[178],"nucleic":[179],"delivery":[181],"platform":[182],"based":[183],"on":[184],"for":[187],"enhanced":[188],"hyperlipidemia":[189],"therapy":[190],"through":[191],"simultaneous":[192],"effects.":[196]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}