{"id":"https://openalex.org/W7225803028","doi":"https://doi.org/10.3389/fvets.2026.2003879","title":"Melatonin promotes the proliferation of dermal papilla cells in cashmere goats through the chi-miR-1388-3p/PDGFA axis","display_name":"Melatonin promotes the proliferation of dermal papilla cells in cashmere goats through the chi-miR-1388-3p/PDGFA axis","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225803028","doi":"https://doi.org/10.3389/fvets.2026.2003879"},"language":"en","primary_location":{"id":"doi:10.3389/fvets.2026.2003879","doi":"https://doi.org/10.3389/fvets.2026.2003879","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2026.2003879","pdf_url":"https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2026.2003879/pdf","source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2026.2003879/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160370580","display_name":"Xiangfei Kong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I120379545","display_name":"Inner Mongolia Agricultural University","ror":"https://ror.org/015d0jq83","country_code":"CN","type":"education","lineage":["https://openalex.org/I120379545"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiangfei Kong","raw_affiliation_strings":["Inner Mongolia Key Laboratory of Sheep & Goat Genetics Breeding and Reproduction, College of Animal Science, Inner Mongolia Agricultural University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inner Mongolia Key Laboratory of Sheep & Goat Genetics Breeding and Reproduction, College of Animal Science, Inner Mongolia Agricultural University","institution_ids":["https://openalex.org/I120379545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160618315","display_name":"Jingya Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jingya Wang","raw_affiliation_strings":["Academy of Agricultural and Animal Husbandry Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Agricultural and Animal Husbandry Sciences","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159809366","display_name":"Yanjun Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I120379545","display_name":"Inner Mongolia Agricultural University","ror":"https://ror.org/015d0jq83","country_code":"CN","type":"education","lineage":["https://openalex.org/I120379545"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanjun Zhang","raw_affiliation_strings":["Inner Mongolia Key Laboratory of Sheep & Goat Genetics Breeding and Reproduction, College of Animal Science, Inner Mongolia Agricultural University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inner Mongolia Key Laboratory of Sheep & Goat Genetics Breeding and Reproduction, College of Animal Science, Inner Mongolia Agricultural University","institution_ids":["https://openalex.org/I120379545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137144423","display_name":"Jiaxin Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I120379545","display_name":"Inner Mongolia Agricultural University","ror":"https://ror.org/015d0jq83","country_code":"CN","type":"education","lineage":["https://openalex.org/I120379545"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaxin Zhang","raw_affiliation_strings":["Inner Mongolia Key Laboratory of Sheep & Goat Genetics Breeding and Reproduction, College of Animal Science, Inner Mongolia Agricultural University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inner Mongolia Key Laboratory of Sheep & Goat Genetics Breeding and Reproduction, College of Animal Science, Inner Mongolia Agricultural University","institution_ids":["https://openalex.org/I120379545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026003867","display_name":"Rui Su","orcid":"https://orcid.org/0000-0001-8386-7408","observed_orcids":["https://orcid.org/0000-0001-8386-7408"]},"institutions":[{"id":"https://openalex.org/I120379545","display_name":"Inner Mongolia Agricultural University","ror":"https://ror.org/015d0jq83","country_code":"CN","type":"education","lineage":["https://openalex.org/I120379545"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Su","raw_affiliation_strings":["Inner Mongolia Key Laboratory of Sheep & Goat Genetics Breeding and Reproduction, College of Animal Science, Inner Mongolia Agricultural University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inner Mongolia Key Laboratory of Sheep & Goat Genetics Breeding and Reproduction, College of Animal Science, Inner Mongolia Agricultural University","institution_ids":["https://openalex.org/I120379545"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5151942894","display_name":"Junyang Liu","orcid":"https://orcid.org/0000-0001-7303-9297","observed_orcids":["https://orcid.org/0000-0001-7303-9297"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Junyang Liu","raw_affiliation_strings":["Academy of Agricultural and Animal Husbandry Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Academy of Agricultural and Animal Husbandry Sciences","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056948182","display_name":"Ruijun Wang","orcid":"https://orcid.org/0000-0003-3477-1105","observed_orcids":["https://orcid.org/0000-0003-3477-1105"]},"institutions":[{"id":"https://openalex.org/I120379545","display_name":"Inner Mongolia Agricultural University","ror":"https://ror.org/015d0jq83","country_code":"CN","type":"education","lineage":["https://openalex.org/I120379545"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ruijun Wang","raw_affiliation_strings":["Inner Mongolia Key Laboratory of Sheep & Goat Genetics Breeding and Reproduction, College of Animal Science, Inner Mongolia Agricultural University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Inner Mongolia Key Laboratory of Sheep & Goat Genetics Breeding and Reproduction, College of Animal Science, Inner Mongolia Agricultural University","institution_ids":["https://openalex.org/I120379545"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5056948182","https://openalex.org/A5151942894"],"corresponding_institution_ids":["https://openalex.org/I120379545"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"13","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2780668125","wikidata":"https://www.wikidata.org/wiki/Q1734883","display_name":"Cashmere goat","level":3,"score":0.9049999713897705},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6730999946594238},{"id":"https://openalex.org/C2777216303","wikidata":"https://www.wikidata.org/wiki/Q866324","display_name":"Hair follicle","level":2,"score":0.6664999723434448},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6310999989509583},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.557699978351593},{"id":"https://openalex.org/C2781085983","wikidata":"https://www.wikidata.org/wiki/Q505531","display_name":"Dermal papillae","level":3,"score":0.5575000047683716},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5533999800682068},{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.510200023651123},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4950000047683716},{"id":"https://openalex.org/C2776637008","wikidata":"https://www.wikidata.org/wiki/Q14860072","display_name":"Sonic hedgehog","level":3,"score":0.4059000015258789},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.3928000032901764},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.36500000953674316},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.364300012588501},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35120001435279846},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3375000059604645},{"id":"https://openalex.org/C22667442","wikidata":"https://www.wikidata.org/wiki/Q3272830","display_name":"Three prime untranslated region","level":5,"score":0.33719998598098755},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.32989999651908875},{"id":"https://openalex.org/C88634738","wikidata":"https://www.wikidata.org/wiki/Q24769543","display_name":"Annexin","level":3,"score":0.31150001287460327},{"id":"https://openalex.org/C89604277","wikidata":"https://www.wikidata.org/wiki/Q424345","display_name":"Untranslated region","level":4,"score":0.3086000084877014},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.30709999799728394},{"id":"https://openalex.org/C48023723","wikidata":"https://www.wikidata.org/wiki/Q856198","display_name":"Real-time polymerase chain reaction","level":3,"score":0.3005000054836273},{"id":"https://openalex.org/C53227056","wikidata":"https://www.wikidata.org/wiki/Q189152","display_name":"Viability assay","level":3,"score":0.28380000591278076},{"id":"https://openalex.org/C66008609","wikidata":"https://www.wikidata.org/wiki/Q14866113","display_name":"Fas ligand","level":4,"score":0.260699987411499},{"id":"https://openalex.org/C88498014","wikidata":"https://www.wikidata.org/wiki/Q14859918","display_name":"Hedgehog signaling pathway","level":3,"score":0.25999999046325684},{"id":"https://openalex.org/C102570824","wikidata":"https://www.wikidata.org/wiki/Q147807","display_name":"Follicle","level":2,"score":0.25589999556541443},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.25360000133514404}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fvets.2026.2003879","doi":"https://doi.org/10.3389/fvets.2026.2003879","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2026.2003879","pdf_url":"https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2026.2003879/pdf","source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fvets.2026.2003879","doi":"https://doi.org/10.3389/fvets.2026.2003879","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fvets.2026.2003879","pdf_url":"https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2026.2003879/pdf","source":{"id":"https://openalex.org/S2594976040","display_name":"Frontiers in Veterinary Science","issn_l":"2297-1769","issn":["2297-1769"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Veterinary Science","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225803028.pdf","grobid_xml":"https://content.openalex.org/works/W7225803028.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1812152564","https://openalex.org/W1857157447","https://openalex.org/W1994248200","https://openalex.org/W2000354005","https://openalex.org/W2012557678","https://openalex.org/W2013760937","https://openalex.org/W2018449783","https://openalex.org/W2045305474","https://openalex.org/W2050585818","https://openalex.org/W2063070366","https://openalex.org/W2076365042","https://openalex.org/W2105549148","https://openalex.org/W2117391818","https://openalex.org/W2132596222","https://openalex.org/W2156108044","https://openalex.org/W2883357866","https://openalex.org/W3121970193","https://openalex.org/W3180201866","https://openalex.org/W3198715869","https://openalex.org/W4220803019","https://openalex.org/W4297999954","https://openalex.org/W4308973276","https://openalex.org/W4312078745","https://openalex.org/W4362677629","https://openalex.org/W4394689174","https://openalex.org/W4398218833","https://openalex.org/W4400919434","https://openalex.org/W4404565527"],"related_works":[],"abstract_inverted_index":{"Background/objectives":[0],"Melatonin":[1],"(MT)":[2],"promotes":[3,210],"secondary":[4],"hair":[5,310],"follicle":[6,311],"development":[7],"and":[8,46,68,78,119,131,138,148,156,188,212,238,277,293,313],"cashmere":[9,12,36,108,327],"growth":[10,312],"in":[11,28,102,273,319],"goats;":[13],"however,":[14],"the":[15,33,48,65,79,170,180,190,206,214,232,245,249,259,266,289,294],"underlying":[16],"molecular":[17],"mechanisms":[18],"remain":[19],"incompletely":[20],"understood.":[21],"This":[22,300],"study":[23,301],"investigated":[24],"whether":[25],"MT-associated":[26],"changes":[27,272],"chi-miR-1388-3p":[29,61,77,101,209,228],"are":[30],"related":[31],"to":[32,96,197,217,325],"regulation":[34],"of":[35,50,60,143,173,182,208,227,235,268,296],"goats":[37,109],"dermal":[38],"papilla":[39],"cell":[40],"(DPC)":[41],"phenotypes":[42],"through":[43],"PDGFA":[44,80,144,174,278,291],",":[45,145,147],"examined":[47,151],"association":[49],"this":[51],"regulatory":[52],"axis":[53,292],"with":[54],"MAPK-related":[55,297],"factors.":[56,298],"Methods":[57],"Candidate":[58],"targets":[59,169],"were":[62,94,122,133],"predicted":[63],"using":[64,87,135],"TargetScan":[66],"database":[67],"previously":[69],"generated":[70],"transcriptomic":[71],"data.":[72],"The":[73,141,225],"direct":[74],"interaction":[75],"between":[76,288],"3\u2032":[81,171],"untranslated":[82],"region":[83],"(UTR)":[84],"was":[85,113,150,161],"evaluated":[86],"a":[88,286,303,315],"dual-luciferase":[89],"reporter":[90],"assay.":[91],"Lentiviral":[92],"vectors":[93],"used":[95],"knock":[97],"down":[98],"or":[99],"overexpress":[100],"DPCs":[103],"isolated":[104],"from":[105,193],"three":[106],"independent":[107],"donors.":[110],"Each":[111],"donor":[112],"treated":[114],"as":[115],"one":[116],"biological":[117],"replicate,":[118],"technical":[120],"replicates":[121],"averaged":[123],"before":[124],"statistical":[125],"analysis.":[126],"Cell":[127],"proliferation,":[128,275],"cell-cycle":[129],"distribution,":[130],"apoptosis":[132,191,215],"assessed":[134],"CCK-8":[136],"assays":[137],"flow":[139],"cytometry.":[140],"expression":[142,233,267,295],"MAP3K1":[146,237],"FGF21":[149,239],"by":[152,271,306],"quantitative":[153],"reverse-transcription":[154],"PCR":[155],"Western":[157],"blotting.":[158],"MT":[159,262,308],"treatment":[160,263],"performed":[162],"for":[163,317],"48":[164],"h.":[165],"Results":[166],"Chi-miR-1388-3p":[167],"directly":[168],"UTR":[172],".":[175],"Its":[176],"overexpression":[177,226],"can":[178,229,264],"inhibit":[179],"proliferation":[181,211],"DPC,":[183],"increase":[184,189],"G0/G1":[185],"phase":[186],"arrest,":[187],"rate":[192,216],"9.28%":[194],"\u00b1":[195,199,219],"0.17%":[196],"17.61%":[198],"0.29%":[200],"(":[201,221,240,252],"p":[202,222,241,253],"<":[203,223,242,254],"0.01).":[204,224],"Conversely,":[205],"inhibition":[207,257],"reduces":[213],"3.07%":[218],"0.11%":[220],"significantly":[230],"reduce":[231],"levels":[234],"PDGFA,":[236],"0.01),":[243,255],"while":[244,256],"inhibitory":[246],"effect":[247,251],"has":[248,258],"opposite":[250,260],"effect.":[261],"decrease":[265],"chi-miR-1388-3p,":[269],"accompanied":[270],"DPC":[274],"apoptosis,":[276],"expression.":[279],"These":[280],"results":[281],"indicate":[282],"that":[283],"there":[284],"is":[285],"correlation":[287],"MT/chi-miR-1388-3p/":[290],"Conclusion":[299],"uncovers":[302],"novel":[304],"mechanism":[305],"which":[307],"regulates":[309],"provides":[314],"foundation":[316],"future":[318],"vivo":[320],"studies":[321],"exploring":[322],"miRNA-based":[323],"strategies":[324],"enhance":[326],"production.":[328]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}