{"id":"https://openalex.org/W7225798773","doi":"https://doi.org/10.1128/jvi.00711-26","title":"Fish TRAF6 shapes interferon antiviral response by targeting the background MAVS for protein degradation","display_name":"Fish TRAF6 shapes interferon antiviral response by targeting the background MAVS for protein degradation","publication_year":2026,"publication_date":"2026-11-11","ids":{"openalex":"https://openalex.org/W7225798773","doi":"https://doi.org/10.1128/jvi.00711-26","pmid":"https://pubmed.ncbi.nlm.nih.gov/43012570"},"language":"en","primary_location":{"id":"doi:10.1128/jvi.00711-26","doi":"https://doi.org/10.1128/jvi.00711-26","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.00711-26","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.1128/jvi.00711-26","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112877355","display_name":"Xiu-Ying Gong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210089584","display_name":"Institute of Hydrobiology","ror":"https://ror.org/00b4mx203","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210089584"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiu-Ying Gong","raw_affiliation_strings":["State Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences","University of Chinese Academy of Sciences"],"raw_orcid":"https://orcid.org/0009-0004-7772-7029","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210089584"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5161477300","display_name":"Xiang Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210089584","display_name":"Institute of Hydrobiology","ror":"https://ror.org/00b4mx203","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210089584"]},{"id":"https://openalex.org/I52180223","display_name":"Hunan Agricultural University","ror":"https://ror.org/01dzed356","country_code":"CN","type":"education","lineage":["https://openalex.org/I52180223"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiang Zhao","raw_affiliation_strings":["Fisheries College, Hunan Agricultural University","State Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Fisheries College, Hunan Agricultural University","institution_ids":["https://openalex.org/I52180223"]},{"raw_affiliation_string":"State Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210089584"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137211322","display_name":"Cheng Dan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210089584","display_name":"Institute of Hydrobiology","ror":"https://ror.org/00b4mx203","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210089584"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng Dan","raw_affiliation_strings":["State Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences","University of Chinese Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210089584"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076750411","display_name":"Wen\u2010Hao Guo","orcid":"https://orcid.org/0000-0003-3724-9726","observed_orcids":["https://orcid.org/0000-0003-3724-9726"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210089584","display_name":"Institute of Hydrobiology","ror":"https://ror.org/00b4mx203","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210089584"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen-Hao Guo","raw_affiliation_strings":["State Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences","University of Chinese Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210089584"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137250787","display_name":"Hong-Yu Luan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210089584","display_name":"Institute of Hydrobiology","ror":"https://ror.org/00b4mx203","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210089584"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong-Yu Luan","raw_affiliation_strings":["State Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences","University of Chinese Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210089584"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103210183","display_name":"Mengyao Wu","orcid":"https://orcid.org/0009-0005-1662-2239","observed_orcids":["https://orcid.org/0009-0005-1662-2239"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210089584","display_name":"Institute of Hydrobiology","ror":"https://ror.org/00b4mx203","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210089584"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng-Yao Wu","raw_affiliation_strings":["State Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences","University of Chinese Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210089584"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101892948","display_name":"Jicheng Yu","orcid":"https://orcid.org/0000-0002-6243-8521","observed_orcids":["https://orcid.org/0000-0002-6243-8521"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210089584","display_name":"Institute of Hydrobiology","ror":"https://ror.org/00b4mx203","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210089584"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ji-Cheng Yu","raw_affiliation_strings":["State Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences","University of Chinese Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210089584"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137269147","display_name":"Zhen-Yang Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210089584","display_name":"Institute of Hydrobiology","ror":"https://ror.org/00b4mx203","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210089584"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen-Yang Zhao","raw_affiliation_strings":["State Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences","University of Chinese Academy of Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210089584"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053146658","display_name":"Yi-Bing Zhang","orcid":"https://orcid.org/0000-0001-7647-9335","observed_orcids":["https://orcid.org/0000-0001-7647-9335"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210089584","display_name":"Institute of Hydrobiology","ror":"https://ror.org/00b4mx203","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210089584"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi-Bing Zhang","raw_affiliation_strings":["State Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences","University of Chinese Academy of Sciences"],"raw_orcid":"https://orcid.org/0000-0001-7647-9335","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Breeding Biotechnology and Sustainable Aquaculture, Institute of Hydrobiology, Chinese Academy of Sciences","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210089584"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences","institution_ids":["https://openalex.org/I4210165038"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"e0071126","last_page":"e0071126"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10506","display_name":"Aquaculture disease management and microbiota","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8798999786376953},{"id":"https://openalex.org/C2776878037","wikidata":"https://www.wikidata.org/wiki/Q169444","display_name":"Zebrafish","level":3,"score":0.8281999826431274},{"id":"https://openalex.org/C134459356","wikidata":"https://www.wikidata.org/wiki/Q4274835","display_name":"Ubiquitin ligase","level":4,"score":0.738099992275238},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.705299973487854},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.7009999752044678},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6306999921798706},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5893999934196472},{"id":"https://openalex.org/C25602115","wikidata":"https://www.wikidata.org/wiki/Q407111","display_name":"Ubiquitin","level":3,"score":0.5458999872207642},{"id":"https://openalex.org/C2776954689","wikidata":"https://www.wikidata.org/wiki/Q21100537","display_name":"RIG-I","level":4,"score":0.48539999127388},{"id":"https://openalex.org/C9173399","wikidata":"https://www.wikidata.org/wiki/Q6046461","display_name":"Interferon regulatory factors","level":4,"score":0.48330000042915344},{"id":"https://openalex.org/C32300475","wikidata":"https://www.wikidata.org/wiki/Q18027992","display_name":"IRF1","level":4,"score":0.48019999265670776},{"id":"https://openalex.org/C2776746152","wikidata":"https://www.wikidata.org/wiki/Q4775355","display_name":"Antiviral protein","level":4,"score":0.4131999909877777},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.397599995136261},{"id":"https://openalex.org/C2778278966","wikidata":"https://www.wikidata.org/wiki/Q6046488","display_name":"Interferon type I","level":3,"score":0.387800008058548},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.36640000343322754},{"id":"https://openalex.org/C2909523446","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"TOR signaling","level":3,"score":0.34459999203681946},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3375999927520752},{"id":"https://openalex.org/C2776966659","wikidata":"https://www.wikidata.org/wiki/Q18028003","display_name":"IRF7","level":4,"score":0.3366999924182892},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3190999925136566},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3131999969482422},{"id":"https://openalex.org/C123298856","wikidata":"https://www.wikidata.org/wiki/Q15317427","display_name":"NFKB1","level":4,"score":0.3102000057697296},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.30250000953674316},{"id":"https://openalex.org/C183786373","wikidata":"https://www.wikidata.org/wiki/Q5964993","display_name":"Signal transducing adaptor protein","level":3,"score":0.29919999837875366},{"id":"https://openalex.org/C2781121885","wikidata":"https://www.wikidata.org/wiki/Q425517","display_name":"Retinoic acid","level":3,"score":0.29280000925064087},{"id":"https://openalex.org/C2909179924","wikidata":"https://www.wikidata.org/wiki/Q6046488","display_name":"Alpha interferon","level":3,"score":0.28439998626708984},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.2685000002384186},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.25529998540878296},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.25200000405311584}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1128/jvi.00711-26","doi":"https://doi.org/10.1128/jvi.00711-26","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.00711-26","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},{"id":"pmid:43012570","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/43012570","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1128/jvi.00711-26","doi":"https://doi.org/10.1128/jvi.00711-26","is_oa":true,"landing_page_url":"https://doi.org/10.1128/jvi.00711-26","pdf_url":null,"source":{"id":"https://openalex.org/S96615428","display_name":"Journal of Virology","issn_l":"0022-538X","issn":["0022-538X","1070-6321","1098-5514"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Virology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":46,"referenced_works":["https://openalex.org/W1538080804","https://openalex.org/W1601709990","https://openalex.org/W1766732272","https://openalex.org/W1969430178","https://openalex.org/W1985272251","https://openalex.org/W1986608275","https://openalex.org/W1994527775","https://openalex.org/W2020613955","https://openalex.org/W2026189702","https://openalex.org/W2030103839","https://openalex.org/W2041309209","https://openalex.org/W2052408514","https://openalex.org/W2067706259","https://openalex.org/W2074517544","https://openalex.org/W2091129202","https://openalex.org/W2099003198","https://openalex.org/W2119055716","https://openalex.org/W2123026728","https://openalex.org/W2148154918","https://openalex.org/W2155763709","https://openalex.org/W2158308264","https://openalex.org/W2170740154","https://openalex.org/W2177325722","https://openalex.org/W2548437544","https://openalex.org/W2621872115","https://openalex.org/W2748043673","https://openalex.org/W2762571407","https://openalex.org/W2802867560","https://openalex.org/W2921197313","https://openalex.org/W2942584592","https://openalex.org/W3011498764","https://openalex.org/W3028964082","https://openalex.org/W3029417048","https://openalex.org/W3048406079","https://openalex.org/W3136025799","https://openalex.org/W3191254859","https://openalex.org/W4206502832","https://openalex.org/W4210270249","https://openalex.org/W4212845444","https://openalex.org/W4226076948","https://openalex.org/W4288885770","https://openalex.org/W4292080749","https://openalex.org/W4297256899","https://openalex.org/W4315486770","https://openalex.org/W4392710002","https://openalex.org/W4408356410"],"related_works":[],"abstract_inverted_index":{"ABSTRACT":[0],"The":[1],"interferon":[2],"(IFN)-mediated":[3,248],"antiviral":[4,243,281,317,344,360],"immune":[5,15],"response":[6],"is":[7,30,251],"tightly":[8],"regulated":[9],"to":[10,121,142,168,201,240,267],"prevent":[11],"insufficient":[12],"or":[13],"excessive":[14,260],"activation.":[16],"In":[17,46,283,311],"mammals,":[18],"the":[19,82,102,122,131,170,188,268,295,348],"E3":[20,114],"ubiquitin":[21],"ligase":[22,115],"tumor":[23],"necrosis":[24],"factor":[25,27],"receptor-associated":[26],"6":[28],"(TRAF6)":[29],"generally":[31],"considered":[32],"a":[33,93,184,229,276,334],"positive":[34],"regulator":[35,278],"of":[36,97,104,128,152,156,191,204,232,279,294,350],"IFN":[37,84,171,261],"signaling":[38,64,289,297,302],"although":[39],"its":[40,76,166],"role":[41,80,96,231,339],"in":[42,66,81,100,112,130,217,221,235,342,357],"fish":[43,83,255,343],"may":[44,179],"differ.":[45],"this":[47,88,143],"study,":[48],"zebrafish":[49,98,196,233,273],"TRAF6":[50,99,119,178,193,234,274,286,314,341],"showed":[51],"opposing":[52],"regulatory":[53,79,338],"effects":[54],"on":[55],"different":[56],"retinoic":[57],"acid-inducible":[58],"gene":[59,318],"I":[60],"(RIG-I)-like":[61],"receptor":[62],"(RLR)":[63],"components":[65],"overexpression":[67,284],"assays,":[68,285],"but":[69,259],"knockdown":[70],"and":[71,133,139,145,164,290,324,346],"knockout":[72,194],"experiments":[73],"further":[74],"supported":[75],"overall":[77],"negative":[78],"response.":[85,172],"To":[86],"investigate":[87],"inhibitory":[89],"mechanism,":[90],"we":[91,271],"uncovered":[92],"previously":[94,335],"unrecognized":[95,336],"promoting":[101,304],"degradation":[103,144,182,306,309,353],"mitochondrial":[105],"antiviral-signaling":[106],"protein":[107,162,211],"(MAVS)":[108],"under":[109,354],"basal":[110,160,237,355],"conditions":[111,356],"an":[113],"activity-dependent":[116],"manner.":[117],"Zebrafish":[118],"bound":[120],"N-terminal":[123],"caspase":[124],"recruitment":[125],"domain":[126],"(CARD)":[127],"MAVS":[129,136,161,181,210,238,305,352],"cytoplasm":[132],"promoted":[134],"lysosome-dependent":[135],"degradation.":[137],"Lys286":[138],"Lys293":[140],"contributed":[141],"were":[146,213],"required":[147],"for":[148,253,340],"TRAF6-enhanced":[149],"K48-linked":[150],"polyubiquitination":[151],"MAVS.":[153,192],"Simultaneous":[154],"mutation":[155],"both":[157],"residues":[158],"increased":[159,291],"levels":[163,212],"enhanced":[165,199,287,316],"ability":[167],"activate":[169],"Our":[173],"data":[174],"also":[175,214,264],"suggest":[176],"that":[177],"promote":[180],"through":[183,307],"proteasome-dependent":[185],"pathway":[186],"involving":[187],"C-terminal":[189],"region":[190],"(TRAF6-KO)":[195],"exhibited":[197],"significantly":[198,215,325],"resistance":[200],"spring":[202],"viremia":[203],"carp":[205],"virus":[206],"(SVCV)":[207],"infection.":[208,330],"Basal":[209],"higher":[216],"TRAF6-KO":[218],"tissues":[219],"than":[220],"wild-type":[222],"(WT)":[223],"zebrafish.":[224],"Collectively,":[225],"our":[226],"results":[227],"reveal":[228,333],"critical":[230],"regulating":[236,358],"expression":[239],"fine-tune":[241],"IFN-mediated":[242,280,359],"innate":[244,249],"immunity.":[245],"IMPORTANCE":[246],"Interferon":[247],"immunity":[250,345],"essential":[252],"protecting":[254],"against":[256],"viral":[257,322],"infection,":[258],"activation":[262],"can":[263],"be":[265],"harmful":[266],"host.":[269],"Here,":[270],"identify":[272],"as":[275],"dual":[277,337],"signaling.":[282],"RIG-I-mediated":[288],"K63-linked":[292],"ubiquitination":[293],"RIG-I":[296],"complex":[298],"while":[299],"suppressing":[300],"MAVS-mediated":[301],"by":[303],"distinct":[308],"pathways.":[310],"vivo":[312],",":[313],"deficiency":[315],"expression,":[319],"reduced":[320],"infectious":[321],"titers,":[323],"improved":[326],"survival":[327],"following":[328],"SVCV":[329],"These":[331],"findings":[332],"highlight":[347],"importance":[349],"TRAF6-mediated":[351],"responses.":[361]},"counts_by_year":[],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2026-11-12T00:00:00"}
