{"id":"https://openalex.org/W7225801408","doi":"https://doi.org/10.3389/fneur.2026.1980642","title":"Gut microbiota features associated with clinical consciousness trajectories in neurosurgical ICU patients","display_name":"Gut microbiota features associated with clinical consciousness trajectories in neurosurgical ICU patients","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225801408","doi":"https://doi.org/10.3389/fneur.2026.1980642"},"language":"en","primary_location":{"id":"doi:10.3389/fneur.2026.1980642","doi":"https://doi.org/10.3389/fneur.2026.1980642","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2026.1980642","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1980642/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1980642/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055224379","display_name":"Yangyang Guo","orcid":"https://orcid.org/0000-0002-6391-9896","observed_orcids":["https://orcid.org/0000-0002-6391-9896"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210087691","display_name":"Beijing Tian Tan Hospital","ror":"https://ror.org/003regz62","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087691"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yangyang Guo","raw_affiliation_strings":["Department of Critical Care, Beijing Tiantan Hospital, Capital Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care, Beijing Tiantan Hospital, Capital Medical University","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210087691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126971421","display_name":"Jingwei Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210087691","display_name":"Beijing Tian Tan Hospital","ror":"https://ror.org/003regz62","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087691"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingwei Zhao","raw_affiliation_strings":["Department of Critical Care, Beijing Tiantan Hospital, Capital Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care, Beijing Tiantan Hospital, Capital Medical University","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210087691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161421465","display_name":"Guangqiang Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210087691","display_name":"Beijing Tian Tan Hospital","ror":"https://ror.org/003regz62","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087691"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Guangqiang Chen","raw_affiliation_strings":["Department of Critical Care, Beijing Tiantan Hospital, Capital Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Critical Care, Beijing Tiantan Hospital, Capital Medical University","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210087691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124189510","display_name":"Jindong Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210141942","display_name":"Peking University Third Hospital","ror":"https://ror.org/04wwqze12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210141942"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jindong Zhang","raw_affiliation_strings":["Beijing Key Laboratory of Human Microbiome Precision Medicine and Microbial Agent Development","Department of Gastroenterology, Peking University Third Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Human Microbiome Precision Medicine and Microbial Agent Development","institution_ids":[]},{"raw_affiliation_string":"Department of Gastroenterology, Peking University Third Hospital","institution_ids":["https://openalex.org/I4210141942"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058133147","display_name":"Guangzhi Shi","orcid":"https://orcid.org/0000-0003-4189-5800","observed_orcids":["https://orcid.org/0000-0003-4189-5800"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210087691","display_name":"Beijing Tian Tan Hospital","ror":"https://ror.org/003regz62","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210087691"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Guangzhi Shi","raw_affiliation_strings":["Beijing Neurosurgical Institute, Capital Medical University","Department of Critical Care, Beijing Tiantan Hospital, Capital Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Neurosurgical Institute, Capital Medical University","institution_ids":["https://openalex.org/I183519381"]},{"raw_affiliation_string":"Department of Critical Care, Beijing Tiantan Hospital, Capital Medical University","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210087691"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5058133147","https://openalex.org/A5124189510"],"corresponding_institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210087691","https://openalex.org/I4210141942"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10867","display_name":"Intensive Care Unit Cognitive Disorders","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10218","display_name":"Sepsis Diagnosis and Treatment","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6169999837875366},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.5922999978065491},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.48190000653266907},{"id":"https://openalex.org/C23131810","wikidata":"https://www.wikidata.org/wiki/Q818574","display_name":"Observational study","level":2,"score":0.4433000087738037},{"id":"https://openalex.org/C192424360","wikidata":"https://www.wikidata.org/wiki/Q929408","display_name":"Multivariate analysis of variance","level":2,"score":0.43459999561309814},{"id":"https://openalex.org/C2780027724","wikidata":"https://www.wikidata.org/wiki/Q288892","display_name":"Ruminococcus","level":3,"score":0.4260999858379364},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42419999837875366},{"id":"https://openalex.org/C143121216","wikidata":"https://www.wikidata.org/wiki/Q1330402","display_name":"Microbiome","level":2,"score":0.41119998693466187},{"id":"https://openalex.org/C2776376669","wikidata":"https://www.wikidata.org/wiki/Q5094647","display_name":"Intensive care unit","level":2,"score":0.40389999747276306},{"id":"https://openalex.org/C127937792","wikidata":"https://www.wikidata.org/wiki/Q256069","display_name":"Species evenness","level":3,"score":0.3765000104904175},{"id":"https://openalex.org/C12770488","wikidata":"https://www.wikidata.org/wiki/Q188449","display_name":"Neurosurgery","level":2,"score":0.37619999051094055},{"id":"https://openalex.org/C102959455","wikidata":"https://www.wikidata.org/wiki/Q7313954","display_name":"Repeated measures design","level":2,"score":0.37599998712539673},{"id":"https://openalex.org/C99476002","wikidata":"https://www.wikidata.org/wiki/Q42297","display_name":"Analysis of variance","level":2,"score":0.35100001096725464},{"id":"https://openalex.org/C165455791","wikidata":"https://www.wikidata.org/wiki/Q7002299","display_name":"Neurointensive care","level":2,"score":0.3483000099658966},{"id":"https://openalex.org/C171525899","wikidata":"https://www.wikidata.org/wiki/Q17029618","display_name":"Level of consciousness","level":2,"score":0.3467999994754791},{"id":"https://openalex.org/C2779825944","wikidata":"https://www.wikidata.org/wiki/Q7097792","display_name":"Operational taxonomic unit","level":4,"score":0.33570000529289246},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.32440000772476196},{"id":"https://openalex.org/C2987404301","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care","level":2,"score":0.30959999561309814},{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.29010000824928284},{"id":"https://openalex.org/C2777938509","wikidata":"https://www.wikidata.org/wiki/Q139720","display_name":"Persistent vegetative state","level":4,"score":0.28439998626708984},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.2815000116825104},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.2799000144004822},{"id":"https://openalex.org/C25147867","wikidata":"https://www.wikidata.org/wiki/Q36039","display_name":"Beta diversity","level":3,"score":0.2619999945163727}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.3389/fneur.2026.1980642","doi":"https://doi.org/10.3389/fneur.2026.1980642","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2026.1980642","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1980642/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.3389/fneur.2026.1980642","doi":"https://doi.org/10.3389/fneur.2026.1980642","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fneur.2026.1980642","pdf_url":"https://www.frontiersin.org/journals/neurology/articles/10.3389/fneur.2026.1980642/pdf","source":{"id":"https://openalex.org/S96975567","display_name":"Frontiers in Neurology","issn_l":"1664-2295","issn":["1664-2295"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Neurology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225801408.pdf","grobid_xml":"https://content.openalex.org/works/W7225801408.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W2616231498","https://openalex.org/W2810245133","https://openalex.org/W2947916426","https://openalex.org/W3113180287","https://openalex.org/W3185007691","https://openalex.org/W3197613318","https://openalex.org/W3217701674","https://openalex.org/W4210649849","https://openalex.org/W4225886569","https://openalex.org/W4282963464","https://openalex.org/W4285087662","https://openalex.org/W4306165896","https://openalex.org/W4309736081","https://openalex.org/W4311117172","https://openalex.org/W4385329373","https://openalex.org/W4387072802","https://openalex.org/W4388095286","https://openalex.org/W4392380997","https://openalex.org/W4392783067","https://openalex.org/W4396939150","https://openalex.org/W4398252319","https://openalex.org/W4402419297","https://openalex.org/W4402768749","https://openalex.org/W4402870983","https://openalex.org/W4402955693","https://openalex.org/W4404967365","https://openalex.org/W4405503332","https://openalex.org/W4405971144","https://openalex.org/W4407111289","https://openalex.org/W4407991972","https://openalex.org/W4408429393","https://openalex.org/W4409164129","https://openalex.org/W4409484940","https://openalex.org/W4409535598","https://openalex.org/W4409823222","https://openalex.org/W4411195695","https://openalex.org/W4412521801","https://openalex.org/W4413133956","https://openalex.org/W4416122216","https://openalex.org/W4416719927","https://openalex.org/W4417325268","https://openalex.org/W7118019014","https://openalex.org/W7203599314"],"related_works":[],"abstract_inverted_index":{"Background":[0],"Recovery":[1],"of":[2,31,157],"consciousness":[3,62,71,201],"after":[4,192],"neurosurgery":[5],"varies":[6],"substantially":[7],"among":[8,149],"critically":[9],"ill":[10],"patients.":[11,38],"Whether":[12],"gut":[13,208],"microbiota":[14],"features":[15],"are":[16],"associated":[17,204],"with":[18,109,205],"these":[19],"clinical":[20],"trajectories":[21,202],"remains":[22],"unclear.":[23],"Methods":[24],"We":[25],"performed":[26],"a":[27,114],"longitudinal":[28],"observational":[29],"analysis":[30,124,156],"postoperative":[32],"neurosurgical":[33],"intensive":[34],"care":[35],"unit":[36],"(ICU)":[37],"Rectal":[39],"swabs":[40],"collected":[41],"on":[42,74],"ICU":[43,81],"Days":[44],"1,":[45],"3,":[46],"7,":[47],"and":[48,80,90,106,128,137,140,175,196,211],"14":[49],"underwent":[50],"16S":[51],"ribosomal":[52],"RNA":[53],"gene":[54],"sequencing.":[55],"Patients":[56],"were":[57,94,177,203],"classified":[58],"as":[59,113],"having":[60],"preserved":[61],"(P1),":[63],"GCS":[64,83],"score":[65],"improvement":[66],"(P2),":[67],"or":[68],"persistent":[69],"impaired":[70],"(P3)":[72],"based":[73],"changes":[75],"between":[76],"the":[77],"lowest":[78],"eligible":[79],"endpoint":[82],"component":[84],"scores.":[85],"Microbial":[86],"diversity,":[87],"community":[88],"composition,":[89],"differentially":[91],"abundant":[92,170,179],"genera":[93,184],"evaluated.":[95],"MaAsLin3":[96,189],"mixed-effects":[97,190],"models":[98,191],"adjusted":[99],"for":[100,119,194],"age,":[101],"sex,":[102],"body":[103],"mass":[104],"index,":[105],"antibiotic":[107],"duration,":[108],"patient":[110],"identifier":[111],"included":[112,125],"random":[115],"effect":[116],"to":[117],"account":[118],"repeated":[120,197],"measurements.":[121,198],"Results":[122],"The":[123],"39":[126],"patients":[127],"118":[129],"rectal":[130],"swabs.":[131],"P3":[132],"showed":[133],"lower":[134],"Shannon":[135],"diversity":[136],"Pielou\u2019s":[138],"evenness":[139,210],"higher":[141],"Simpson":[142],"index":[143],"values.":[144],"Community":[145],"composition":[146],"differed":[147],"modestly":[148],"groups":[150],"despite":[151],"substantial":[152],"overlap":[153],"(permutational":[154],"multivariate":[155],"variance":[158],"[PERMANOVA],":[159],"R":[160],"2":[161],"=":[162,165],"0.03575;":[163],"p":[164],"0.002).":[166],"Enterococcus":[167],"was":[168],"more":[169,178],"in":[171,180,187,207,219],"P3,":[172],"whereas":[173],"Ruminococcus":[174],"Romboutsia":[176],"P2.":[181],"These":[182,214],"group-associated":[183],"remained":[185],"consistent":[186],"multivariable":[188],"adjustment":[193],"covariates":[195],"Conclusion":[199],"Clinical":[200],"differences":[206],"microbial":[209],"selected":[212],"genera.":[213],"exploratory":[215],"findings":[216],"require":[217],"validation":[218],"larger":[220],"cohorts.":[221]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}