{"id":"https://openalex.org/W7225801919","doi":"https://doi.org/10.1038/s41598-026-80486-1","title":"Analysis of incidence and risk factors for intra-abdominal hypertension in critically Ill neurosurgical patients: a prospective-observational study","display_name":"Analysis of incidence and risk factors for intra-abdominal hypertension in critically Ill neurosurgical patients: a prospective-observational study","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225801919","doi":"https://doi.org/10.1038/s41598-026-80486-1"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-80486-1","doi":"https://doi.org/10.1038/s41598-026-80486-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-80486-1","pdf_url":null,"source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1038/s41598-026-80486-1","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5161478515","display_name":"Lei Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108688024","display_name":"Qingdao University","ror":"https://ror.org/021cj6z65","country_code":"CN","type":"education","lineage":["https://openalex.org/I108688024"]},{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Li","raw_affiliation_strings":["Department of Intravenous Medication Preparation Center, the Affiliated Hospital of Qingdao University, Qingdao, China","Department of Neurosurgery, the Affiliated Hospital of Qingdao University, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Intravenous Medication Preparation Center, the Affiliated Hospital of Qingdao University, Qingdao, China","institution_ids":["https://openalex.org/I108688024","https://openalex.org/I4210116869"]},{"raw_affiliation_string":"Department of Neurosurgery, the Affiliated Hospital of Qingdao University, Qingdao, China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161477920","display_name":"Qiaoling Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qiaoling Wang","raw_affiliation_strings":["The Community Medical Service Center of Zhenjiang Street, North City District, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Community Medical Service Center of Zhenjiang Street, North City District, Qingdao, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161420871","display_name":"Feng Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Zhang","raw_affiliation_strings":["Department of Neurosurgical Intensive Care Unit, the Affiliated Hospital of Qingdao University, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgical Intensive Care Unit, the Affiliated Hospital of Qingdao University, Qingdao, China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161468145","display_name":"Yang Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Li","raw_affiliation_strings":["Department of Neurosurgical Intensive Care Unit, the Affiliated Hospital of Qingdao University, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgical Intensive Care Unit, the Affiliated Hospital of Qingdao University, Qingdao, China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101141656","display_name":"Xiaowei Sun","orcid":"https://orcid.org/0000-0001-7650-6997","observed_orcids":["https://orcid.org/0000-0001-7650-6997"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaowei Sun","raw_affiliation_strings":["Department of Neurosurgical Intensive Care Unit, the Affiliated Hospital of Qingdao University, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgical Intensive Care Unit, the Affiliated Hospital of Qingdao University, Qingdao, China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102210781","display_name":"Xianghong Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianghong Sun","raw_affiliation_strings":["Department of Neurosurgical Intensive Care Unit, the Affiliated Hospital of Qingdao University, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgical Intensive Care Unit, the Affiliated Hospital of Qingdao University, Qingdao, China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161456778","display_name":"Jian Sun","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jian Sun","raw_affiliation_strings":["Department of Neurosurgical Intensive Care Unit, the Affiliated Hospital of Qingdao University, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgical Intensive Care Unit, the Affiliated Hospital of Qingdao University, Qingdao, China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147626002","display_name":"Shifang Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shifang Li","raw_affiliation_strings":["Department of Neurosurgery, the Affiliated Hospital of Qingdao University, Qingdao, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, the Affiliated Hospital of Qingdao University, Qingdao, China","institution_ids":["https://openalex.org/I4210116869"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074913394","display_name":"Ming-chao Fan","orcid":"https://orcid.org/0000-0003-2946-5816","observed_orcids":["https://orcid.org/0000-0003-2946-5816"]},"institutions":[{"id":"https://openalex.org/I4210116869","display_name":"Affiliated Hospital of Qingdao University","ror":"https://ror.org/026e9yy16","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116869"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mingchao Fan","raw_affiliation_strings":["Department of Neurosurgery, the Affiliated Hospital of Qingdao University, Qingdao, China","Department of Neurosurgical Intensive Care Unit, the Affiliated Hospital of Qingdao University, Qingdao, China"],"raw_orcid":"https://orcid.org/0000-0003-2946-5816","affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, the Affiliated Hospital of Qingdao University, Qingdao, China","institution_ids":["https://openalex.org/I4210116869"]},{"raw_affiliation_string":"Department of Neurosurgical Intensive Care Unit, the Affiliated Hospital of Qingdao University, Qingdao, China","institution_ids":["https://openalex.org/I4210116869"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5074913394","https://openalex.org/A5147626002"],"corresponding_institution_ids":["https://openalex.org/I4210116869"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12333","display_name":"Abdominal Surgery and Complications","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12333","display_name":"Abdominal Surgery and Complications","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11623","display_name":"Hyperglycemia and glycemic control in critically ill and hospitalized patients","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9350000023841858},{"id":"https://openalex.org/C17624336","wikidata":"https://www.wikidata.org/wiki/Q461644","display_name":"Glasgow Coma Scale","level":2,"score":0.7721999883651733},{"id":"https://openalex.org/C2778931659","wikidata":"https://www.wikidata.org/wiki/Q4665123","display_name":"Abdominal compartment syndrome","level":3,"score":0.6880000233650208},{"id":"https://openalex.org/C2991859549","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Critically ill","level":2,"score":0.6586999893188477},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.6507999897003174},{"id":"https://openalex.org/C2777080012","wikidata":"https://www.wikidata.org/wiki/Q3766250","display_name":"Mechanical ventilation","level":2,"score":0.6254000067710876},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5641999840736389},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5479000210762024},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4496999979019165},{"id":"https://openalex.org/C194828623","wikidata":"https://www.wikidata.org/wiki/Q2861470","display_name":"Emergency medicine","level":1,"score":0.44440001249313354},{"id":"https://openalex.org/C201903717","wikidata":"https://www.wikidata.org/wiki/Q1778788","display_name":"Cohort study","level":2,"score":0.44350001215934753},{"id":"https://openalex.org/C2778551211","wikidata":"https://www.wikidata.org/wiki/Q324921","display_name":"Tracheotomy","level":2,"score":0.44350001215934753},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.3944999873638153},{"id":"https://openalex.org/C100136789","wikidata":"https://www.wikidata.org/wiki/Q1772448","display_name":"Coma (optics)","level":2,"score":0.3894999921321869},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.38449999690055847},{"id":"https://openalex.org/C2987404301","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care","level":2,"score":0.3808000087738037},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.33730000257492065},{"id":"https://openalex.org/C2780347030","wikidata":"https://www.wikidata.org/wiki/Q344843","display_name":"APACHE II","level":3,"score":0.3310999870300293},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.31859999895095825},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.2874000072479248},{"id":"https://openalex.org/C30036603","wikidata":"https://www.wikidata.org/wiki/Q17125150","display_name":"Severity of illness","level":2,"score":0.28209999203681946},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.2784000039100647},{"id":"https://openalex.org/C85004164","wikidata":"https://www.wikidata.org/wiki/Q1089964","display_name":"Injury Severity Score","level":4,"score":0.2689000070095062},{"id":"https://openalex.org/C2780835948","wikidata":"https://www.wikidata.org/wiki/Q1193870","display_name":"Multiple organ dysfunction syndrome","level":3,"score":0.26829999685287476},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.2678999900817871},{"id":"https://openalex.org/C179755657","wikidata":"https://www.wikidata.org/wiki/Q58702","display_name":"Mortality rate","level":2,"score":0.26669999957084656},{"id":"https://openalex.org/C2779159551","wikidata":"https://www.wikidata.org/wiki/Q1414874","display_name":"Comorbidity","level":2,"score":0.2581000030040741}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s41598-026-80486-1","doi":"https://doi.org/10.1038/s41598-026-80486-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-80486-1","pdf_url":null,"source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-80486-1","doi":"https://doi.org/10.1038/s41598-026-80486-1","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-80486-1","pdf_url":null,"source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Intra-abdominal":[0],"hypertension":[1],"(IAH)":[2],"is":[3],"associated":[4,260,268,291],"with":[5,81,149,240,269],"high":[6],"morbidity":[7],"and":[8,35,103,128,224,256,282],"mortality":[9,143],"in":[10,17,39,49,147,242,249,271,297],"critically":[11,18,64,243,252],"ill":[12,19,65,244,253],"patients.":[13,246,299],"However,":[14],"its":[15],"characteristics":[16],"neurosurgical":[20,66,245,254],"cohort":[21,273],"remain":[22],"poorly":[23],"understood.":[24],"This":[25,43],"study":[26,46],"aimed":[27],"to":[28,59,135],"investigate":[29],"the":[30,86],"prevalence,":[31],"risk":[32,105],"factors,":[33],"severity":[34],"outcomes":[36],"of":[37,84,113,131,251],"IAH":[38,92,108,123,132,150,154,241,247,270,286],"this":[40,272],"specific":[41],"population.":[42],"prospective":[44],"observational":[45],"was":[47,90,93,144,257,287],"conducted":[48],"a":[50,78,290],"Neurosurgical":[51],"Intensive":[52],"Care":[53],"Unit":[54],"(NICU)":[55],"between":[56],"Apr":[57,60],"2022":[58],"2024.":[61],"All":[62],"eligible":[63],"patients":[67,115,148,255],"had":[68],"their":[69,125],"intra-abdominal":[70],"pressure":[71,296],"(IAP)":[72],"measured":[73],"three":[74],"times":[75],"daily":[76,88],"via":[77],"urinary":[79],"catheter":[80],"25":[82],"mL":[83],"saline;":[85],"mean":[87],"value":[89],"recorded.":[91],"defined":[94],"as":[95,289],"IAP":[96],"\u2265":[97],"12mmHg.":[98],"Demographic":[99],"data,":[100],"clinical":[101],"parameters,":[102],"potential":[104],"factors":[106,266],"for":[107,262,293],"were":[109,116,237],"analyzed.":[110],"A":[111],"Total":[112],"283":[114],"enrolled.":[117],"Among":[118],"them,":[119],"53":[120],"(18.73%)":[121],"developed":[122],"during":[124],"NICU":[126],"stay,":[127],"two":[129],"(3.78%":[130],"patients)":[133],"progressed":[134],"abdominal":[136],"compartment":[137],"syndrome":[138],"(ACS).":[139],"The":[140],"180-day":[141,263],"all-cause":[142],"significantly":[145],"higher":[146,277],"than":[151],"those":[152],"without":[153],"(33.96%":[155],"vs.":[156],"12.17%,":[157],"P":[158,177,190,202,211,221,234],"<":[159],"0.001).":[160],"Multivariate":[161],"logistic":[162],"regression":[163],"analysis":[164],"revealed":[165],"that":[166],"Glasgow":[167],"Coma":[168],"Scale":[169],"scores":[170],"(GCS)":[171],"(OR,":[172,185,197,206,216,229],"0.733;":[173],"95%":[174,187,199,208,218,231],"CI,":[175,188,200,209,219,232],"0.567\u20130.947;":[176],"=":[178,191,203,212,222,235],"0.018),":[179],"Sequential":[180],"Organ":[181],"Failure":[182],"Assessment":[183],"scores(SOFAs)":[184],"1.830;":[186],"1.280\u20132.616;":[189],"0.001),":[192],"positive":[193],"fluid":[194],"balance":[195],"(PFB)":[196],"3.855;":[198],"1.485\u201310.004;":[201],"0.006),":[204],"tracheotomy":[205],"3.283;":[207],"1.241\u20138.681;":[210],"0.017),":[213],"platelet":[214,283],"count":[215],"1.006;":[217],"1.001\u20131.010;":[220],"0.010)":[223],"invasive":[225],"Mechanical":[226],"Ventilation":[227],"(IMV)":[228],"5.915;":[230],"1.481\u201323.624;":[233],"0.012)":[236],"significant":[238],"associations":[239],"occurred":[248],"18.73%":[250],"an":[258],"important":[259],"factor":[261,292],"mortality.":[264],"Associated":[265],"independently":[267],"included":[274],"lower":[275],"GCS,":[276],"SOFAs,":[278],"IMV,":[279],"PFB,":[280],"tracheotomy,":[281],"count.":[284],"Moreover,":[285],"identified":[288],"elevated":[294],"intracranial":[295],"these":[298]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}