{"id":"https://openalex.org/W7225800462","doi":"https://doi.org/10.1186/s12951-026-05230-3","title":"Phage@CeO\u2082 nanozyme nanoplatform: concurrent bactericidal and detoxifying therapy for sepsis","display_name":"Phage@CeO\u2082 nanozyme nanoplatform: concurrent bactericidal and detoxifying therapy for sepsis","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225800462","doi":"https://doi.org/10.1186/s12951-026-05230-3"},"language":"en","primary_location":{"id":"doi:10.1186/s12951-026-05230-3","doi":"https://doi.org/10.1186/s12951-026-05230-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12951-026-05230-3","pdf_url":null,"source":{"id":"https://openalex.org/S41231013","display_name":"Journal of Nanobiotechnology","issn_l":"1477-3155","issn":["1477-3155"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nanobiotechnology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12951-026-05230-3","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024581695","display_name":"Yuexue Mai","orcid":"https://orcid.org/0000-0002-6382-2349","observed_orcids":["https://orcid.org/0000-0002-6382-2349"]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuexue Mai","raw_affiliation_strings":["Department of Plastic Surgery, The Second Affiliated Hospital of Zhejiang, University College of Medicine, Hangzhou, 310000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic Surgery, The Second Affiliated Hospital of Zhejiang, University College of Medicine, Hangzhou, 310000, China","institution_ids":["https://openalex.org/I4210158318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160464615","display_name":"Yufei Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yufei Li","raw_affiliation_strings":["Department of Plastic Surgery, The Second Affiliated Hospital of Zhejiang, University College of Medicine, Hangzhou, 310000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic Surgery, The Second Affiliated Hospital of Zhejiang, University College of Medicine, Hangzhou, 310000, China","institution_ids":["https://openalex.org/I4210158318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161425124","display_name":"Luokai Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163399","display_name":"Shandong First Medical University","ror":"https://ror.org/05jb9pq57","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210163399"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Luokai Wang","raw_affiliation_strings":["School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Clinical and Basic Medical Sciences, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, 250117, China","institution_ids":["https://openalex.org/I4210163399"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082575697","display_name":"Chenggang Yi","orcid":"https://orcid.org/0000-0002-9722-0872","observed_orcids":["https://orcid.org/0000-0002-9722-0872"]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenggang Yi","raw_affiliation_strings":["Department of Plastic Surgery, The Second Affiliated Hospital of Zhejiang, University College of Medicine, Hangzhou, 310000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic Surgery, The Second Affiliated Hospital of Zhejiang, University College of Medicine, Hangzhou, 310000, China","institution_ids":["https://openalex.org/I4210158318"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015891432","display_name":"Zhengwei Mao","orcid":"https://orcid.org/0000-0001-7990-2856","observed_orcids":["https://orcid.org/0000-0001-7990-2856"]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhengwei Mao","raw_affiliation_strings":["MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161467335","display_name":"Lulu Jin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I76130692","display_name":"Zhejiang University","ror":"https://ror.org/00a2xv884","country_code":"CN","type":"education","lineage":["https://openalex.org/I76130692"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lulu Jin","raw_affiliation_strings":["MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China","institution_ids":["https://openalex.org/I76130692"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068108499","display_name":"\u718a\u7ecd\u6052","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210158318","display_name":"Second Affiliated Hospital of Zhejiang University","ror":"https://ror.org/059cjpv64","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210158318"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shaoheng Xiong","raw_affiliation_strings":["Department of Plastic Surgery, The Second Affiliated Hospital of Zhejiang, University College of Medicine, Hangzhou, 310000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic Surgery, The Second Affiliated Hospital of Zhejiang, University College of Medicine, Hangzhou, 310000, China","institution_ids":["https://openalex.org/I4210158318"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5068108499","https://openalex.org/A5161467335"],"corresponding_institution_ids":["https://openalex.org/I4210158318","https://openalex.org/I76130692"],"apc_list":{"value":3790,"currency":"USD","value_usd":3790},"apc_paid":{"value":3790,"currency":"USD","value_usd":3790},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.8798999786376953,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11048","display_name":"Bacteriophages and microbial interactions","score":0.8798999786376953,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12302","display_name":"Advanced Nanomaterials in Catalysis","score":0.08150000125169754,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.00430000014603138,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.8019999861717224},{"id":"https://openalex.org/C2777637488","wikidata":"https://www.wikidata.org/wiki/Q31856","display_name":"Pseudomonas aeruginosa","level":3,"score":0.7724999785423279},{"id":"https://openalex.org/C2778754761","wikidata":"https://www.wikidata.org/wiki/Q421804","display_name":"Lipopolysaccharide","level":2,"score":0.6866999864578247},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6675000190734863},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.590499997138977},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.5641999840736389},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5299000144004822},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.48510000109672546},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4097000062465668},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4025999903678894},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.39329999685287476},{"id":"https://openalex.org/C57409179","wikidata":"https://www.wikidata.org/wiki/Q1218293","display_name":"Lysis","level":2,"score":0.3734999895095825},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.3714999854564667},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3562000095844269},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.3384999930858612},{"id":"https://openalex.org/C19655278","wikidata":"https://www.wikidata.org/wiki/Q3293735","display_name":"Bacterial cell structure","level":3,"score":0.3296000063419342},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3174000084400177},{"id":"https://openalex.org/C2779256223","wikidata":"https://www.wikidata.org/wiki/Q611870","display_name":"Phage therapy","level":5,"score":0.3149000108242035},{"id":"https://openalex.org/C134897094","wikidata":"https://www.wikidata.org/wiki/Q7003141","display_name":"Neutrophil extracellular traps","level":3,"score":0.30709999799728394},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3061999976634979},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3025999963283539},{"id":"https://openalex.org/C136622501","wikidata":"https://www.wikidata.org/wiki/Q6934671","display_name":"Multidrug tolerance","level":4,"score":0.29760000109672546},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.2806999981403351},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.2630000114440918},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.26249998807907104},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.25870001316070557},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.25209999084472656}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s12951-026-05230-3","doi":"https://doi.org/10.1186/s12951-026-05230-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12951-026-05230-3","pdf_url":null,"source":{"id":"https://openalex.org/S41231013","display_name":"Journal of Nanobiotechnology","issn_l":"1477-3155","issn":["1477-3155"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nanobiotechnology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s12951-026-05230-3","doi":"https://doi.org/10.1186/s12951-026-05230-3","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12951-026-05230-3","pdf_url":null,"source":{"id":"https://openalex.org/S41231013","display_name":"Journal of Nanobiotechnology","issn_l":"1477-3155","issn":["1477-3155"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Nanobiotechnology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Sepsis":[0],"caused":[1],"by":[2,78],"drug-resistant":[3,160],"bacteria":[4],"remains":[5],"a":[6,16,26,106,155],"global":[7],"health":[8],"crisis.":[9],"Under":[10],"such":[11],"circumstances,":[12],"phage":[13,41],"therapy":[14],"represents":[15],"promising":[17,156],"option.":[18],"However,":[19],"phage-mediated":[20],"bacterial":[21,121,161],"lysis":[22],"process":[23],"can":[24],"release":[25],"large":[27],"amount":[28],"of":[29,81,85,93,100],"lipopolysaccharide":[30],"(LPS),":[31],"which":[32],"in":[33],"turn":[34],"triggers":[35],"inflammatory":[36],"storms.":[37],"Herein,":[38],"we":[39],"equipped":[40],"with":[42],"LPS-degrading":[43],"CeO\u2082":[44],"nanozymes":[45],"(X03@CeO\u2082).":[46],"In":[47,105],"vitro,":[48],"X03@CeO\u2082":[49,113,133],"achieved":[50],"99.99%":[51],"bactericidal":[52],"efficiency":[53],"against":[54],"Pseudomonas":[55],"aeruginosa":[56,59,108],"(":[57],"P.":[58,107],"),":[60],"63.76%":[61],"biofilm":[62],"clearance,":[63],"and":[64,87,98,123,126,130],"reduced":[65,119],"lysis-released":[66],"LPS":[67,124],"to":[68,117],"49.60%.":[69],"It":[70],"protected":[71],"cells":[72],"from":[73],"LPS-induced":[74],"inflammation,":[75],"as":[76],"evidenced":[77],"the":[79,146],"prevention":[80],"cell":[82],"death,":[83],"normalization":[84],"interleukin-6":[86],"tumor":[88],"necrosis":[89],"factor-\u03b1":[90],"levels,":[91],"inhibition":[92],"reactive":[94],"oxygen":[95],"species":[96],"production,":[97],"blockade":[99],"Toll-like":[101],"receptor":[102],"4":[103],"activation.":[104],"-induced":[109],"sepsis":[110],"mouse":[111],"model,":[112],"boosted":[114],"24-h":[115],"survival":[116],"87.50%,":[118],"blood":[120],"load":[122],"content,":[125],"reversed":[127],"hematological":[128],"abnormalities":[129],"multi-organ":[131],"damage.":[132],"not":[134],"only":[135],"eradicates":[136],"pathogens":[137],"but":[138],"also":[139],"degrades":[140],"leaked":[141],"virulence":[142],"factors,":[143],"thereby":[144],"mitigating":[145],"excessive":[147],"host":[148],"immune":[149],"response.":[150],"This":[151],"multimodal":[152],"strategy":[153],"presents":[154],"therapeutic":[157],"approach":[158],"for":[159],"sepsis.":[162]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}