{"id":"https://openalex.org/W7225802776","doi":"https://doi.org/10.64898/2026.11.10.26367691","title":"Near point of care C-Reactive Protein and Serum Amyloid-A Test met WHO target product profile for TB screening","display_name":"Near point of care C-Reactive Protein and Serum Amyloid-A Test met WHO target product profile for TB screening","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225802776","doi":"https://doi.org/10.64898/2026.11.10.26367691"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.10.26367691","doi":"https://doi.org/10.64898/2026.11.10.26367691","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.11.10.26367691","pdf_url":null,"source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072064639","display_name":"Todia Pediatama Setiabudiawan","orcid":"https://orcid.org/0000-0002-3252-1201","observed_orcids":["https://orcid.org/0000-0002-3252-1201"]},"institutions":[{"id":"https://openalex.org/I91819753","display_name":"Padjadjaran University","ror":"https://ror.org/00xqf8t64","country_code":"ID","type":"education","lineage":["https://openalex.org/I91819753"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Todia Pediatama Setiabudiawan","raw_affiliation_strings":["Research Center for Care and Control of Infectious Diseases, Universitas Padjadjaran, Bandung, Indonesia;"],"raw_orcid":"https://orcid.org/0000-0002-3252-1201","affiliations":[{"raw_affiliation_string":"Research Center for Care and Control of Infectious Diseases, Universitas Padjadjaran, Bandung, Indonesia;","institution_ids":["https://openalex.org/I91819753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064609448","display_name":"Nadya Iswandari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086620","display_name":"Dr. Hasan Sadikin General Hospital","ror":"https://ror.org/003392690","country_code":"ID","type":"healthcare","lineage":["https://openalex.org/I4210086620"]},{"id":"https://openalex.org/I91819753","display_name":"Padjadjaran University","ror":"https://ror.org/00xqf8t64","country_code":"ID","type":"education","lineage":["https://openalex.org/I91819753"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Nadya Iswandari","raw_affiliation_strings":["Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran / Hasan Sadikin General Hospital, Bandung, Indonesia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran / Hasan Sadikin General Hospital, Bandung, Indonesia;","institution_ids":["https://openalex.org/I4210086620","https://openalex.org/I91819753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067568149","display_name":"Marcellus","orcid":"https://orcid.org/0000-0002-4457-1767","observed_orcids":["https://orcid.org/0000-0002-4457-1767"]},"institutions":[{"id":"https://openalex.org/I91819753","display_name":"Padjadjaran University","ror":"https://ror.org/00xqf8t64","country_code":"ID","type":"education","lineage":["https://openalex.org/I91819753"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Marcellus Korompis","raw_affiliation_strings":["Research Center for Care and Control of Infectious Diseases, Universitas Padjadjaran, Bandung, Indonesia.;"],"raw_orcid":"https://orcid.org/0000-0002-4457-1767","affiliations":[{"raw_affiliation_string":"Research Center for Care and Control of Infectious Diseases, Universitas Padjadjaran, Bandung, Indonesia.;","institution_ids":["https://openalex.org/I91819753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082768843","display_name":"Raspati Cundarani Koesoemadinata","orcid":"https://orcid.org/0000-0002-3817-4589","observed_orcids":["https://orcid.org/0000-0002-3817-4589"]},"institutions":[{"id":"https://openalex.org/I130218214","display_name":"Indonesia University of Education","ror":"https://ror.org/044b0xj37","country_code":"ID","type":"education","lineage":["https://openalex.org/I130218214"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Raspati Cundarani Koesoemadinata","raw_affiliation_strings":["Universitas Pendidikan Indonesia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universitas Pendidikan Indonesia;","institution_ids":["https://openalex.org/I130218214"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061603602","display_name":"Evan Susandi","orcid":"https://orcid.org/0000-0002-0178-7138","observed_orcids":["https://orcid.org/0000-0002-0178-7138"]},"institutions":[{"id":"https://openalex.org/I4210086620","display_name":"Dr. Hasan Sadikin General Hospital","ror":"https://ror.org/003392690","country_code":"ID","type":"healthcare","lineage":["https://openalex.org/I4210086620"]},{"id":"https://openalex.org/I91819753","display_name":"Padjadjaran University","ror":"https://ror.org/00xqf8t64","country_code":"ID","type":"education","lineage":["https://openalex.org/I91819753"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Evan Susandi","raw_affiliation_strings":["Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran / Hasan Sadikin General Hospital, Bandung, Indonesia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran / Hasan Sadikin General Hospital, Bandung, Indonesia;","institution_ids":["https://openalex.org/I4210086620","https://openalex.org/I91819753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035618279","display_name":"Iceu Dimas Kulsum","orcid":"https://orcid.org/0000-0003-3710-8288","observed_orcids":["https://orcid.org/0000-0003-3710-8288"]},"institutions":[{"id":"https://openalex.org/I4210086620","display_name":"Dr. Hasan Sadikin General Hospital","ror":"https://ror.org/003392690","country_code":"ID","type":"healthcare","lineage":["https://openalex.org/I4210086620"]},{"id":"https://openalex.org/I91819753","display_name":"Padjadjaran University","ror":"https://ror.org/00xqf8t64","country_code":"ID","type":"education","lineage":["https://openalex.org/I91819753"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Iceu D Kulsum","raw_affiliation_strings":["Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran / Hasan Sadikin General Hospital, Bandung, Indonesia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran / Hasan Sadikin General Hospital, Bandung, Indonesia;","institution_ids":["https://openalex.org/I4210086620","https://openalex.org/I91819753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072772520","display_name":"Dewi Kartika Turbawaty","orcid":"https://orcid.org/0000-0001-5391-7574","observed_orcids":["https://orcid.org/0000-0001-5391-7574"]},"institutions":[{"id":"https://openalex.org/I4210086620","display_name":"Dr. Hasan Sadikin General Hospital","ror":"https://ror.org/003392690","country_code":"ID","type":"healthcare","lineage":["https://openalex.org/I4210086620"]},{"id":"https://openalex.org/I91819753","display_name":"Padjadjaran University","ror":"https://ror.org/00xqf8t64","country_code":"ID","type":"education","lineage":["https://openalex.org/I91819753"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Dewi K Turbawaty","raw_affiliation_strings":["Department of Clinical Pathology, Faculty of Medicine, Padjadjaran University/Dr. Hasan Sadikin Hospital Bandung"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pathology, Faculty of Medicine, Padjadjaran University/Dr. Hasan Sadikin Hospital Bandung","institution_ids":["https://openalex.org/I4210086620","https://openalex.org/I91819753"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045516341","display_name":"Bachti Alisjahbana","orcid":"https://orcid.org/0000-0003-3745-8229","observed_orcids":["https://orcid.org/0000-0003-3745-8229"]},"institutions":[{"id":"https://openalex.org/I4210086620","display_name":"Dr. Hasan Sadikin General Hospital","ror":"https://ror.org/003392690","country_code":"ID","type":"healthcare","lineage":["https://openalex.org/I4210086620"]},{"id":"https://openalex.org/I91819753","display_name":"Padjadjaran University","ror":"https://ror.org/00xqf8t64","country_code":"ID","type":"education","lineage":["https://openalex.org/I91819753"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Bachti Alisjahbana","raw_affiliation_strings":["Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran / Hasan Sadikin General Hospital, Bandung, Indonesia;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran / Hasan Sadikin General Hospital, Bandung, Indonesia;","institution_ids":["https://openalex.org/I4210086620","https://openalex.org/I91819753"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9735999703407288,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11381","display_name":"Infectious Diseases and Tuberculosis","score":0.004800000227987766,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14245","display_name":"Biomarkers in Disease Mechanisms","score":0.003100000089034438,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7998999953269958},{"id":"https://openalex.org/C55359608","wikidata":"https://www.wikidata.org/wiki/Q3113038","display_name":"Serum amyloid A","level":3,"score":0.7153000235557556},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.6234999895095825},{"id":"https://openalex.org/C2781195455","wikidata":"https://www.wikidata.org/wiki/Q422766","display_name":"C-reactive protein","level":3,"score":0.5853999853134155},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5472000241279602},{"id":"https://openalex.org/C64841741","wikidata":"https://www.wikidata.org/wiki/Q491983","display_name":"Point-of-care testing","level":2,"score":0.5407000184059143},{"id":"https://openalex.org/C2910060150","wikidata":"https://www.wikidata.org/wiki/Q3113038","display_name":"Serum Amyloid A Protein","level":4,"score":0.5356000065803528},{"id":"https://openalex.org/C2780420688","wikidata":"https://www.wikidata.org/wiki/Q759183","display_name":"Immunoassay","level":3,"score":0.4918999969959259},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.46639999747276306},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4661000072956085},{"id":"https://openalex.org/C2780639635","wikidata":"https://www.wikidata.org/wiki/Q4888238","display_name":"Tuberculosis diagnosis","level":4,"score":0.4309000074863434},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4187999963760376},{"id":"https://openalex.org/C3020132585","wikidata":"https://www.wikidata.org/wiki/Q2671652","display_name":"Diagnostic accuracy","level":2,"score":0.4066999852657318},{"id":"https://openalex.org/C2777120189","wikidata":"https://www.wikidata.org/wiki/Q780067","display_name":"Triage","level":2,"score":0.376800000667572},{"id":"https://openalex.org/C51915194","wikidata":"https://www.wikidata.org/wiki/Q17075487","display_name":"Point of care","level":2,"score":0.3601999878883362},{"id":"https://openalex.org/C82157600","wikidata":"https://www.wikidata.org/wiki/Q2671652","display_name":"Diagnostic test","level":2,"score":0.29589998722076416},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.2799000144004822},{"id":"https://openalex.org/C3020067899","wikidata":"https://www.wikidata.org/wiki/Q1163564","display_name":"Screening test","level":2,"score":0.2782999873161316},{"id":"https://openalex.org/C146543888","wikidata":"https://www.wikidata.org/wiki/Q425056","display_name":"Blood proteins","level":2,"score":0.26899999380111694},{"id":"https://openalex.org/C57194454","wikidata":"https://www.wikidata.org/wiki/Q424211","display_name":"Acute-phase protein","level":3,"score":0.2563999891281128}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.10.26367691","doi":"https://doi.org/10.64898/2026.11.10.26367691","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.11.10.26367691","pdf_url":null,"source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Background:":[0],"TB":[1,57,61,123,189],"eradication":[2],"strategies":[3],"in":[4],"high":[5],"burden":[6],"countries":[7],"need":[8],"affordable,":[9],"scalable,":[10],"and":[11,29,63,68,92,111,124,139,155,170,175,180],"accessible":[12],"screening":[13,37],"tools.":[14,38],"This":[15,40],"study":[16,43],"investigated":[17,44],"the":[18],"diagnostic":[19,42,104],"accuracy":[20],"of":[21,52,90,106,131,147],"C-reactive":[22,112],"protein":[23,32,113,160],"(CRP),":[24],"serum":[25,47,107],"amyloid":[26,108],"A":[27,109],"(SAA),":[28],"interferon":[30],"gamma-induced":[31,159],"10":[33,161],"(IP-10)":[34,162],"as":[35],"potential":[36],"Methods.":[39],"cross-sectional":[41],"stored":[45],"archived":[46],"samples":[48],"from":[49],"three":[50],"groups":[51],"subjects;":[53],"bacteriology":[54],"confirmed":[55,117],"symptomatic":[56],"group":[58],"(n=57),":[59],"probable":[60,122],"(n=56)":[62],"healthy":[64,125],"controls":[65],"(n=60).":[66],"CRP":[67,143,169,181],"SAA":[69,127,171,179],"concentrations":[70],"were":[71],"measured":[72,82],"using":[73,83],"near":[74],"point-of-care":[75],"fluorescence":[76],"immunoassay":[77],"(NPOCT-FIA),":[78],"while":[79,142],"IP-10":[80],"was":[81,95],"enzyme-linked":[84],"immunosorbent":[85],"assay":[86],"(ELISA).":[87],"Diagnostic":[88],"performance":[89,105],"individual":[91],"combined":[93],"biomarkers":[94],"evaluated":[96],"Results":[97],"Receiver":[98],"operating":[99],"characteristic":[100],"analysis":[101],"demonstrated":[102],"excellent":[103],"(SAA)":[110],"(CRP)":[114],"for":[115,188],"identifying":[116],"tuberculosis":[118],"(TB).":[119],"Compared":[120],"with":[121,136,152],"controls,":[126],"achieved":[128,144,172],"an":[129,145],"AUC":[130,146],"0.961":[132],"(cut-off":[133,149],">31.0":[134],"mg/L),":[135,151],"96.5%":[137,153],"sensitivity":[138,154,174],"88.6%":[140],"specificity,":[141],"0.953":[148],"21.3":[150],"86.0%":[156],"specificity.":[157,177],"Interferon":[158],"showed":[163],"poor":[164],"discrimination":[165],"(AUC":[166],"0.545).":[167],"Combined":[168],"100.0%":[173],"83.3%":[176],"Conclusion:":[178],"met":[182],"WHO":[183],"target":[184],"product":[185],"profile":[186],"criteria":[187],"triage":[190],"screening.":[191]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}