{"id":"https://openalex.org/W7225803629","doi":"https://doi.org/10.3390/md24110404","title":"Targeted Protein Translation Suppression in the Dinoflagellate, Prorocentrum lima, Using Cell-Penetrating Peptides","display_name":"Targeted Protein Translation Suppression in the Dinoflagellate, Prorocentrum lima, Using Cell-Penetrating Peptides","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225803629","doi":"https://doi.org/10.3390/md24110404"},"language":"en","primary_location":{"id":"doi:10.3390/md24110404","doi":"https://doi.org/10.3390/md24110404","is_oa":true,"landing_page_url":"https://doi.org/10.3390/md24110404","pdf_url":null,"source":{"id":"https://openalex.org/S146563757","display_name":"Marine Drugs","issn_l":"1660-3397","issn":["1660-3397"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine Drugs","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/md24110404","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161447724","display_name":"Qisya M. Amirul","orcid":"https://orcid.org/0000-0001-8421-5399","observed_orcids":["https://orcid.org/0000-0001-8421-5399"]},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Qisya M. Amirul","raw_affiliation_strings":["Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Naka-cho, Koganei-shi 184-8588, Tokyo, Japan"],"raw_orcid":"https://orcid.org/0000-0001-8421-5399","affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Naka-cho, Koganei-shi 184-8588, Tokyo, Japan","institution_ids":["https://openalex.org/I92614990"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161427352","display_name":"Moka Tsunoda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Moka Tsunoda","raw_affiliation_strings":["Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Naka-cho, Koganei-shi 184-8588, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Naka-cho, Koganei-shi 184-8588, Tokyo, Japan","institution_ids":["https://openalex.org/I92614990"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010483530","display_name":"Tetsushi Mori","orcid":"https://orcid.org/0000-0001-7096-4161","observed_orcids":["https://orcid.org/0000-0001-7096-4161"]},"institutions":[{"id":"https://openalex.org/I92614990","display_name":"Tokyo University of Agriculture and Technology","ror":"https://ror.org/00qg0kr10","country_code":"JP","type":"education","lineage":["https://openalex.org/I92614990"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tetsushi Mori","raw_affiliation_strings":["Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Naka-cho, Koganei-shi 184-8588, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Naka-cho, Koganei-shi 184-8588, Tokyo, Japan","institution_ids":["https://openalex.org/I92614990"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5010483530"],"corresponding_institution_ids":["https://openalex.org/I92614990"],"apc_list":{"value":2900,"currency":"CHF","value_usd":3499},"apc_paid":{"value":2900,"currency":"CHF","value_usd":3499},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"24","issue":"11","first_page":"404","last_page":"404"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.9071999788284302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11985","display_name":"Marine Toxins and Detection Methods","score":0.06679999828338623,"subfield":{"id":"https://openalex.org/subfields/2304","display_name":"Environmental Chemistry"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.7720000147819519},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.7318000197410583},{"id":"https://openalex.org/C2776953658","wikidata":"https://www.wikidata.org/wiki/Q414042","display_name":"Okadaic acid","level":4,"score":0.5343000292778015},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48820000886917114},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4848000109195709},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.45719999074935913},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43630000948905945},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.39329999685287476},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.3797999918460846},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.37549999356269836},{"id":"https://openalex.org/C178666793","wikidata":"https://www.wikidata.org/wiki/Q422476","display_name":"Phosphatase","level":3,"score":0.3499999940395355},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3488999903202057},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.3246999979019165},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.320499986410141},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.3084999918937683},{"id":"https://openalex.org/C57581600","wikidata":"https://www.wikidata.org/wiki/Q2449730","display_name":"Transport protein","level":2,"score":0.2930000126361847},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.29269999265670776},{"id":"https://openalex.org/C98539663","wikidata":"https://www.wikidata.org/wiki/Q220599","display_name":"Cytosol","level":3,"score":0.274399995803833},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.27140000462532043},{"id":"https://openalex.org/C2777343594","wikidata":"https://www.wikidata.org/wiki/Q412152","display_name":"Peptide nucleic acid","level":3,"score":0.2676999866962433},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.2653999924659729}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3390/md24110404","doi":"https://doi.org/10.3390/md24110404","is_oa":true,"landing_page_url":"https://doi.org/10.3390/md24110404","pdf_url":null,"source":{"id":"https://openalex.org/S146563757","display_name":"Marine Drugs","issn_l":"1660-3397","issn":["1660-3397"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine Drugs","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3390/md24110404","doi":"https://doi.org/10.3390/md24110404","is_oa":true,"landing_page_url":"https://doi.org/10.3390/md24110404","pdf_url":null,"source":{"id":"https://openalex.org/S146563757","display_name":"Marine Drugs","issn_l":"1660-3397","issn":["1660-3397"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Marine Drugs","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":34,"referenced_works":["https://openalex.org/W27039284","https://openalex.org/W1984523024","https://openalex.org/W2004035920","https://openalex.org/W2021862171","https://openalex.org/W2104564418","https://openalex.org/W2110258322","https://openalex.org/W2122268077","https://openalex.org/W2134786208","https://openalex.org/W2162442646","https://openalex.org/W2170188719","https://openalex.org/W2170856052","https://openalex.org/W2584579518","https://openalex.org/W2775877335","https://openalex.org/W2795705353","https://openalex.org/W2883127924","https://openalex.org/W2895955401","https://openalex.org/W2902202170","https://openalex.org/W2942848503","https://openalex.org/W2978224857","https://openalex.org/W3015829343","https://openalex.org/W3112308706","https://openalex.org/W3137794311","https://openalex.org/W4211061702","https://openalex.org/W4281769345","https://openalex.org/W4283014301","https://openalex.org/W4312210112","https://openalex.org/W4392879264","https://openalex.org/W4404058470","https://openalex.org/W4409015143","https://openalex.org/W4414723314","https://openalex.org/W4416763956","https://openalex.org/W7117304938","https://openalex.org/W7117959247","https://openalex.org/W7162315948"],"related_works":[],"abstract_inverted_index":{"Dinoflagellates":[0],"remain":[1],"among":[2],"the":[3,20,53,109,121,177,188],"most":[4],"challenging":[5],"eukaryotic":[6],"systems":[7],"for":[8,24,46,67,123,201],"functional":[9,207],"molecular":[10],"studies":[11],"due":[12],"to":[13,32,79],"their":[14],"complex":[15],"genetic":[16],"architecture,":[17],"which":[18],"limits":[19],"availability":[21],"of":[22,129,140,190],"tools":[23],"targeted":[25,47],"translational":[26,48,192],"regulation.":[27],"This":[28],"study":[29],"therefore":[30],"aimed":[31],"evaluate":[33],"whether":[34],"cell-penetrating":[35],"peptide\u2013conjugated":[36],"peptide":[37],"nucleic":[38],"acids":[39],"(CPP-PNAs)":[40],"could":[41],"provide":[42,198],"an":[43],"alternative":[44],"approach":[45],"regulation":[49,193],"in":[50,151,194,209],"dinoflagellates,":[51],"using":[52,70,101],"okadaic":[54],"acid":[55],"(OA)-producing":[56],"Prorocentrum":[57],"lima":[58,196],"as":[59,120,205],"a":[60,102,199,206],"model":[61],"species.":[62],"Fluorescence-labeled":[63],"CPPs":[64,110],"were":[65,77,99],"screened":[66],"intracellular":[68,96,115,152],"delivery":[69,116],"fluorescence":[71],"and":[72,75,92,95,117,182,197],"confocal":[73],"microscopy,":[74],"CPP-PNAs":[76],"designed":[78],"target":[80],"three":[81,142],"ATP-binding":[82],"cassette":[83],"(ABC)":[84],"transporters":[85,143],"associated":[86],"with":[87,156],"OA":[88,97,153,166],"export:":[89],"ABCB1,":[90,130],"ABCG2,":[91,131],"ABCC1.":[93],"Extracellular":[94,165],"levels":[98,171],"quantified":[100],"protein":[103],"phosphatase":[104],"inhibition":[105],"assay":[106],"(PPIA).":[107],"Among":[108],"screened,":[111],"(DabFF)4Dab-K-FAM":[112],"showed":[113],"effective":[114],"was":[118,154,180],"selected":[119],"scaffold":[122],"PNA":[124],"conjugation.":[125],"Whereas":[126],"individual":[127],"targeting":[128,139],"or":[132],"ABCC1":[133],"produced":[134],"only":[135],"limited":[136],"effects,":[137],"simultaneous":[138],"all":[141],"significantly":[144],"reduced":[145,157,162],"extracellular":[146],"OA.":[147],"The":[148],"accompanying":[149],"increase":[150],"consistent":[155],"toxin":[158,163],"release":[159],"rather":[160],"than":[161],"production.":[164],"subsequently":[167],"recovered":[168],"toward":[169],"control":[170],"by":[172],"day":[173],"10,":[174],"indicating":[175],"that":[176],"CPP-PNA-mediated":[178,191],"effect":[179],"transient":[181],"reversible.":[183],"Together,":[184],"these":[185],"findings":[186],"establish":[187],"feasibility":[189],"P.":[195],"basis":[200],"exploring":[202],"its":[203],"application":[204],"tool":[208],"other":[210],"dinoflagellates.":[211]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
