{"id":"https://openalex.org/W7225803055","doi":"https://doi.org/10.1186/s12951-026-05249-6","title":"Sphinganine (d17:0)-enriched outer membrane vesicles from Parabacteroides goldsteinii alleviate obesity via modulating mitochondrial dynamics","display_name":"Sphinganine (d17:0)-enriched outer membrane vesicles from Parabacteroides goldsteinii alleviate obesity via modulating mitochondrial dynamics","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225803055","doi":"https://doi.org/10.1186/s12951-026-05249-6"},"language":"en","primary_location":{"id":"doi:10.1186/s12951-026-05249-6","doi":"https://doi.org/10.1186/s12951-026-05249-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12951-026-05249-6","pdf_url":null,"source":{"id":"https://openalex.org/S41231013","display_name":"Journal of Nanobiotechnology","issn_l":"1477-3155","issn":["1477-3155"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nanobiotechnology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12951-026-05249-6","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161425879","display_name":"Guowen Lv","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guowen Lv","raw_affiliation_strings":["College of Life Sciences, Northwest A&F University, Yangling, 712100, Shaanxi, China","School of Pharmaceutical Sciences, Sun Yat-sen University Shenzhen Campus, Shenzhen, 518107, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences, Northwest A&F University, Yangling, 712100, Shaanxi, China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"School of Pharmaceutical Sciences, Sun Yat-sen University Shenzhen Campus, Shenzhen, 518107, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109326972","display_name":"Huixing Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huixing Wu","raw_affiliation_strings":["School of Pharmaceutical Sciences, Sun Yat-sen University Shenzhen Campus, Shenzhen, 518107, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Sun Yat-sen University Shenzhen Campus, Shenzhen, 518107, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101598779","display_name":"Dandan Su","orcid":"https://orcid.org/0000-0003-4549-2339","observed_orcids":["https://orcid.org/0000-0003-4549-2339"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dandan Su","raw_affiliation_strings":["School of Pharmaceutical Sciences, Sun Yat-sen University Shenzhen Campus, Shenzhen, 518107, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Sun Yat-sen University Shenzhen Campus, Shenzhen, 518107, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161451765","display_name":"Yuedong Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuedong Xie","raw_affiliation_strings":["School of Pharmaceutical Sciences, Sun Yat-sen University Shenzhen Campus, Shenzhen, 518107, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Sun Yat-sen University Shenzhen Campus, Shenzhen, 518107, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020117442","display_name":"Liqian Su","orcid":"https://orcid.org/0009-0002-4123-0649","observed_orcids":["https://orcid.org/0009-0002-4123-0649"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210152664","display_name":"Shenzhen Children's Hospital","ror":"https://ror.org/0409k5a27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152664"]},{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liqian Su","raw_affiliation_strings":["College of Life Sciences, Northwest A&F University, Yangling, 712100, Shaanxi, China","International Medical Center, Endoscopy Center and Gastroenterology Department Shenzhen Children\u2019s Hospital, Shenzhen, 518036, China","School of Pharmaceutical Sciences, Sun Yat-sen University Shenzhen Campus, Shenzhen, 518107, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences, Northwest A&F University, Yangling, 712100, Shaanxi, China","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"International Medical Center, Endoscopy Center and Gastroenterology Department Shenzhen Children\u2019s Hospital, Shenzhen, 518036, China","institution_ids":["https://openalex.org/I4210152664"]},{"raw_affiliation_string":"School of Pharmaceutical Sciences, Sun Yat-sen University Shenzhen Campus, Shenzhen, 518107, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053577332","display_name":"Yuhang Han","orcid":"https://orcid.org/0000-0002-1546-6925","observed_orcids":["https://orcid.org/0000-0002-1546-6925"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuhang Han","raw_affiliation_strings":["School of Pharmaceutical Sciences, Sun Yat-sen University Shenzhen Campus, Shenzhen, 518107, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Sun Yat-sen University Shenzhen Campus, Shenzhen, 518107, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077438329","display_name":"Fan Shen","orcid":"https://orcid.org/0000-0002-8284-6629","observed_orcids":["https://orcid.org/0000-0002-8284-6629"]},"institutions":[{"id":"https://openalex.org/I101479585","display_name":"South China Agricultural University","ror":"https://ror.org/05v9jqt67","country_code":"CN","type":"education","lineage":["https://openalex.org/I101479585"]},{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fan Shen","raw_affiliation_strings":["Guangzhou Dublin International College of Life Sciences and Technology, South China Agricultural University, Guangzhou, 510000, China","School of Pharmaceutical Sciences, Sun Yat-sen University Shenzhen Campus, Shenzhen, 518107, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou Dublin International College of Life Sciences and Technology, South China Agricultural University, Guangzhou, 510000, China","institution_ids":["https://openalex.org/I101479585"]},{"raw_affiliation_string":"School of Pharmaceutical Sciences, Sun Yat-sen University Shenzhen Campus, Shenzhen, 518107, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161493639","display_name":"Donglin Dai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210152664","display_name":"Shenzhen Children's Hospital","ror":"https://ror.org/0409k5a27","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210152664"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Donglin Dai","raw_affiliation_strings":["International Medical Center, Endoscopy Center and Gastroenterology Department Shenzhen Children\u2019s Hospital, Shenzhen, 518036, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Medical Center, Endoscopy Center and Gastroenterology Department Shenzhen Children\u2019s Hospital, Shenzhen, 518036, China","institution_ids":["https://openalex.org/I4210152664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075488814","display_name":"Xu Quanle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Quanle Xu","raw_affiliation_strings":["College of Life Sciences, Northwest A&F University, Yangling, 712100, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences, Northwest A&F University, Yangling, 712100, Shaanxi, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5136202877","display_name":"Hongbo Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hongbo Chen","raw_affiliation_strings":["School of Pharmaceutical Sciences, Sun Yat-sen University Shenzhen Campus, Shenzhen, 518107, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Sun Yat-sen University Shenzhen Campus, Shenzhen, 518107, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5013847668","display_name":"Fang Cheng","orcid":"https://orcid.org/0000-0002-8260-9244","observed_orcids":["https://orcid.org/0000-0002-8260-9244"]},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fang Cheng","raw_affiliation_strings":["School of Pharmaceutical Sciences, Sun Yat-sen University Shenzhen Campus, Shenzhen, 518107, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmaceutical Sciences, Sun Yat-sen University Shenzhen Campus, Shenzhen, 518107, China","institution_ids":["https://openalex.org/I157773358"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5013847668","https://openalex.org/A5075488814","https://openalex.org/A5136202877"],"corresponding_institution_ids":["https://openalex.org/I157773358","https://openalex.org/I89652312"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":{"value":3790,"currency":"USD","value_usd":3790},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9448000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9448000192642212,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.01769999973475933,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10528","display_name":"Adipokines, Inflammation, and Metabolic Diseases","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5837000012397766},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5142999887466431},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.49480000138282776},{"id":"https://openalex.org/C75385678","wikidata":"https://www.wikidata.org/wiki/Q4896390","display_name":"Inner mitochondrial membrane","level":3,"score":0.4927999973297119},{"id":"https://openalex.org/C17619807","wikidata":"https://www.wikidata.org/wiki/Q6881852","display_name":"Mitochondrial fission","level":3,"score":0.49070000648498535},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.46790000796318054},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.4327999949455261},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.40369999408721924},{"id":"https://openalex.org/C163950672","wikidata":"https://www.wikidata.org/wiki/Q14905375","display_name":"mitochondrial fusion","level":4,"score":0.3280999958515167},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.30329999327659607},{"id":"https://openalex.org/C146587185","wikidata":"https://www.wikidata.org/wiki/Q258248","display_name":"Bacterial outer membrane","level":4,"score":0.2971999943256378},{"id":"https://openalex.org/C57600042","wikidata":"https://www.wikidata.org/wiki/Q227564","display_name":"Oxidative phosphorylation","level":2,"score":0.27649998664855957},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2750000059604645},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.273499995470047},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.25690001249313354}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s12951-026-05249-6","doi":"https://doi.org/10.1186/s12951-026-05249-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12951-026-05249-6","pdf_url":null,"source":{"id":"https://openalex.org/S41231013","display_name":"Journal of Nanobiotechnology","issn_l":"1477-3155","issn":["1477-3155"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nanobiotechnology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s12951-026-05249-6","doi":"https://doi.org/10.1186/s12951-026-05249-6","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12951-026-05249-6","pdf_url":null,"source":{"id":"https://openalex.org/S41231013","display_name":"Journal of Nanobiotechnology","issn_l":"1477-3155","issn":["1477-3155"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nanobiotechnology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Obesity,":[0],"a":[1,142,182,207],"global":[2],"crisis":[3],"linking":[4],"metabolic":[5,46,120,137,171,204],"syndrome":[6],"and":[7,59,80,89,91,114,122,138,170,195,202,214],"inflammation,":[8,90,205],"remains":[9],"inadequately":[10],"addressed.":[11],"In":[12,109],"this":[13],"study,":[14],"we":[15,101,179],"found":[16],"that":[17,43,129],"outer":[18,153],"membrane":[19,154],"vesicles":[20,134,155],"derived":[21],"from":[22],"Parabacteroides":[23,150],"goldsteinii":[24,151],"(PGOMV)":[25],"were":[26],"more":[27],"effective":[28],"than":[29],"live":[30],"or":[31],"pasteurized":[32],"bacteria":[33],"in":[34],"alleviating":[35,86,168],"high\u2011fat":[36],"diet":[37],"(HFD)\u2011induced":[38],"obesity.":[39],"Multi-omics":[40],"analysis":[41],"indicates":[42],"PGOMV":[44],"regulates":[45],"homeostasis":[47],"by":[48,60],"modulating":[49,61],"the":[50,62,75,93,185],"levels":[51],"of":[52,111],"key":[53,66],"metabolites":[54],"such":[55,162],"as":[56,163],"3-hydroxybutyric":[57],"acid":[58],"gut":[63],"microbiota.":[64],"Its":[65,188],"bioactive":[67],"component,":[68],"sphinganine":[69,164],"(d17:0,":[70,165],"SA),":[71,166],"directly":[72,191],"binds":[73,192],"to":[74,193],"mitochondrial":[76,200],"fission":[77,201],"proteins":[78],"DRP1":[79,194],"MFF,":[81,196],"inhibiting":[82],"excessive":[83],"fission,":[84],"thereby":[85,197],"oxidative":[87],"stress":[88],"disrupting":[92],"lipid\u2013inflammation\u2013oxidative":[94],"damage":[95],"vicious":[96],"cycle.":[97],"Based":[98],"on":[99],"this,":[100],"engineered":[102,180],"an":[103],"orally":[104],"deliverable":[105],"SA\u2011enriched":[106],"system,":[107],"PGOMV@SA.":[108],"models":[110],"HFD-induced":[112],"obesity":[113,169,213],"obesity-comorbid":[115],"psoriasis,":[116],"PGOMV@SA":[117],"simultaneously":[118],"ameliorated":[119],"disorders":[121],"inflammatory":[123,148,216],"skin":[124],"lesions.":[125],"This":[126],"study":[127],"demonstrates":[128],"SA":[130],"delivered":[131],"via":[132],"bacterial":[133],"exhibits":[135],"dual":[136],"immunomodulatory":[139],"functions,":[140],"providing":[141,206],"novel":[143,208],"nanotherapeutic":[144,183],"strategy":[145,211],"for":[146,212],"obesity\u2011associated":[147],"diseases.":[149,217],"-derived":[152],"(PGOMVs)":[156],"are":[157],"enriched":[158],"with":[159],"active":[160],"components":[161],"effectively":[167],"inflammation.":[172],"To":[173],"further":[174],"enhance":[175],"its":[176],"therapeutic":[177],"efficacy,":[178],"PGOMV@SA,":[181],"targeting":[184],"gut\u2013liver":[186],"axis.":[187],"cargo,":[189],"SA,":[190],"blocking":[198],"pathological":[199],"mitigating":[203],"microbiome-inspired":[209],"intervention":[210],"related":[215]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}