{"id":"https://openalex.org/W7225799337","doi":"https://doi.org/10.1038/s41598-026-78035-x","title":"Evaluation of extracellular vesicle-enriched fraction-derived miR-105, miR-1908, and miR-122 expression profiles in prostate cancer and benign prostatic hyperplasia","display_name":"Evaluation of extracellular vesicle-enriched fraction-derived miR-105, miR-1908, and miR-122 expression profiles in prostate cancer and benign prostatic hyperplasia","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225799337","doi":"https://doi.org/10.1038/s41598-026-78035-x"},"language":"en","primary_location":{"id":"doi:10.1038/s41598-026-78035-x","doi":"https://doi.org/10.1038/s41598-026-78035-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-78035-x","pdf_url":null,"source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1038/s41598-026-78035-x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016792955","display_name":"Emine Ya\u011fc\u0131","orcid":"https://orcid.org/0000-0003-2179-1318","observed_orcids":["https://orcid.org/0000-0003-2179-1318"]},"institutions":[{"id":"https://openalex.org/I4387156457","display_name":"Kutahya Saglik Bilimleri Universitesi","ror":"https://ror.org/01fxqs415","country_code":"TR","type":"education","lineage":["https://openalex.org/I4387156457"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Emine Yagci","raw_affiliation_strings":["Department of Medical Biology, Kutahya Health Sciences University, Faculty of Medicine, Kutahya, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0003-2179-1318","affiliations":[{"raw_affiliation_string":"Department of Medical Biology, Kutahya Health Sciences University, Faculty of Medicine, Kutahya, T\u00fcrkiye","institution_ids":["https://openalex.org/I4387156457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009473014","display_name":"H\u00fclyam Kurt","orcid":"https://orcid.org/0000-0003-2433-9925","observed_orcids":["https://orcid.org/0000-0003-2433-9925"]},"institutions":[{"id":"https://openalex.org/I51209816","display_name":"Eski\u015fehir Osmangazi University","ror":"https://ror.org/01dzjez04","country_code":"TR","type":"education","lineage":["https://openalex.org/I51209816"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Hulyam Kurt","raw_affiliation_strings":["Department of Medical Biology, Eskisehir Osmangazi University, Faculty of Medicine, Eskisehir, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0003-2433-9925","affiliations":[{"raw_affiliation_string":"Department of Medical Biology, Eskisehir Osmangazi University, Faculty of Medicine, Eskisehir, T\u00fcrkiye","institution_ids":["https://openalex.org/I51209816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031923011","display_name":"Ata \u00d6zen","orcid":"https://orcid.org/0000-0002-0890-486X","observed_orcids":["https://orcid.org/0000-0002-0890-486X"]},"institutions":[{"id":"https://openalex.org/I51209816","display_name":"Eski\u015fehir Osmangazi University","ror":"https://ror.org/01dzjez04","country_code":"TR","type":"education","lineage":["https://openalex.org/I51209816"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ata Ozen","raw_affiliation_strings":["Department of Urology, Eskisehir Osmangazi University, Faculty of Medicine, Eskisehir, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0002-0890-486X","affiliations":[{"raw_affiliation_string":"Department of Urology, Eskisehir Osmangazi University, Faculty of Medicine, Eskisehir, T\u00fcrkiye","institution_ids":["https://openalex.org/I51209816"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001976004","display_name":"Cansu \u00d6zbayer","orcid":"https://orcid.org/0000-0002-1120-1874","observed_orcids":["https://orcid.org/0000-0002-1120-1874"]},"institutions":[{"id":"https://openalex.org/I4387156457","display_name":"Kutahya Saglik Bilimleri Universitesi","ror":"https://ror.org/01fxqs415","country_code":"TR","type":"education","lineage":["https://openalex.org/I4387156457"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Cansu Ozbayer","raw_affiliation_strings":["Department of Medical Biology, Kutahya Health Sciences University, Faculty of Medicine, Kutahya, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0002-1120-1874","affiliations":[{"raw_affiliation_string":"Department of Medical Biology, Kutahya Health Sciences University, Faculty of Medicine, Kutahya, T\u00fcrkiye","institution_ids":["https://openalex.org/I4387156457"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042446203","display_name":"Selma Metinta\u015f","orcid":"https://orcid.org/0000-0002-5002-5041","observed_orcids":["https://orcid.org/0000-0002-5002-5041"]},"institutions":[{"id":"https://openalex.org/I51209816","display_name":"Eski\u015fehir Osmangazi University","ror":"https://ror.org/01dzjez04","country_code":"TR","type":"education","lineage":["https://openalex.org/I51209816"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Selma Metintas","raw_affiliation_strings":["Department of Public Health, Lung and Pleural Cancers Research and Clinical Center, Eskisehir Osmangazi University, Faculty of Medicine, Eskisehir, T\u00fcrkiye"],"raw_orcid":"https://orcid.org/0000-0002-5002-5041","affiliations":[{"raw_affiliation_string":"Department of Public Health, Lung and Pleural Cancers Research and Clinical Center, Eskisehir Osmangazi University, Faculty of Medicine, Eskisehir, T\u00fcrkiye","institution_ids":["https://openalex.org/I51209816"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5016792955"],"corresponding_institution_ids":["https://openalex.org/I4387156457"],"apc_list":{"value":2690,"currency":"USD","value_usd":2690},"apc_paid":{"value":2690,"currency":"USD","value_usd":2690},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9653000235557556,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.033900000154972076,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8123999834060669},{"id":"https://openalex.org/C2777562237","wikidata":"https://www.wikidata.org/wiki/Q835051","display_name":"Hyperplasia","level":2,"score":0.775600016117096},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.6807000041007996},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5708000063896179},{"id":"https://openalex.org/C87874733","wikidata":"https://www.wikidata.org/wiki/Q18039844","display_name":"PCA3","level":4,"score":0.5418000221252441},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5325000286102295},{"id":"https://openalex.org/C2780435053","wikidata":"https://www.wikidata.org/wiki/Q506659","display_name":"Benign prostatic hyperplasia (BPH)","level":4,"score":0.5236999988555908},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.45820000767707825},{"id":"https://openalex.org/C2908689518","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicle","level":5,"score":0.4408000111579895},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.4050000011920929},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4018999934196472},{"id":"https://openalex.org/C2781406297","wikidata":"https://www.wikidata.org/wiki/Q409450","display_name":"Prostate-specific antigen","level":4,"score":0.388700008392334},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3815000057220459},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3806999921798706},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.36250001192092896},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.3303000032901764},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.30970001220703125},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.30640000104904175},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.2922999858856201},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.28209999203681946},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.27570000290870667},{"id":"https://openalex.org/C146304588","wikidata":"https://www.wikidata.org/wiki/Q961652","display_name":"Case-control study","level":2,"score":0.2727000117301941},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2563999891281128}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1038/s41598-026-78035-x","doi":"https://doi.org/10.1038/s41598-026-78035-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-78035-x","pdf_url":null,"source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1038/s41598-026-78035-x","doi":"https://doi.org/10.1038/s41598-026-78035-x","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41598-026-78035-x","pdf_url":null,"source":{"id":"https://openalex.org/S196734849","display_name":"Scientific Reports","issn_l":"2045-2322","issn":["2045-2322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Scientific Reports","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Prostate":[1],"cancer":[2],"(PCa)":[3],"remains":[4],"a":[5,12,115],"critical":[6],"challenge":[7],"in":[8,118,147,169],"oncology.":[9],"There":[10],"is":[11,40],"need":[13],"to":[14,20,73,126,156,203],"explore":[15],"novel,":[16],"minimally":[17],"invasive":[18],"indicators":[19],"help":[21],"evaluate":[22,74],"differences":[23,166],"between":[24],"PCa":[25,34,95,123,149],"and":[26,36,60,70,100,113,129,139,152,175,208],"benign":[27],"prostatic":[28],"hyperplasia":[29],"(BPH),":[30],"which":[31],"often":[32],"mimics":[33],"symptoms":[35],"whose":[37],"clinical":[38,212],"evaluation":[39],"complicated":[41],"by":[42],"overlapping":[43],"PSA":[44],"levels.":[45],"This":[46],"study":[47],"exploratively":[48],"investigated":[49],"the":[50,86,108,122,127,148,157,170],"expression":[51,143,171],"profiles":[52],"of":[53,88,110,173],"extracellular":[54],"vesicle":[55],"(EV)-enriched":[56],"fraction-derived":[57],"miR-105,":[58],"miR-1908,":[59],"miR-122":[61],"miRNAs":[62],"previously":[63],"associated":[64,185],"with":[65,78,91,94,186],"epithelial-mesenchymal":[66],"transition,":[67],"metastatic":[68],"signaling,":[69],"metabolic":[71],"reprogramming":[72],"their":[75,210],"potential":[76,211],"associations":[77,207],"urological":[79],"malignancies.":[80],"EV-like":[81,111],"particles":[82,112],"were":[83,167],"isolated":[84],"from":[85],"plasma":[87],"25":[89,98],"patients":[90],"BPH,":[92],"50":[93],"(25":[96],"localized,":[97],"metastatic),":[99],"21":[101],"healthy":[102],"controls.":[103],"Transmission":[104],"electron":[105],"microscopy":[106],"characterized":[107],"morphology":[109],"revealed":[114],"significant":[116,165],"increase":[117],"particle":[119],"size":[120],"within":[121],"cohorts":[124],"compared":[125],"BPH":[128,158],"control":[130],"groups":[131,150],"(":[132,160],"p":[133,161],"<":[134,162],"0.05).":[135,163],"Following":[136],"cDNA":[137],"synthesis":[138],"miRNA":[140],"profiling,":[141],"miR-1908":[142,181,191],"was":[144],"significantly":[145],"downregulated":[146],"(LPCa":[151],"especially":[153],"MPCa)":[154],"relative":[155],"group":[159],"No":[164],"observed":[168],"levels":[172,182],"miR-105":[174],"miR-122.":[176],"These":[177],"results":[178],"suggest":[179],"that":[180],"may":[183],"be":[184],"prostate":[187],"pathological":[188],"status.":[189],"While":[190],"warrants":[192],"further":[193],"investigation":[194],"as":[195],"an":[196],"exploratory":[197],"candidate,":[198],"large-scale":[199],"studies":[200],"are":[201],"necessary":[202],"validate":[204],"these":[205],"preliminary":[206],"determine":[209],"relevance.":[213]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
