{"id":"https://openalex.org/W7225801883","doi":"https://doi.org/10.1021/acsnano.6c13621","title":"Cucurbit[ n ]uril-Programmed Chlorogenic Acid Release for Collagen Mineralization and Pulp\u2013Dentin Repair in Near-Pulp Bonding","display_name":"Cucurbit[ n ]uril-Programmed Chlorogenic Acid Release for Collagen Mineralization and Pulp\u2013Dentin Repair in Near-Pulp Bonding","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225801883","doi":"https://doi.org/10.1021/acsnano.6c13621"},"language":"en","primary_location":{"id":"doi:10.1021/acsnano.6c13621","doi":"https://doi.org/10.1021/acsnano.6c13621","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsnano.6c13621","pdf_url":null,"source":{"id":"https://openalex.org/S145476921","display_name":"ACS Nano","issn_l":"1936-0851","issn":["1936-0851","1936-086X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Nano","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102747962","display_name":"Haotian Dong","orcid":"https://orcid.org/0009-0009-8097-3796","observed_orcids":["https://orcid.org/0009-0009-8097-3796","https://orcid.org/0009-0008-8558-1997"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haotian Dong","raw_affiliation_strings":["The Affiliated Stomatological Hospital of Nanjing Medical University, State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases (Nanjing Medical University), Jiangsu Province Engineering Research Center of Stomatological Translational Medicine (Nanjing Medical University) , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Stomatological Hospital of Nanjing Medical University, State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases (Nanjing Medical University), Jiangsu Province Engineering Research Center of Stomatological Translational Medicine (Nanjing Medical University) , , ,","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121425933","display_name":"Wenhui Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenhui Wang","raw_affiliation_strings":["The Affiliated Stomatological Hospital of Nanjing Medical University, State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases (Nanjing Medical University), Jiangsu Province Engineering Research Center of Stomatological Translational Medicine (Nanjing Medical University) , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Stomatological Hospital of Nanjing Medical University, State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases (Nanjing Medical University), Jiangsu Province Engineering Research Center of Stomatological Translational Medicine (Nanjing Medical University) , , ,","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161440857","display_name":"Shujing Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shujing Wang","raw_affiliation_strings":["The Affiliated Stomatological Hospital of Nanjing Medical University, State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases (Nanjing Medical University), Jiangsu Province Engineering Research Center of Stomatological Translational Medicine (Nanjing Medical University) , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Stomatological Hospital of Nanjing Medical University, State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases (Nanjing Medical University), Jiangsu Province Engineering Research Center of Stomatological Translational Medicine (Nanjing Medical University) , , ,","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130073425","display_name":"Suqing Tu","orcid":"https://orcid.org/0009-0001-3503-2446","observed_orcids":["https://orcid.org/0009-0001-3503-2446"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Suqing Tu","raw_affiliation_strings":["The Affiliated Stomatological Hospital of Nanjing Medical University, State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases (Nanjing Medical University), Jiangsu Province Engineering Research Center of Stomatological Translational Medicine (Nanjing Medical University) , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Stomatological Hospital of Nanjing Medical University, State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases (Nanjing Medical University), Jiangsu Province Engineering Research Center of Stomatological Translational Medicine (Nanjing Medical University) , , ,","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127328293","display_name":"Xinyu Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyu Yang","raw_affiliation_strings":["The Affiliated Stomatological Hospital of Nanjing Medical University, State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases (Nanjing Medical University), Jiangsu Province Engineering Research Center of Stomatological Translational Medicine (Nanjing Medical University) , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Stomatological Hospital of Nanjing Medical University, State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases (Nanjing Medical University), Jiangsu Province Engineering Research Center of Stomatological Translational Medicine (Nanjing Medical University) , , ,","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161459250","display_name":"Ran You","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ran You","raw_affiliation_strings":["The Affiliated Stomatological Hospital of Nanjing Medical University, State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases (Nanjing Medical University), Jiangsu Province Engineering Research Center of Stomatological Translational Medicine (Nanjing Medical University) , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Stomatological Hospital of Nanjing Medical University, State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases (Nanjing Medical University), Jiangsu Province Engineering Research Center of Stomatological Translational Medicine (Nanjing Medical University) , , ,","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161463907","display_name":"Haifeng Xie","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haifeng Xie","raw_affiliation_strings":["The Affiliated Stomatological Hospital of Nanjing Medical University, State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases (Nanjing Medical University), Jiangsu Province Engineering Research Center of Stomatological Translational Medicine (Nanjing Medical University) , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Affiliated Stomatological Hospital of Nanjing Medical University, State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases (Nanjing Medical University), Jiangsu Province Engineering Research Center of Stomatological Translational Medicine (Nanjing Medical University) , , ,","institution_ids":["https://openalex.org/I83519826"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100418424","display_name":"Chen Chen","orcid":"https://orcid.org/0000-0002-2989-180X","observed_orcids":["https://orcid.org/0000-0002-2989-180X"]},"institutions":[{"id":"https://openalex.org/I83519826","display_name":"Nanjing Medical University","ror":"https://ror.org/059gcgy73","country_code":"CN","type":"education","lineage":["https://openalex.org/I83519826"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Chen","raw_affiliation_strings":["The Affiliated Stomatological Hospital of Nanjing Medical University, State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases (Nanjing Medical University), Jiangsu Province Engineering Research Center of Stomatological Translational Medicine (Nanjing Medical University) , , ,"],"raw_orcid":"https://orcid.org/0000-0002-2989-180X","affiliations":[{"raw_affiliation_string":"The Affiliated Stomatological Hospital of Nanjing Medical University, State Key Laboratory Cultivation Base of Research, Prevention and Treatment for Oral Diseases (Nanjing Medical University), Jiangsu Province Engineering Research Center of Stomatological Translational Medicine (Nanjing Medical University) , , ,","institution_ids":["https://openalex.org/I83519826"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I83519826"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10113","display_name":"Dental materials and restorations","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10113","display_name":"Dental materials and restorations","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/3500","display_name":"General Dentistry"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10536","display_name":"Endodontics and Root Canal Treatments","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/3504","display_name":"Oral Surgery"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11570","display_name":"Periodontal Regeneration and Treatments","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.784600019454956},{"id":"https://openalex.org/C111696902","wikidata":"https://www.wikidata.org/wiki/Q6864413","display_name":"Mineralization (soil science)","level":3,"score":0.7225000262260437},{"id":"https://openalex.org/C2779263046","wikidata":"https://www.wikidata.org/wiki/Q189637","display_name":"Dentin","level":2,"score":0.6438000202178955},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5893999934196472},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.5288000106811523},{"id":"https://openalex.org/C188442228","wikidata":"https://www.wikidata.org/wiki/Q48286","display_name":"Pulp (tooth)","level":2,"score":0.5217999815940857},{"id":"https://openalex.org/C2910267089","wikidata":"https://www.wikidata.org/wiki/Q1189904","display_name":"Dentinal Tubule","level":3,"score":0.5170999765396118},{"id":"https://openalex.org/C161312837","wikidata":"https://www.wikidata.org/wiki/Q17146150","display_name":"Pulp capping","level":3,"score":0.47839999198913574},{"id":"https://openalex.org/C2780498532","wikidata":"https://www.wikidata.org/wiki/Q7850941","display_name":"Tubule","level":3,"score":0.39100000262260437},{"id":"https://openalex.org/C148318117","wikidata":"https://www.wikidata.org/wiki/Q7311813","display_name":"Remineralisation","level":3,"score":0.3452000021934509},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3325999975204468},{"id":"https://openalex.org/C2777746296","wikidata":"https://www.wikidata.org/wiki/Q178397","display_name":"Apatite","level":2,"score":0.30880001187324524},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.3061999976634979},{"id":"https://openalex.org/C102951782","wikidata":"https://www.wikidata.org/wiki/Q49295","display_name":"Atomic force microscopy","level":2,"score":0.2939000129699707},{"id":"https://openalex.org/C163588942","wikidata":"https://www.wikidata.org/wiki/Q5165929","display_name":"Controlled release","level":2,"score":0.28459998965263367},{"id":"https://openalex.org/C2780644872","wikidata":"https://www.wikidata.org/wiki/Q14881714","display_name":"Type I collagen","level":2,"score":0.2824999988079071},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.27549999952316284},{"id":"https://openalex.org/C69103154","wikidata":"https://www.wikidata.org/wiki/Q3023350","display_name":"Dentinogenesis","level":4,"score":0.26649999618530273},{"id":"https://openalex.org/C2780117898","wikidata":"https://www.wikidata.org/wiki/Q421964","display_name":"Chlorogenic acid","level":2,"score":0.2587999999523163}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acsnano.6c13621","doi":"https://doi.org/10.1021/acsnano.6c13621","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acsnano.6c13621","pdf_url":null,"source":{"id":"https://openalex.org/S145476921","display_name":"ACS Nano","issn_l":"1936-0851","issn":["1936-0851","1936-086X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Nano","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W1996715553","https://openalex.org/W3006987229","https://openalex.org/W3020934897","https://openalex.org/W3041969281","https://openalex.org/W3080268149","https://openalex.org/W3091986402","https://openalex.org/W3120138675","https://openalex.org/W3135602363","https://openalex.org/W3144939003","https://openalex.org/W3147609771","https://openalex.org/W3167537548","https://openalex.org/W3186294919","https://openalex.org/W3199041259","https://openalex.org/W3214856148","https://openalex.org/W4210418914","https://openalex.org/W4210460802","https://openalex.org/W4210902355","https://openalex.org/W4214559553","https://openalex.org/W4221017949","https://openalex.org/W4224015716","https://openalex.org/W4225410653","https://openalex.org/W4283022157","https://openalex.org/W4285891325","https://openalex.org/W4318542321","https://openalex.org/W4360874924","https://openalex.org/W4382933916","https://openalex.org/W4385988723","https://openalex.org/W4386373121","https://openalex.org/W4387067171","https://openalex.org/W4388979597","https://openalex.org/W4389148931","https://openalex.org/W4389352496","https://openalex.org/W4389390685","https://openalex.org/W4391887492","https://openalex.org/W4393513339","https://openalex.org/W4393983411","https://openalex.org/W4394749838","https://openalex.org/W4396936712","https://openalex.org/W4399166278","https://openalex.org/W4399238628","https://openalex.org/W4399648369","https://openalex.org/W4400390725","https://openalex.org/W4401511071","https://openalex.org/W4402121420","https://openalex.org/W4402305911","https://openalex.org/W4403463577","https://openalex.org/W4404206420","https://openalex.org/W4405011445","https://openalex.org/W4406499020","https://openalex.org/W4407621232","https://openalex.org/W4408244770","https://openalex.org/W4410132179","https://openalex.org/W4410999190","https://openalex.org/W4411114600","https://openalex.org/W4411486942","https://openalex.org/W4414163670","https://openalex.org/W4414795523","https://openalex.org/W4415091572","https://openalex.org/W4415311533","https://openalex.org/W4415625987","https://openalex.org/W4416061307","https://openalex.org/W7134197369"],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Long-term":[1],"failure":[2],"of":[3,13,23,59,202],"resin\u2013dentin":[4],"bonding":[5,176],"arises":[6],"from":[7,135],"persistent":[8],"hydration":[9],"and":[10,44,52,63,70,81,89,97,120,140,157,171,184,196,199,222,236],"enzymatic":[11],"degradation":[12],"exposed":[14],"collagen":[15,42,100,139,155],"in":[16],"the":[17,30,108,232],"deep":[18],"hybrid":[19],"layer,":[20],"whereas":[21,105],"diffusion":[22],"bioactive":[24],"components":[25],"through":[26],"dentinal":[27],"tubules":[28],"toward":[29],"pulp":[31,205],"may":[32],"cause":[33],"pulpal":[34,220],"irritation.":[35],"An":[36],"ideal":[37],"pretreatment":[38],"should":[39],"therefore":[40],"promote":[41],"remineralization":[43],"interfacial":[45,82,217],"stabilization":[46],"while":[47],"reducing":[48],"pulp-adjacent":[49],"cellular":[50],"irritation":[51],"supporting":[53],"pulp\u2013dentin":[54],"repair.":[55,225,250],"Herein,":[56],"supramolecular":[57],"complexes":[58],"chlorogenic":[60],"acid":[61],"(CGA)":[62],"cucurbit[n]uril":[64],"(Q[n],":[65],"n":[66],"=":[67],"6,":[68],"7,":[69],"8),":[71],"denoted":[72],"CGA@Q[n],":[73],"were":[74],"constructed":[75],"to":[76,138,153,193],"regulate":[77],"CGA":[78,113,133,195,243],"loading,":[79,87],"release,":[80,88],"exposure.":[83],"CGA@Q[6]":[84],"showed":[85,107],"limited":[86],"mineralization":[90,101,116,198],"capacity.":[91],"CGA@Q[7]":[92],"exhibited":[93],"faster":[94],"early":[95],"release":[96],"achieved":[98],"complete":[99,115],"within":[102,146],"24":[103],"h,":[104,119],"CGA@Q[8]":[106,178,211,230],"highest":[109],"encapsulation":[110],"efficiency,":[111],"sustained":[112],"supply,":[114],"at":[117],"36":[118],"a":[121,175],"continuous,":[122],"dense,":[123],"integrated":[124],"intrafibrillar":[125,148],"mineral":[126,144],"phase.":[127],"Molecular":[128],"dynamics":[129],"simulations":[130],"indicated":[131],"that":[132,238],"released":[134],"Q[8]":[136],"reanchored":[137],"recruited":[141],"Ca2+,":[142],"promoting":[143],"formation":[145],"confined":[147],"spaces.":[149],"These":[150],"advantages":[151],"extended":[152],"three-dimensional":[154],"networks":[156],"demineralized":[158],"dentin,":[159],"yielding":[160],"higher":[161],"HAp":[162],"content,":[163],"enhanced":[164,223],"mineral\u2013collagen":[165],"integration,":[166],"tubule":[167],"occlusion,":[168],"mechanical":[169],"recovery,":[170],"MMP-9":[172],"inhibition.":[173],"As":[174],"pretreatment,":[177],"reduced":[179],"nanoleakage,":[180],"endogenous":[181],"gelatinolytic":[182],"activity,":[183],"aging-induced":[185],"bond-strength":[186],"loss.":[187],"It":[188],"also":[189],"improved":[190],"cytocompatibility":[191],"relative":[192],"free":[194],"promoted":[197,212],"odontogenic":[200,224],"differentiation":[201],"human":[203],"dental":[204],"stem":[206],"cells":[207],"(hDPSCs).":[208],"In":[209],"vivo,":[210],"dentin":[213,248],"remineralization,":[214],"maintained":[215],"near-pulp":[216],"stability,":[218],"alleviated":[219],"irritation,":[221],"Together,":[226],"these":[227],"findings":[228],"identify":[229],"as":[231],"most":[233],"effective":[234],"formulation":[235],"show":[237],"homologue":[239],"selection":[240],"can":[241],"tune":[242],"exposure":[244],"kinetics":[245],"for":[246],"coordinated":[247],"interface":[249]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}