{"id":"https://openalex.org/W7225803877","doi":"https://doi.org/10.3389/fnut.2026.1955585","title":"Association of the CALLY index with malnutrition risk in patients with nasopharyngeal carcinoma: a cross-sectional study","display_name":"Association of the CALLY index with malnutrition risk in patients with nasopharyngeal carcinoma: a cross-sectional study","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225803877","doi":"https://doi.org/10.3389/fnut.2026.1955585"},"language":"en","primary_location":{"id":"doi:10.3389/fnut.2026.1955585","doi":"https://doi.org/10.3389/fnut.2026.1955585","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnut.2026.1955585","pdf_url":"https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2026.1955585/pdf","source":{"id":"https://openalex.org/S2596909297","display_name":"Frontiers in Nutrition","issn_l":"2296-861X","issn":["2296-861X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Nutrition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2026.1955585/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5148554349","display_name":"Meixiang Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]},{"id":"https://openalex.org/I4210087327","display_name":"First Affiliated Hospital of Xiamen University","ror":"https://ror.org/0006swh35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087327"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meixiang Huang","raw_affiliation_strings":["Department of Radiation Oncology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4210087327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137550163","display_name":"Xiaoyan Huang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]},{"id":"https://openalex.org/I4210087327","display_name":"First Affiliated Hospital of Xiamen University","ror":"https://ror.org/0006swh35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087327"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyan Huang","raw_affiliation_strings":["Department of Radiation Oncology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4210087327"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087426410","display_name":"Wenzhen Deng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]},{"id":"https://openalex.org/I4210087327","display_name":"First Affiliated Hospital of Xiamen University","ror":"https://ror.org/0006swh35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087327"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wenzhen Deng","raw_affiliation_strings":["Department of Radiation Oncology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4210087327"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5148533728","display_name":"Yajuan Du","orcid":"https://orcid.org/0009-0007-9403-367X","observed_orcids":["https://orcid.org/0009-0007-9403-367X"]},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]},{"id":"https://openalex.org/I4210087327","display_name":"First Affiliated Hospital of Xiamen University","ror":"https://ror.org/0006swh35","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087327"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yajuan Du","raw_affiliation_strings":["Department of Radiation Oncology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiation Oncology, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University","institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4210087327"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5087426410","https://openalex.org/A5148533728"],"corresponding_institution_ids":["https://openalex.org/I191208505","https://openalex.org/I4210087327"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.524399995803833,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.524399995803833,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11355","display_name":"Inflammatory Biomarkers in Disease Prognosis","score":0.2705000042915344,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.17759999632835388,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7839999794960022},{"id":"https://openalex.org/C551997983","wikidata":"https://www.wikidata.org/wiki/Q12167","display_name":"Malnutrition","level":2,"score":0.7551000118255615},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.7354000210762024},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6614000201225281},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.5206000208854675},{"id":"https://openalex.org/C143095724","wikidata":"https://www.wikidata.org/wiki/Q515895","display_name":"Odds","level":3,"score":0.4875999987125397},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45649999380111694},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.36579999327659607},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.3594000041484833},{"id":"https://openalex.org/C2778997737","wikidata":"https://www.wikidata.org/wiki/Q1693598","display_name":"Nasopharyngeal carcinoma","level":3,"score":0.3564999997615814},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.33889999985694885},{"id":"https://openalex.org/C61427482","wikidata":"https://www.wikidata.org/wiki/Q6656244","display_name":"Anthropometry","level":2,"score":0.3361000120639801},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.31279999017715454},{"id":"https://openalex.org/C81182388","wikidata":"https://www.wikidata.org/wiki/Q353963","display_name":"Complication","level":2,"score":0.30320000648498535},{"id":"https://openalex.org/C5274069","wikidata":"https://www.wikidata.org/wiki/Q2285707","display_name":"Categorical variable","level":2,"score":0.29350000619888306},{"id":"https://openalex.org/C2777382242","wikidata":"https://www.wikidata.org/wiki/Q6017816","display_name":"Index (typography)","level":2,"score":0.2915000021457672},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.2874999940395355},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.28679999709129333},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.2867000102996826},{"id":"https://openalex.org/C152877465","wikidata":"https://www.wikidata.org/wiki/Q208042","display_name":"Regression analysis","level":2,"score":0.28380000591278076},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.28349998593330383},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.27570000290870667},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.2711000144481659},{"id":"https://openalex.org/C74545648","wikidata":"https://www.wikidata.org/wiki/Q212794","display_name":"Inflection point","level":2,"score":0.2671999931335449},{"id":"https://openalex.org/C87227347","wikidata":"https://www.wikidata.org/wiki/Q7100713","display_name":"Ordered logit","level":2,"score":0.2653999924659729},{"id":"https://openalex.org/C48921125","wikidata":"https://www.wikidata.org/wiki/Q10861030","display_name":"Linear regression","level":2,"score":0.26350000500679016},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2628999948501587},{"id":"https://openalex.org/C117312493","wikidata":"https://www.wikidata.org/wiki/Q2035437","display_name":"Multivariable calculus","level":2,"score":0.2590999901294708},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.2563000023365021},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.2549000084400177},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.2547999918460846},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2542000114917755},{"id":"https://openalex.org/C2992261824","wikidata":"https://www.wikidata.org/wiki/Q1693598","display_name":"Nasopharyngeal cancer","level":4,"score":0.2517000138759613},{"id":"https://openalex.org/C2779543058","wikidata":"https://www.wikidata.org/wiki/Q4200712","display_name":"Mass index","level":3,"score":0.2502000033855438}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fnut.2026.1955585","doi":"https://doi.org/10.3389/fnut.2026.1955585","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnut.2026.1955585","pdf_url":"https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2026.1955585/pdf","source":{"id":"https://openalex.org/S2596909297","display_name":"Frontiers in Nutrition","issn_l":"2296-861X","issn":["2296-861X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Nutrition","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fnut.2026.1955585","doi":"https://doi.org/10.3389/fnut.2026.1955585","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnut.2026.1955585","pdf_url":"https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2026.1955585/pdf","source":{"id":"https://openalex.org/S2596909297","display_name":"Frontiers in Nutrition","issn_l":"2296-861X","issn":["2296-861X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Nutrition","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225803877.pdf","grobid_xml":"https://content.openalex.org/works/W7225803877.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W2952439359","https://openalex.org/W3173877793","https://openalex.org/W3181217153","https://openalex.org/W4211017340","https://openalex.org/W4214653616","https://openalex.org/W4294116629","https://openalex.org/W4317814995","https://openalex.org/W4361272976","https://openalex.org/W4377291403","https://openalex.org/W4378470665","https://openalex.org/W4385186811","https://openalex.org/W4386254857","https://openalex.org/W4398240634","https://openalex.org/W4401194165","https://openalex.org/W4403556671","https://openalex.org/W4405079918","https://openalex.org/W4409843695","https://openalex.org/W4410795846","https://openalex.org/W4412109402","https://openalex.org/W4412520537","https://openalex.org/W4413942804","https://openalex.org/W4414168635","https://openalex.org/W4415618069","https://openalex.org/W4415767164","https://openalex.org/W4417280321","https://openalex.org/W4417483574","https://openalex.org/W7123338494","https://openalex.org/W7129099796","https://openalex.org/W7130516346"],"related_works":[],"abstract_inverted_index":{"Background":[0],"Malnutrition":[1,68,107],"is":[2,265],"a":[3,124,140,152,255,276,296],"prevalent":[4],"complication":[5],"in":[6,29,44,118,202,272],"nasopharyngeal":[7],"carcinoma":[8],"(NPC)":[9],"patients,":[10,274],"yet":[11],"simple":[12],"screening":[13],"tools":[14],"are":[15,306],"lacking.":[16],"The":[17,262,290],"CALLY":[18,40,119,263,291],"index,":[19],"integrating":[20],"CRP,":[21],"albumin,":[22],"and":[23,42,65,81,213,250,267],"lymphocytes,":[24],"has":[25],"not":[26,176],"been":[27],"evaluated":[28],"this":[30,159],"population.":[31],"We":[32],"aimed":[33],"to":[34,87,98,210],"investigate":[35],"the":[36,39,56,89,100,103,161,173,199,244],"association":[37,174],"between":[38,63],"index":[41,120,264,292],"malnutrition":[43,129,271],"NPC":[45,53,273],"patients.":[46],"Methods":[47],"This":[48,282],"cross-sectional":[49],"study":[50],"enrolled":[51],"148":[52],"patients":[54],"at":[55,154,280],"First":[57],"Affiliated":[58],"Hospital":[59],"of":[60,102,128,252,259],"Xiamen":[61],"University":[62],"June":[64],"December":[66],"2025.":[67],"was":[69,96,109,121,156,163,175,248],"defined":[70],"as":[71,295],"PG-SGA":[72],"\u2265":[73],"4.":[74],"Multivariable":[75],"logistic":[76],"regression,":[77],"restricted":[78],"cubic":[79],"spline,":[80],"two-piecewise":[82],"regression":[83],"models":[84],"were":[85,207],"used":[86],"evaluate":[88],"association.":[90],"Bootstrap":[91,240],"internal":[92],"validation":[93,241,286],"(2,000":[94],"resamples)":[95],"performed":[97],"assess":[99],"stability":[101],"identified":[104,254],"threshold.":[105],"Results":[106],"prevalence":[108],"44.6%":[110],"(66/148).":[111],"After":[112],"multivariable":[113],"adjustment,":[114],"each":[115],"1-unit":[116],"increase":[117],"associated":[122,269],"with":[123,139,151,198,217,270,275],"18%":[125],"lower":[126],"odds":[127],"(OR":[130,179],"=":[131,137,169,180,186,221,227,231,237],"0.82,":[132],"95%":[133,182,223,233],"CI:":[134,166,183,224,234],"0.73\u20130.92,":[135],"p":[136,145,168,185,226,236],"0.001),":[138],"significant":[141,178],"dose\u2013response":[142],"trend":[143],"(":[144],"<":[146],"0.001).":[147],"A":[148],"non-linear":[149],"relationship":[150],"threshold":[153,256,279,283],"3.147":[155],"identified:":[157],"below":[158],"value,":[160],"OR":[162,220,230],"0.215":[164],"(95%":[165],"0.086\u20130.538,":[167],"0.001);":[170],"above":[171],"it,":[172],"statistically":[177],"1.01,":[181],"0.65\u20131.57,":[184],"0.970).":[187],"Sensitivity":[188],"analyses":[189],"excluding":[190],"BMI":[191],"or":[192],"prior":[193],"therapy":[194],"yielded":[195],"results":[196],"consistent":[197],"primary":[200],"analysis":[201],"direction,":[203],"but":[204,303],"categorical":[205],"estimates":[206],"unstable":[208],"due":[209],"sparse":[211],"events":[212],"should":[214],"be":[215],"interpreted":[216],"caution":[218],"(adjusted":[219],"0.81,":[222],"0.71\u20130.93,":[225],"0.003;":[228],"adjusted":[229],"0.44,":[232],"0.24\u20130.82,":[235],"0.009,":[238],"respectively).":[239],"showed":[242],"that":[243],"median":[245],"inflection":[246],"point":[247],"3.130,":[249],"91.9%":[251],"resamples":[253],"within":[257],"\u00b10.5":[258],"3.147.":[260,281],"Conclusion":[261],"independently":[266],"inversely":[268],"potential":[277,297],"exploratory":[278],"requires":[284],"external":[285],"before":[287],"clinical":[288],"application.":[289],"may":[293],"serve":[294],"biomarker":[298],"for":[299],"nutritional":[300],"risk":[301],"stratification,":[302],"further":[304],"studies":[305],"needed.":[307]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}