{"id":"https://openalex.org/W7225801894","doi":"https://doi.org/10.64898/2026.11.10.765716","title":"Transcriptional and DNA Methylation Changes in the Hippocampus and Prefrontal Cortex after Fractionated Cranial Radiation in Mice","display_name":"Transcriptional and DNA Methylation Changes in the Hippocampus and Prefrontal Cortex after Fractionated Cranial Radiation in Mice","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225801894","doi":"https://doi.org/10.64898/2026.11.10.765716"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.10.765716","doi":"https://doi.org/10.64898/2026.11.10.765716","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.11.10.765716","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072888139","display_name":"Tuba Aksoy","orcid":"https://orcid.org/0000-0002-2287-6199","observed_orcids":["https://orcid.org/0000-0002-2287-6199"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tuba Aksoy","raw_affiliation_strings":["Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, 6565 MD Anderson Blvd, Houston, TX 77030, USA;"],"raw_orcid":"https://orcid.org/0000-0002-2287-6199","affiliations":[{"raw_affiliation_string":"Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, 6565 MD Anderson Blvd, Houston, TX 77030, USA;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003039585","display_name":"Pavel Sumazin","orcid":"https://orcid.org/0000-0002-1215-4977","observed_orcids":["https://orcid.org/0000-0002-1215-4977"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4390039366","display_name":"Dan L Duncan Comprehensive Cancer Center","ror":"https://ror.org/02nre0x31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370","https://openalex.org/I4390039366"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pavel Sumazin","raw_affiliation_strings":["Department of Pediatrics, Hematology-Oncology Section, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, 1 Baylor Plaza #450A, Houston, TX 77030, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Hematology-Oncology Section, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, 1 Baylor Plaza #450A, Houston, TX 77030, USA;","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4390039366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035705032","display_name":"Yue L\u00fc","orcid":"https://orcid.org/0000-0001-6827-8146","observed_orcids":["https://orcid.org/0000-0001-6827-8146"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yue Lu","raw_affiliation_strings":["Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, 6767 Bertner Ave, Houston, TX 77030, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, 6767 Bertner Ave, Houston, TX 77030, USA;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059596722","display_name":"Mohammad Javad Najaf Panah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4390039366","display_name":"Dan L Duncan Comprehensive Cancer Center","ror":"https://ror.org/02nre0x31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370","https://openalex.org/I4390039366"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammad Javad Najaf Panah","raw_affiliation_strings":["Department of Pediatrics, Hematology-Oncology Section, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, 1 Baylor Plaza #450A, Houston, TX 77030, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Hematology-Oncology Section, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, 1 Baylor Plaza #450A, Houston, TX 77030, USA;","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4390039366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109419978","display_name":"Miriam Zamorano","orcid":"https://orcid.org/0009-0006-6331-6733","observed_orcids":["https://orcid.org/0009-0006-6331-6733"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miriam Zamorano","raw_affiliation_strings":["Department of Symptom Research, The University of Texas MD Anderson Cancer Center, 6565 MD Anderson Blvd, Houston, TX 77030, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Symptom Research, The University of Texas MD Anderson Cancer Center, 6565 MD Anderson Blvd, Houston, TX 77030, USA;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103627316","display_name":"Thanh Lam","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thanh Lam","raw_affiliation_strings":["Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, 6565 MD Anderson Blvd, Houston, TX 77030, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, 6565 MD Anderson Blvd, Houston, TX 77030, USA;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161444613","display_name":"Wei Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Zhou","raw_affiliation_strings":["Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, 6565 MD Anderson Blvd, Houston, TX 77030, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, 6565 MD Anderson Blvd, Houston, TX 77030, USA;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161431073","display_name":"Ines Veselinovic","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ines Veselinovic","raw_affiliation_strings":["Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, 6565 MD Anderson Blvd, Houston, TX 77030, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, 6565 MD Anderson Blvd, Houston, TX 77030, USA;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013259270","display_name":"Joseph G. Duman","orcid":"https://orcid.org/0000-0002-6711-0656","observed_orcids":["https://orcid.org/0000-0002-6711-0656"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph G Duman","raw_affiliation_strings":["Department of Neuroscience, Baylor College of Medicine, 1 Baylor Plaza #450A, Houston, TX 77030, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Baylor College of Medicine, 1 Baylor Plaza #450A, Houston, TX 77030, USA;","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010322049","display_name":"M. Waleed Gaber","orcid":"https://orcid.org/0000-0002-6192-0367","observed_orcids":["https://orcid.org/0000-0002-6192-0367"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I4390039366","display_name":"Dan L Duncan Comprehensive Cancer Center","ror":"https://ror.org/02nre0x31","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370","https://openalex.org/I4390039366"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Waleed Gaber","raw_affiliation_strings":["Department of Pediatrics, Hematology-Oncology Section, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, 1 Baylor Plaza #450A, Houston, TX 77030, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Hematology-Oncology Section, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, 1 Baylor Plaza #450A, Houston, TX 77030, USA;","institution_ids":["https://openalex.org/I181547552","https://openalex.org/I4390039366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007674783","display_name":"Cobi J. Heijnen","orcid":"https://orcid.org/0000-0002-1928-3050","observed_orcids":["https://orcid.org/0000-0002-1928-3050"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cobi J. Heijnen","raw_affiliation_strings":["Department of Symptom Research, The University of Texas MD Anderson Cancer Center, 6565 MD Anderson Blvd, Houston, TX 77030;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Symptom Research, The University of Texas MD Anderson Cancer Center, 6565 MD Anderson Blvd, Houston, TX 77030;","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5037851639","display_name":"David R. Grosshans","orcid":"https://orcid.org/0009-0001-4569-7548","observed_orcids":["https://orcid.org/0009-0001-4569-7548"]},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David R. Grosshans","raw_affiliation_strings":["The University of Texas MD Anderson Cancer Center, 1840 Old Spanish Trail, Houston, TX 77054, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The University of Texas MD Anderson Cancer Center, 1840 Old Spanish Trail, Houston, TX 77054, USA","institution_ids":["https://openalex.org/I1343551460"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.5419999957084656,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.5419999957084656,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":0.18479999899864197,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11600","display_name":"Brain Metastases and Treatment","score":0.08169999718666077,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2781195155","wikidata":"https://www.wikidata.org/wiki/Q18680","display_name":"Prefrontal cortex","level":3,"score":0.8334000110626221},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.745199978351593},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.7447999715805054},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.6898000240325928},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6104999780654907},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5313000082969666},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.504800021648407},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.4819999933242798},{"id":"https://openalex.org/C189235521","wikidata":"https://www.wikidata.org/wiki/Q4087270","display_name":"Bisulfite sequencing","level":5,"score":0.39239999651908875},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3797999918460846},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3734999895095825},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.3637000024318695},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.3560999929904938},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.35510000586509705},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3073999881744385},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.30649998784065247},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.3052000105381012},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.2994999885559082},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.2897000014781952},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.2768000066280365},{"id":"https://openalex.org/C2781041448","wikidata":"https://www.wikidata.org/wiki/Q75839","display_name":"Cerebral cortex","level":2,"score":0.2727999985218048},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.2605000138282776},{"id":"https://openalex.org/C154253233","wikidata":"https://www.wikidata.org/wiki/Q14862240","display_name":"Differentially methylated regions","level":5,"score":0.2502000033855438}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.10.765716","doi":"https://doi.org/10.64898/2026.11.10.765716","is_oa":false,"landing_page_url":"https://doi.org/10.64898/2026.11.10.765716","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Fractionated":[0],"whole-brain":[1,57],"irradiation":[2,58],"is":[3,19],"essential":[4],"for":[5],"treating":[6],"brain":[7],"tumors,":[8],"but":[9],"many":[10],"long-term":[11],"survivors":[12],"develop":[13],"cognitive":[14],"decline":[15],"whose":[16],"molecular":[17],"basis":[18],"poorly":[20],"understood.":[21],"We":[22],"asked":[23],"which":[24],"cell":[25],"types":[26],"and":[27,37,41,53,74,84,92,111,123,148,156],"gene":[28,109,126,149],"programs":[29],"change":[30],"late":[31],"after":[32,79],"irradiation,":[33,80],"how":[34],"the":[35,47,143],"hippocampus":[36],"prefrontal":[38,93,121],"cortex":[39],"compare,":[40],"whether":[42],"DNA":[43],"methylation":[44],"changes":[45,98,112,127,151],"affect":[46],"same":[48],"genes":[49,119],"or":[50,63],"programs.":[51],"Male":[52],"female":[54],"mice":[55,67],"received":[56],"(5":[59],"x":[60],"4":[61],"Gy)":[62],"anesthesia":[64],"alone.":[65],"Irradiated":[66],"showed":[68,95,106],"persistent":[69],"deficits":[70],"in":[71,99,113,120,128,140],"executive":[72],"function":[73],"spatial":[75],"memory.":[76],"Eleven":[77],"weeks":[78],"single-nucleus":[81],"RNA":[82],"sequencing":[83,87],"whole-genome":[85],"bisulfite":[86],"of":[88,101,142],"pooled":[89],"hippocampal":[90],"(CA1-3)":[91],"tissue":[94],"cell-type-specific":[96],"transcriptional":[97],"neurons":[100,122],"both":[102],"regions.":[103],"Both":[104],"regions":[105,132],"reduced":[107,117],"ribosomal-protein":[108],"expression":[110,150],"adhesion":[114],"genes,":[115],"with":[116,137],"respiratory-chain":[118],"bidirectional":[124],"synaptic":[125,155],"hippocampus.":[129],"Differentially":[130],"methylated":[131],"were":[133],"enriched":[134],"at":[135],"promoters,":[136],"hypermethylation":[138],"predominating":[139],"three":[141],"four":[144],"sex-by-region":[145],"contrasts.":[146],"Methylation":[147],"pointed":[152],"to":[153],"overlapping":[154],"signaling":[157],"programs,":[158],"largely":[159],"through":[160],"different":[161],"genes.":[162]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
